LOCUS       XM_006511707            5302 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  PREDICTED: Mus musculus topoisomerase (DNA) II binding protein 1
            (Topbp1), transcript variant X2, mRNA.
ACCESSION   XM_006511707
VERSION     XM_006511707.4
DBLINK      BioProject: PRJNA169
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000075.7) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Aug 8, 2019 this sequence version replaced XM_006511707.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001635.27-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/01/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5302
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6J"
                     /db_xref="taxon:10090"
                     /chromosome="9"
     gene            1..5302
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /note="topoisomerase (DNA) II binding protein 1; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 8 mRNAs, 167 ESTs, 721 long SRA reads, 7 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 17 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:235559"
                     /db_xref="MGI:MGI:1920018"
     CDS             243..4790
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /codon_start=1
                     /product="DNA topoisomerase 2-binding protein 1 isoform
                     X2"
                     /protein_id="XP_006511770.1"
                     /db_xref="GeneID:235559"
                     /db_xref="MGI:MGI:1920018"
                     /translation="MSRNDQEPFLVKFLKSSDNSECFFKALESIKELQSEDYLQIITD
                     EEALKIRENDKSLYICDRFSGTVFDHLKQLGCRIVGPQVVTFCMRHQQCVPRAEHPVY
                     NMIMSDVTVSCTSLDKDKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAA
                     NLKKPILLPSWIKTLWEKSQEKKITKYTDVNMEDFKCPIFLGCIICVTGLNGIHRKTV
                     QQLTAKHGGQYMGQLKMNECTHLIVQEPKGQKYECARRWNVHCVTLQWFHDSIEKGFC
                     QDESIYKAETRVEAKMVPDTSTPTAQSNAESHTLADVSHISNINGSCVNETMFGSTTS
                     KLECSLENLENLDISMFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLN
                     EDVTHVIVGDYDDDVRQFWSKSSHRPHVVGAKWLLECFTKGYILPEESYIHTNYQPAG
                     IAVSDQPGNQTAVLDKSGSFSKSALVPAERLQQADEDLLAQYGNDDSTMVEAKLSEAL
                     EPEVGPCPGSAHREPCDDSTHISVQEENKSSVSHCILDDSTVREEGLFSQKSFLVLGF
                     SVENKCNIVDIIREHAGKIVSLPSRIVADYAVVPLLGCEVDVTVGEVVTNTWLVTCID
                     NQTLVDPKSNPLFTPVSVMSGVTPLEDCVISFSQCVGAERDSLVFLANHLGASVQEFF
                     VRKANAKKGMLASTHLIVKEPTGSKYEAAKKWSLPAVNISWLLETARIGKRADENHFL
                     VDNAPKQEQVLETKIPNGVSSNPDLPAHPDAHLEIHRKKAVTPLDMNRFQSRAFRAVI
                     SQQRGQDPTFPPVRQPLTKEPSLHLDTPSKFLSKDKLFKPSFDVTDALAALETPNAAS
                     QKRKLSSPLSEVIVRNLTVALANSSRNTDSHSASPQLKGAHLEEEETRKPLDSVVVCV
                     SKKLSKKQSELNGVAASLGAEYRWSFDETVTHFIYQGRANDSNREYKSAKERGVHIVS
                     EHWLLECAQEYKHLPESLYPHTYNPKMSLDINTVQDGRLCNSRAPLAVSASKDDGPDH
                     LSVEGNETNTMGTNDKESPLLNGSGRDDCKGALTQALEMRENFQKQLQEIMSATCIVK
                     TPAQKTCMSRSSCNSASSTPDSARSVRSGRSRVLEALRQSRQAVPDVNTEPSQNEQII
                     WDDPTAREERARLASNLQWPSDPTQHSELQVEIKMPDDSPSRKPVYHSEIAEQASCVT
                     QAPGHPGSEEPEPPVAERPLIPEPQAPAVASPLAKPPVAPQPADKIETQEETHRKVKK
                     QYVFQMSSLNSQERIDYCRLIKDLGGSVIEKQCSDPSCTHMVVGYPLRNEKYLASMAA
                     GKWVLHRSYLDACKTAGRFVQEEDYEWGSSSILDALPDVTEHQQKLALAAMRWRKRIQ
                     QSQESGIVEGAFSGWKAILRVDRPREAGFKRLLQAGGAKVLSGHPEPLLKDATHLFCD
                     FNKLKPDDCRVFIAEATAQNMVCLKTEYIADYLMLESPPCADNYRVSEAALFHNKKGG
                     PGLPQKRKTPAENVVKRPRVH"
ORIGIN      
        1 cgcccggcgc ctcttgcggc cttcgcgcct ctcctaaccg gcgggtgggc ctcaggtccc
       61 tggggagccg cggcctggac gctcctttcc ctgggagctg ggccgagcgt gcacgacctt
      121 gcacggtggc tgcttgcgtt cagagttcgt taacttagga gcaaatcttg cgggctgtgg
      181 gtacccgtag ccgcagcggc gccctgcgtc gtcttaagcc ccatgcaagt gaacattcag
      241 ctatgtccag aaatgaccaa gagccgtttc ttgtgaagtt tttaaagtct tcggacaatt
      301 cagaatgctt ttttaaagct cttgagtcaa taaaggaatt acaatcagaa gattatcttc
      361 agattattac agatgaggaa gcattgaaga taagagagaa tgacaaatcg ctttatatct
      421 gtgaccgttt cagtggcact gtttttgatc accttaaaca gcttggctgc aggattgttg
      481 gtcctcaagt ggtcacattt tgtatgcgcc accagcaatg tgtcccaaga gctgagcatc
      541 cagtctacaa catgataatg tctgacgtaa ctgtatcctg tacaagcctg gataaagaca
      601 aacgggaaga agttcataaa tacgtacaaa tgatgggtgg acgagtatac agagacctta
      661 atgtatcagt cactcacctt attgcaggag aagttgggag caaaaagtac ttagttgctg
      721 ctaatctgaa gaagcctatt ttgctacctt cttggataaa aaccctttgg gagaagtcac
      781 aagaaaaaaa aataaccaag tacactgatg taaacatgga agactttaag tgtcctattt
      841 ttcttggttg cattatctgt gtgactggct taaatggaat acacagaaag acagtccagc
      901 aactcacggc taagcacgga ggccagtaca tgggacagtt gaagatgaat gagtgtacac
      961 acctcattgt gcaagaacca aaaggacaaa aatacgaatg tgccaggaga tggaatgtgc
     1021 actgtgtgac cctgcaatgg tttcatgaca gtattgagaa aggcttttgt caggatgaat
     1081 ctatatacaa ggctgaaacc agagtagaag caaagatggt gcctgatact tcaacaccca
     1141 ctgctcagag caatgctgaa agtcacacgc tcgcagatgt cagccatata tccaacataa
     1201 atggcagctg tgtaaatgaa acaatgtttg gttcaactac tagcaaactt gaatgttccc
     1261 ttgaaaacct agaaaatctg gacatcagta tgtttcaagc tcctgaagac ttattagatg
     1321 gctgtcggat atatctttgt ggttttagtg gcagaaagct ggataagctg agaaggctta
     1381 ttaacagtgg aggtggagtt cgatttaatc aactaaatga agatgtaact catgtaattg
     1441 tgggagatta tgatgacgac gtgaggcagt tctggagcaa atcatctcac aggcctcacg
     1501 tagtgggagc aaagtggttg ctggagtgtt ttactaaagg atatatactt cctgaagagt
     1561 cctatatcca cactaactac cagccagctg gaattgcagt ttccgatcag cctggaaacc
     1621 agacagctgt cttagacaag agcggctcat tctccaagag cgcccttgtt cctgctgaga
     1681 ggcttcagca ggccgacgag gatctgcttg ctcagtatgg aaatgacgac tccacgatgg
     1741 ttgaagctaa gctatctgaa gctttagagc ctgaagtcgg gccttgccct ggttctgctc
     1801 accgtgagcc ctgtgatgat tccactcaca tttctgtgca agaggaaaac aagtcgtctg
     1861 tcagtcattg catccttgat gactctacag ttcgtgaaga aggcttattt agccagaaga
     1921 gtttccttgt tttgggtttt agtgttgaaa ataaatgtaa tattgtagac atcataagag
     1981 agcatgctgg caagattgtg tcccttccca gcagaattgt tgctgactat gctgtggttc
     2041 cactgctggg atgtgaggta gacgtgacgg tgggagaagt tgttacaaac acgtggctgg
     2101 ttacgtgtat agacaaccag acattagttg atcccaagtc gaatcccctc ttcacaccag
     2161 tctcagtaat gtcgggagtg actcctttag aggactgtgt gatttccttc agtcagtgtg
     2221 tgggagcaga aagagattcc ttggtattct tagcaaatca ccttggagca agtgttcaag
     2281 aattctttgt tcgcaaagcc aatgcaaaga aaggcatgct cgccagcaca catcttatag
     2341 tgaaggaacc gactggttcc aaatacgaag ctgcaaagaa atggagtttg ccggcagtta
     2401 acatttcatg gctcttagaa actgcgagaa tcgggaagag agcagatgaa aaccattttc
     2461 tggttgacaa cgcacctaaa caagaacaag ttttagaaac taagatacca aatggagtga
     2521 gttcaaatcc agatttacca gcacatcctg acgcacactt ggaaattcac agaaaaaagg
     2581 cggttacacc tttggacatg aatcgctttc agagtagagc cttccgtgct gtcatttcac
     2641 agcagagggg gcaggacccc acctttccac cagtacggca gccccttact aaggagccct
     2701 ctttacacct ggacacacca tcaaagtttc tgtccaagga caagcttttc aagccatcct
     2761 ttgatgtgac ggatgcactt gcagccctgg aaaccccaaa tgctgccagc cagaagcgga
     2821 aactaagctc accactctct gaagtcatcg tcagaaacct gacagttgct ttggcaaata
     2881 gttcccgaaa cactgacagt cattctgcca gccctcagct gaagggtgcc catttggagg
     2941 aggaagagac tcggaaacca cttgacagcg ttgtggtgtg tgtgagtaag aagctcagta
     3001 agaagcagag tgagctcaat ggggtcgcag catcactggg agcagagtac aggtggagtt
     3061 tcgatgagac tgttactcat ttcatttacc agggtcgggc aaatgacagt aatcgagaat
     3121 ataaatctgc aaaggaaaga ggggtgcaca tcgtgtccga gcattggcta ttagagtgtg
     3181 ctcaagagta taagcatctt cctgaatctc tttatccaca cacttacaat cccaaaatga
     3241 gtttggacat caacacagtg caagatgggc ggctctgtaa cagccgggca cccttggcag
     3301 tttctgcatc taaggatgat gggccagatc atctgtctgt agaaggaaat gagacaaaca
     3361 ctatgggcac aaatgacaaa gagtcacctc tgttgaatgg gagtggaaga gatgactgta
     3421 aaggagctct gacccaggcc ttggagatga gagagaactt ccagaagcag ctgcaagaga
     3481 tcatgtcagc cacctgcatt gtgaagacgc ctgcccagaa gacttgcatg tcaagaagca
     3541 gctgtaacag cgcctcttca actcctgaca gcgctcgctc tgtgcggagc ggacgaagcc
     3601 gagtcctgga ggcactcagg cagtctcggc aggcagtgcc tgatgtgaac acggagccgt
     3661 cccagaacga gcagatcatt tgggacgacc cgacagcaag ggaagagaga gcaaggcttg
     3721 ccagcaactt acagtggccc agcgacccca cacagcattc tgagcttcag gttgagataa
     3781 aaatgccgga tgactctccc tctcgaaagc ctgtgtacca ttcagaaatt gctgagcagg
     3841 cctcgtgtgt tactcaagcc ccagggcacc caggctctga agaaccagag cctccagtag
     3901 cagaaaggcc tttgatcccc gagccgcaag cccccgctgt agcttccccc ctggctaagc
     3961 cgcctgtggc cccacaacct gcagacaaga ttgaaacaca ggaggagacg cacagaaaag
     4021 ttaaaaaaca gtatgtgttc cagatgtcgt ctctgaattc tcaagagcgg attgattact
     4081 gtcgcctgat taaagactta ggtgggtcgg tgatcgagaa gcagtgctct gaccccagct
     4141 gcacacacat ggttgtgggc tacccactgc gcaatgagaa gtacttagct tctatggcag
     4201 ctggtaaatg ggtgcttcat cgctcctacc tagacgcttg caagacagct gggcgctttg
     4261 tgcaggaaga agactacgag tggggaagta gctccatact tgatgctctc cctgacgtca
     4321 ctgagcacca gcagaagctc gcactggcgg caatgagatg gaggaaaaga atccagcaaa
     4381 gtcaagaatc cggcattgtt gagggagcat ttagtggctg gaaagctatt ttacgtgttg
     4441 atcggccccg agaagctggg ttcaaacgcc ttcttcaggc aggaggagca aaggtgttat
     4501 ctggtcatcc agaaccttta cttaaagatg ctacgcatct cttttgtgac ttcaataaac
     4561 tgaaacctga tgactgcaga gttttcatcg cagaggctac tgcccagaac atggtctgct
     4621 tgaaaacaga atatatcgct gattatctca tgctggaatc ccctccttgt gcagacaatt
     4681 accgtgtatc cgaagctgct ttattccata ataagaaagg tgggcctgga ttaccacaga
     4741 agaggaaaac tcctgcagag aatgtagtca aacggcctcg agtacactga agtgagccat
     4801 acacaaccac ccaacgaatg tttttgagtt tagtgtgctt gcctaaaatg tataaagtgc
     4861 actagaaaat tttcagctac aacctgaaca ttgctgtgat gcatttgtgt agcagtttaa
     4921 aggcatacat ctgaaggact atgcttcaga ttctaatgat cctgtaaact ggataccttt
     4981 aacctgaatt tgaatcactg gttattgact gttcctaatg aggctgaaat agttttaaca
     5041 aggagatttg tttcaaaaat gtcatagttc ataaaagcaa aagttataca ttagggttat
     5101 ttcatgtttt cctgattttt atatatgtat tcttgccatt taacctcttt aacagcctga
     5161 gcagagagtt taacaatgaa gctggggctc taaacttaaa atatgtatat atgtaaatgt
     5221 gtgtatgtat aaacttctat catttgccaa acttgggcac caaaactttg agataaagaa
     5281 taaaaaaaaa tagcaactta aa
//
