LOCUS       NM_176979               5112 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus topoisomerase (DNA) II binding protein 1 (Topbp1),
            mRNA.
ACCESSION   NM_176979
VERSION     NM_176979.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5112)
  AUTHORS   Ascencao,C., Sims,J.R., Dziubek,A., Comstock,W., Fogarty,E.A.,
            Badar,J., Freire,R., Grimson,A., Weiss,R.S., Cohen,P.E. and
            Smolka,M.B.
  TITLE     A TOPBP1 allele causing male infertility uncouples XY silencing
            dynamics from sex body formation
  JOURNAL   Elife 12, 90887 (2024)
   PUBMED   38391183
  REMARK    GeneRIF: A TOPBP1 allele causing male infertility uncouples XY
            silencing dynamics from sex body formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5112)
  AUTHORS   Leem,J., Kim,J.S. and Oh,J.S.
  TITLE     Oocytes can repair DNA damage during meiosis via a
            microtubule-dependent recruitment of CIP2A-MDC1-TOPBP1 complex from
            spindle pole to chromosomes
  JOURNAL   Nucleic Acids Res 51 (10), 4899-4913 (2023)
   PUBMED   36999590
  REMARK    GeneRIF: Oocytes can repair DNA damage during meiosis via a
            microtubule-dependent recruitment of CIP2A-MDC1-TOPBP1 complex from
            spindle pole to chromosomes.
REFERENCE   3  (bases 1 to 5112)
  AUTHORS   Hoye,M.L., Calviello,L., Poff,A.J., Ejimogu,N.E., Newman,C.R.,
            Montgomery,M.D., Ou,J., Floor,S.N. and Silver,D.L.
  TITLE     Aberrant cortical development is driven by impaired cell cycle and
            translational control in a DDX3X syndrome model
  JOURNAL   Elife 11, e78203 (2022)
   PUBMED   35762573
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5112)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5112)
  AUTHORS   Jeon,Y., Park,M.K., Kim,S.M., Bae,J.S., Lee,C.W. and Lee,H.
  TITLE     TopBP1 deficiency impairs the localization of proteins involved in
            early recombination and results in meiotic chromosome defects
            during spermatogenesis
  JOURNAL   Biochem Biophys Res Commun 508 (3), 722-728 (2019)
   PUBMED   30528234
  REMARK    GeneRIF: TopBP1 deficiency during spermatogenesis impairs the
            localization of proteins involved in early recombination at DNA
            double-strand break, results in meiotic chromosome defects and
            leads to infertility.
REFERENCE   6  (bases 1 to 5112)
  AUTHORS   Perera,D., Perez-Hidalgo,L., Moens,P.B., Reini,K., Lakin,N.,
            Syvaoja,J.E., San-Segundo,P.A. and Freire,R.
  TITLE     TopBP1 and ATR colocalization at meiotic chromosomes: role of
            TopBP1/Cut5 in the meiotic recombination checkpoint
  JOURNAL   Mol Biol Cell 15 (4), 1568-1579 (2004)
   PUBMED   14718568
  REMARK    GeneRIF: ATR and TopBP1 monitor meiotic recombination and are
            required for activation of the meiotic recombination checkpoint
REFERENCE   7  (bases 1 to 5112)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 5112)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 5112)
  AUTHORS   Lemon,W.J., Bernert,H., Sun,H., Wang,Y. and You,M.
  TITLE     Identification of candidate lung cancer susceptibility genes in
            mouse using oligonucleotide arrays
  JOURNAL   J Med Genet 39 (9), 644-655 (2002)
   PUBMED   12205107
REFERENCE   10 (bases 1 to 5112)
  AUTHORS   Omran,H., Haffner,K., Burth,S., Fernandez,C., Fargier,B.,
            Villaquiran,A., Nothwang,H.G., Schnittger,S., Lehrach,H., Woo,D.,
            Brandis,M., Sudbrak,R. and Hildebrandt,F.
  TITLE     Human adolescent nephronophthisis: gene locus synteny with
            polycystic kidney disease in pcy mice
  JOURNAL   J Am Soc Nephrol 12 (1), 107-113 (2001)
   PUBMED   11134256
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC122747.11.
            
            On Nov 17, 2006 this sequence version replaced NM_176979.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049797.1, AK129104.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC122747.11        86612-86656
            46-136              AC122747.11        87382-87472
            137-271             AC122747.11        90030-90164
            272-415             AC122747.11        91102-91245
            416-597             AC122747.11        92779-92960
            598-794             AC122747.11        94057-94253
            795-971             AC122747.11        96339-96515
            972-1138            AC122747.11        99272-99438
            1139-1302           AC122747.11        101454-101617
            1303-1550           AC122747.11        101759-102006
            1551-1909           AC122747.11        104553-104911
            1910-2082           AC122747.11        105612-105784
            2083-2294           AC122747.11        106927-107138
            2295-2581           AC122747.11        109692-109978
            2582-2752           AC122747.11        113970-114140
            2753-2862           AC122747.11        114230-114339
            2863-2986           AC122747.11        115341-115464
            2987-3133           AC122747.11        117097-117243
            3134-3236           AC122747.11        117349-117451
            3237-3429           AC122747.11        119465-119657
            3430-3650           AC122747.11        123213-123433
            3651-3799           AC122747.11        124833-124981
            3800-3911           AC122747.11        125210-125321
            3912-4075           AC122747.11        126076-126239
            4076-4213           AC122747.11        127027-127164
            4214-4303           AC122747.11        127969-128058
            4304-4465           AC122747.11        128212-128373
            4466-5112           AC122747.11        131067-131713
FEATURES             Location/Qualifiers
     source          1..5112
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 55.19 cM"
     gene            1..5112
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /note="topoisomerase (DNA) II binding protein 1"
                     /db_xref="GeneID:235559"
                     /db_xref="MGI:MGI:1920018"
     exon            1..45
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            46..136
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..4600
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /note="topoisomerase (DNA) II beta binding protein; DNA
                     topoisomerase II-binding protein 1; DNA topoisomerase
                     II-beta-binding protein 1"
                     /codon_start=1
                     /product="DNA topoisomerase 2-binding protein 1"
                     /protein_id="NP_795953.2"
                     /db_xref="CCDS:CCDS23453.1"
                     /db_xref="GeneID:235559"
                     /db_xref="MGI:MGI:1920018"
                     /translation="MSRNDQEPFLVKFLKSSDNSECFFKALESIKELQSEDYLQIITD
                     EEALKIRENDKSLYICDRFSGTVFDHLKQLGCRIVGPQVVTFCMRHQQCVPRAEHPVY
                     NMIMSDVTVSCTSLDKDKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAA
                     NLKKPILLPSWIKTLWEKSQEKKITKYTDVNMEDFKCPIFLGCIICVTGLNGIHRKTV
                     QQLTAKHGGQYMGQLKMNECTHLIVQEPKGQKYECARRWNVHCVTLQWFHDSIEKGFC
                     QDESIYKAETRVEAKMVPDTSTPTAQSNAESHTLADVSHISNINGSCVNETMFGSTTS
                     KLECSLENLENLDISMFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLN
                     EDVTHVIVGDYDDDVRQFWSKSSHRPHVVGAKWLLECFTKGYILPEESYIHTNYQPAG
                     IAVSDQPGNQTAVLDKSGSFSKSALVPAERLQQADEDLLAQYGNDDSTMVEAKLSEAL
                     EPEVGPCPGSAHREPCDDSTHISVQEENKSSVSHCILDDSTVREEGLFSQKSFLVLGF
                     SVENKCNIVDIIREHAGKIVSLPSRIVADYAVVPLLGCEVDVTVGEVVTNTWLVTCID
                     NQTLVDPKSNPLFTPVSVMSGVTPLEDCVISFSQCVGAERDSLVFLANHLGASVQEFF
                     VRKANAKKGMLASTHLIVKEPTGSKYEAAKKWSLPAVNISWLLETARIGKRADENHFL
                     VDNAPKQEQVLETKIPNGVSSNPDLPAHPDAHLEIHRKKAVTPLDMNRFQSRAFRAVI
                     SQQRGQDPTFPPVRQPLTKEPSLHLDTPSKFLSKDKLFKPSFDVTDALAALETPNAAS
                     QKRKLSSPLSEVIVRNLTVALANSSRNTDSHSASPQLKGAHLEEEETRKPLDSVVVCV
                     SKKLSKKQSELNGVAASLGAEYRWSFDETVTHFIYQGRANDSNREYKSAKERGVHIVS
                     EHWLLECAQEYKHLPESLYPHTYNPKMSLDINTVQDGRLCNSRAPLAVSASKDDGPDH
                     LSVEGNETNTMGTNDKESPLLNGSGRDDCKGALTQALEMRENFQKQLQEIMSATCIVK
                     TPAQKTCMSRSSCNSASSTPDSARSVRSGRSRVLEALRQSRQAVPDVNTEPSQNEQII
                     WDDPTAREERARLASNLQWPSDPTQHSELQVEIKMPDDSPSRKPVYHSEIAEQASCVT
                     QAPGHPGSEEPEPPVAERPLIPEPQAPAVASPLAKPPVAPQPADKIETQEETHRKVKK
                     QYVFQMSSLNSQERIDYCRLIKDLGGSVIEKQCSDPSCTHMVVGYPLRNEKYLASMAA
                     GKWVLHRSYLDACKTAGRFVQEEDYEWGSSSILDALPDVTEHQQKLALAAMRWRKRIQ
                     QSQESGIVEGAFSGWKAILRVDRPREAGFKRLLQAGGAKVLSGHPEPLLKDATHLFCD
                     FNKLKPDDCRVFIAEATAQNMVCLKTEYIADYLMLESPPCADNYRVSEAALFHNKKGG
                     PGLPQKRKTPAENVVKRPRVH"
     exon            137..271
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            272..415
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            416..597
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            598..794
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            795..971
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1138
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1302
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1550
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1909
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2082
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2294
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2581
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2752
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2862
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..2986
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3133
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3236
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            3237..3429
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            3430..3650
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            3651..3799
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            3800..3911
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            3912..4075
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            4076..4213
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            4214..4303
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            4304..4465
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     exon            4466..5112
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5089..5094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /note="hexamer: AATAAA"
     polyA_site      5112
                     /gene="Topbp1"
                     /gene_synonym="1110031N14Rik; 2810429C13Rik;
                     D430026L04Rik; mKIAA0259"
                     /note="major polyA site"
ORIGIN      
        1 cgcgcccccc gacttggtgc ccgtgggccc tcgggctcca cctagttcag ctatgtccag
       61 aaatgaccaa gagccgtttc ttgtgaagtt tttaaagtct tcggacaatt cagaatgctt
      121 ttttaaagct cttgagtcaa taaaggaatt acaatcagaa gattatcttc agattattac
      181 agatgaggaa gcattgaaga taagagagaa tgacaaatcg ctttatatct gtgaccgttt
      241 cagtggcact gtttttgatc accttaaaca gcttggctgc aggattgttg gtcctcaagt
      301 ggtcacattt tgtatgcgcc accagcaatg tgtcccaaga gctgagcatc cagtctacaa
      361 catgataatg tctgacgtaa ctgtatcctg tacaagcctg gataaagaca aacgggaaga
      421 agttcataaa tacgtacaaa tgatgggtgg acgagtatac agagacctta atgtatcagt
      481 cactcacctt attgcaggag aagttgggag caaaaagtac ttagttgctg ctaatctgaa
      541 gaagcctatt ttgctacctt cttggataaa aaccctttgg gagaagtcac aagaaaaaaa
      601 aataaccaag tacactgatg taaacatgga agactttaag tgtcctattt ttcttggttg
      661 cattatctgt gtgactggct taaatggaat acacagaaag acagtccagc aactcacggc
      721 taagcacgga ggccagtaca tgggacagtt gaagatgaat gagtgtacac acctcattgt
      781 gcaagaacca aaaggacaaa aatacgaatg tgccaggaga tggaatgtgc actgtgtgac
      841 cctgcaatgg tttcatgaca gtattgagaa aggcttttgt caggatgaat ctatatacaa
      901 ggctgaaacc agagtagaag caaagatggt gcctgatact tcaacaccca ctgctcagag
      961 caatgctgaa agtcacacgc tcgcagatgt cagccatata tccaacataa atggcagctg
     1021 tgtaaatgaa acaatgtttg gttcaactac tagcaaactt gaatgttccc ttgaaaacct
     1081 agaaaatctg gacatcagta tgtttcaagc tcctgaagac ttattagatg gctgtcggat
     1141 atatctttgt ggttttagtg gcagaaagct ggataagctg agaaggctta ttaacagtgg
     1201 aggtggagtt cgatttaatc aactaaatga agatgtaact catgtaattg tgggagatta
     1261 tgatgacgac gtgaggcagt tctggagcaa atcatctcac aggcctcacg tagtgggagc
     1321 aaagtggttg ctggagtgtt ttactaaagg atatatactt cctgaagagt cctatatcca
     1381 cactaactac cagccagctg gaattgcagt ttccgatcag cctggaaacc agacagctgt
     1441 cttagacaag agcggctcat tctccaagag cgcccttgtt cctgctgaga ggcttcagca
     1501 ggccgacgag gatctgcttg ctcagtatgg aaatgacgac tccacgatgg ttgaagctaa
     1561 gctatctgaa gctttagagc ctgaagtcgg gccttgccct ggttctgctc accgtgagcc
     1621 ctgtgatgat tccactcaca tttctgtgca agaggaaaac aagtcgtctg tcagtcattg
     1681 catccttgat gactctacag ttcgtgaaga aggcttattt agccagaaga gtttccttgt
     1741 tttgggtttt agtgttgaaa ataaatgtaa tattgtagac atcataagag agcatgctgg
     1801 caagattgtg tcccttccca gcagaattgt tgctgactat gctgtggttc cactgctggg
     1861 atgtgaggta gacgtgacgg tgggagaagt tgttacaaac acgtggctgg ttacgtgtat
     1921 agacaaccag acattagttg atcccaagtc gaatcccctc ttcacaccag tctcagtaat
     1981 gtcgggagtg actcctttag aggactgtgt gatttccttc agtcagtgtg tgggagcaga
     2041 aagagattcc ttggtattct tagcaaatca ccttggagca agtgttcaag aattctttgt
     2101 tcgcaaagcc aatgcaaaga aaggcatgct cgccagcaca catcttatag tgaaggaacc
     2161 gactggttcc aaatacgaag ctgcaaagaa atggagtttg ccggcagtta acatttcatg
     2221 gctcttagaa actgcgagaa tcgggaagag agcagatgaa aaccattttc tggttgacaa
     2281 cgcacctaaa caagaacaag ttttagaaac taagatacca aatggagtga gttcaaatcc
     2341 agatttacca gcacatcctg acgcacactt ggaaattcac agaaaaaagg cggttacacc
     2401 tttggacatg aatcgctttc agagtagagc cttccgtgct gtcatttcac agcagagggg
     2461 gcaggacccc acctttccac cagtacggca gccccttact aaggagccct ctttacacct
     2521 ggacacacca tcaaagtttc tgtccaagga caagcttttc aagccatcct ttgatgtgac
     2581 ggatgcactt gcagccctgg aaaccccaaa tgctgccagc cagaagcgga aactaagctc
     2641 accactctct gaagtcatcg tcagaaacct gacagttgct ttggcaaata gttcccgaaa
     2701 cactgacagt cattctgcca gccctcagct gaagggtgcc catttggagg aggaagagac
     2761 tcggaaacca cttgacagcg ttgtggtgtg tgtgagtaag aagctcagta agaagcagag
     2821 tgagctcaat ggggtcgcag catcactggg agcagagtac aggtggagtt tcgatgagac
     2881 tgttactcat ttcatttacc agggtcgggc aaatgacagt aatcgagaat ataaatctgc
     2941 aaaggaaaga ggggtgcaca tcgtgtccga gcattggcta ttagagtgtg ctcaagagta
     3001 taagcatctt cctgaatctc tttatccaca cacttacaat cccaaaatga gtttggacat
     3061 caacacagtg caagatgggc ggctctgtaa cagccgggca cccttggcag tttctgcatc
     3121 taaggatgat gggccagatc atctgtctgt agaaggaaat gagacaaaca ctatgggcac
     3181 aaatgacaaa gagtcacctc tgttgaatgg gagtggaaga gatgactgta aaggagctct
     3241 gacccaggcc ttggagatga gagagaactt ccagaagcag ctgcaagaga tcatgtcagc
     3301 cacctgcatt gtgaagacgc ctgcccagaa gacttgcatg tcaagaagca gctgtaacag
     3361 cgcctcttca actcctgaca gcgctcgctc tgtgcggagc ggacgaagcc gagtcctgga
     3421 ggcactcagg cagtctcggc aggcagtgcc tgatgtgaac acggagccgt cccagaacga
     3481 gcagatcatt tgggacgacc cgacagcaag ggaagagaga gcaaggcttg ccagcaactt
     3541 acagtggccc agcgacccca cacagcattc tgagcttcag gttgagataa aaatgccgga
     3601 tgactctccc tctcgaaagc ctgtgtacca ttcagaaatt gctgagcagg cctcgtgtgt
     3661 tactcaagcc ccagggcacc caggctctga agaaccagag cctccagtag cagaaaggcc
     3721 tttgatcccc gagccgcaag cccccgctgt agcttccccc ctggctaagc cgcctgtggc
     3781 cccacaacct gcagacaaga ttgaaacaca ggaggagacg cacagaaaag ttaaaaaaca
     3841 gtatgtgttc cagatgtcgt ctctgaattc tcaagagcgg attgattact gtcgcctgat
     3901 taaagactta ggtgggtcgg tgatcgagaa gcagtgctct gaccccagct gcacacacat
     3961 ggttgtgggc tacccactgc gcaatgagaa gtacttagct tctatggcag ctggtaaatg
     4021 ggtgcttcat cgctcctacc tagacgcttg caagacagct gggcgctttg tgcaggaaga
     4081 agactacgag tggggaagta gctccatact tgatgctctc cctgacgtca ctgagcacca
     4141 gcagaagctc gcactggcgg caatgagatg gaggaaaaga atccagcaaa gtcaagaatc
     4201 cggcattgtt gagggagcat ttagtggctg gaaagctatt ttacgtgttg atcggccccg
     4261 agaagctggg ttcaaacgcc ttcttcaggc aggaggagca aaggtgttat ctggtcatcc
     4321 agaaccttta cttaaagatg ctacgcatct cttttgtgac ttcaataaac tgaaacctga
     4381 tgactgcaga gttttcatcg cagaggctac tgcccagaac atggtctgct tgaaaacaga
     4441 atatatcgct gattatctca tgctggaatc ccctccttgt gcagacaatt accgtgtatc
     4501 cgaagctgct ttattccata ataagaaagg tgggcctgga ttaccacaga agaggaaaac
     4561 tcctgcagag aatgtagtca aacggcctcg agtacactga agtgagccat acacaaccac
     4621 ccaacgaatg tttttgagtt tagtgtgctt gcctaaaatg tataaagtgc actagaaaat
     4681 tttcagctac aacctgaaca ttgctgtgat gcatttgtgt agcagtttaa aggcatacat
     4741 ctgaaggact atgcttcaga ttctaatgat cctgtaaact ggataccttt aacctgaatt
     4801 tgaatcactg gttattgact gttcctaatg aggctgaaat agttttaaca aggagatttg
     4861 tttcaaaaat gtcatagttc ataaaagcaa aagttataca ttagggttat ttcatgtttt
     4921 cctgattttt atatatgtat tcttgccatt taacctcttt aacagcctga gcagagagtt
     4981 taacaatgaa gctggggctc taaacttaaa atatgtatat atgtaaatgt gtgtatgtat
     5041 aaacttctat catttgccaa acttgggcac caaaactttg agataaagaa taaaaaaaaa
     5101 tagcaactta aa
//
