LOCUS       NM_011624               3129 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus topoisomerase (DNA) III beta (Top3b), transcript
            variant 1, mRNA.
ACCESSION   NM_011624
VERSION     NM_011624.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3129)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3129)
  AUTHORS   Zhu,X., Joo,Y., Bossi,S., McDevitt,R.A., Xie,A., Wang,Y., Xue,Y.,
            Su,S., Lee,S.K., Sah,N., Zhang,S., Ye,R., Pinto,A., Zhang,Y.,
            Araki,K., Araki,M., Morales,M., Mattson,M.P., van Praag,H. and
            Wang,W.
  TITLE     Tdrd3-null mice show post-transcriptional and behavioral
            impairments associated with neurogenesis and synaptic plasticity
  JOURNAL   Prog Neurobiol 233, 102568 (2024)
   PUBMED   38216113
REFERENCE   3  (bases 1 to 3129)
  AUTHORS   Cuarenta,A., Kigar,S.L., Keese,A.P., Guagliardo,S.E., Chang,L.,
            Bakshi,V.P. and Auger,A.P.
  TITLE     DNA topoisomerase Top3beta is impacted by early life stress in the
            developing female and male rat brain
  JOURNAL   Brain Res 1809, 148339 (2023)
   PUBMED   36966960
  REMARK    GeneRIF: DNA topoisomerase Top3beta is impacted by early life
            stress in the developing female and male rat brain.
REFERENCE   4  (bases 1 to 3129)
  AUTHORS   Rahman,F.U., Kim,Y.R., Kim,E.K., Kim,H.R., Cho,S.M., Lee,C.S.,
            Kim,S.J., Araki,K., Yamamura,K.I., Lee,M.N., Park,S.G., Yoon,W.K.,
            Lee,K., Won,Y.S., Kim,H.C., Lee,Y., Lee,H.Y. and Nam,K.H.
  TITLE     Topoisomerase IIIbeta Deficiency Induces Neuro-Behavioral Changes
            and Brain Connectivity Alterations in Mice
  JOURNAL   Int J Mol Sci 22 (23), 12806 (2021)
   PUBMED   34884616
  REMARK    GeneRIF: Topoisomerase IIIbeta Deficiency Induces Neuro-Behavioral
            Changes and Brain Connectivity Alterations in Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3129)
  AUTHORS   Joo,Y., Xue,Y., Wang,Y., McDevitt,R.A., Sah,N., Bossi,S., Su,S.,
            Lee,S.K., Peng,W., Xie,A., Zhang,Y., Ding,Y., Ku,W.L., Ghosh,S.,
            Fishbein,K., Shen,W., Spencer,R., Becker,K., Zhao,K., Mattson,M.P.,
            van Praag,H., Sharov,A. and Wang,W.
  TITLE     Topoisomerase 3beta knockout mice show transcriptional and
            behavioural impairments associated with neurogenesis and synaptic
            plasticity
  JOURNAL   Nat Commun 11 (1), 3143 (2020)
   PUBMED   32561719
  REMARK    GeneRIF: Topoisomerase 3beta knockout mice show transcriptional and
            behavioural impairments associated with neurogenesis and synaptic
            plasticity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3129)
  AUTHORS   Kwan,K.Y., Moens,P.B. and Wang,J.C.
  TITLE     Infertility and aneuploidy in mice lacking a type IA DNA
            topoisomerase III beta
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2526-2531 (2003)
   PUBMED   12591952
  REMARK    GeneRIF: DNA topoisomerase III beta has a role in infertility and
            aneuploidy
REFERENCE   7  (bases 1 to 3129)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3129)
  AUTHORS   Kwan,K.Y. and Wang,J.C.
  TITLE     Mice lacking DNA topoisomerase IIIbeta develop to maturity but show
            a reduced mean lifespan
  JOURNAL   Proc Natl Acad Sci U S A 98 (10), 5717-5721 (2001)
   PUBMED   11331780
REFERENCE   9  (bases 1 to 3129)
  AUTHORS   Wilson,T.M., Chen,A.D. and Hsieh,T.
  TITLE     Cloning and characterization of Drosophila topoisomerase IIIbeta.
            Relaxation of hypernegatively supercoiled DNA
  JOURNAL   J Biol Chem 275 (3), 1533-1540 (2000)
   PUBMED   10636841
REFERENCE   10 (bases 1 to 3129)
  AUTHORS   Seki,T., Seki,M., Onodera,R., Katada,T. and Enomoto,T.
  TITLE     Cloning of cDNA encoding a novel mouse DNA topoisomerase III (Topo
            IIIbeta) possessing negatively supercoiled DNA relaxing activity,
            whose message is highly expressed in the testis
  JOURNAL   J Biol Chem 273 (44), 28553-28556 (1998)
   PUBMED   9786843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166832.2, BY035336.1, AK146475.1 and AW122701.1.
            
            On May 21, 2016 this sequence version replaced NM_011624.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031723.1, AK146475.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC166832.2         38093-38137
            46-134              BY035336.1         2-90
            135-3112            AK146475.1         2-2979
            3113-3129           AW122701.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..3129
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.46 cM"
     gene            1..3129
                     /gene="Top3b"
                     /note="topoisomerase (DNA) III beta"
                     /db_xref="GeneID:21976"
                     /db_xref="MGI:MGI:1333803"
     exon            1..320
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            321..505
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             436..3024
                     /gene="Top3b"
                     /EC_number="5.6.2.1"
                     /note="DNA topoisomerase III beta-1; Topo III beta"
                     /codon_start=1
                     /product="DNA topoisomerase 3-beta-1"
                     /protein_id="NP_035754.1"
                     /db_xref="CCDS:CCDS27990.1"
                     /db_xref="GeneID:21976"
                     /db_xref="MGI:MGI:1333803"
                     /translation="MKTVLMVAEKPSLAQSIAKILSRGNMSSHKGLNGACSVHKYTGT
                     FAGQPVHFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFL
                     QVEGRGCDYVVLWLDCDKEGENICFEVLDAVLPVMNNAHNGEKTVFRARFSSITDTDI
                     CNAMTRLSEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQ
                     TPTLGFCVERHDKIQSFKPETYWVLQAKVHTDKEESLLLDWDRVRVFDWEIAQMFLNM
                     TKLEKEAWVEATSRKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQIAERLYTQGYI
                     SYPRTETTHYPENFDLKGSLRQQANHPYWADSVKQLLAEGINRPRKGHDAGDHPPITP
                     MKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPEHFTCMGKTVISP
                     GFTEIMPWQSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGI
                     GTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEK
                     QLNLIAQGKADYHQVLGHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRC
                     GKCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRG
                     KSYPLCPYCYNHPPFRDMKKGMGCNECTHPTCQHSLSMLGIGQCVECENGVLVLDPTS
                     GPKWKVACNTCNVVAHCFENAHRVRVSADTCNTCEAALLDVDFNKAKSPLPGNETQHT
                     GCIFCDPVFQELVELKHAASCHPMHRGGPGRRQGRGRGRGRRPPGKPNPRRPKDKMSA
                     LAAYFV"
     exon            506..637
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            638..744
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            745..819
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1016
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1173
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1287
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1378
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1533
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1639
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1786
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1960
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2089
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2239
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2340
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2542
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..3114
                     /gene="Top3b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3082..3087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Top3b"
                     /note="hexamer: ATTAAA"
     polyA_site      3114
                     /gene="Top3b"
                     /note="major polyA site"
ORIGIN      
        1 gaggggacgc cacagacgga cagagccgga agtgagttcg tgagtggcca ccggggaaag
       61 cacagccgga gcgagaggcg cagcggcacg gcgggtgagc agtgggatgc tggctgctcg
      121 aggaagcgga agacgctggc tttccccagg catttccgga atggtagcag cgctccgacc
      181 cgggcggggg cgtgggggag ggtcctgccc tggcgcggct ttttcgccat ccagccctcg
      241 ccgtggggcc tctgggcggc ggtggagccg cgtttagtgg gcagtggtcg cttttccaac
      301 gagctccccg cggccccgag gagtcagcat tggcagtcgt gttgagctac agaggagaca
      361 tttctaagct tttttattgc tgctgttctg ggtctgggtg caacggtctg tgggccctga
      421 cagccaggag caagaatgaa gaccgtgctc atggtagcag aaaagccatc cctggcacag
      481 tccattgcca aaatcctctc ccgaggaaac atgtcctcac acaaagggct gaatggggca
      541 tgttcagtgc acaagtacac aggaaccttt gctggccaac ctgtccactt caagatgacg
      601 tctgtctgcg gtcatgtgat gacactggat tttctgggga agtacaacaa gtgggataag
      661 gtggatcctg cagagctctt cagccaagct ccaacagaga aaaaggaagc taaccccaag
      721 ctgaacatgg tcaagttcct gcaggtggag ggcagaggct gtgactatgt tgtgctgtgg
      781 ctggactgtg acaaggaagg ggagaatatt tgctttgagg tccttgatgc cgttctgcct
      841 gtcatgaata atgcccacaa tggtgagaag acagtgtttc gtgccaggtt cagctccatc
      901 actgatacag acatctgtaa tgccatgacc cgcctgagcg agccagacca caatgaggca
      961 ctctcagtgg atgcccgcca ggagctagac ctgcgcatcg gctgtgcatt cactaggttt
     1021 caaacaaagt atttccaggg aaaatatggc gatttagaca gctctctcat ctcctttggg
     1081 ccatgtcaga ctcctaccct gggattctgt gtagaaagac atgataaaat ccagtccttc
     1141 aagccagaga cctactgggt gcttcaggcc aaggttcata cagataaaga ggagtcactc
     1201 cttctggact gggaccgtgt tagagttttc gactgggaga ttgcacagat gtttttaaac
     1261 atgacaaagt tagaaaaaga agcttgggtg gaggctacaa gcaggaaaga aaaagccaag
     1321 cagagaccac ttgctctgaa cactgtggag atgttgcgtg tggccagctc agctctgggt
     1381 atgggaccac agcacgccat gcaaatagct gagagattat acacacaggg ctatatcagc
     1441 tacccacgga cagaaaccac ccactatccc gagaactttg acctgaaggg ctctttgcga
     1501 cagcaggcca atcacccata ctgggcagac tcggtaaagc agttgttagc ggaaggcatc
     1561 aaccgccctc ggaaaggtca tgatgctggt gaccatcctc caatcacacc tatgaagtcg
     1621 gctacagagg ctgaattagg aggtgacgca tggagactct acgagtatat caccagacac
     1681 ttcattgcca cagtgagcca tgactgcaag tatctccaga gcactatctc cttcaggatc
     1741 gggcctgaac actttacatg catgggaaaa acagttattt ctccaggctt cacagagatc
     1801 atgccttggc agagcgtgcc cctggaagag agtctgccca cgtgccagaa gggtgatacc
     1861 ttcactgtgg gtgaagtgaa gatgctagag aagcagacga gcccaccgga ctatctgact
     1921 gaggctgagc tcatcactct catggagaag catggtatcg ggactgatgc cagtatccct
     1981 gtgcacatca acaatatctg ccagcgcaac tatgttactg tggagagtgg ccgccgactc
     2041 aagcccacca accttggcat agttctggtg catggttact acaagattga tgcagagctg
     2101 gtactcccca ccatccgaag cgcagtggag aagcagctga atcttattgc ccagggcaaa
     2161 gctgactacc accaagttct gggccatacc ctggatatct tcaagagaaa gttccactac
     2221 ttcgttgatt ctattgctgg catggacgag ttgatggagg tttccttttc acccctggct
     2281 gccactggca agcccctctc acgctgtggg aagtgccatc gatttatgaa gtacatccag
     2341 gccaagccaa gtcgcctgca ctgctcccac tgtgatgaga cctacaccct cccccagaat
     2401 ggtaccatca agctctacaa ggagctgcgg tgcccattgg atgactttga actggtcctg
     2461 tggtcctcag gctcccgggg caagagctac ccactatgtc cctactgcta taaccaccca
     2521 cccttccgag acatgaagaa aggcatgggc tgcaatgagt gcacacaccc cacctgccag
     2581 cactcactga gtatgctggg cattggccag tgcgtggaat gcgagaatgg agtccttgtt
     2641 ctggacccca cttctggtcc caagtggaag gtggcctgca atacatgcaa tgtggtggca
     2701 cactgctttg aaaatgccca ccgagtacgg gtatctgctg acacctgcaa cacctgcgag
     2761 gctgccttgc tcgatgtaga cttcaacaag gccaagtctc cccttcctgg caatgagaca
     2821 cagcacacag gctgcatctt ctgtgacccc gtcttccagg agctggtgga gcttaagcat
     2881 gcagcctcct gccaccccat gcaccgaggt gggcctggaa ggaggcaggg tcgtgggcgg
     2941 ggccggggcc ggagacctcc aggaaagccc aaccctaggc ggccaaaaga caagatgtca
     3001 gctctggctg cttactttgt atgacaacct atcttttccc cactccagac acatcgtggt
     3061 tatctttgag ccactgaaac cattaaaatg ctttttattt tgtattctct ggaaaaaaaa
     3121 aaaaaaaaa
//
