LOCUS       NM_009410               5590 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus topoisomerase (DNA) III alpha (Top3a), mRNA.
ACCESSION   NM_009410 XM_906155
VERSION     NM_009410.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5590)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   2  (bases 1 to 5590)
  AUTHORS   Guiraldelli MF, Eyster C and Pezza RJ.
  TITLE     Genome instability and embryonic developmental defects in RMI1
            deficient mice
  JOURNAL   DNA Repair (Amst) 12 (10), 835-843 (2013)
   PUBMED   23900276
REFERENCE   3  (bases 1 to 5590)
  AUTHORS   Xue X, Raynard S, Busygina V, Singh AK and Sung P.
  TITLE     Role of replication protein A in double holliday junction
            dissolution mediated by the BLM-Topo IIIalpha-RMI1-RMI2 protein
            complex
  JOURNAL   J Biol Chem 288 (20), 14221-14227 (2013)
   PUBMED   23543748
REFERENCE   4  (bases 1 to 5590)
  AUTHORS   Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu
            HS, Brennan J, Armstrong J, Little MH, McMahon AP and
            Southard-Smith EM.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5590)
  AUTHORS   Yan J, Bi W and Lupski JR.
  TITLE     Penetrance of craniofacial anomalies in mouse models of
            Smith-Magenis syndrome is modified by genomic sequence surrounding
            Rai1: not all null alleles are alike
  JOURNAL   Am J Hum Genet 80 (3), 518-525 (2007)
   PUBMED   17273973
REFERENCE   6  (bases 1 to 5590)
  AUTHORS   McKee AE, Minet E, Stern C, Riahi S, Stiles CD and Silver PA.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5590)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 5590)
  AUTHORS   Park EJ, Han SY and Chung IK.
  TITLE     Regulation of mouse DNA topoisomerase IIIalpha gene expression by
            YY1 and USF transcription factors
  JOURNAL   Biochem Biophys Res Commun 283 (2), 384-391 (2001)
   PUBMED   11327713
REFERENCE   9  (bases 1 to 5590)
  AUTHORS   Seki T, Seki M, Katada T and Enomoto T.
  TITLE     Isolation of a cDNA encoding mouse DNA topoisomerase III which is
            highly expressed at the mRNA level in the testis
  JOURNAL   Biochim Biophys Acta 1396 (2), 127-131 (1998)
   PUBMED   9540825
REFERENCE   10 (bases 1 to 5590)
  AUTHORS   Li W and Wang JC.
  TITLE     Mammalian DNA topoisomerase IIIalpha is essential in early
            embryogenesis
  JOURNAL   Proc Natl Acad Sci U S A 95 (3), 1010-1013 (1998)
   PUBMED   9448276
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596215.7.
            
            [WARNING] On Jan 25, 2024 this sequence was replaced by
            NM_009410.4.
            
            On Feb 24, 2018 this sequence version replaced NM_009410.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB006074.1, BC099689.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-444               AL596215.7         109347-109790
            445-504             AL596215.7         123287-123346
            505-578             AL596215.7         124171-124244
            579-654             AL596215.7         124905-124980
            655-763             AL596215.7         127307-127415
            764-907             AL596215.7         129964-130107
            908-1078            AL596215.7         130264-130434
            1079-1179           AL596215.7         130668-130768
            1180-1254           AL596215.7         132751-132825
            1255-1337           AL596215.7         134347-134429
            1338-1545           AL596215.7         135929-136136
            1546-1731           AL596215.7         137123-137308
            1732-1861           AL596215.7         137417-137546
            1862-1975           AL596215.7         138487-138600
            1976-2141           AL596215.7         138681-138846
            2142-2285           AL596215.7         140752-140895
            2286-2408           AL596215.7         142657-142779
            2409-3097           AL596215.7         143588-144276
            3098-5590           AL596215.7         146011-148503
FEATURES             Location/Qualifiers
     source          1..5590
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.81 cM"
     gene            1..5590
                     /gene="Top3a"
                     /note="topoisomerase (DNA) III alpha"
                     /db_xref="GeneID:21975"
                     /db_xref="MGI:MGI:1197527"
     exon            1..444
                     /gene="Top3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..3276
                     /gene="Top3a"
                     /EC_number="5.6.2.1"
                     /note="DNA topoisomerase III alpha; topoisomerase 3 alpha;
                     Top IIIa; topoisomerase (DNA) 3 alpha"
                     /codon_start=1
                     /product="DNA topoisomerase 3-alpha"
                     /protein_id="NP_033436.1"
                     /db_xref="CCDS:CCDS24797.1"
                     /db_xref="GeneID:21975"
                     /db_xref="MGI:MGI:1197527"
                     /translation="MIFPVTLLAFQWHRRPGGRALSRAAMEVAFRGVRKVLCVAEKND
                     AAKGIADLLSNGRMRRKEGLSKFNKIYEFDYHLYGQNVTMIMTSVSGHLLAHDFQMQF
                     RKWQSCNPLVLFEAEIEKYCPENFIDIKKTLERETHHCQALVIWTDCDREGENIGFEI
                     IHVCKAVKPNLRVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAF
                     TRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEVFHKIKVTHDH
                     KDGTVEFNWKRYRLFNHTACLVLYQLCMEDPMATVVEVRSKPKSKWRPQALDTVELEK
                     LASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPKDLNLVALVEQQTVDPHWGAF
                     AQTILERGGPTPRNGSKSDQAHPPIHPTKYTSGLQGDDRRLYEFIVRHFLACCSQDAQ
                     GQETTVEIDIAQERFVAHGLIILARNYLDVYPYDHWSDKLLPVYEQGSHFQPSTVEMV
                     DGETSPPQLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTSDKRFLPGHLGM
                     GLVEGYDSMGYEMSKPDLRAELEADLKLICEGKKDKFQVLRQQVQKYKQVFIEAVAKA
                     KKLDEALSQYLGERTEMAQQEEIYPAMPEPVRKCPQCNKDMVLKTKKSGGFYLSCMGF
                     PECRSAVWFPDSVLEASRDNSVCSVCQPPPVYRLKLKFKRGSLPPAMPLEFVGCIGGC
                     DETLKEIFGLRFPRALPRASQPSGHLQASQALNRMDSSQHNLSQPLVNRHTRPSKTVA
                     QALLPPTTAGESNSVTCNCGREAVLLTVRKQGPNQGRHFYKCSNGDCNFFLWADSSHS
                     TGGGTPTSASGPPGSSVGCPSSVGSHMDGFGSLGSDSDGGTPCLCGQPAVTRTVQKDG
                     PNKGRQFHTCAKPREQQCGFFQWVDENVAPGSFAAPAWPGGRGKAQRPEAASKRPRAG
                     SSDAGSTVKKPRKCSLCHQPGHTRTFCPQNR"
     exon            445..504
                     /gene="Top3a"
                     /inference="alignment:Splign:2.1.0"
     exon            505..578
                     /gene="Top3a"
                     /inference="alignment:Splign:2.1.0"
     exon            579..654
                     /gene="Top3a"
                     /inference="alignment:Splign:2.1.0"
     exon            655..763
                     /gene="Top3a"
                     /inference="alignment:Splign:2.1.0"
     exon            764..907
                     /gene="Top3a"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1078
                     /gene="Top3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1179
                     /gene="Top3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1254
                     /gene="Top3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1337
                     /gene="Top3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1545
                     /gene="Top3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1731
                     /gene="Top3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1861
                     /gene="Top3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1975
                     /gene="Top3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2141
                     /gene="Top3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2285
                     /gene="Top3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2408
                     /gene="Top3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..3097
                     /gene="Top3a"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..5590
                     /gene="Top3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaacggtgt tggaggaacg tgcacagggc atgaggcatt ctgggagttg tagttcaagg
       61 ctgcttagtg gcgcagtggg cggaagttgt ctgtgagcgc gagtttaagc gagactcgga
      121 cgtgtgggtt tctgatcgag gcggcagttg cctggaaaaa ctgcatttat taaggtggct
      181 ctcacagttc ctcgtggctt ttcctctggg ttctccagca tgcacgggca cccgtggagt
      241 tgctgctgga gcaggaccta gggaatgatc ttcccggtca ccctcttagc gtttcagtgg
      301 caccgacggc ctggaggccg tgccctgtcc cgcgctgcca tggaagtggc cttccgagga
      361 gtgcgaaaag ttctctgcgt ggcggagaaa aacgacgctg ccaaggggat cgccgacttg
      421 ctgtccaacg ggcgtatgag gcggaaagaa ggcctttcta aattcaacaa gatttatgaa
      481 tttgactatc atctgtatgg ccagaatgtt actatgataa tgacttcagt ctctggacat
      541 ttgctggctc atgacttcca gatgcagttt cggaaatggc agagctgcaa tccccttgtc
      601 ctctttgaag cagaaattga aaagtattgc ccagaaaatt ttatagacat caagaaaact
      661 ctagaacgag agacacatca ttgtcaggcc ctggtgatct ggacggactg tgatagggaa
      721 ggtgagaaca tcggctttga gattatccac gtatgcaagg ctgtaaaacc caatctacgg
      781 gtgctgagag cccgcttctc tgagatcacg ccacacgccg tcagaacagc ctgtgaaaac
      841 ctaactgagc ctgaccagag agtgagtgac gcagtggatg tgaggcaaga gctggacctg
      901 aggatcggag ctgccttcac aaggttccag accctgcggc tccagaggat cttccctgag
      961 gtgctggcag agcagctcat cagctacggc agttgccagt tcccaacact ggggtttgtg
     1021 gtggagaggt tcaaggccat tcaggctttt gtgccagaag tcttccacaa aattaaagta
     1081 actcatgacc acaaagatgg gaccgtagag ttcaactgga aacgataccg tctctttaac
     1141 cacacagctt gtcttgtcct ttatcagttg tgcatggagg atcccatggc gactgtggta
     1201 gaggtcagat ctaagccaaa gagcaagtgg aggccgcagg ctttggacac ggtggagcta
     1261 gagaaactgg catctcggaa attgagaata aatgccaaag aaaccatgag gatcgcggaa
     1321 aagctctata cacaagggta catcagctac ccccggacag aaacaaacat cttccccaaa
     1381 gacttaaacc tggttgcatt ggtagaacag cagaccgtgg atccacactg gggggctttt
     1441 gctcagacca ttctagagcg aggtggccct actccccgaa acgggagcaa gtctgatcaa
     1501 gctcaccctc ccattcaccc caccaaatac accagcggct tgcagggaga tgatcggcga
     1561 ctgtacgagt tcattgttcg ccatttcctg gcttgctgct ctcaggacgc tcaggggcaa
     1621 gagactaccg tagagatcga cattgcccaa gagcgctttg tggcccacgg gctcatcatt
     1681 ctggcccgta actacctaga tgtgtatccg tatgatcact ggagtgacaa gctcctcccc
     1741 gtctatgaac aaggctccca cttccagccc agcactgtgg aaatggtgga tggagagact
     1801 agcccacccc aactgcttac cgaagctgac ctcatcgccc tcatggagaa acatgggatc
     1861 ggtactgatg caactcatgc agaacacatt gagaccatca aagcccggat gtatgtggga
     1921 ctcacctcag acaagcggtt cctgccgggg cacctgggca tgggacttgt agaaggttac
     1981 gattccatgg gttatgagat gtccaagcct gacctccgtg ccgagctgga agctgatctc
     2041 aagctgatct gtgagggcaa gaaggataag tttcaagttc taaggcagca agtgcaaaaa
     2101 tacaagcagg ttttcattga agcagtggcg aaggcaaaga agttggatga ggctttatct
     2161 cagtacttag gagaaagaac agagatggcc cagcaagaag agatctaccc agccatgcca
     2221 gagcctgttc ggaagtgccc acagtgtaac aaggatatgg tcctcaagac caagaagagt
     2281 ggtgggttct acctcagctg catggggttc ccagagtgtc ggtcagctgt gtggtttcct
     2341 gactcggtgc tggaggccag cagggacaac agtgtgtgtt ctgtttgtca gccaccccct
     2401 gtgtacaggt tgaagttgaa gtttaagcgt ggtagccttc ccccagctat gcccctggag
     2461 tttgtcggct gcataggtgg atgtgatgag actttgaagg aaatcttcgg cctgcgattt
     2521 ccacgggctc tcccaagagc tagccagccc tctggccacc tgcaggccag ccaggccctc
     2581 aacaggatgg acagcagtca gcataacctg tctcaacctc tggttaacag acatactaga
     2641 ccttcaaaga cagtggccca agccttgcta ccacccacta ctgctggtga aagcaactct
     2701 gtgacttgca attgtggccg ggaggctgtg ctgctcactg tccgcaagca gggccccaac
     2761 cagggccggc atttctacaa gtgcagtaat ggtgactgca acttcttcct gtgggctgac
     2821 agcagccatt ccactggagg agggaccccc acctctgcat caggaccccc aggcagctct
     2881 gtaggatgcc catccagtgt aggcagccac atggatgggt ttggcagcct tggcagcgac
     2941 agtgatggag gtacaccctg cctgtgcggg cagcctgctg tcacacggac tgttcagaag
     3001 gatggaccca acaaaggacg ccagttccac acctgtgcca agccacgaga gcagcagtgt
     3061 ggcttctttc agtgggtgga tgagaatgtg gccccaggaa gttttgcagc ccctgcatgg
     3121 ccaggaggca gaggaaaagc ccagagacca gaggctgcaa gcaaaagacc aagagctggt
     3181 tcctcagatg cagggtccac agtaaaaaag cctcggaaat gtagcctttg tcaccagcct
     3241 ggacacaccc gaaccttttg tcctcagaac agatgatagc cggggaggtg gaagaaattg
     3301 cctagaccag gaatgaacta gctaggacca ggtggctgtg cactgtcctg gaaacctagg
     3361 gaggtactgg gttttaaagt tggccttctt ttgttgagta caaagaccag acatgtctgg
     3421 agagtctggc tggctctgct ggatgctgca gctctgtctg cagctcacag tgactctggc
     3481 tgctgcactg atggaaaatg agaaatgggc agtcagcatg taagcagaac tgaccttgag
     3541 tggccttcca agccctgacc gtggccacag tctgccaggt gaaaagcagg tactgctttc
     3601 ggccagcccc ggcatccgcg tgggccttct ctgcacagct gttggagagg tggctagcct
     3661 gtgtgtcccc agaagcttcc gctcctgctc catctaggac acccatagct catgtgcctt
     3721 aataaaaaaa atgcatccat attttctggt ggcattcagt ctgggatgcc agcaggagcc
     3781 agtgaaggcc aagggacctc ttcttgggac tctctagctc atctctgtac cctcttgcct
     3841 ggttcttccc tgctgtggct tgtcccttga aactggcaga tcctgggatg ctgacctttg
     3901 cagaggaagg agactgtgac tgtaccctta caaacttcta gacgagtcat gctagcattg
     3961 tcccacactt gagaagtgaa atgggagttg ttccttgagt tacaagttag tgaagcaact
     4021 cgggttgtct tgaggtcaga gcaatagcct tgattagaca ggaactctca gcctggccgg
     4081 cagcagggtt tcactggtga ctgttcctac cactgctcag gggcactgtt tgcagcctgc
     4141 atttaggatc tgaccctggt ccaccactca cagctggcct tacctgtttg aacacttcaa
     4201 tggaaacctc atgtacctgc tgtgcctagg ccagcctcaa gctcagagat cgcctgcctc
     4261 tgcctccaga gggctggaga taaaggtgtg tgctgccctg ccgccttcca tttgtttatt
     4321 tggaaatttt gtccaaggtc tatattgctg cttagacttt gtttttcaag acagtatttc
     4381 tctgtgtagc cctagagatc gcctgcctcc tgagtgctgg agtttaaggc atacaccacc
     4441 acatctggca cttgagagtg agaatgacag ggtttgacat tctagcaaag ctggcaagga
     4501 taacagctga ccttggacag gcagttgtct cagtctaagc acaagactgg agacatagcc
     4561 accaatgtgt gttgattcta caattgaaag ttctggattc taaagtcagc tgctacctta
     4621 aaaaacaaaa caaaacctga aggaaatagc aagtagttag ttttcctgga ggaccagagg
     4681 aagagagaaa aagagggaga aatggagagg agagtgaagg ggaggggagg ctggctgtcc
     4741 agggctaggg gctggagagt ctgttaggcc cagtgatggc agactagacc tagagcagtt
     4801 tgtgtttggg atggatctgt cagggggaag gggacacata cccagatagt gttgaggtct
     4861 ctgttagctg ccttgtcaag ggacacatgt tgggagggag taataattgt tccctgggct
     4921 cactgtatga agtccttgaa tgaatgggag ggaggagatg tgtgtgggta aggaagcaca
     4981 gtgggaggga accaaaccgg gagaggagag gggaggatgg aagtgggatt gccagatgga
     5041 ggggcgctgg aggatggagg ggtgctggtg gcagagacgc tgaaggttga gtgggggctt
     5101 acatggccat caaggatgtc atcagaggct gagttcaggg atgcacctat tagagtccca
     5161 tgctaaggcc aggaagtact ggataggagg tttcattatg catgtctgaa tgtatgctac
     5221 atgtgcacag atatcaccaa ggccagaaaa gggcatcaag tccatggagc tgaagttaca
     5281 ggtagttgta aaccacccag tgtgggtgct aggaaccaaa ctctagtcct ctagaagggc
     5341 gatgtggtgg tttgaatatg cttggcccag gaagtggcac tattaggagg tgtggctttg
     5401 ttggaggaag tgtgtcacta tatgggtggg caatgagacc ctcctagcca catggatgtg
     5461 gcttcacttg tctgcctttg gatcaagatg tagagctctc agctcctcta gccccatgtc
     5521 tgcctggatg ctgccatgct tcctgccatg attataatag actgaacctt tgaacctgta
     5581 agccagcccc
//
