LOCUS       NM_183091               4239 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tonsoku-like, DNA repair protein (Tonsl), mRNA.
ACCESSION   NM_183091
VERSION     NM_183091.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4239)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4239)
  AUTHORS   Chang,H.R., Cho,S.Y., Lee,J.H., Lee,E., Seo,J., Lee,H.R.,
            Cavalcanti,D.P., Makitie,O., Valta,H., Girisha,K.M., Lee,C.,
            Neethukrishna,K., Bhavani,G.S., Shukla,A., Nampoothiri,S.,
            Phadke,S.R., Park,M.J., Ikegawa,S., Wang,Z., Higgs,M.R.,
            Stewart,G.S., Jung,E., Lee,M.S., Park,J.H., Lee,E.A., Kim,H.,
            Myung,K., Jeon,W., Lee,K., Kim,D., Kim,O.H., Choi,M., Lee,H.W.,
            Kim,Y. and Cho,T.J.
  TITLE     Hypomorphic Mutations in TONSL Cause SPONASTRIME Dysplasia
  JOURNAL   Am J Hum Genet 104 (3), 439-453 (2019)
   PUBMED   30773278
REFERENCE   3  (bases 1 to 4239)
  AUTHORS   Burrage,L.C., Reynolds,J.J., Baratang,N.V., Phillips,J.B.,
            Wegner,J., McFarquhar,A., Higgs,M.R., Christiansen,A.E.,
            Lanza,D.G., Seavitt,J.R., Jain,M., Li,X., Parry,D.A., Raman,V.,
            Chitayat,D., Chinn,I.K., Bertuch,A.A., Karaviti,L.,
            Schlesinger,A.E., Earl,D., Bamshad,M., Savarirayan,R.,
            Doddapaneni,H., Muzny,D., Jhangiani,S.N., Eng,C.M., Gibbs,R.A.,
            Bi,W., Emrick,L., Rosenfeld,J.A., Postlethwait,J., Westerfield,M.,
            Dickinson,M.E., Beaudet,A.L., Ranza,E., Huber,C., Cormier-Daire,V.,
            Shen,W., Mao,R., Heaney,J.D., Orange,J.S., Bertola,D.,
            Yamamoto,G.L., Baratela,W.A.R., Butler,M.G., Ali,A., Adeli,M.,
            Cohn,D.H., Krakow,D., Jackson,A.P., Lees,M., Offiah,A.C.,
            Carlston,C.M., Carey,J.C., Stewart,G.S., Bacino,C.A., Campeau,P.M.
            and Lee,B.
  CONSRTM   University of Washington Center for Mendelian Genomics; Undiagnosed
            Diseases Network
  TITLE     Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a
            Spectrum of Skeletal Dysplasia Phenotypes
  JOURNAL   Am J Hum Genet 104 (3), 422-438 (2019)
   PUBMED   30773277
REFERENCE   4  (bases 1 to 4239)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK139173.1 and BC066068.1.
            
            On May 7, 2008 this sequence version replaced NM_183091.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066068.1, SRR13422597.1174716.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AK139173.1         2-19
            19-2034             BC066068.1         1-2016
            2035-2617           AK139173.1         2207-2789
            2618-4239           BC066068.1         2600-4221
FEATURES             Location/Qualifiers
     source          1..4239
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 36.18 cM"
     gene            1..4239
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /note="tonsoku-like, DNA repair protein"
                     /db_xref="GeneID:72749"
                     /db_xref="MGI:MGI:1919999"
     exon            1..76
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..4143
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /note="nuclear factor of kappa light polypeptide gene
                     enhancer in B-cells inhibitor-like 2; NF-kappa-B
                     inhibitor-like protein 2; ikappaBR; I-kappa-B-related
                     protein; inhibitor of kappa B-related protein"
                     /codon_start=1
                     /product="tonsoku-like protein"
                     /protein_id="NP_898914.3"
                     /db_xref="CCDS:CCDS27580.2"
                     /db_xref="GeneID:72749"
                     /db_xref="MGI:MGI:1919999"
                     /translation="MTLEQELRQLSKAKTRAQRNGQLREEAAYCHQLGELLASHGRFK
                     DALEEHQQELHLLESVQDTLGCAVAHRKIGERLAEMENYSAALKHQHLYLDLAGSLSN
                     HTELQRAWATIGRTHLDIYDHCQSRDSLLQAQAAFEKSLAIVDEKLEGMLTQRELSEM
                     RTRLYLNLGLTCESLQQTALCNNYFKKSIFLAEQNHLYEDLFRARYNLGAIHWRGGQH
                     SQAMRCLEGARECARAMKMRFMESECCVLVSQVLQDLGDFLAAKRALKKAYRLGSQKP
                     NQRVTVCQSLKYVLAVIQLQQQLEEAEGNDLQGAMAICEQLGDLFSKAGDFPKAAEAY
                     QKQLHLAELLNRPDLELAVIHVSLATTLGDMKDHRKAVHHYEEELRLRKGNALEEAKT
                     WFNIALSREEAGDAYELLAPCFQKAFCCAQQAQRFQLQRQILQHLYTVQLKLQPQEAR
                     DTEIRLQELSMAKDTEEEEEEEEEEEEEASEAPETSELELSESEDDADGLSQQLEEDE
                     ELQGCVGRRKVNKWNRRNDMGETLLHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPL
                     HEACNYGHLEIVRFLLDHGAAVDDPGGQGCDGITPLHDALNCGHFEVAELLIERGASV
                     TLRTRKGLSPLETLQQWVKLYFRDLDLETRQKAATMEKRLQMASSGQASRSSPALQTI
                     PSNHLFDPETSPPSSPCPEPSSYTPRPPEASPAPAKVFLEETVSAVSRPRKTRHRPTS
                     SSSSSEDEDNPSPCRPSQKRLRHTTQQGEVKIPDPPKSRETATSSACRAAYQAAIRGV
                     GSAQSRRLVPSLPRGSEEVPAPKTALIPEEEYLAGEWLEVDTPLTRSGRPSTSVSDYE
                     RCPARPRTRVKQSRLTSLDGWCARTQAGDGSLNAEPAENPSVPRTSGPNKENYAAGQP
                     LLLVQPPPIRVRVQIQDNLFLIPVPQSDIRPVAWLTEQAAQRYFQTCGLLPRLTLRKD
                     GALLAPQDPIPDVLQSNDEVLAEVTSWDLPPLKDRYRRACLSLGQGEHQQVLHAMDHQ
                     SSSPSFSACSLALCQAQLTPLLRALKLHTALRELRLAGNRLGDACATELLATLGTTPN
                     LVLLDLSSNHLGQEGLRQLVEGSSGQAALQNLEELDLSMNPLGDGCGQALASLLRACP
                     MLSTLRLQACGFSSSFFLSHQAALGGAFQDAVHLKTLSLSYNLLGAPALARVLQTLPA
                     CTLKRLDLSSVAASKSNSGIIEPVIKYLTKEGCALAHLTLSANCLGDKAVRELSRCLP
                     CCPSLTSLDLSANPEVSCASLEELLSALQERSQGLSFLGLSGCSIQGPLNSDLWDKIF
                     VQLQELQLCTKDLSTKDRDSVCQRLPEGACTMDQSSKLFFKCL"
     exon            77..172
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            173..315
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            316..499
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            500..629
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            630..801
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            802..916
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1062
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1215
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1341
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1531
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1614
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1704
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1777
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1941
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2065
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2796
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..2873
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..3024
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3103
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3405
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..3577
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            3578..3753
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            3754..3827
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            3828..3961
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     exon            3962..4207
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4186..4191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /note="hexamer: AATAAA"
     polyA_site      4207
                     /gene="Tonsl"
                     /gene_synonym="2810439M11Rik; Nfkbil2"
                     /note="major polyA site"
ORIGIN      
        1 agggaagcgc gggaagtgca gattttcgcg gcggcggtgg cttgtctggc tatgaccctg
       61 gaacaggagc ttcgccagct gagcaaggcc aagaccaggg cccagaggaa tggacagctg
      121 cgcgaggagg cggcctactg ccaccagctg ggggagctgc tggctagcca cggccgcttc
      181 aaggacgctt tggaggagca ccagcaggaa ctacatctgc tagagagcgt ccaggacact
      241 ctaggctgcg ctgtggccca ccgcaagatt ggagaacggc tggctgaaat ggagaattac
      301 tctgctgctc tgaagcacca gcatctctac ctggatctgg ctggttccct gtccaaccac
      361 actgaactac agcgagcctg ggccaccatt ggccgcaccc atctggatat atatgaccac
      421 tgccaatcaa gagattcctt gttgcaggca caagctgcct ttgagaagag cttggctatt
      481 gtggatgaga aactagaggg gatgctgacc cagcgggaac tgagtgagat gaggacccgt
      541 ctctacctca atctgggtct cacctgtgag agcctgcaac agacagccct gtgcaacaac
      601 tacttcaaaa agagcatctt tcttgctgag cagaaccatc tctatgaaga tctgttccgg
      661 gcccgataca acctgggtgc catccactgg cgcggagggc agcactctca ggccatgcgc
      721 tgcttagaag gggcccggga atgtgcccgt gctatgaaga tgagattcat ggagagtgaa
      781 tgttgcgtgc tagtgtccca ggtgctccaa gatctggggg acttcttagc tgccaaacga
      841 gccctgaaga aggcctatag gttgggctct cagaagccta accagagagt gactgtctgt
      901 cagagtctca agtatgtatt ggcagtgatc cagctgcagc agcagctgga agaggctgag
      961 ggcaatgatc ttcaaggtgc catggctatc tgtgaacagt tgggggacct gttctccaaa
     1021 gcgggtgact ttcccaaggc agctgaggct taccagaagc agctgcactt ggctgagctg
     1081 ctgaacagac cagatctgga gctggctgtt atccacgtat ccctggccac cacactggga
     1141 gacatgaagg atcaccgcaa ggctgtgcac cactatgagg aagaactgag gctgcgcaag
     1201 ggcaacgctc tggaggaagc taagacttgg ttcaacattg ccctgtcacg tgaggaggct
     1261 ggagacgcat acgagctgct agctccatgc ttccagaagg ctttttgctg tgcccagcag
     1321 gcccagagat tccagctgca gaggcagatc ttacagcacc tttataccgt gcaactaaag
     1381 ttgcagccac aagaagcccg tgacactgaa atcagactgc aggaactgag tatggcaaaa
     1441 gacacagaag aagaggagga ggaagaggag gaagaagagg aagaagccag tgaggcccca
     1501 gagaccagtg aactggaact ctcagagagc gaggatgatg ctgacggcct gtctcagcag
     1561 ctggaagaag atgaggagct tcagggctgt gtgggccggc ggaaggtgaa caagtggaac
     1621 cggcgcaatg acatgggaga gaccctgctg caccgagctt gcattgaagg ccaactgcgt
     1681 cgtgtccagg atcttgtgaa gcagggccat cccctgaatc cccgagacta ctgcggctgg
     1741 acacctctcc atgaagcatg caactatgga catcttgaga ttgttcgctt ccttctggac
     1801 catggagcag cagtggatga cccaggtggc caggggtgtg atggcatcac ccccctgcat
     1861 gacgccctca actgtggcca ctttgaggta gctgaattac tcattgagcg aggggcatcc
     1921 gtgactctcc gtaccaggaa gggcctcagc ccactggaga cactgcagca gtgggtgaag
     1981 ttgtacttca gggaccttga ccttgagaca agacagaagg cggcaaccat ggagaagagg
     2041 ctccagatgg cctcctcagg ccaagcttcc cgcagctccc ctgccctcca gaccattcca
     2101 agtaaccatc tatttgaccc tgagacctct cctccctcaa gcccctgtcc agaaccctcc
     2161 tcatatactc ctagacctcc agaggcctct ccggcccctg ctaaagtctt tctggaggaa
     2221 actgtgtctg ccgtgtcccg acctcgaaag accaggcaca gaccaaccag cagcagtagc
     2281 agctcagagg atgaggataa cccaagtccc tgcaggccat cgcagaaaag actgagacat
     2341 accacacagc agggtgaagt caagattcct gacccaccca aaagtagaga gacagccacg
     2401 tcaagtgctt gccgggcggc ttaccaagcg gccatccgag gcgtgggtag tgcccagagc
     2461 cgtcgcttgg tgcctagcct gcctcggggc tcagaggaag tccctgcccc caagacagca
     2521 ctcattcccg aggaggaata cctggctggg gaatggctgg aggtagatac acctctgacc
     2581 cgcagcggca ggcccagcac ctcggtgtca gactatgagc gatgtcctgc aaggccccgg
     2641 acccgtgtca agcagagtcg cctgacaagt cttgatggtt ggtgtgcacg gactcaagca
     2701 ggagatggca gcttgaatgc agagcctgca gagaacccca gcgtgcctag gacctcagga
     2761 cccaacaagg aaaattatgc agcaggccag cctttgcttc tggtccagcc ccctcccatc
     2821 cgggttcgag ttcaaattca ggataacctt ttcctcatcc ccgttcccca gagtgacatc
     2881 cgccccgtgg cttggctcac agagcaagcc gcccagcgct atttccaaac gtgtgggctg
     2941 ctcccaaggc tcaccctgcg gaaggatggc gcactgctgg ccccgcagga ccccatccct
     3001 gacgtgctgc agagcaacga tgaggtgtta gctgaggtaa cttcgtggga ccttcctccg
     3061 ctaaaggacc gctaccgcag ggcctgcctg agcctggggc aaggggagca ccagcaagtg
     3121 ctgcatgcca tggaccacca gagttccagc ccttcgttca gtgcctgctc cctagccttg
     3181 tgccaagccc agctcacacc cctgctgagg gccctcaagt tacacacagc actccgggag
     3241 ctacgccttg cagggaaccg actaggtgat gcctgcgcta ccgagctgct ggccaccctg
     3301 ggcaccacgc ctaacctggt cctcctcgat ctctcttcca atcacttggg ccaggaaggt
     3361 ctgcgtcagc ttgtggaagg ctcctcgggc caggctgctt tgcagaactt ggaggagctg
     3421 gacttgagta tgaacccact aggagatggc tgtggtcagg ccctggcctc ccttctgcgg
     3481 gcctgcccca tgctcagcac cctgcgccta caggcctgtg gcttcagctc cagtttcttc
     3541 ctgagccacc aggctgccct gggcggtgcc ttccaagatg ctgtgcacct gaaaaccttg
     3601 tccttatcgt acaatctgct cggcgctcct gccctggcga gggtgctgca gaccttaccc
     3661 gcctgtaccc tcaaacgtct ggacctaagc tctgtggcag ccagcaagag caactcgggt
     3721 atcatagagc ctgttatcaa atacttgacc aaggaaggct gtgctctggc ccacctaacc
     3781 ctgtccgcaa actgcctggg tgacaaggcc gtgagagaac tgagcagatg tctcccttgc
     3841 tgcccctcac tcacctctct ggacctgtct gccaaccccg aggtcagctg tgccagtcta
     3901 gaggagctct tgtctgccct ccaagagcgg tcccaaggcc tcagcttcct tggcctatca
     3961 ggctgctcta ttcaagggcc gctgaactct gacctctggg acaagatctt cgtgcagttg
     4021 caggagttgc aactgtgcac caaagacctg agcaccaaag accgagactc ggtgtgtcag
     4081 agactgccag agggtgcgtg cacaatggac caaagttcca agctcttctt taaatgcctc
     4141 tgatcctagt cctgccgttt cctccagaag aaaaagaaaa accttaataa actatgctgc
     4201 tatctcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
