LOCUS       NM_001282088            1358 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transmembrane O-methyltransferase (Tomt), transcript
            variant 2, mRNA.
ACCESSION   NM_001282088
VERSION     NM_001282088.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1358)
  AUTHORS   Erickson,T., Morgan,C.P., Olt,J., Hardy,K., Busch-Nentwich,E.,
            Maeda,R., Clemens,R., Krey,J.F., Nechiporuk,A.,
            Barr-Gillespie,P.G., Marcotti,W. and Nicolson,T.
  TITLE     Integration of Tmc1/2 into the mechanotransduction complex in
            zebrafish hair cells is regulated by Transmembrane
            O-methyltransferase (Tomt)
  JOURNAL   Elife 6, e28474 (2017)
   PUBMED   28534737
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1358)
  AUTHORS   Cunningham,C.L., Wu,Z., Jafari,A., Zhao,B., Schrode,K.,
            Harkins-Perry,S., Lauer,A. and Muller,U.
  TITLE     The murine catecholamine methyltransferase mTOMT is essential for
            mechanotransduction by cochlear hair cells
  JOURNAL   Elife 6, e24318 (2017)
   PUBMED   28504928
  REMARK    GeneRIF: These studies thus suggest functional diversification
            between mCOMT and mTOMT, where mTOMT is critical for the assembly
            of the mechanotransduction machinery of hair cells.
            Erratum:[Elife. 2017 Nov 08;6:e33307. doi: 10.7554/eLife.33307..
            PMID: 29116042]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1358)
  AUTHORS   Ahmed,Z.M., Masmoudi,S., Kalay,E., Belyantseva,I.A., Mosrati,M.A.,
            Collin,R.W., Riazuddin,S., Hmani-Aifa,M., Venselaar,H., Kawar,M.N.,
            Tlili,A., van der Zwaag,B., Khan,S.Y., Ayadi,L., Riazuddin,S.A.,
            Morell,R.J., Griffith,A.J., Charfedine,I., Caylan,R., Oostrik,J.,
            Karaguzel,A., Ghorbel,A., Riazuddin,S., Friedman,T.B., Ayadi,H. and
            Kremer,H.
  TITLE     Mutations of LRTOMT, a fusion gene with alternative reading frames,
            cause nonsyndromic deafness in humans
  JOURNAL   Nat Genet 40 (11), 1335-1340 (2008)
   PUBMED   18953341
REFERENCE   4  (bases 1 to 1358)
  AUTHORS   Du,X., Schwander,M., Moresco,E.M., Viviani,P., Haller,C.,
            Hildebrand,M.S., Pak,K., Tarantino,L., Roberts,A., Richardson,H.,
            Koob,G., Najmabadi,H., Ryan,A.F., Smith,R.J., Muller,U. and
            Beutler,B.
  TITLE     A catechol-O-methyltransferase that is essential for auditory
            function in mice and humans
  JOURNAL   Proc Natl Acad Sci U S A 105 (38), 14609-14614 (2008)
   PUBMED   18794526
  REMARK    GeneRIF: Mice homozygous for a missense mutation in Comt2 show
            vestibular impairment, profound sensorineuronal deafness, and
            progressive degeneration of the organ of Corti
REFERENCE   5  (bases 1 to 1358)
  AUTHORS   Hoebe,K., Du,X., Goode,J., Mann,N. and Beutler,B.
  TITLE     Lps2: a new locus required for responses to lipopolysaccharide,
            revealed by germline mutagenesis and phenotypic screening
  JOURNAL   J Endotoxin Res 9 (4), 250-255 (2003)
   PUBMED   12935356
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EU627091.1.
            
            Transcript Variant: This variant (2) has an alternate 5' UTR exon,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU627091.1, AK158024.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1358              EU627091.1         1-1358
FEATURES             Location/Qualifiers
     source          1..1358
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.68 cM"
     gene            1..1358
                     /gene="Tomt"
                     /gene_synonym="Comt2; F930017I19Rik"
                     /note="transmembrane O-methyltransferase"
                     /db_xref="GeneID:791260"
                     /db_xref="MGI:MGI:3769724"
     exon            1..70
                     /gene="Tomt"
                     /gene_synonym="Comt2; F930017I19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            71..345
                     /gene="Tomt"
                     /gene_synonym="Comt2; F930017I19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..863
                     /gene="Tomt"
                     /gene_synonym="Comt2; F930017I19Rik"
                     /EC_number="2.1.1.6"
                     /note="catechol O-methyltransferase 2"
                     /codon_start=1
                     /product="transmembrane O-methyltransferase homolog"
                     /protein_id="NP_001269017.1"
                     /db_xref="CCDS:CCDS40044.1"
                     /db_xref="GeneID:791260"
                     /db_xref="MGI:MGI:3769724"
                     /translation="MSPAIALAFLPLVVTLLVRYRHHFRLLVRTVLLRGFRDCLSGLR
                     IEERAFSYVLTHALPGDPGHILTTLDHWSSCCEYLSHMGPVKGQILMRLVEEKAPACV
                     LELGTYCGYSTLLIARALPPGSRLLTVERDSRTAAVAEKVIRLAGFDEQMVELIAGSS
                     EEVIPRLRAQHQLNRADLVLLAHRPRYYLRDLQLLEAHALLPHGATVLADHVLFPGAP
                     RFLQYTKSCGRYRCRLHHTSLPDFPAIKDGIAQLTYTGPG"
     exon            346..542
                     /gene="Tomt"
                     /gene_synonym="Comt2; F930017I19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            543..1358
                     /gene="Tomt"
                     /gene_synonym="Comt2; F930017I19Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccttgggg ttagtcctct gaaggactcc cattccggta cctggtcttt cttaggagcc
       61 ttcagctcag gacccaggta gggacaatgt cccctgccat tgcactggca ttcctgccac
      121 tcgtggtaac actgctggtg agataccggc accatttccg actgctggtg cgtacagtcc
      181 tgctgagagg atttcgagac tgcctgtcag gacttcggat tgaggagcgg gctttcagct
      241 atgtgctcac ccatgccctg cctggagacc ctggtcacat cctcaccacg cttgaccatt
      301 ggagcagctg ctgcgagtac ctgagccaca tgggccctgt taaaggtcag attctgatgc
      361 ggctggtgga agagaaggcc cctgcttgtg tgctggagct gggcacatac tgtggatact
      421 ctacactgct tattgcgcga gccttgcccc ctggaagtcg ccttctcact gtggagcggg
      481 actcacgtac agcagcagtg gctgaaaaag tcatccggct ggcaggcttc gatgagcaaa
      541 tggtggagct cattgcaggc agctcagagg aagtgatccc acgcctaaga gctcagcacc
      601 agctgaatcg tgcagatctg gtgctcctgg cacaccgacc tcggtattac ttaagggatc
      661 tgcagctact ggaggcccat gctctgctcc cacatggcgc cactgtattg gctgaccatg
      721 tgctttttcc tggtgcaccc cgcttcctac agtacaccaa gagctgtggt cgctatcgct
      781 gccgccttca ccacaccagc ctcccagact tccctgccat taaagatggc atagcccaac
      841 tcacctatac tggacccggc tgaggtccag gacctgagat atttactaat acaattccaa
      901 ccccattcaa gcagacctca gaatatctcg tttccctctc tgtcttgtat ccaacacatg
      961 ctatggtcag gctggggagg cattcttttc aactttgtcc ccctccaacc tccatattaa
     1021 tctgaagtgt caaattctat tagccttttt ggtcctacaa ggtcccctca tagaaaatca
     1081 ggaactggaa gcaagaggct tgagctgtca atttagttat tgattgctcc ctccaagtga
     1141 atctttccct cctctgagat tcagtttact cttaacactg agacagctgg ctgaaggggc
     1201 tggagagata attcaacagt taagagcact gccagacgct ccctacctaa aggacctggg
     1261 ttcaattccc agcactcaca tagcacaggc acacatgtga tatacataca tacagacaaa
     1321 acacttttaa gcataacata aataaattaa aacaacaa
//
