LOCUS       NM_138599               3778 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus translocase of outer mitochondrial membrane 70A
            (Tomm70a), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_138599
VERSION     NM_138599.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3778)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3778)
  AUTHORS   Ma,L., Wang,Y., Li,X., Wang,Z., Zhang,B., Luo,Y., Wu,Y., Li,Z. and
            Niu,W.
  TITLE     Tom70-regulated mitochondrial biogenesis via TFAM improves
            hypoxia-induced dysfunction of pulmonary vascular endothelial cells
            and alleviates hypoxic pulmonary hypertension
  JOURNAL   Respir Res 24 (1), 310 (2023)
   PUBMED   38093274
  REMARK    GeneRIF: Tom70-regulated mitochondrial biogenesis via TFAM improves
            hypoxia-induced dysfunction of pulmonary vascular endothelial cells
            and alleviates hypoxic pulmonary hypertension.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3778)
  AUTHORS   Li,X., Straub,J., Medeiros,T.C., Mehra,C., den Brave,F., Peker,E.,
            Atanassov,I., Stillger,K., Michaelis,J.B., Burbridge,E., Adrain,C.,
            Munch,C., Riemer,J., Becker,T. and Pernas,L.F.
  TITLE     Mitochondria shed their outer membrane in response to
            infection-induced stress
  JOURNAL   Science 375 (6577), eabi4343 (2022)
   PUBMED   35025629
  REMARK    GeneRIF: Mitochondria shed their outer membrane in response to
            infection-induced stress.
REFERENCE   4  (bases 1 to 3778)
  AUTHORS   Wang,P., Wang,D., Yang,Y., Hou,J., Wan,J., Ran,F., Dai,X., Zhou,P.
            and Yang,Y.
  TITLE     Tom70 protects against diabetic cardiomyopathy through its
            antioxidant and antiapoptotic properties
  JOURNAL   Hypertens Res 43 (10), 1047-1056 (2020)
   PUBMED   32724135
  REMARK    GeneRIF: Tom70 protects against diabetic cardiomyopathy through its
            antioxidant and antiapoptotic properties.
REFERENCE   5  (bases 1 to 3778)
  AUTHORS   Filadi,R., Leal,N.S., Schreiner,B., Rossi,A., Dentoni,G.,
            Pinho,C.M., Wiehager,B., Cieri,D., Cali,T., Pizzo,P. and
            Ankarcrona,M.
  TITLE     TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to
            Mitochondria Ca2+ Transfer
  JOURNAL   Curr Biol 28 (3), 369-382 (2018)
   PUBMED   29395920
  REMARK    GeneRIF: TOM70, but not TOM20, clusters in distinct OMM foci,
            frequently overlapping with sites in which the endoplasmic
            reticulum (ER) contacts mitochondria. Functionally, TOM70 depletion
            specifically impairs inositol trisphosphates (IP3)-linked ER to
            mitochondria Ca(2+) transfer. This phenomenon is dependent on the
            capacity of TOM70 to interact with IP3-receptors and favor their
            functional recruitment close to mitochondria.
REFERENCE   6  (bases 1 to 3778)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   7  (bases 1 to 3778)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 3778)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (bases 1 to 3778)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   10 (bases 1 to 3778)
  AUTHORS   Wei,J., Hodes,M.E., Wang,Y., Feng,Y., Ghetti,B. and Dlouhy,S.R.
  TITLE     Direct cDNA selection with DNA microdissected from mouse chromosome
            16: isolation of novel clones and construction of a partial
            transcription map of the C3-C4 region
  JOURNAL   Genome Res 6 (8), 678-687 (1996)
   PUBMED   8858343
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC154625.3.
            
            On Oct 19, 2007 this sequence version replaced NM_138599.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083586.1, AK150429.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-481               AC154625.3         49808-50288
            482-655             AC154625.3         61171-61344
            656-782             AC154625.3         62747-62873
            783-892             AC154625.3         64792-64901
            893-1041            AC154625.3         66124-66272
            1042-1249           AC154625.3         68673-68880
            1250-1384           AC154625.3         70815-70949
            1385-1492           AC154625.3         72785-72892
            1493-1609           AC154625.3         74124-74240
            1610-1707           AC154625.3         75827-75924
            1708-1830           AC154625.3         77914-78036
            1831-3778           AC154625.3         80677-82624
FEATURES             Location/Qualifiers
     source          1..3778
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 34.22 cM"
     gene            1..3778
                     /gene="Tomm70a"
                     /gene_synonym="2610044B22Rik; D16Ium22; D16Ium22e;
                     D16Wsu109e; mKIAA0719; Tom70; Tomm70"
                     /note="translocase of outer mitochondrial membrane 70A"
                     /db_xref="GeneID:28185"
                     /db_xref="MGI:MGI:106295"
     exon            1..481
                     /gene="Tomm70a"
                     /gene_synonym="2610044B22Rik; D16Ium22; D16Ium22e;
                     D16Wsu109e; mKIAA0719; Tom70; Tomm70"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1984
                     /gene="Tomm70a"
                     /gene_synonym="2610044B22Rik; D16Ium22; D16Ium22e;
                     D16Wsu109e; mKIAA0719; Tom70; Tomm70"
                     /note="translocase of outer membrane 70 kDa subunit;
                     mitochondrial precursor proteins import receptor;
                     translocase of outer mitochondrial membrane protein 70;
                     translocase of outer mitochondrial membrane 70 homolog A"
                     /codon_start=1
                     /product="mitochondrial import receptor subunit TOM70"
                     /protein_id="NP_613065.2"
                     /db_xref="CCDS:CCDS28227.1"
                     /db_xref="GeneID:28185"
                     /db_xref="MGI:MGI:106295"
                     /translation="MAASKPIEAAMAAAAAPGSGNGVGGGGGTAGPGSGAGTLPRWHV
                     ALAIGAPLLLGAGAMYLWSRRRRRREAGGRGDASGLKRNSERKTPEGRASPALGSGHH
                     DGSGDSLEMSSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQ
                     NRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCI
                     LEGFQNEQSMLLADKVLKLLGKENAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPM
                     LKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEIDAQGKYMAEA
                     LLLRATFYLLIGSANAAKPDLDKVISLKEANVKLRANALIKRGTMCMQQQQPMLSTQD
                     FNMAAEIDPMNSDVYHHRGQLKILLDLVEEAVADFDACIRLRPKFALAQAQKCFALYR
                     QAYTANNSSQVQAAMKGFEEIIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDL
                     EPDNATTYVHKGLLQLQWKQDLDKGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEK
                     AIDMFNKAINLAKSEMEMAHLYSLCDAAHAQTEVAKKYGLKPPTL"
     exon            482..655
                     /gene="Tomm70a"
                     /gene_synonym="2610044B22Rik; D16Ium22; D16Ium22e;
                     D16Wsu109e; mKIAA0719; Tom70; Tomm70"
                     /inference="alignment:Splign:2.1.0"
     exon            656..782
                     /gene="Tomm70a"
                     /gene_synonym="2610044B22Rik; D16Ium22; D16Ium22e;
                     D16Wsu109e; mKIAA0719; Tom70; Tomm70"
                     /inference="alignment:Splign:2.1.0"
     exon            783..892
                     /gene="Tomm70a"
                     /gene_synonym="2610044B22Rik; D16Ium22; D16Ium22e;
                     D16Wsu109e; mKIAA0719; Tom70; Tomm70"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1041
                     /gene="Tomm70a"
                     /gene_synonym="2610044B22Rik; D16Ium22; D16Ium22e;
                     D16Wsu109e; mKIAA0719; Tom70; Tomm70"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1249
                     /gene="Tomm70a"
                     /gene_synonym="2610044B22Rik; D16Ium22; D16Ium22e;
                     D16Wsu109e; mKIAA0719; Tom70; Tomm70"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1384
                     /gene="Tomm70a"
                     /gene_synonym="2610044B22Rik; D16Ium22; D16Ium22e;
                     D16Wsu109e; mKIAA0719; Tom70; Tomm70"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1492
                     /gene="Tomm70a"
                     /gene_synonym="2610044B22Rik; D16Ium22; D16Ium22e;
                     D16Wsu109e; mKIAA0719; Tom70; Tomm70"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1609
                     /gene="Tomm70a"
                     /gene_synonym="2610044B22Rik; D16Ium22; D16Ium22e;
                     D16Wsu109e; mKIAA0719; Tom70; Tomm70"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1707
                     /gene="Tomm70a"
                     /gene_synonym="2610044B22Rik; D16Ium22; D16Ium22e;
                     D16Wsu109e; mKIAA0719; Tom70; Tomm70"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1830
                     /gene="Tomm70a"
                     /gene_synonym="2610044B22Rik; D16Ium22; D16Ium22e;
                     D16Wsu109e; mKIAA0719; Tom70; Tomm70"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..3778
                     /gene="Tomm70a"
                     /gene_synonym="2610044B22Rik; D16Ium22; D16Ium22e;
                     D16Wsu109e; mKIAA0719; Tom70; Tomm70"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2261..2266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tomm70a"
                     /gene_synonym="2610044B22Rik; D16Ium22; D16Ium22e;
                     D16Wsu109e; mKIAA0719; Tom70; Tomm70"
                     /note="hexamer: AATAAA"
     polyA_site      2280
                     /gene="Tomm70a"
                     /gene_synonym="2610044B22Rik; D16Ium22; D16Ium22e;
                     D16Wsu109e; mKIAA0719; Tom70; Tomm70"
                     /note="major polyA site"
ORIGIN      
        1 gacctctggc ccttttctgt cgtccgctcc tgctgcttag cgtgctcgct cgcgcgttgc
       61 tttccctcca cgctcccggc ttcctcccca cgctgcccgg tgaccgtggc gcccgcgacc
      121 ggcgcggcgg cggcggagga cagtcgtcat ggccgcctct aagcccatag aggcggcgat
      181 ggcggcggct gctgcgcccg gttctggaaa tggagtgggc ggtggcggtg ggactgcggg
      241 ccccggctcg ggcgcgggga ccctgccgcg atggcacgtg gcgctggcca tcggggcgcc
      301 cctgttgctg ggtgctgggg ctatgtacct gtggagccga aggcggaggc gccgggaagc
      361 gggaggccgg ggcgacgcca gcggcctgaa gcgcaacagt gaacggaaga cccccgaggg
      421 cagggccagt ccggccctgg gcagtggcca ccacgacggt tctggggact ccctggaaat
      481 gagctctctg gacagagcgc aagcagccaa aaacaaaggc aacaaatatt tcaaagcagg
      541 aaaatacgag caagctattc agtgctacac tgaggctatt agtttgtgcc ctactgagaa
      601 gaatgtagac ctttctacat tttatcagaa cagagctgct gcctttgaac aattgcaaaa
      661 atggaaagaa gtggcccaag attgtacaaa ggctgttgaa cttaatccca aatatgtgaa
      721 agccctcttt agacgtgcaa aagcccatga gaagctagac aataagaagg agtgtttaga
      781 agacgtcact gctgtgtgta tattagaagg gtttcaaaat gagcagagca tgctgttagc
      841 tgataaagtt cttaaacttc ttgggaaaga gaatgccaaa gaaaaataca agaaccgtga
      901 acctctgatg ccatctccac agtttattaa atcttacttc agttctttca ccgatgatat
      961 aatttctcaa ccaatgctta agggagagaa gtctgatgaa gataaagaca aggagggaga
     1021 ggctttagaa gtgaaagaaa attctgggta tttgaaagct aaacaatata tggaagaaga
     1081 aaactatgac aaaatcataa gtgaatgttc aaaggaaata gatgctcaag gcaaatacat
     1141 ggcagaagca ttacttctgc gagccacctt ctacctactt attggcagtg ccaacgcggc
     1201 caagcctgac ttagataagg tcatcagttt gaaggaagct aatgtgaagc ttcgagcaaa
     1261 tgcccttatc aagagaggca ccatgtgcat gcagcagcaa caacctatgc tgtctactca
     1321 ggacttcaac atggctgccg agatcgatcc tatgaactca gacgtttatc accaccgagg
     1381 acagctgaaa attctgctgg atctggttga agaagcagtg gcggattttg atgcatgtat
     1441 cagattaaga ccaaagtttg ctttggcgca ggctcagaag tgttttgcat tgtatcgcca
     1501 ggcatataca gcaaacaatt cttcgcaagt ccaggcagct atgaaaggtt ttgaagagat
     1561 cataaagaaa tttccaagat gtgctgaagg ctatgcactt tatgcccagg cattaacaga
     1621 tcaacaacag tttggtaaag ctgatgaaat gtatgataag tgtattgatt tggaaccaga
     1681 taatgctaca acttatgttc ataaaggttt acttcaactt cagtggaagc aagatttgga
     1741 taaaggtttg gagcttatca gcaaggctat tgaaattgac aacaaatgtg actttgcata
     1801 tgagaccatg gggactattg aagtgcagag aggaaacatg gagaaagcca ttgacatgtt
     1861 caacaaagct atcaacttgg ccaagtcgga aatggagatg gctcatctgt attcactttg
     1921 tgatgctgcc catgcccaga cagaagtagc aaagaaatac ggattaaaac cgccgacatt
     1981 ataaacacag gggaaacaga ctgactcttt tcaaagaagt ttaccccctc ttcaactcaa
     2041 ccctgaagac actgtcataa attgttgaac ggtggaactt agtagtccct ttgtgatgtt
     2101 gtcattcatt acatctgttt catgtttagg tgtagtgggc gtggctgttg aaggaagttt
     2161 gcagtcttgc agcttttatt ccctgtgcaa caaaagctta gaacctgtta aagggatatt
     2221 aaaacaaagt tgtagaatac aaacagtaat tggccatgca aataaaaact ttgatttgtt
     2281 gatttgtttt ttttttttaa tattggggtg gggattatgt tctgaatgat tttgtttttt
     2341 tatagctgtt tgtataatat gtgagtattt tatagtatgt tagtttttaa catagtaagt
     2401 gctgtaaaat atacttcttt tgtattcaat taatcctttt taattttttt tgaaggatga
     2461 aaagcttcaa tgtggatttc agtaaaattg aaagacttta agctattgtc agcatgcaca
     2521 gtgcctctga ttctgtagaa ctttagtaaa ttatgcagaa gcaaaatatt ctcattgata
     2581 cttgtacagg aagacttaat gagggactga acaaggcagg taagatgaac aagacatgta
     2641 tatacttggc cgtgcctatt ccatagtaag tactatttaa tagtatgctt ttaaatgaaa
     2701 gtgggtgtat gtgagcaacc cacgtacagg tggagtacat gtgatgatat ataggagtat
     2761 ttaattagct tcaattttct agtgacagaa atttggtaaa ggttctaaag gatgtcagtc
     2821 ctgaagccag gacatacttg tttgaaatgg aaacctcagt ggtgtagctg tggctgctaa
     2881 cttagggatt tgagccagta tttccagagc tgtccaatac atagagtact tctgtattga
     2941 ggtgaccttc acctctaagg acggatggcc cacatccaca tctccaggga tgctgacagt
     3001 tggttctgtt cattttgatc tgtacctcat cctcttttga ctctctaagc tgtttctctt
     3061 cctcactttc acagcctatc cttttactta cttatctgct ggagttttct ggttggggag
     3121 ggatgtgttc ttactgagtc tgtttccaag atccaggaca ggttgaggtt tatttaagta
     3181 aaatgatttt ttaaaaaagc aagcctgctt ataattatag tttacattgt tgagagtaaa
     3241 ggagcatttt acactcttat tttaaaaggg tgctttatcc cactgaaacc aaaatgattt
     3301 tgtctacaga tgctgtcttt ttagaaaata ttagaaatga ctcctcttat aaagtcagtt
     3361 tttggacgat gctggttagc ctatggctga tatcattagg aacaattaat gtaatttaag
     3421 gtgactggga taatggaaag ttggagagat cttcattttg ttgtgaaata attctccaat
     3481 gatgataacc ttaaatacag aaatgtccta catctctgaa tgtgacctct tcgcttaaaa
     3541 gttttttatt tgcatggctg tatttacatt aatagggaca tcttctactc ttctcccttc
     3601 tttcttgggg tagggtagga aacactgaag catgtgccgt tcaatactgt cattccagat
     3661 actcaaatgt tttgcttgtt gtgaacatgt ttgaaactgc actgaaagct gcatctgtct
     3721 gtatctttac ttttgtaaat ggcttcacat gtaaattcac aaaataaata ctacattc
//
