LOCUS       NM_025394               1126 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus translocase of outer mitochondrial membrane 7 (Tomm7),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_025394
VERSION     NM_025394.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1126)
  AUTHORS   Young,C., Batkovskyte,D., Kitamura,M., Shvedova,M., Mihara,Y.,
            Akiba,J., Zhou,W., Hammarsjo,A., Nishimura,G., Yatsuga,S.,
            Grigelioniene,G. and Kobayashi,T.
  TITLE     A hypomorphic variant in the translocase of the outer mitochondrial
            membrane complex subunit TOMM7 causes short stature and
            developmental delay
  JOURNAL   HGG Adv 4 (1), 100148 (2022)
   PUBMED   36299998
  REMARK    GeneRIF: A hypomorphic variant in the translocase of the outer
            mitochondrial membrane complex subunit TOMM7 causes short stature
            and developmental delay.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1126)
  AUTHORS   Shi,D., Qi,M., Zhou,L., Li,X., Ni,L., Li,C., Yuan,T., Wang,Y.,
            Chen,Y., Hu,C., Liang,D., Li,L., Liu,Y., Li,J. and Chen,Y.H.
  TITLE     Endothelial Mitochondrial Preprotein Translocase Tomm7-Rac1
            Signaling Axis Dominates Cerebrovascular Network Homeostasis
  JOURNAL   Arterioscler Thromb Vasc Biol 38 (11), 2665-2677 (2018)
   PUBMED   30354240
  REMARK    GeneRIF: Tomm7 drives brain angiogenesis and cerebrovascular
            network formation through modulating mitochondrial Rac1 signaling
            within the endothelium.
REFERENCE   3  (bases 1 to 1126)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
REFERENCE   4  (bases 1 to 1126)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU555283.1, BY773505.1, AK003864.1, BE647192.1 and CO039527.1.
            
            On Oct 19, 2007 this sequence version replaced NM_025394.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU555283.1, BY395497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BU555283.1         4-10
            8-38                BY773505.1         1-31
            39-399              AK003864.1         2-362
            400-550             BE647192.1         202-352
            551-1126            CO039527.1         1-576               c
FEATURES             Location/Qualifiers
     source          1..1126
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 10.48 cM"
     gene            1..1126
                     /gene="Tomm7"
                     /gene_synonym="1110020J08Rik; Tom7"
                     /note="translocase of outer mitochondrial membrane 7"
                     /db_xref="GeneID:66169"
                     /db_xref="MGI:MGI:1913419"
     exon            1..175
                     /gene="Tomm7"
                     /gene_synonym="1110020J08Rik; Tom7"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..240
                     /gene="Tomm7"
                     /gene_synonym="1110020J08Rik; Tom7"
                     /note="translocase of outer membrane 7 kDa subunit
                     homolog; translocase of outer mitochondrial membrane 7
                     homolog"
                     /codon_start=1
                     /product="mitochondrial import receptor subunit TOM7
                     homolog"
                     /protein_id="NP_079670.1"
                     /db_xref="CCDS:CCDS39026.1"
                     /db_xref="GeneID:66169"
                     /db_xref="MGI:MGI:1913419"
                     /translation="MVKLSKEAKQRLQQLFKGGQFAIRWGFIPLVIYLGFTRGADPGM
                     PEPSVLSLLWG"
     exon            176..224
                     /gene="Tomm7"
                     /gene_synonym="1110020J08Rik; Tom7"
                     /inference="alignment:Splign:2.1.0"
     exon            225..1109
                     /gene="Tomm7"
                     /gene_synonym="1110020J08Rik; Tom7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      379..384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tomm7"
                     /gene_synonym="1110020J08Rik; Tom7"
                     /note="hexamer: AATAAA"
     polyA_site      401
                     /gene="Tomm7"
                     /gene_synonym="1110020J08Rik; Tom7"
                     /note="major polyA site"
     polyA_site      427
                     /gene="Tomm7"
                     /gene_synonym="1110020J08Rik; Tom7"
     regulatory      710..715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tomm7"
                     /gene_synonym="1110020J08Rik; Tom7"
                     /note="hexamer: AGTAAA"
     polyA_site      730
                     /gene="Tomm7"
                     /gene_synonym="1110020J08Rik; Tom7"
     regulatory      1090..1095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tomm7"
                     /gene_synonym="1110020J08Rik; Tom7"
                     /note="hexamer: AATAAA"
     polyA_site      1109
                     /gene="Tomm7"
                     /gene_synonym="1110020J08Rik; Tom7"
ORIGIN      
        1 gctcctctcc cttccgggat ccggacacgg tggtggttgt tgggctcctc gttccgctgg
       61 tccgtcgtcg ccatggtgaa gctgagcaaa gaagccaaac agaggctgca gcagctcttc
      121 aagggcggcc agtttgccat ccgctggggc tttattcctc tcgtgattta cctgggattt
      181 acaaggggtg cagatcctgg aatgcctgaa ccgtcggttt taagcctact ttggggataa
      241 aggactgttt gaacatctgg atttggacgc gatccaacat ggaaggtgta tactccagct
      301 ggacaagaaa ggagacgtca tttcaacgat tctgtggcag agtggaggag cctatactga
      361 tttatgatag actatcaaaa taaatatttt taacaatgta atattttgcc tttcatactt
      421 tttgaaacct atgtgtgtgt gtctctctct tggtatgtat gtttatatta tattgtacca
      481 gtgtagaagt aagaggacaa actactgcag aaatttgttc tctccttcta ccatgtggtc
      541 tgaggaggta acttggtagc agatgttttg acccactgaa gctatctgtc tggtctgcct
      601 tgatcttctt ggattaagta tgctgggact aatagatgag gttcaagcgt tttattacat
      661 ctttctttag aacagaaaat ctatgtgtgt gcttgagtac tgccttaaaa gtaaaagcct
      721 ttcctaggga gttcctggtt ggtcatttgt caggtgcagt tcccttttgc agatcatcag
      781 cctcagaaac gttccaagtc aggagaggag gcatgtcagt tttggacatc ttggacgtga
      841 agctaactgt aagaaatgac ggtttagtgt ttgcactgct aggggatagg aatagtgttg
      901 ggggattgtg cctaatttat ttgtagatta aatgagtcta gaattttctt caggtgtaag
      961 caaagtagag ctggctttgg ccgaggctca atacagcact ttctcccagt agaagaaaag
     1021 acagctaatg gaatgagtca tgtctttcac tgctttcctg ggactttctg tattttgttt
     1081 tggcctttaa ataaaactgt ttagcatcaa aaaaaaaaaa aaaaaa
//
