LOCUS       NM_016871               1571 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus translocase of outer mitochondrial membrane 40
            (Tomm40), transcript variant 2, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_016871
VERSION     NM_016871.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1571)
  AUTHORS   Zhai,D.S., Wang,X.S., Yang,L., Jiang,Y.L., Jin,Y.C., Yan,Y.X.,
            Song,D.K., Zhang,K., Han,Z.K., Liu,M.Y., Wu,Y.M., Ma,X., Qi,J.Y.,
            Yang,F., Tian,F., Li,X.B. and Liu,S.B.
  TITLE     TOM40 mediates the effect of TSPO on postpartum depression
            partially through regulating calcium homeostasis in microglia
  JOURNAL   J Affect Disord 348, 283-296 (2024)
   PUBMED   38159656
  REMARK    GeneRIF: TOM40 mediates the effect of TSPO on postpartum depression
            partially through regulating calcium homeostasis in microglia.
REFERENCE   2  (bases 1 to 1571)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1571)
  AUTHORS   Hilander,T., Zhou,X.L., Konovalova,S., Zhang,F.P., Euro,L.,
            Chilov,D., Poutanen,M., Chihade,J., Wang,E.D. and Tyynismaa,H.
  TITLE     Editing activity for eliminating mischarged tRNAs is essential in
            mammalian mitochondria
  JOURNAL   Nucleic Acids Res 46 (2), 849-860 (2018)
   PUBMED   29228266
REFERENCE   4  (bases 1 to 1571)
  AUTHORS   Terzenidou,M.E., Segklia,A., Kano,T., Papastefanaki,F.,
            Karakostas,A., Charalambous,M., Ioakeimidis,F., Papadaki,M.,
            Kloukina,I., Chrysanthou-Piterou,M., Samiotaki,M., Panayotou,G.,
            Matsas,R. and Douni,E.
  TITLE     Novel insights into SLC25A46-related pathologies in a genetic mouse
            model
  JOURNAL   PLoS Genet 13 (4), e1006656 (2017)
   PUBMED   28376086
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1571)
  AUTHORS   Ishihara,T., Ban-Ishihara,R., Maeda,M., Matsunaga,Y., Ichimura,A.,
            Kyogoku,S., Aoki,H., Katada,S., Nakada,K., Nomura,M., Mizushima,N.,
            Mihara,K. and Ishihara,N.
  TITLE     Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial
            fission is essential for maintenance of homogeneously active
            mitochondria during neonatal heart development
  JOURNAL   Mol Cell Biol 35 (1), 211-223 (2015)
   PUBMED   25348719
REFERENCE   6  (bases 1 to 1571)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1571)
  AUTHORS   Danial,N.N., Gramm,C.F., Scorrano,L., Zhang,C.Y., Krauss,S.,
            Ranger,A.M., Datta,S.R., Greenberg,M.E., Licklider,L.J.,
            Lowell,B.B., Gygi,S.P. and Korsmeyer,S.J.
  TITLE     BAD and glucokinase reside in a mitochondrial complex that
            integrates glycolysis and apoptosis
  JOURNAL   Nature 424 (6951), 952-956 (2003)
   PUBMED   12931191
REFERENCE   8  (bases 1 to 1571)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1571)
  AUTHORS   Das,B., Tao,S.Z., Mushnitsky,R. and Norin,A.J.
  TITLE     Genetic identity and differential expression of p38.5 (Haymaker) in
            human malignant and nonmalignant cells
  JOURNAL   Int J Cancer 94 (6), 800-806 (2001)
   PUBMED   11745481
REFERENCE   10 (bases 1 to 1571)
  AUTHORS   Rivera,I.L., Shore,G.C. and Schleiff,E.
  TITLE     Cloning and characterization of a 35-kDa mouse mitochondrial outer
            membrane protein MOM35 with high homology to Tom40
  JOURNAL   J Bioenerg Biomembr 32 (1), 111-121 (2000)
   PUBMED   11768756
  REMARK    GeneRIF: imported into the outer mitochondrial membrane
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY231811.1, AK165173.1 and AW493492.1.
            
            On Oct 5, 2007 this sequence version replaced NM_016871.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK164570.1, AK170991.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BY231811.1         3-8
            7-1532              AK165173.1         2-1527
            1533-1571           AW493492.1         1-39                c
FEATURES             Location/Qualifiers
     source          1..1571
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.94 cM"
     gene            1..1571
                     /gene="Tomm40"
                     /gene_synonym="Mom35; Tom40"
                     /note="translocase of outer mitochondrial membrane 40"
                     /db_xref="GeneID:53333"
                     /db_xref="MGI:MGI:1858259"
     exon            1..72
                     /gene="Tomm40"
                     /gene_synonym="Mom35; Tom40"
                     /inference="alignment:Splign:2.1.0"
     exon            73..351
                     /gene="Tomm40"
                     /gene_synonym="Mom35; Tom40"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1163
                     /gene="Tomm40"
                     /gene_synonym="Mom35; Tom40"
                     /note="mitochondrial outer membrane protein 35; haymaker
                     protein; mitochondrial outer membrane protein of 35 kDa;
                     translocase of outer membrane 40 kDa subunit homolog;
                     translocase of outer mitochondrial membrane 40 homolog"
                     /codon_start=1
                     /product="mitochondrial import receptor subunit TOM40
                     homolog"
                     /protein_id="NP_058567.2"
                     /db_xref="CCDS:CCDS52062.1"
                     /db_xref="GeneID:53333"
                     /db_xref="MGI:MGI:1858259"
                     /translation="MGNVLAASSPPAGPPPPPTPSLVGLPPPPPSPPGFTLPPLGGGL
                     GTGSSTGRGSERTPGAAASGAAAASEDGSCGCLPNPGTFEECHRKCKELFPVQMEGVK
                     LTVNKGLSNRFQVTHTVALGTIGESNYHFGVTYVGTKQLSPTEAFPVLVGDMDNSGSL
                     NAQVIHQLSPGLRSKMAIQTQQSKFVNWQVDGEYRGSDFTAAVTLGNPDVLVGSGILV
                     AHYLQSITPCLALGGELVYHRRPGEEGTVMSLAGKYTLNNWLATVTLGQAGMHATYYH
                     KASDQLQVGVEFEASTRMQDTSASFGYQLDLPKANFLFKGSVNSNWIVGATLEKKLPP
                     LPLTLSLCAFLNHRKNKFLCGFGLTIG"
     exon            352..419
                     /gene="Tomm40"
                     /gene_synonym="Mom35; Tom40"
                     /inference="alignment:Splign:2.1.0"
     exon            420..512
                     /gene="Tomm40"
                     /gene_synonym="Mom35; Tom40"
                     /inference="alignment:Splign:2.1.0"
     exon            513..614
                     /gene="Tomm40"
                     /gene_synonym="Mom35; Tom40"
                     /inference="alignment:Splign:2.1.0"
     exon            615..720
                     /gene="Tomm40"
                     /gene_synonym="Mom35; Tom40"
                     /inference="alignment:Splign:2.1.0"
     exon            721..843
                     /gene="Tomm40"
                     /gene_synonym="Mom35; Tom40"
                     /inference="alignment:Splign:2.1.0"
     exon            844..920
                     /gene="Tomm40"
                     /gene_synonym="Mom35; Tom40"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1023
                     /gene="Tomm40"
                     /gene_synonym="Mom35; Tom40"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1568
                     /gene="Tomm40"
                     /gene_synonym="Mom35; Tom40"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1404
                     /gene="Tomm40"
                     /gene_synonym="Mom35; Tom40"
                     /note="major polyA site"
ORIGIN      
        1 gggttcggtt gcgcttagcg cacggggtag gagcggagcc caggccggga agaggagccg
       61 ccgcggccgc caataccatg gggaacgtgt tggctgccag ctctccgccc gcagggccac
      121 cgccgcctcc tacgccgtcc ctcgtggggc tcccgccgcc gcctccttcg ccgccaggct
      181 tcactctgcc gccgctcggc ggcggcctgg gcactgggtc aagcactggc cgtggttcgg
      241 aacggactcc cggggctgcg gccagcggcg ctgcggcggc ctcggaagat gggagctgcg
      301 gatgcctgcc caacccgggg acgttcgagg agtgccaccg gaagtgcaag gagctgtttc
      361 cagttcagat ggaaggtgtc aaacttacag tcaacaaagg gttgagcaac cgtttccagg
      421 tgacccacac agtagccctc ggcacaattg gggagtccaa ctaccacttt ggggtcacat
      481 acgtggggac gaagcagctg agtcccacag aggcgttccc cgtgctggtg ggtgacatgg
      541 acaatagtgg cagcctcaat gcacaggtca tccaccagct gagcccaggc ctcaggtcca
      601 aaatggccat ccagacccag cagtccaagt tcgtgaactg gcaggtggat ggcgagtacc
      661 gtggttctga cttcacagct gctgtcaccc tgggcaaccc agatgtcttg gtgggttcag
      721 gaatcctcgt ggcccactac ctccagagca tcacaccgtg tctggccctg ggtggagagc
      781 tcgtctacca ccggcggcca ggagaggagg gcactgtcat gtctctagct gggaaataca
      841 cactgaacaa ctggttggct acagtaacgc tgggccaggc aggcatgcat gcgacgtatt
      901 accacaaagc cagtgaccag ctgcaggtgg gtgtggagtt tgaggccagc accaggatgc
      961 aggacaccag tgcctccttt gggtatcagc tggacctgcc caaggccaac ttccttttta
     1021 aaggctctgt gaacagtaac tggatcgtgg gcgccacgct ggagaagaag cttccgccct
     1081 tgcccctgac actgtccctc tgcgccttcc tgaaccaccg caagaataag ttcctgtgtg
     1141 gcttcggcct caccatcggc tgagccctcc tgtccttcct ctgcagacca tcgctgggcc
     1201 ggctgccctc ccctcctctc cctctctctt ggggttgggg cagtgggaag gaggggacct
     1261 cccatgccca aggatcccca gcgccagggg acagtgccca gggggcctgg ggtcccggag
     1321 ggagtcctgg gatctgaagg gcattcgatt gtgagcgccc aggcagaggc gcagaggcgg
     1381 ctgtacacag gctcagaaag gaaagacttg atgtcctcct gagggcagca gaggagcgcc
     1441 gagccgcctg tcacttcccc ctccacccct ccatagaaat catgtttata agttatggaa
     1501 aaccgggaca ttttacagaa aaaaaaaaac ttaaaaaaca aaaaatatac gtggaaaaaa
     1561 aaataggaaa a
//
