LOCUS       NM_172609               1024 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus translocase of outer mitochondrial membrane 22
            (Tomm22), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_172609 XM_489635
VERSION     NM_172609.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1024)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1024)
  AUTHORS   Kravic,B., Harbauer,A.B., Romanello,V., Simeone,L., Vogtle,F.N.,
            Kaiser,T., Straubinger,M., Huraskin,D., Bottcher,M., Cerqua,C.,
            Martin,E.D., Poveda-Huertes,D., Buttgereit,A., Rabalski,A.J.,
            Heuss,D., Rudolf,R., Friedrich,O., Litchfield,D., Marber,M.,
            Salviati,L., Mougiakakos,D., Neuhuber,W., Sandri,M., Meisinger,C.
            and Hashemolhosseini,S.
  TITLE     In mammalian skeletal muscle, phosphorylation of TOMM22 by protein
            kinase CSNK2/CK2 controls mitophagy
  JOURNAL   Autophagy 14 (2), 311-335 (2018)
   PUBMED   29165030
  REMARK    GeneRIF: these data show that mammalian CSNK2-dependent
            phosphorylation of TOMM22 is a critical switch for mitophagy and
            reveal CSNK2-dependent physiological implications on metabolism,
            muscle integrity and behavior.
REFERENCE   3  (bases 1 to 1024)
  AUTHORS   Rajapaksha,M., Kaur,J., Prasad,M., Pawlak,K.J., Marshall,B.,
            Perry,E.W., Whittal,R.M. and Bose,H.S.
  TITLE     An Outer Mitochondrial Translocase, Tom22, Is Crucial for Inner
            Mitochondrial Steroidogenic Regulation in Adrenal and Gonadal
            Tissues
  JOURNAL   Mol Cell Biol 36 (6), 1032-1047 (2016)
   PUBMED   26787839
  REMARK    GeneRIF: Tom22 is essential for metabolic conversion, as its
            knockdown by small interfering RNA (siRNA) completely ablated
            progesterone conversion in both steroidogenic mouse Leydig MA-10
            and human adrenal NCI cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1024)
  AUTHORS   Tummala,H., Li,X. and Homayouni,R.
  TITLE     Interaction of a novel mitochondrial protein,
            4-nitrophenylphosphatase domain and non-neuronal SNAP25-like
            protein homolog 1 (NIPSNAP1), with the amyloid precursor protein
            family
  JOURNAL   Eur J Neurosci 31 (11), 1926-1934 (2010)
   PUBMED   20497468
REFERENCE   5  (bases 1 to 1024)
  AUTHORS   Ishihara,N., Nomura,M., Jofuku,A., Kato,H., Suzuki,S.O., Masuda,K.,
            Otera,H., Nakanishi,Y., Nonaka,I., Goto,Y., Taguchi,N.,
            Morinaga,H., Maeda,M., Takayanagi,R., Yokota,S. and Mihara,K.
  TITLE     Mitochondrial fission factor Drp1 is essential for embryonic
            development and synapse formation in mice
  JOURNAL   Nat Cell Biol 11 (8), 958-966 (2009)
   PUBMED   19578372
REFERENCE   6  (bases 1 to 1024)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK009868.1.
            
            On Apr 6, 2007 this sequence version replaced NM_172609.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009868.1, AK150787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1024              AK009868.1         1-1024
FEATURES             Location/Qualifiers
     source          1..1024
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.85 cM"
     gene            1..1024
                     /gene="Tomm22"
                     /gene_synonym="2310047D01; Tom22"
                     /note="translocase of outer mitochondrial membrane 22"
                     /db_xref="GeneID:223696"
                     /db_xref="MGI:MGI:2450248"
     exon            1..141
                     /gene="Tomm22"
                     /gene_synonym="2310047D01; Tom22"
                     /inference="alignment:Splign:2.1.0"
     exon            142..260
                     /gene="Tomm22"
                     /gene_synonym="2310047D01; Tom22"
                     /inference="alignment:Splign:2.1.0"
     exon            261..378
                     /gene="Tomm22"
                     /gene_synonym="2310047D01; Tom22"
                     /inference="alignment:Splign:2.1.0"
     exon            379..1024
                     /gene="Tomm22"
                     /gene_synonym="2310047D01; Tom22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      710..715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tomm22"
                     /gene_synonym="2310047D01; Tom22"
                     /note="hexamer: AATAAA"
     polyA_site      729
                     /gene="Tomm22"
                     /gene_synonym="2310047D01; Tom22"
                     /note="major polyA site"
ORIGIN      
        1 ttccgcttcc ggtgtcctac agccatggcc gccgccgtcg ctgcagccgg cgctggggag
       61 cctctgtccc ccgaggaatt actcccgaaa gccgaggcag agaaagccga ggaggagctg
      121 gaagaagacg acgacgacga gctagacgag accctgtcgg agagactctg gggtctgacg
      181 gagatgtttc ccgagagggt ccggtcagcc gccggagcca cctttgacct ctcgctcttc
      241 gtggctcaga agatgtacag attttccagg gcagctttgt ggattgggac cacttccttc
      301 atgatcctgg ttcttcccgt tgtctttgag acagaaaagt tgcagatgga gcaacagcag
      361 caactgcagc aacggcagat acttttaggg cctaacacag ggctgtcagg aggaatgcca
      421 ggggctctac ctccacttcc tggaaagatg tagattcttc cttcggtatt tgtccttgtg
      481 ggagaacttt gaaattcatt tgtgtttgaa ctgctgattg ttggaacttt ttattctttt
      541 ttttaacctt ggcacatgga tctatttgaa catagtggga actttctctg tttctcatgg
      601 agagacccca ggtacacctg tgccctacat aatgaagtcc ctcacttact tcttcctgtt
      661 ctcactccaa tgctggagta cagccatgtg gaaggttagc ctactctcta ataaactgct
      721 cctaaggaag ttcttacatg cccattgtgg gaaagaagta agtacccctg accataagga
      781 ctttttttta atggaaatgt ctaggacatg taagcaccgt ggcactgaca aaattcatta
      841 tacctgagta cagaagtcac caggaatccc agagagaagg gaggctggct gtagctttag
      901 ccagaggggg actgggcaga gcaggcactc atttcctctg cagagtttgg ctcttagacc
      961 tgcttatgta taaaaaagaa gtcagcgctc actttttgta tttaaatatt aaaagaactc
     1021 gaac
//
