LOCUS       NM_153080               5017 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus target of myb1-like 2 (chicken) (Tom1l2), transcript
            variant 1, mRNA.
ACCESSION   NM_153080 XM_906389
VERSION     NM_153080.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5017)
  AUTHORS   Shinde,S.R., Mick,D.U., Aoki,E., Rodrigues,R.B., Gygi,S.P. and
            Nachury,M.V.
  TITLE     The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes
            for retrieval from cilia
  JOURNAL   Dev Cell 58 (8), 677-693 (2023)
   PUBMED   37019113
  REMARK    GeneRIF: The ancestral ESCRT protein TOM1L2 selects ubiquitinated
            cargoes for retrieval from cilia.
REFERENCE   2  (bases 1 to 5017)
  AUTHORS   Ricard,G., Molina,J., Chrast,J., Gu,W., Gheldof,N., Pradervand,S.,
            Schutz,F., Young,J.I., Lupski,J.R., Reymond,A. and Walz,K.
  TITLE     Phenotypic consequences of copy number variation: insights from
            Smith-Magenis and Potocki-Lupski syndrome mouse models
  JOURNAL   PLoS Biol 8 (11), e1000543 (2010)
   PUBMED   21124890
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5017)
  AUTHORS   Girirajan,S., Hauck,P.M., Williams,S., Vlangos,C.N., Szomju,B.B.,
            Solaymani-Kohal,S., Mosier,P.D., White,K.L. Jr., McCoy,K. and
            Elsea,S.H.
  TITLE     Tom1l2 hypomorphic mice exhibit increased incidence of infections
            and tumors and abnormal immunologic response
  JOURNAL   Mamm Genome 19 (4), 246-262 (2008)
   PUBMED   18343975
  REMARK    GeneRIF: Tom1l2plays a role in the immune response and possibly in
            tumor suppression.
REFERENCE   4  (bases 1 to 5017)
  AUTHORS   Larter,C.Z., Yeh,M.M., Haigh,W.G., Williams,J., Brown,S.,
            Bell-Anderson,K.S., Lee,S.P. and Farrell,G.C.
  TITLE     Hepatic free fatty acids accumulate in experimental
            steatohepatitis: role of adaptive pathways
  JOURNAL   J Hepatol 48 (4), 638-647 (2008)
   PUBMED   18280001
  REMARK    GeneRIF: Consistent with pathways of hepatic triglyceride
            synthesis, expression of diacylglycerol acyltransferase-1 and -2
            was increased, as were delta-5- and delta-6- fatty acid desaturase
            mRNA levels.
REFERENCE   5  (bases 1 to 5017)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 5017)
  AUTHORS   Bi,W., Yan,J., Stankiewicz,P., Park,S.S., Walz,K., Boerkoel,C.F.,
            Potocki,L., Shaffer,L.G., Devriendt,K., Nowaczyk,M.J., Inoue,K. and
            Lupski,J.R.
  TITLE     Genes in a refined Smith-Magenis syndrome critical deletion
            interval on chromosome 17p11.2 and the syntenic region of the mouse
  JOURNAL   Genome Res 12 (5), 713-728 (2002)
   PUBMED   11997338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596090.11, AF467887.1, AL669954.6, BC127266.1 and AI848036.1.
            
            On Jan 13, 2018 this sequence version replaced NM_153080.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.13341.1,
                                           SRR7652917.50424.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AL596090.11        74394-74414         c
            22-642              AF467887.1         2-622
            643-643             AL669954.6         99957-99957         c
            644-1336            AF467887.1         624-1316
            1337-1337           AL669954.6         80644-80644         c
            1338-1539           AF467887.1         1318-1519
            1540-4928           BC127266.1         1446-4834
            4929-5017           AI848036.1         1-89                c
FEATURES             Location/Qualifiers
     source          1..5017
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.81 cM"
     gene            1..5017
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /note="target of myb1-like 2 (chicken)"
                     /db_xref="GeneID:216810"
                     /db_xref="MGI:MGI:2443306"
     exon            1..149
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            150..234
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            235..313
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            314..463
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            464..598
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            599..757
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            758..874
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1008
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1057
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1181
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1299
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1375
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1435
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1472
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..5000
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4981..4986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /note="hexamer: AATAAA"
     polyA_site      4999
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /note="major polyA site"
ORIGIN      
        1 ggtggggcgg gggcaagtgt cagtcagggc agaacgcggc gcgggcagcg gagacccgtg
       61 gcacacagga gtccgggctg gaacgaggcc cgccgagatg gagttcctgc tggggaatcc
      121 gttcagcacc cctgtagggc agtgtcttga gaaggcaaca gatggctccc tgcagagcga
      181 ggactggaca ctgaatatgg agatctgtga catcatcaac gagacagagg aagggccaaa
      241 ggatgccatc cgggctctaa agaagcggct tagtgggaac cgaaactaca gagaagtgat
      301 gttggccctg acggtgctgg agacttgtgt gaagaactgt ggccaccgct ttcatctcct
      361 cgtggccaac cgagacttca tcgacagcgt tctggtcaaa attatctctc ccaagaataa
      421 ccctcccact atcgtccagg acaaagtgct ggctctaatt caggcatggg cagatgcctt
      481 taggagcagt cctgacctca caggtgttgt gcacatatat gaagaactga agaggagggg
      541 gattgagttc cccatggcgg acttggacgc cctgtctcct atccacacac cccagcggag
      601 tgtcccagaa atggatccag ctgccaccat tcccaggtcc cagacacagc ccaggacaac
      661 cgctggcacc tattcctcac ctcctccagc ttcctactct actctgcagg ccccggctct
      721 gagtgtgacg ggccccatca cagccaattc agaacagatt gccaggctgc gcagtgagct
      781 ggacattgtt cggggaaaca caaaagtcat gtctgagatg ttaacagaaa tggtccctgg
      841 gcaggaggat tcttctgatc tggaactact acaggaattg aacaggacct gccgagccat
      901 gcagcaccgc atagtggagc tcatctcccg agtgtccaat gaggaggtca ccgaggagct
      961 gctgcacgtc aacgatgacc tcaacaatgt cttcctccgc tatgagaggt tcgagaggta
     1021 caggtccggc cgatccgttc agaatgccag caatggagta ctaagcgaag ttactgaaga
     1081 caacttaata gacctgggcc ccggctcccc cgctgtggtt agccccatgg tggggagcac
     1141 agcaccccca tcttctctct cctcccaact cgcaggcttg gacttgggga cagagagtgt
     1201 cagtggcacc ctcagttcac ttcagcagtg caagccacaa gatggttttg acatgtttgc
     1261 ccagaccaga ggaaactcct tggctgaaca gcgaaaaacg gtcacctatg aggatcccca
     1321 ggctgttgga ggactcgctt ctgcacttga caatcggaaa cagaactcag aaatgattcc
     1381 cgttgcgcag ccctctgtca tggacgacat tgaggtgtgg ctcaggacag acctgaaggg
     1441 tgacgaccta gaagagggtg tcacaagtga agagttcgat aagttcctgg aagaaagagc
     1501 caaagctgca gaaacagttc cagacctgcc ctcacccccg acagaggccc ctgcaccagc
     1561 ctcaaacact tcaacccgga agaagccaga gcgctccgac gatgcgctct ttgccctgtg
     1621 agcggtcctg aggtttgcct caccctggca ggtcactact gactctccca gtggacactg
     1681 ggcactggcc actcccccag cctgcatacc tgtatctcca tggaaacgcc actgtgtttg
     1741 cgcccaggcc accctggtca ggaccggctt tgccaccttc tctctgtgtg gctggcgaaa
     1801 gcagcactga ccagaggtcc cgccttccct ctccccaagg gctctcatgg ccttcagtct
     1861 tcccaggaag agccagtggc cagcgccagg cagggaagtc ccttgacact tatggacagc
     1921 actcctaaac tgaccctctc atctcccctc cttgcttctg cctagctcca tggcttcctt
     1981 caggcaaaca ctgctccact ggacccttct tccatcaagg actctgggaa agcagggctt
     2041 gagcatttgt cactgcaggc ttgggttccc tccttagact gtgtggtacc tgtggcaccg
     2101 agtgtctgta cttgagtggg ctctgtgggt tactaccttg aaggtccctc acatccattt
     2161 ccccatcagt cagctgccag gcctgggacc aagacaggga cctgtggctc ttggtgtgac
     2221 agcagctgtg aggccagcat gtgccctgca gatggttgac agcctacccc aagcagggca
     2281 tgcacactca cattcaccct ggtcctggtg tccacagagg gctatgtggc attaatgcat
     2341 ccatgactag acctcgcctg cagcagtccc cacagctatc tgcagcccag cagaaggtag
     2401 ctgtgtgctg tccctggagg tccccaggac cgggagccgt actccactcc tctcctctcc
     2461 ctgacacggc ctcagccttc gtggctgtcc ccagctcaca tatcccccag ccaacagttt
     2521 catcctgaag cttgctaaca gcttcagtct gagcaaagga gagctgggga tgcctgctcc
     2581 tgtcctgtgt ctttgctggt ttgtttcctg gctctgagca aatgactcag tgctacttta
     2641 atcttagtct agctgctgct gcagctatgt tactacatac tgtgcaggtc accacacatt
     2701 cctcacccat gtgtggccag cctttcccac tgttaggagg actcagcact atacctgttg
     2761 ccatttgagc tcccacccca gtagggagag gggaatgggc tgcacttgca gtcagatcag
     2821 tgtgtgggtt ctatgcagct cggaggatga aaacagaagt ggccttcccc aggcccaacc
     2881 cagcacctct ccttcagcaa tctccggaag gtctggtgag gcctcatctg gcaggacctg
     2941 tggaggatgt cattctggct cgtgaaaggc actcaggaag cccctcctgc aggaagctca
     3001 actgacctgt taagtgccca gtcctctctg acccctgtct cacctccacc ctctacttag
     3061 ggcccttggc caaccacagc ttctctgtca gtgtttctca agagcagagc cctcaaaggc
     3121 tagactgact gctaaggcct ctgaaggctt gtcacagcag aggaggctgg gggtccagta
     3181 cacctggaag cctggccttt ggcacagttc tagaagggtt gtctgtgagg gtcagctgca
     3241 cacagcctac aagagttaga cgtgtggaca gtagcaatca agccagcatc tctctctgaa
     3301 ttaggaggct gccccctatt tatgggtgat atagaaagga aggtaggctt ccatcaggga
     3361 gagagactgt gtgggcccac cttggggatg ggaggggtct ccaacaaggc tgtttctaga
     3421 accagtgtcc agagctgtcc cttaacctcc tgactgtagc tgctgggtct ggctgaagcc
     3481 gggctgctgt ggggacagca ggtactcaag gactcccacc aggcatcaag aggctacctt
     3541 tctggctggg accagcccag ctggtggttt ggtttgtgtt ctacacgtca tgtctggagg
     3601 tggtctgcct tatctgtggg ctgaagtgac atgtgcctga ggcctttacc agaagcaaga
     3661 ttgggcttgg ggacctggag gacctgaagg gggttcaact cttgtgaact gtcctgtcct
     3721 gaggactctt tcctacctgt tccccaccat ctgtgggcaa agtccttaga agctgggtcc
     3781 cctcaagcca gcagcctcta caagtgttag aaatcacaga tagagtgtgt acttaattac
     3841 actaaattat tgccgggact cctcataagc actaattaca cctgattata ggttaaaata
     3901 tttattttgt caaaatattt tcttgaggat gtatttaacc ttttcttgtt cattgtatgc
     3961 tgaagtgtga agactgctcc ttcctacctt tttggccatc aggcagcagt aaaagaaagt
     4021 caccaggtgc cctagaggga cctctaccca ggtaccaaga aggcaggctg gggttgggta
     4081 gagagtttcc aacttgttta tctgtacatg ggacatgggg ggttggagct aaaagggctt
     4141 cttagtagct gtggccaggg ctggctccca cttactctgt cagcccctca gtgtgagtga
     4201 ctgtgacctg gctcattatc ctttctcccc acctggccca tgcttcctgc cacagcactg
     4261 ctcagccaag aaagaggtgg caggtcctac tggcccaggg gcaatgagct cctttgtccc
     4321 accacaaagc ttccctgcct accatcctct gactgatggt ctctcagatg gctcaggaca
     4381 ggccatgggc actcttgggg ccaggtcagc cctaggtggc tggcagggca gagtgagggc
     4441 ctttgtccct gcctggctag tctgcagcct ccctggggtc tgctgttggg atgcctgggg
     4501 tcttcctgtg ggctcagcca cacaggaggc cagtagggga acatgtctcc acttggagat
     4561 cctccctttg tggccctctg gaacctactt agcccagtgc ccagccccag cccttaccgt
     4621 tcatggggtc taagctaggc ttcccctggc tcccaagaac aactgtggac cccatgtcct
     4681 tactgctcct gccacactca caccctaggc tctctgggag agccggggta gaattttctt
     4741 ccttagggtt tgcacttcct ttgtgaggat ctgaggatct ttggagctgc tgaaaagatg
     4801 gtattgagtt tgttatcctg ttgtctcacg agtcgggttc ttgtccctgt cttatgtttc
     4861 tatgggtaga gctggttctg gagggtgact cagagtgaca gctagtgtgt tccccccacc
     4921 ccactggctc tgcttccaaa tactgtctca atttgtgttc ttgcatgtga agtactccac
     4981 aataaatagt tgaaccagcc aaaaaaaaaa aaaaaaa
//
