LOCUS       NM_001403888            5097 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus target of myb1-like 2 (chicken) (Tom1l2), transcript
            variant 5, mRNA.
ACCESSION   NM_001403888 XM_006532861
VERSION     NM_001403888.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5097)
  AUTHORS   Shinde,S.R., Mick,D.U., Aoki,E., Rodrigues,R.B., Gygi,S.P. and
            Nachury,M.V.
  TITLE     The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes
            for retrieval from cilia
  JOURNAL   Dev Cell 58 (8), 677-693 (2023)
   PUBMED   37019113
  REMARK    GeneRIF: The ancestral ESCRT protein TOM1L2 selects ubiquitinated
            cargoes for retrieval from cilia.
REFERENCE   2  (bases 1 to 5097)
  AUTHORS   Ricard,G., Molina,J., Chrast,J., Gu,W., Gheldof,N., Pradervand,S.,
            Schutz,F., Young,J.I., Lupski,J.R., Reymond,A. and Walz,K.
  TITLE     Phenotypic consequences of copy number variation: insights from
            Smith-Magenis and Potocki-Lupski syndrome mouse models
  JOURNAL   PLoS Biol 8 (11), e1000543 (2010)
   PUBMED   21124890
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5097)
  AUTHORS   Girirajan,S., Hauck,P.M., Williams,S., Vlangos,C.N., Szomju,B.B.,
            Solaymani-Kohal,S., Mosier,P.D., White,K.L. Jr., McCoy,K. and
            Elsea,S.H.
  TITLE     Tom1l2 hypomorphic mice exhibit increased incidence of infections
            and tumors and abnormal immunologic response
  JOURNAL   Mamm Genome 19 (4), 246-262 (2008)
   PUBMED   18343975
  REMARK    GeneRIF: Tom1l2plays a role in the immune response and possibly in
            tumor suppression.
REFERENCE   4  (bases 1 to 5097)
  AUTHORS   Larter,C.Z., Yeh,M.M., Haigh,W.G., Williams,J., Brown,S.,
            Bell-Anderson,K.S., Lee,S.P. and Farrell,G.C.
  TITLE     Hepatic free fatty acids accumulate in experimental
            steatohepatitis: role of adaptive pathways
  JOURNAL   J Hepatol 48 (4), 638-647 (2008)
   PUBMED   18280001
  REMARK    GeneRIF: Consistent with pathways of hepatic triglyceride
            synthesis, expression of diacylglycerol acyltransferase-1 and -2
            was increased, as were delta-5- and delta-6- fatty acid desaturase
            mRNA levels.
REFERENCE   5  (bases 1 to 5097)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 5097)
  AUTHORS   Bi,W., Yan,J., Stankiewicz,P., Park,S.S., Walz,K., Boerkoel,C.F.,
            Potocki,L., Shaffer,L.G., Devriendt,K., Nowaczyk,M.J., Inoue,K. and
            Lupski,J.R.
  TITLE     Genes in a refined Smith-Magenis syndrome critical deletion
            interval on chromosome 17p11.2 and the syntenic region of the mouse
  JOURNAL   Genome Res 12 (5), 713-728 (2002)
   PUBMED   11997338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596090.11 and AL669954.6.
            
            On Apr 5, 2022 this sequence version replaced XM_006532861.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.89471.1,
                                           SRR9219382.192920.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               AL596090.11        74266-74449         c
            185-269             AL669954.6         118987-119071       c
            270-348             AL669954.6         113712-113790       c
            349-498             AL669954.6         109106-109255       c
            499-633             AL669954.6         101437-101571       c
            634-792             AL669954.6         99843-100001        c
            793-909             AL669954.6         97644-97760         c
            910-1043            AL669954.6         87719-87852         c
            1044-1092           AL669954.6         84424-84472         c
            1093-1216           AL669954.6         83850-83973         c
            1217-1334           AL669954.6         81496-81613         c
            1335-1410           AL669954.6         80606-80681         c
            1411-1473           AL669954.6         77798-77860         c
            1474-1533           AL669954.6         71686-71745         c
            1534-1570           AL669954.6         69889-69925         c
            1571-5097           AL669954.6         65503-69029         c
FEATURES             Location/Qualifiers
     source          1..5097
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.81 cM"
     gene            1..5097
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /note="target of myb1-like 2 (chicken)"
                     /db_xref="GeneID:216810"
                     /db_xref="MGI:MGI:2443306"
     exon            1..184
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1719
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /note="isoform e is encoded by transcript variant 5;
                     TOM1-like protein 2; target of Myb-like protein 2;
                     myb1-like protein 2"
                     /codon_start=1
                     /product="TOM1-like protein 2 isoform e"
                     /protein_id="NP_001390817.1"
                     /db_xref="GeneID:216810"
                     /db_xref="MGI:MGI:2443306"
                     /translation="MEFLLGNPFSTPVGQCLEKATDGSLQSEDWTLNMEICDIINETE
                     EGPKDAIRALKKRLSGNRNYREVMLALTVLETCVKNCGHRFHLLVANRDFIDSVLVKI
                     ISPKNNPPTIVQDKVLALIQAWADAFRSSPDLTGVVHIYEELKRRGIEFPMADLDALS
                     PIHTPQRSVPEMDPAATIPRSQTQPRTTAGTYSSPPPASYSTLQAPALSVTGPITANS
                     EQIARLRSELDIVRGNTKVMSEMLTEMVPGQEDSSDLELLQELNRTCRAMQHRIVELI
                     SRVSNEEVTEELLHVNDDLNNVFLRYERFERYRSGRSVQNASNGVLSEVTEDNLIDLG
                     PGSPAVVSPMVGSTAPPSSLSSQLAGLDLGTESVSGTLSSLQQCKPQDGFDMFAQTRG
                     NSLAEQRKTVTYEDPQAVGGLASALDNRKQNSEMRGRGGDSDLQPIDSWLMTQGMIPV
                     AQPSVMDDIEVWLRTDLKGDDLEEGVTSEEFDKFLEERAKAAETVPDLPSPPTEAPAP
                     ASNTSTRKKPERSDDALFAL"
     exon            185..269
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            270..348
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            349..498
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..633
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..792
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            793..909
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1043
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1092
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1216
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1334
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1410
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1473
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1533
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1570
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..5097
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5079..5084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /note="hexamer: AATAAA"
     polyA_site      5097
                     /gene="Tom1l2"
                     /gene_synonym="2900016I08Rik; A730055F12Rik; Srebf1"
                     /note="major polyA site"
ORIGIN      
        1 gggcgaggtc aggccgggcg ctcagcgttc cggagggtgg ggcgggggca agtgtcagtc
       61 agggcagaac gcggcgcggg cagcggagac ccgtggcaca caggagtccg ggctggaacg
      121 aggcccgccg agatggagtt cctgctgggg aatccgttca gcacccctgt agggcagtgt
      181 cttgagaagg caacagatgg ctccctgcag agcgaggact ggacactgaa tatggagatc
      241 tgtgacatca tcaacgagac agaggaaggg ccaaaggatg ccatccgggc tctaaagaag
      301 cggcttagtg ggaaccgaaa ctacagagaa gtgatgttgg ccctgacggt gctggagact
      361 tgtgtgaaga actgtggcca ccgctttcat ctcctcgtgg ccaaccgaga cttcatcgac
      421 agcgttctgg tcaaaattat ctctcccaag aataaccctc ccactatcgt ccaggacaaa
      481 gtgctggctc taattcaggc atgggcagat gcctttagga gcagtcctga cctcacaggt
      541 gttgtgcaca tatatgaaga actgaagagg agggggattg agttccccat ggcggacttg
      601 gacgccctgt ctcctatcca cacaccccag cggagtgtcc cagaaatgga tccagctgcc
      661 accattccca ggtcccagac acagcccagg acaaccgctg gcacctattc ctcacctcct
      721 ccagcttcct actctactct gcaggccccg gctctgagtg tgacgggccc catcacagcc
      781 aattcagaac agattgccag gctgcgcagt gagctggaca ttgttcgggg aaacacaaaa
      841 gtcatgtctg agatgttaac agaaatggtc cctgggcagg aggattcttc tgatctggaa
      901 ctactacagg aattgaacag gacctgccga gccatgcagc accgcatagt ggagctcatc
      961 tcccgagtgt ccaatgagga ggtcaccgag gagctgctgc acgtcaacga tgacctcaac
     1021 aatgtcttcc tccgctatga gaggttcgag aggtacaggt ccggccgatc cgttcagaat
     1081 gccagcaatg gagtactaag cgaagttact gaagacaact taatagacct gggccccggc
     1141 tcccccgctg tggttagccc catggtgggg agcacagcac ccccatcttc tctctcctcc
     1201 caactcgcag gcttggactt ggggacagag agtgtcagtg gcaccctcag ttcacttcag
     1261 cagtgcaagc cacaagatgg ttttgacatg tttgcccaga ccagaggaaa ctccttggct
     1321 gaacagcgaa aaacggtcac ctatgaggat ccccaggctg ttggaggact cgcttctgca
     1381 cttgacaatc ggaaacagaa ctcagaaatg agagggagag gtggggactc tgacctgcag
     1441 cccatagaca gctggctcat gacccaagga atgattcccg ttgcgcagcc ctctgtcatg
     1501 gacgacattg aggtgtggct caggacagac ctgaagggtg acgacctaga agagggtgtc
     1561 acaagtgaag agttcgataa gttcctggaa gaaagagcca aagctgcaga aacagttcca
     1621 gacctgccct cacccccgac agaggcccct gcaccagcct caaacacttc aacccggaag
     1681 aagccagagc gctccgacga tgcgctcttt gccctgtgag cggtcctgag gtttgcctca
     1741 ccctggcagg tcactactga ctctcccagt ggacactggg cactggccac tcccccagcc
     1801 tgcatacctg tatctccatg gaaacgccac tgtgtttgcg cccaggccac cctggtcagg
     1861 accggctttg ccaccttctc tctgtgtggc tggcgaaagc agcactgacc agaggtcccg
     1921 ccttccctct ccccaagggc tctcatggcc ttcagtcttc ccaggaagag ccagtggcca
     1981 gcgccaggca gggaagtccc ttgacactta tggacagcac tcctaaactg accctctcat
     2041 ctcccctcct tgcttctgcc tagctccatg gcttccttca ggcaaacact gctccactgg
     2101 acccttcttc catcaaggac tctgggaaag cagggcttga gcatttgtca ctgcaggctt
     2161 gggttccctc cttagactgt gtggtacctg tggcaccgag tgtctgtact tgagtgggct
     2221 ctgtgggtta ctaccttgaa ggtccctcac atccatttcc ccatcagtca gctgccaggc
     2281 ctgggaccaa gacagggacc tgtggctctt ggtgtgacag cagctgtgag gccagcatgt
     2341 gccctgcaga tggttgacag cctaccccaa gcagggcatg cacactcaca ttcaccctgg
     2401 tcctggtgtc cacagagggc tatgtggcat taatgcatcc atgactagac ctcgcctgca
     2461 gcagtcccca cagctatctg cagcccagca gaaggtagct gtgtgctgtc cctggaggtc
     2521 cccaggaccg ggagccgtac tccactcctc tcctctccct gacacggcct cagccttcgt
     2581 ggctgtcccc agctcacata tcccccagcc aacagtttca tcctgaagct tgctaacagc
     2641 ttcagtctga gcaaaggaga gctggggatg cctgctcctg tcctgtgtct ttgctggttt
     2701 gtttcctggc tctgagcaaa tgactcagtg ctactttaat cttagtctag ctgctgctgc
     2761 agctatgtta ctacatactg tgcaggtcac cacacattcc tcacccatgt gtggccagcc
     2821 tttcccactg ttaggaggac tcagcactat acctgttgcc atttgagctc ccaccccagt
     2881 agggagaggg gaatgggctg cacttgcagt cagatcagtg tgtgggttct atgcagctcg
     2941 gaggatgaaa acagaagtgg ccttccccag gcccaaccca gcacctctcc ttcagcaatc
     3001 tccggaaggt ctggtgaggc ctcatctggc aggacctgtg gaggatgtca ttctggctcg
     3061 tgaaaggcac tcaggaagcc cctcctgcag gaagctcaac tgacctgtta agtgcccagt
     3121 cctctctgac ccctgtctca cctccaccct ctacttaggg cccttggcca accacagctt
     3181 ctctgtcagt gtttctcaag agcagagccc tcaaaggcta gactgactgc taaggcctct
     3241 gaaggcttgt cacagcagag gaggctgggg gtccagtaca cctggaagcc tggcctttgg
     3301 cacagttcta gaagggttgt ctgtgagggt cagctgcaca cagcctacaa gagttagacg
     3361 tgtggacagt agcaatcaag ccagcatctc tctctgaatt aggaggctgc cccctattta
     3421 tgggtgatat agaaaggaag gtaggcttcc atcagggaga gagactgtgt gggcccacct
     3481 tggggatggg aggggtctcc aacaaggctg tttctagaac cagtgtccag agctgtccct
     3541 taacctcctg actgtagctg ctgggtctgg ctgaagccgg gctgctgtgg ggacagcagg
     3601 tactcaagga ctcccaccag gcatcaagag gctacctttc tggctgggac cagcccagct
     3661 ggtggtttgg tttgtgttct acacgtcatg tctggaggtg gtctgcctta tctgtgggct
     3721 gaagtgacat gtgcctgagg cctttaccag aagcaagatt gggcttgggg acctggagga
     3781 cctgaagggg gttcaactct tgtgaactgt cctgtcctga ggactctttc ctacctgttc
     3841 cccaccatct gtgggcaaag tccttagaag ctgggtcccc tcaagccagc agcctctaca
     3901 agtgttagaa atcacagata gagtgtgtac ttaattacac taaattattg ccgggactcc
     3961 tcataagcac taattacacc tgattatagg ttaaaatatt tattttgtca aaatattttc
     4021 ttgaggatgt atttaacctt ttcttgttca ttgtatgctg aagtgtgaag actgctcctt
     4081 cctacctttt tggccatcag gcagcagtaa aagaaagtca ccaggtgccc tagagggacc
     4141 tctacccagg taccaagaag gcaggctggg gttgggtaga gagtttccaa cttgtttatc
     4201 tgtacatggg acatgggggg ttggagctaa aagggcttct tagtagctgt ggccagggct
     4261 ggctcccact tactctgtca gcccctcagt gtgagtgact gtgacctggc tcattatcct
     4321 ttctccccac ctggcccatg cttcctgcca cagcactgct cagccaagaa agaggtggca
     4381 ggtcctactg gcccaggggc aatgagctcc tttgtcccac cacaaagctt ccctgcctac
     4441 catcctctga ctgatggtct ctcagatggc tcaggacagg ccatgggcac tcttggggcc
     4501 aggtcagccc taggtggctg gcagggcaga gtgagggcct ttgtccctgc ctggctagtc
     4561 tgcagcctcc ctggggtctg ctgttgggat gcctggggtc ttcctgtggg ctcagccaca
     4621 caggaggcca gtaggggaac atgtctccac ttggagatcc tccctttgtg gccctctgga
     4681 acctacttag cccagtgccc agccccagcc cttaccgttc atggggtcta agctaggctt
     4741 cccctggctc ccaagaacaa ctgtggaccc catgtcctta ctgctcctgc cacactcaca
     4801 ccctaggctc tctgggagag ccggggtaga attttcttcc ttagggtttg cacttccttt
     4861 gtgaggatct gaggatcttt ggagctgctg aaaagatggt attgagtttg ttatcctgtt
     4921 gtctcacgag tcgggttctt gtccctgtct tatgtttcta tgggtagagc tggttctgga
     4981 gggtgactca gagtgacagc tagtgtgttc cccccacccc actggctctg cttccaaata
     5041 ctgtctcaat ttgtgttctt gcatgtgaag tactccacaa taaatagttg aaccagc
//
