LOCUS       NM_001357543            2093 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus target of myb1-like 1 (chicken) (Tom1l1), transcript
            variant 1, mRNA.
ACCESSION   NM_001357543 XM_006534268
VERSION     NM_001357543.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2093)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2093)
  AUTHORS   Chaboub,L.S., Manalo,J.M., Lee,H.K., Glasgow,S.M., Chen,F.,
            Kawasaki,Y., Akiyama,T., Kuo,C.T., Creighton,C.J., Mohila,C.A. and
            Deneen,B.
  TITLE     Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles
            for Asef during Development and after Injury
  JOURNAL   J Neurosci 36 (47), 11904-11917 (2016)
   PUBMED   27881777
REFERENCE   3  (bases 1 to 2093)
  AUTHORS   Liu,N.S., Loo,L.S., Loh,E., Seet,L.F. and Hong,W.
  TITLE     Participation of Tom1L1 in EGF-stimulated endocytosis of EGF
            receptor
  JOURNAL   EMBO J 28 (22), 3485-3499 (2009)
   PUBMED   19798056
REFERENCE   4  (bases 1 to 2093)
  AUTHORS   Collin,G., Franco,M., Simon,V., Benistant,C. and Roche,S.
  TITLE     The Tom1L1-clathrin heavy chain complex regulates membrane
            partitioning of the tyrosine kinase Src required for mitogenic and
            transforming activities
  JOURNAL   Mol Cell Biol 27 (21), 7631-7640 (2007)
   PUBMED   17785434
  REMARK    GeneRIF: Tom1L1-clathrin heavy chain (CHC) complex negatively
            regulates the level of SFK in caveolae needed for the induction of
            DNA synthesis.
REFERENCE   5  (bases 1 to 2093)
  AUTHORS   Yan,J., Bi,W. and Lupski,J.R.
  TITLE     Penetrance of craniofacial anomalies in mouse models of
            Smith-Magenis syndrome is modified by genomic sequence surrounding
            Rai1: not all null alleles are alike
  JOURNAL   Am J Hum Genet 80 (3), 518-525 (2007)
   PUBMED   17273973
REFERENCE   6  (bases 1 to 2093)
  AUTHORS   Li,W., Marshall,C., Mei,L., Gelfand,J. and Seykora,J.T.
  TITLE     Srcasm corrects Fyn-induced epidermal hyperplasia by kinase
            down-regulation
  JOURNAL   J Biol Chem 282 (2), 1161-1169 (2007)
   PUBMED   17046829
  REMARK    GeneRIF: Srcasm may act as a molecular 'rheostat' for activated Src
            family tyrosine kinases
REFERENCE   7  (bases 1 to 2093)
  AUTHORS   Franco,M., Furstoss,O., Simon,V., Benistant,C., Hong,W.J. and
            Roche,S.
  TITLE     The adaptor protein Tom1L1 is a negative regulator of Src mitogenic
            signaling induced by growth factors
  JOURNAL   Mol Cell Biol 26 (5), 1932-1947 (2006)
   PUBMED   16479011
  REMARK    GeneRIF: Tom1L1 defines a novel mechanism for regulation of Src
            family of protein-tyrosine kinases mitogenic signaling induced by
            growth factors.
REFERENCE   8  (bases 1 to 2093)
  AUTHORS   Seykora,J.T., Mei,L., Dotto,G.P. and Stein,P.L.
  TITLE     'Srcasm: a novel Src activating and signaling molecule
  JOURNAL   J Biol Chem 277 (4), 2812-2822 (2002)
   PUBMED   11711534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK033712.1, AK083630.1 and AI851737.1.
            
            On Nov 4, 2017 this sequence version replaced XM_006534268.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF395837.1, SRR1660815.256318.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AK033712.1         3-24
            23-2071             AK083630.1         2-2050
            2072-2093           AI851737.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..2093
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 55.47 cM"
     gene            1..2093
                     /gene="Tom1l1"
                     /gene_synonym="2310045L10Rik; Srcasm"
                     /note="target of myb1-like 1 (chicken)"
                     /db_xref="GeneID:71943"
                     /db_xref="MGI:MGI:1919193"
     exon            1..89
                     /gene="Tom1l1"
                     /gene_synonym="2310045L10Rik; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1456
                     /gene="Tom1l1"
                     /gene_synonym="2310045L10Rik; Srcasm"
                     /note="isoform 1 is encoded by transcript variant 1; Src
                     activating and signaling molecule; TOM1-like protein 1;
                     Jerry protein; target of Myb-like protein 1;
                     src-activating and signaling molecule protein"
                     /codon_start=1
                     /product="TOM1-like protein 1 isoform 1"
                     /protein_id="NP_001344472.1"
                     /db_xref="CCDS:CCDS88221.1"
                     /db_xref="GeneID:71943"
                     /db_xref="MGI:MGI:1919193"
                     /translation="MAFGKSHRDPYATSVGHLIEKATFAGVLTEDWGQFLHICDIINT
                     TQDGPKDAVKALKKRISKNYNHKEIQLSLSLIDMCVQNCGPSFQSLIVKKEFIKDTLV
                     KLLNPRYTLPLETQNRILNFIKTWSQGFPGGVDVSEVKEVYLDLLKKGVQFPPSDGEP
                     ETRQEAGQISPNRPTSVPTAPALSSIIAPKNPTISLVPEQIGKLHSELDMVKMNVKVM
                     TAILMENTPGSENHEDIELLRKLYKTGREMQERIMDLLVVVENEDVTMELIQVNEDLN
                     NAVLGYERFTRNQQRLLEQKRNRTEATRTSSEPSAPSCDLLDLSPIVPVPTPNEGALN
                     SVNAQLSGLSVSSLSPVITNNLYPSLQPQRDLLASEDIEIPTLFPQRTSQNLASSHTY
                     DNFHSNSVLLQPVSLHTATAAAAANQRLPPLPSSHPVLKDGDLQPPNYYEVMEFDPLA
                     PTTEAVYEEIDGYHQKEAQSHSDC"
     exon            90..174
                     /gene="Tom1l1"
                     /gene_synonym="2310045L10Rik; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            175..253
                     /gene="Tom1l1"
                     /gene_synonym="2310045L10Rik; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            254..403
                     /gene="Tom1l1"
                     /gene_synonym="2310045L10Rik; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            404..526
                     /gene="Tom1l1"
                     /gene_synonym="2310045L10Rik; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            527..631
                     /gene="Tom1l1"
                     /gene_synonym="2310045L10Rik; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            632..748
                     /gene="Tom1l1"
                     /gene_synonym="2310045L10Rik; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            749..882
                     /gene="Tom1l1"
                     /gene_synonym="2310045L10Rik; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            883..943
                     /gene="Tom1l1"
                     /gene_synonym="2310045L10Rik; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1061
                     /gene="Tom1l1"
                     /gene_synonym="2310045L10Rik; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1161
                     /gene="Tom1l1"
                     /gene_synonym="2310045L10Rik; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1213
                     /gene="Tom1l1"
                     /gene_synonym="2310045L10Rik; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1316
                     /gene="Tom1l1"
                     /gene_synonym="2310045L10Rik; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1392
                     /gene="Tom1l1"
                     /gene_synonym="2310045L10Rik; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1457
                     /gene="Tom1l1"
                     /gene_synonym="2310045L10Rik; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..2077
                     /gene="Tom1l1"
                     /gene_synonym="2310045L10Rik; Srcasm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2055..2060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tom1l1"
                     /gene_synonym="2310045L10Rik; Srcasm"
                     /note="hexamer: ATTAAA"
     polyA_site      2077
                     /gene="Tom1l1"
                     /gene_synonym="2310045L10Rik; Srcasm"
                     /note="major polyA site"
ORIGIN      
        1 ggatttcctg ggagggctct ctggagctac catggcgttt gggaagagtc accgcgatcc
       61 ttacgctacc tctgtgggtc acctcataga aaaggccact tttgctggag ttctgactga
      121 agactggggc cagttcctgc acatctgtga cataattaac accacacagg acgggccaaa
      181 agatgcagta aaagctttga agaaaaggat ctccaaaaac tataaccaca aagaaatcca
      241 actttcctta tcactcattg acatgtgcgt gcagaactgt ggcccgagtt tccaatctct
      301 gattgtgaag aaggagttca ttaaagatac tctagttaag ctgctgaatc ccagatacac
      361 cttaccgctg gagacccaga acagaatctt gaatttcatt aagacctggt cccagggctt
      421 cccaggaggt gtagatgtga gtgaggtgaa ggaagtgtac cttgacctgc tgaagaaagg
      481 ggttcaattc ccgccctcgg atggagagcc tgagacaagg caggaggctg gtcagatctc
      541 accaaatcga ccgacatctg tccccactgc acctgcactt tcttctataa ttgctcccaa
      601 gaacccaact atttccttag tcccagaaca gatcgggaag ctgcatagtg aactagatat
      661 ggtgaaaatg aatgtgaaag tgatgacagc catattgatg gagaatactc ctggctctga
      721 aaaccatgaa gacatcgagc tcctgcggaa actttacaag acaggtcggg agatgcagga
      781 gaggatcatg gacctgctgg tggtggtgga aaatgaagac gtgactatgg agctaattca
      841 agtgaacgag gatctgaata atgccgtcct tggatatgag aggtttactc gaaaccaaca
      901 aaggcttttg gaacagaaga ggaaccggac agaagcaacc cgtacttcca gcgagccctc
      961 tgctccttcc tgcgatctcc tcgacctaag ccccatcgtg ccagtgccta cgcccaatga
     1021 gggagcactc aactccgtga acgcccagct ttcaggccta agtgtcagct ctctgagccc
     1081 tgttataaca aacaacttgt atcccagtct tcagccacag agggatttac tagcatcaga
     1141 agatatagaa atacccacct tgtttcccca gaggaccagc caaaacctcg cctcgagtca
     1201 cacatatgat aattttcact ccaattcagt attactccag ccagttagcc tacacaccgc
     1261 cacagcagca gcagcagcaa accagaggct gccacccttg ccaagcagtc atccagtgct
     1321 aaaagacggc gatctccagc cacccaatta ctacgaggta atggagtttg atcccttagc
     1381 tcccactaca gaagctgttt atgaagaaat tgatggttac caccagaaag aagctcaaag
     1441 tcatagtgac tgctaagata cacaaagggc cagctctcta aaggaatact tgatcagcag
     1501 aggcctgaca gacaagacct gccaacaggg agagccccag tggaccattt ctctgctgga
     1561 agcttcaaca gaagagttaa cacttcctgg ccaacactgc tgttcctgac aatgccttga
     1621 gacttcagga aaatcttgtt gtgaggaaaa ctgcctagaa ctaggccaac tggttaaact
     1681 gtggactctt acattgtgca ggcattgcta tcagtacaaa tcatgacaga tctatgatgg
     1741 ggtactttaa gatcaatcat cctactataa aatattgtaa acagatgggg aaaggaagaa
     1801 aatgagtgcc tttatttaac tgaatctgaa tgtacaattc agtttgtact tgtttataaa
     1861 taacattttg gtttagaatt gcttgaaaga cttgtttaat tatatttcaa gtgcctgagt
     1921 aggccactgc atcaggtggc ctaagatgta gttagtccta tgtaatgttt aacattcttg
     1981 ccttttatta taattcacat tctgatttga aacaatgact cttggaaaac tggacaatgc
     2041 atcatttaca taaaattaaa ttactattaa tttgtcaaaa aaaaaaaaaa aaa
//
