LOCUS       NM_001136259            2358 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus target of myb1 trafficking protein (Tom1), transcript
            variant 2, mRNA.
ACCESSION   NM_001136259
VERSION     NM_001136259.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2358)
  AUTHORS   Gwon Y, Kam TI, Kim SH, Song S, Park H, Lim B, Lee H, Lee W, Jo DG
            and Jung YK.
  TITLE     TOM1 Regulates Neuronal Accumulation of Amyloid-beta Oligomers by
            FcgammaRIIb2 Variant in Alzheimer's Disease
  JOURNAL   J Neurosci 38 (42), 9001-9018 (2018)
   PUBMED   30185465
  REMARK    GeneRIF: Study shows that TOM1 regulates neuronal accumulation of
            amyloid-beta oligomers by FcgammaRIIb2 variant in Alzheimer's
            Disease (AD). Study provides a molecular mechanism responsible for
            neuronal uptake of pathogenic Abeta found in AD.
REFERENCE   2  (bases 1 to 2358)
  AUTHORS   Katoh Y, Imakagura H, Futatsumori M and Nakayama K.
  TITLE     Recruitment of clathrin onto endosomes by the Tom1-Tollip complex
  JOURNAL   Biochem Biophys Res Commun 341 (1), 143-149 (2006)
   PUBMED   16412388
  REMARK    GeneRIF: These results indicate that, in conjunction with Tollip,
            Tom1 family proteins play an important role in recruiting clathrin
            onto endosomes and suggest that they modulate endosomal functions.
REFERENCE   3  (bases 1 to 2358)
  AUTHORS   Yamakami M, Yoshimori T and Yokosawa H.
  TITLE     Tom1, a VHS domain-containing protein, interacts with tollip,
            ubiquitin, and clathrin
  JOURNAL   J Biol Chem 278 (52), 52865-52872 (2003)
   PUBMED   14563850
  REMARK    GeneRIF: a Tom1-Tollip complex functions as a factor that links
            polyubiquitinated proteins to clathrin
REFERENCE   4  (bases 1 to 2358)
  AUTHORS   Seroussi E, Kedra D, Kost-Alimova M, Sandberg-Nordqvist AC,
            Fransson I, Jacobs JF, Fu Y, Pan HQ, Roe BA, Imreh S and Dumanski
            JP.
  TITLE     TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1
            and encode proteins similar to the endosomal proteins HGS and STAM
  JOURNAL   Genomics 57 (3), 380-388 (1999)
   PUBMED   10329004
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603864.8.
            
            [WARNING] On Oct 17, 2023 this sequence was replaced by
            NM_001136259.2.
            
            Transcript Variant: This variant (2) represents the longer
            transcript and encodes the longer protein (isoform 2).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150143.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AL603864.8         41901-42042         c
            143-227             AL603864.8         27651-27735         c
            228-306             AL603864.8         25460-25538         c
            307-456             AL603864.8         24071-24220         c
            457-591             AL603864.8         23671-23805         c
            592-738             AL603864.8         23432-23578         c
            739-855             AL603864.8         21035-21151         c
            856-989             AL603864.8         18440-18573         c
            990-1023            AL603864.8         17254-17287         c
            1024-1117           AL603864.8         16822-16915         c
            1118-1189           AL603864.8         16468-16539         c
            1190-1310           AL603864.8         15175-15295         c
            1311-1386           AL603864.8         11259-11334         c
            1387-1446           AL603864.8         8147-8206           c
            1447-1486           AL603864.8         6593-6632           c
            1487-2358           AL603864.8         5607-6478           c
FEATURES             Location/Qualifiers
     source          1..2358
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 35.57 cM"
     gene            1..2358
                     /gene="Tom1"
                     /note="target of myb1 trafficking protein"
                     /db_xref="GeneID:21968"
                     /db_xref="MGI:MGI:1338026"
     exon            1..142
                     /gene="Tom1"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1641
                     /gene="Tom1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     target of Myb protein 1; target of myb1 homolog; target of
                     Myb1 membrane trafficking protein"
                     /codon_start=1
                     /product="target of Myb1 membrane trafficking protein
                     isoform 2"
                     /protein_id="NP_001129731.1"
                     /db_xref="CCDS:CCDS52600.1"
                     /db_xref="GeneID:21968"
                     /db_xref="MGI:MGI:1338026"
                     /translation="MDFLLGNPFSSPVGQRIEKATDGSLQSEDWALNMEICDIINETE
                     EGPKDAFRAVKKRIMGNKNFHEVMLALTVLETCVKNCGHRFHVLVANQDFVENVLVRT
                     ILPKNNPPTIVHDKVLNLIQSWADAFRSSPDLTGVVAVYEDLRRKGLEFPMTDLDMLS
                     PIHTPQRTVFNSETPSRQNSVSSNTSQRGDLSQHATPLPTPAVLPGDSPITPTPEQIG
                     KLRSELEMVSGNVRVMSEMLTELVPTQVEPADLELLQELNRTCRAMQQRILELIPRIS
                     NEQLTEELLMINDNLNNVFLRHERFERFRTGQTAKASSEAELATDLIDMGPDPAATNN
                     LSSQLAGMNNRLLSLSNHFLLEEGKKEWAPLQDLGSRSVRAGLQSLETSGHLEDDFDM
                     FALTRGSSLADQRKGVKYEAPQTTDGLAGALDARQQSTGAIPATQARIMEDIEQWLST
                     DVGNSAEEPSGVTSEEFDKFLEERAKAADRLPNLASPSAEGPPRPSPGTAPRRKTQEK
                     DDDMLFAL"
     exon            143..227
                     /gene="Tom1"
                     /inference="alignment:Splign:2.1.0"
     exon            228..306
                     /gene="Tom1"
                     /inference="alignment:Splign:2.1.0"
     exon            307..456
                     /gene="Tom1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..591
                     /gene="Tom1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..738
                     /gene="Tom1"
                     /inference="alignment:Splign:2.1.0"
     exon            739..855
                     /gene="Tom1"
                     /inference="alignment:Splign:2.1.0"
     exon            856..989
                     /gene="Tom1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1023
                     /gene="Tom1"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1117
                     /gene="Tom1"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1189
                     /gene="Tom1"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1310
                     /gene="Tom1"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1386
                     /gene="Tom1"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1446
                     /gene="Tom1"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1486
                     /gene="Tom1"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..2358
                     /gene="Tom1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctggcca acgggtcacg tggcgggtcg gcggcgccgg cggttgctgt cacctgattc
       61 tgggagctgg tggcagcggt agccgcggca atggactttc tcctgggaaa tccgttcagc
      121 tctccggtgg gacaacggat cgagaaagct acagatggct ccctgcagag cgaggactgg
      181 gccctcaaca tggaaatctg tgacatcatc aacgagacgg aggaaggccc caaagatgcc
      241 ttccgagcag tgaagaagcg aattatgggg aataagaatt tccatgaggt catgctggcc
      301 cttacggtct tggaaacatg tgttaagaac tgtgggcacc gcttccatgt actggtggcc
      361 aaccaggact ttgtagagaa tgtgctggtg aggaccatcc tgccgaagaa caatccaccc
      421 accattgtgc atgacaaggt gttgaacctc atccagtcct gggctgacgc gttccgcagc
      481 tcacctgatt tgacaggtgt tgttgctgtc tacgaggacc tgcgaaggaa gggcctagaa
      541 tttcccatga ctgacctgga catgctgtcg cccatccaca caccccagag aactgtattc
      601 aactcagaga caccatccag acagaactct gtgagttcca acaccagtca gcgtggagac
      661 ctgagccagc atgccacccc tctgcccact ccagctgttc tcccgggtga ctcacccatc
      721 acaccgactc ctgagcagat tgggaagctg cgcagtgagc tggagatggt gagcggaaac
      781 gtgcgagtga tgtcagagat gctgacagag ctggtgccca cccaggtaga gcctgcagac
      841 ctggagctac tacaggaact gaaccgcacc tgccgtgcca tgcagcagcg gatcctggag
      901 cttatcccac gcatctccaa tgagcagctg acggaggagc tgctcatgat caacgacaac
      961 ctcaacaacg tgtttctgcg ccatgaacgg tttgaacgct tccgaacagg ccagactgct
     1021 aaggcctcca gtgaagctga gctagctact gacctgattg acatgggtcc tgaccccgca
     1081 gccacaaaca acctctcatc tcaactggca ggaatgaaca atcgactgct cagcctcagt
     1141 aatcacttcc tacttgaaga aggaaagaag gaatgggccc ctcttcaaga ccttggctcc
     1201 agaagtgtga gagctggcct gcagtctctg gagacctcag gtcacctgga agatgacttt
     1261 gacatgtttg ctctgactcg gggcagctca ctggctgacc aacggaaagg ggtcaaatat
     1321 gaagctcccc aaaccacaga tggcctggct ggggccctag atgcccggca gcagagcacc
     1381 ggagcgatcc cagccactca ggcccgcatc atggaggaca ttgagcagtg gctgtccaca
     1441 gatgtgggga acagtgctga ggagccctct ggtgtcacca gtgaagaatt tgacaaattt
     1501 ctggaagaac gagccaaagc tgctgatcga cttcccaacc tggccagccc ttcagccgag
     1561 ggacccccca gaccatctcc tggaacagcc cctcggagga agacccagga gaaggacgat
     1621 gacatgctgt ttgccttatg aatgcagggt ctggcatcct gcagcccagg gcctgacact
     1681 ctcataccca ctggggcccc tccctccctt ggtattaaag ctgcttgggg gtgttttgtt
     1741 accccgcttc tcttctccca gagcctgggc agcaaggggg tcaactgaag gaataagtca
     1801 gccctccact ggaatcctgg ctggtcctgc cttcttccca tcctgctaac gactatgatt
     1861 ttactgagac ctggggcccc agacaagctg acctgatagg acctaattga cctggtgtaa
     1921 ggctgcttct gtgatattcc cctggtccct tccccagaga atcccacggg agccctccag
     1981 actctacact aacagtctag gcaatagagg agacattacc acagccttgc ctatcccatc
     2041 cccctgcaga gtggggcccg aaaaaagctt cagtggcttt tgggatgggc tatggtggcc
     2101 cctgctgagc tgcccactgt cctggtacga aactgcaccc atcgaggaaa catctcactg
     2161 cccaggtgtc aagatgagac ctcgaggatt ctgggtaccc agagctcccc agttcctcca
     2221 ctgcctttcc cctatccttg ctctgtacct ccagcagggc tccacccacc tggggctcac
     2281 ctgttgattg gtcctcaggt acagggagag gtgccttttg tatccccaaa taaaagtaga
     2341 aaaccacctg tcagcatg
//
