LOCUS       NM_023764               3765 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus toll interacting protein (Tollip), transcript variant
            1, mRNA.
ACCESSION   NM_023764
VERSION     NM_023764.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3765)
  AUTHORS   Venkatasubramanian,S., Plumlee,C.R., Dill-McFarland,K.A.,
            Cohen,S.B., Gern,B.H., Rane,D.A., Meyer,M.K., Saha,A.,
            Hinderstein,S.A., Pearson,G.L., Lietzke,A.C., Pacheco,A.,
            Chow,Y.H., Hung,C.F., Soleimanpour,S.A., Altman,M., Urdahl,K.B. and
            Shah,J.A.
  TITLE     TOLLIP inhibits lipid accumulation and the integrated stress
            response in alveolar macrophages to control Mycobacterium
            tuberculosis infection
  JOURNAL   Nat Microbiol 9 (4), 949-963 (2024)
   PUBMED   38528148
  REMARK    GeneRIF: TOLLIP inhibits lipid accumulation and the integrated
            stress response in alveolar macrophages to control Mycobacterium
            tuberculosis infection.
REFERENCE   2  (bases 1 to 3765)
  AUTHORS   Li,W.W., Fan,X.X., Xu,Z.S., Zhu,Z.X., Zhu,Z.Y., Cao,X.J., Pei,D.S.,
            Wang,Y.Z., Zhang,J.Y., Wang,Y.Y. and Zheng,H.X.
  TITLE     BLK positively regulates TLR/IL-1R signaling by catalyzing TOLLIP
            phosphorylation
  JOURNAL   J Cell Biol 223 (2) (2024)
   PUBMED   38078859
  REMARK    GeneRIF: BLK positively regulates TLR/IL-1R signaling by catalyzing
            TOLLIP phosphorylation.
REFERENCE   3  (bases 1 to 3765)
  AUTHORS   Nouri,H.R., Schaunaman,N., Kraft,M., Li,L., Numata,M. and Chu,H.W.
  TITLE     Tollip deficiency exaggerates airway type 2 inflammation in mice
            exposed to allergen and influenza A virus: role of the ATP/IL-33
            signaling axis
  JOURNAL   Front Immunol 14, 1304758 (2023)
   PUBMED   38124753
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3765)
  AUTHORS   Schaunaman,N., Dimasuay,K.G., Cervantes,D., Li,L., Numata,M.,
            Kraft,M. and Chu,H.W.
  TITLE     Tollip Inhibits IL-33 Release and Inflammation in Influenza A
            Virus-Infected Mouse Airways
  JOURNAL   J Innate Immun 15 (1), 67-77 (2023)
   PUBMED   35760043
  REMARK    GeneRIF: Tollip Inhibits IL-33 Release and Inflammation in
            Influenza A Virus-Infected Mouse Airways.
REFERENCE   5  (bases 1 to 3765)
  AUTHORS   Venkatasubramanian,S., Pryor,R., Plumlee,C., Cohen,S.B.,
            Simmons,J.D., Warr,A.J., Graustein,A.D., Saha,A., Hawn,T.R.,
            Urdahl,K.B. and Shah,J.A.
  TITLE     TOLLIP Optimizes Dendritic Cell Maturation to Lipopolysaccharide
            and Mycobacterium tuberculosis
  JOURNAL   J Immunol 209 (3), 435-445 (2022)
   PUBMED   35803695
  REMARK    GeneRIF: TOLLIP Optimizes Dendritic Cell Maturation to
            Lipopolysaccharide and Mycobacterium tuberculosis.
REFERENCE   6  (bases 1 to 3765)
  AUTHORS   Yamakami,M., Yoshimori,T. and Yokosawa,H.
  TITLE     Tom1, a VHS domain-containing protein, interacts with tollip,
            ubiquitin, and clathrin
  JOURNAL   J Biol Chem 278 (52), 52865-52872 (2003)
   PUBMED   14563850
  REMARK    GeneRIF: a Tom1-Tollip complex functions as a factor that links
            polyubiquitinated proteins to clathrin
REFERENCE   7  (bases 1 to 3765)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 3765)
  AUTHORS   Bulut,Y., Faure,E., Thomas,L., Equils,O. and Arditi,M.
  TITLE     Cooperation of Toll-like receptor 2 and 6 for cellular activation
            by soluble tuberculosis factor and Borrelia burgdorferi outer
            surface protein A lipoprotein: role of Toll-interacting protein and
            IL-1 receptor signaling molecules in Toll-like receptor 2 signaling
  JOURNAL   J Immunol 167 (2), 987-994 (2001)
   PUBMED   11441107
REFERENCE   9  (bases 1 to 3765)
  AUTHORS   Burns,K., Clatworthy,J., Martin,L., Martinon,F., Plumpton,C.,
            Maschera,B., Lewis,A., Ray,K., Tschopp,J. and Volpe,F.
  TITLE     Tollip, a new component of the IL-1RI pathway, links IRAK to the
            IL-1 receptor
  JOURNAL   Nat Cell Biol 2 (6), 346-351 (2000)
   PUBMED   10854325
REFERENCE   10 (bases 1 to 3765)
  AUTHORS   Volpe,F., Clatworthy,J., Kaptein,A., Maschera,B., Griffin,A.M. and
            Ray,K.
  TITLE     The IL1 receptor accessory protein is responsible for the
            recruitment of the interleukin-1 receptor associated kinase to the
            IL1/IL1 receptor I complex
  JOURNAL   FEBS Lett 419 (1), 41-44 (1997)
   PUBMED   9426216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF171126.1, AK016482.1 and AL772165.15.
            
            On Mar 26, 2018 this sequence version replaced NM_023764.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062139.1, AK016482.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                CF171126.1         1-55
            56-3760             AK016482.1         2-3706
            3761-3765           AL772165.15        52673-52677         c
FEATURES             Location/Qualifiers
     source          1..3765
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 87.34 cM"
     gene            1..3765
                     /gene="Tollip"
                     /gene_synonym="4930403G24Rik; 4931428G15Rik"
                     /note="toll interacting protein"
                     /db_xref="GeneID:54473"
                     /db_xref="MGI:MGI:1891808"
     exon            1..186
                     /gene="Tollip"
                     /gene_synonym="4930403G24Rik; 4931428G15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..978
                     /gene="Tollip"
                     /gene_synonym="4930403G24Rik; 4931428G15Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="toll-interacting protein isoform 1"
                     /protein_id="NP_076253.1"
                     /db_xref="CCDS:CCDS22020.1"
                     /db_xref="GeneID:54473"
                     /db_xref="MGI:MGI:1891808"
                     /translation="MATTVSTQRGPVYIGELPQDFLRITPTQQQQQIQLDAQAAQQLQ
                     YGGTVGTVGRLSITVVQAKLAKNYGMTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNK
                     VIQCTVPPGVDSFYLEIFDERAFSMDDRIAWTHITIPESLKQGQVEDEWYSLSGRQGD
                     DKEGMINLVMSYTSLPAAMMMPPQPVVLMPTVYQQGVGYVPIAGMPAVCSPGMVPMAM
                     PPPAVAPQPRCNEEDLKAIQDMFPNMDREVIRSVLEAQRGNKDAAINSLLQMGEES"
     exon            187..336
                     /gene="Tollip"
                     /gene_synonym="4930403G24Rik; 4931428G15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            337..519
                     /gene="Tollip"
                     /gene_synonym="4930403G24Rik; 4931428G15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            520..672
                     /gene="Tollip"
                     /gene_synonym="4930403G24Rik; 4931428G15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            673..763
                     /gene="Tollip"
                     /gene_synonym="4930403G24Rik; 4931428G15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            764..3765
                     /gene="Tollip"
                     /gene_synonym="4930403G24Rik; 4931428G15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3737..3742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tollip"
                     /gene_synonym="4930403G24Rik; 4931428G15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3762
                     /gene="Tollip"
                     /gene_synonym="4930403G24Rik; 4931428G15Rik"
                     /note="major polyA site"
ORIGIN      
        1 gccggggtgg ggcggggcgg ggcgactgtc agctgactga agagccgatt gcctcgcggg
       61 acaacggtcg gcgacgcagc ttgtggtggg agcggaagag ctctcccggc gggtctctgt
      121 gcagttggcg aggcagaggg ccgccgcagc accatggcga ccaccgtcag cacgcagcgc
      181 gggccggtgt acattggtga actcccccag gacttcctcc gtataacacc cacacaacag
      241 cagcagcaga tccagctgga tgcccaggca gcccagcagc tgcagtatgg aggaacagtt
      301 ggtaccgtgg gtcgcctcag catcactgtg gtacaggcaa aattggcaaa gaattatggc
      361 atgactcgta tggaccctta ctgccgtctg cgtctgggct atgctgttta tgaaactccc
      421 acagcacaca atggggccaa gaaccctcgc tggaacaaag tcattcagtg cacagtgccc
      481 ccaggtgtgg actcgttcta ccttgagatc ttcgatgagc gcgccttctc catggatgac
      541 cgcatagctt ggacccacat caccatcccc gagtccctga agcagggcca agtggaggac
      601 gagtggtata gcctgagtgg gaggcagggc gatgacaagg agggcatgat taacctggtc
      661 atgtcctaca cgtccctccc agctgccatg atgatgcctc ctcagcctgt ggtcctgatg
      721 ccaactgtgt accagcaggg tgttggctat gtgcccattg cagggatgcc tgctgtctgc
      781 agccctggca tggtgccgat ggccatgccc ccaccagctg tggctcctca gccccgctgt
      841 aatgaagagg acctcaaagc tatccaggac atgtttccca acatggacag ggaagtaatc
      901 cgttctgtgc ttgaagccca gagagggaac aaagatgctg ccatcaattc cttgctgcaa
      961 atgggtgaag agtcctagac ccgcctgtgg cccttggctt cacaccactg acccttggac
     1021 ttgtccaccc agggctcccc agggtcacca tccccacaag attccaatga aagaccatcc
     1081 acatacccct tccttggaca tctgcgccgc cccttcctac atatttcggg gatgcatgtg
     1141 gatttttggt tctaagcagg cagtcctctt cattgttgct gggggacaga gttaggggac
     1201 agttctctcc tagtctctag ctgggtgatg gtggcatggc cctgttattg cacagatcag
     1261 tggtcctgtt tggggacctg catctcctgt cctcacccta ttctggaaag cattcttaca
     1321 gaaagcaact gcctctgcca agatactaga aattgtacag catccttctg agttgatgga
     1381 tggatggcat ggagttactc agtccagctg ggatggttgt tgagggtgca ctgagttcat
     1441 gtgcacttac ttacaggtta tttttagaac tttcaagcta aaagctcctt ccctcttctg
     1501 atgttgtatg tgaacatggg cccctcagct agtcctggcc agtgagatat gcttcccagc
     1561 catatccagt gggtctctaa cctcctgtct agcttatctg ccactgtctg gctaggcttc
     1621 agccacagaa atccaacttg aatacagaag gtatccagac ctggtgcttg gttggccagg
     1681 ccccacatta gccctcactg ctggaggctg ctttccacat cctcttgttt agtaccagca
     1741 tcatgggtct tactccaggg gctgttcttg ttgatagacc ttcatcacag agcccagagt
     1801 caagcgaagg agatgggtgg gtgtggcact atgtgcttac tactaaaatt caagcattgt
     1861 gacactactg acctgcagta tactctgtgg acccatactg tagcttggct tgagtgataa
     1921 aaattcatgc ttaaattaaa ctttcataaa ggtagaggtg cctgtacctg accagtggat
     1981 attgtatagt gtattttagg ttgcaaacct ttgagcccgt gacctggcca tacatgtatt
     2041 tagggagaaa ttgagtggtg ccttgtgcta agatacagac cgtgaaagct ttctcagaac
     2101 cagtactgtc acaaggtgct gttaggaagc tccagcattg ccacagggtt atggtgggac
     2161 agttttgcct tacattgccg ttactttttg ttttctgaga atctgcacac ccggtttgga
     2221 tatgtgatcc accaataagg gcatgaaggt gactcctagc agtttggact gttgtgaagg
     2281 acttcaaata agaaaattag tgcttcagtt tttggtcttt gcctcctaaa aacgcggtaa
     2341 aatatcctac ttgctgttat ctacaggggt gctttttgtc aaatgtattg tttataagta
     2401 tttatttttg taagcctaaa ggcagtatgt ggtgatggtg agcatgggat ggtggtaaca
     2461 agcacttttc tttagttgta ggtctttaaa ccttttaact gcaaaatgga gaagaaagac
     2521 caatgtttat taaatagatt caaccactta ctttaacaca accaggcact ggaagcctcc
     2581 attctagact gttgatcggc cttgtgcttg gtaagcagat gccctcttgc agggtggatg
     2641 agtcaggcag gcagaacctc cttaagtggt ccacttagtg ttaccagcag actgcagaca
     2701 ctgcagagca ggaacctcac tcagtacctg tctctaggtc tcaggtgtgg cggctgtgtg
     2761 catccgcatc tgccttacgg aggtataggt tgaacacagg gccactttgt tctgtgaggt
     2821 tctataggaa gcatcacgat ttgctgccag cccctgagca gtcccacagc actcagaggc
     2881 agcgttcact aacttacgac tgcttaaatg aggaagagtg atggttttaa gacagattta
     2941 agacttgagc tgaacacaga ctcttccctt tgtcatgaac attttatttt tttaatagat
     3001 tgaagaaaga tcacatttta taaggcctga gtgatactcc taggttttgc tgtttttttg
     3061 tcttggaatt tcatgtcagc gcccatctag tgcaaggaga gaggcagcac ttgtcagcgc
     3121 ctgtgtaggt accagggcat cagagcatgg cttgttggct tccatcccat cctgaatctt
     3181 gttgagatga agagtcatcc ctagaaggag ctcagaggca gaggccacag ccgagtcaga
     3241 caggcttctg catggggacc aggctctcac tgggtgtaat tgctgctctt gccaagtttg
     3301 aagattgatg ttggtagcaa aatttctcaa ggtgttcact ggagccccct cccctcgggc
     3361 cagctctagt gtaggcatgc atctagggat ggcctggcct gttttcttct ctggacatgt
     3421 tggttggctg aagttgtaac ctgctgcacg cttgtgggct gacatggcca gaggctttca
     3481 tctcaccatg tgagtgatgc ctacccgatg acagaagtgt tgtgcgactg ggctctgccc
     3541 tcgccctccc aggccaccct ttacagacac tggtatcatc tggtacactg tctggaggtt
     3601 ggtgggaatg gttctcagaa ctgtctgtga ttattttggg aatggggggg tccatgtcca
     3661 tatttttctt tgattatatg atatattttt acttttcagc cttctaattt aataagtggt
     3721 ctatataaaa tagaaaaata aagtcctctg aggaaatgtt tacta
//
