LOCUS       NM_026654               2038 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus target of EGR1, member 1 (nuclear) (Toe1), transcript
            variant 1, mRNA.
ACCESSION   NM_026654
VERSION     NM_026654.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2038)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2038)
  AUTHORS   Wang,H., Ming,X., Zhang,S., Chen,J., Liu,X., Wu,X., Zhang,S.,
            Zhang,Y., Cui,W., Li,W. and Liu,Y.
  TITLE     Knockdown of Toe1 causes developmental arrest during the
            morula-to-blastocyst transition in mice
  JOURNAL   Theriogenology 194, 154-161 (2022)
   PUBMED   36257135
  REMARK    GeneRIF: Knockdown of Toe1 causes developmental arrest during the
            morula-to-blastocyst transition in mice.
REFERENCE   3  (bases 1 to 2038)
  AUTHORS   Lardelli,R.M., Schaffer,A.E., Eggens,V.R., Zaki,M.S., Grainger,S.,
            Sathe,S., Van Nostrand,E.L., Schlachetzki,Z., Rosti,B., Akizu,N.,
            Scott,E., Silhavy,J.L., Heckman,L.D., Rosti,R.O., Dikoglu,E.,
            Gregor,A., Guemez-Gamboa,A., Musaev,D., Mande,R., Widjaja,A.,
            Shaw,T.L., Markmiller,S., Marin-Valencia,I., Davies,J.H., de
            Meirleir,L., Kayserili,H., Altunoglu,U., Freckmann,M.L.,
            Warwick,L., Chitayat,D., Blaser,S., Caglayan,A.O., Bilguvar,K.,
            Per,H., Fagerberg,C., Christesen,H.T., Kibaek,M., Aldinger,K.A.,
            Manchester,D., Matsumoto,N., Muramatsu,K., Saitsu,H., Shiina,M.,
            Ogata,K., Foulds,N., Dobyns,W.B., Chi,N.C., Traver,D., Spaccini,L.,
            Bova,S.M., Gabriel,S.B., Gunel,M., Valente,E.M., Nassogne,M.C.,
            Bennett,E.J., Yeo,G.W., Baas,F., Lykke-Andersen,J. and Gleeson,J.G.
  TITLE     Biallelic mutations in the 3' exonuclease TOE1 cause
            pontocerebellar hypoplasia and uncover a role in snRNA processing
  JOURNAL   Nat Genet 49 (3), 457-464 (2017)
   PUBMED   28092684
REFERENCE   4  (bases 1 to 2038)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2038)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   6  (bases 1 to 2038)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL683847.12.
            
            On Mar 29, 2023 this sequence version replaced NM_026654.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023109.1, AK046576.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AL683847.12        102579-102699       c
            122-264             AL683847.12        101728-101870       c
            265-305             AL683847.12        101597-101637       c
            306-402             AL683847.12        101370-101466       c
            403-561             AL683847.12        101096-101254       c
            562-821             AL683847.12        100597-100856       c
            822-984             AL683847.12        100243-100405       c
            985-2038            AL683847.12        99113-100166        c
FEATURES             Location/Qualifiers
     source          1..2038
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.33 cM"
     gene            1..2038
                     /gene="Toe1"
                     /gene_synonym="4930584N22Rik; 4933424D16Rik"
                     /note="target of EGR1, member 1 (nuclear)"
                     /db_xref="GeneID:68276"
                     /db_xref="MGI:MGI:1915526"
     exon            1..121
                     /gene="Toe1"
                     /gene_synonym="4930584N22Rik; 4933424D16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1605
                     /gene="Toe1"
                     /gene_synonym="4930584N22Rik; 4933424D16Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     target of EGR1 protein 1"
                     /codon_start=1
                     /product="target of EGR1 protein 1 isoform 1"
                     /protein_id="NP_080930.1"
                     /db_xref="CCDS:CCDS18517.1"
                     /db_xref="GeneID:68276"
                     /db_xref="MGI:MGI:1915526"
                     /translation="MAADSDDDVPPVPTPSDGGVNKNTQPAEEFVVRVPVVDVQSDNF
                     KEIWPSLLLALKTASFVAVDTELSGLGDRKSLLNQCIEERYKAVCHAARTRSVLSLGL
                     ACFRQQPDKGENSYLAQVFNLTLLCIEEYVIEPKSVQFLVQHGFNFNRQYAQGIPYHK
                     GNDKGDESQSQSVRTLFLELIRARRPLVLHNGLIDLVFLYQNFYAHLPENLGTFTADL
                     CEMFPAGIYDTKYAAEFHARFVASYLEYAFRKCERENGKQRAAGSPHLALEFCSYPSS
                     MSGHIDYRCCMSPGTCRRSRTTGICDKFSAYGWCPLGPQCPQSHDIDLIIDTDEAVAE
                     DKRRRRRRKDKRKRSLQSQPGTQTLAEAEDGPPTKQVCEDSLETEKMEQKVAEGEAGD
                     QPGSREGHTSSLEMAHRRTSAETADVATSELLVNQASTNPVPGDGLHRAGFDAFMTGY
                     VMAYVGLSQGLQLCSSEPWLPECHNKVYLSGKTVPLTVTKSQFSRPSKAHNQKMKLAW
                     GSS"
     exon            122..264
                     /gene="Toe1"
                     /gene_synonym="4930584N22Rik; 4933424D16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            265..305
                     /gene="Toe1"
                     /gene_synonym="4930584N22Rik; 4933424D16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            306..402
                     /gene="Toe1"
                     /gene_synonym="4930584N22Rik; 4933424D16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            403..561
                     /gene="Toe1"
                     /gene_synonym="4930584N22Rik; 4933424D16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            562..821
                     /gene="Toe1"
                     /gene_synonym="4930584N22Rik; 4933424D16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            822..984
                     /gene="Toe1"
                     /gene_synonym="4930584N22Rik; 4933424D16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            985..2038
                     /gene="Toe1"
                     /gene_synonym="4930584N22Rik; 4933424D16Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2038
                     /gene="Toe1"
                     /gene_synonym="4930584N22Rik; 4933424D16Rik"
                     /note="major polyA site"
ORIGIN      
        1 agatccgtgt cgcttctgga gacgaagcgg aagtctctgc gtacctccag aaggctggcg
       61 aggggcgtca tggccgcgga cagtgacgat gatgtgcctc cagttccaac gccctctgac
      121 ggtggtgtca acaaaaacac acaacctgca gaggagtttg tggttcgggt tcctgtggta
      181 gacgtgcaga gtgacaactt caaggagata tggccatcac tcttgctagc cttaaagaca
      241 gctagctttg tggctgtgga cacggagctg agtgggctcg gggataggaa gagtttgctg
      301 aaccagtgca ttgaggaacg ttacaaggcc gtgtgtcatg ctgccaggac ccgttctgtc
      361 ctgtccctgg gcctcgcctg cttcaggcag caaccagata agggtgaaaa ttcttacttg
      421 gctcaagtgt tcaatctcac cctgctatgc atagaggagt acgttataga accgaagtct
      481 gtgcagttcc tggtacagca tggcttcaac ttcaaccggc agtacgccca gggtatcccc
      541 taccataagg gcaatgacaa gggagatgag agccagagcc agtcggtacg gacgctgttc
      601 cttgaactga ttcgggcccg acggcccctg gtgctacata atggccttat agacttggtg
      661 ttcctgtacc agaatttcta cgcgcacctg cctgagaact tggggacctt cactgctgac
      721 ctgtgtgaga tgttcccagc aggcatctat gacaccaaat atgccgccga gttccatgcc
      781 cgatttgtag cttcctactt agaatacgct ttccggaaat gtgagcggga gaatgggaag
      841 cagcgggcag ctggcagccc acatcttgcc ctggaattct gcagctatcc atctagcatg
      901 agcgggcaca ttgactaccg ctgctgtatg tcccctggga cctgccgtcg ttctcgtacc
      961 actggcatct gtgacaagtt ctcggcctat ggctggtgtc ctctgggacc acagtgtcct
     1021 cagtcacacg atattgacct tataattgac actgatgagg ctgtggcaga agataagcgg
     1081 cggagacggc gacgtaagga caaacggaag aggtctttac agagccaacc agggacacag
     1141 acccttgcgg aagctgaaga tggtcctccc acaaaacagg tctgtgaaga tagcctcgag
     1201 actgagaaaa tggaacaaaa agtggcagaa ggtgaggctg gggatcagcc tggctccagg
     1261 gaaggtcaca caagtagctt ggagatggca cataggagga caagtgctga aacagctgat
     1321 gtggccacct cagagctgct ggtgaaccaa gccagcacta accccgtgcc tggggacgga
     1381 ctgcatcgtg ctggttttga cgcctttatg acaggctatg tgatggccta tgtgggcctg
     1441 agccagggac ttcaactctg cagctctgaa ccttggcttc ctgaatgtca caacaaggta
     1501 tatctaagtg gcaaaactgt acccctcaca gtgaccaaga gccagttttc ccgtccatcc
     1561 aaagcccaca accagaaaat gaagctggct tggggcagca gctgactcca acatctgcct
     1621 ggtaactagg cccagggaaa gaagcgaaga gtaggagaag agatgtttgg cagagtgtag
     1681 tggcttgtgt tggtcattcc aggaacctaa gggctaaggc aggaggactg ttacaagttc
     1741 atggtctaca tagtcccaag tcacccagag ctatacagca aaatcatatt tcaaaaataa
     1801 gtcatttgag tctttaatct aattatgtca catttaactg ctacagagtt gtcgagcagg
     1861 tcctggcaaa cactgactac ttcagtactg tcttcttttg cagactcaga ggcctgggta
     1921 caaataaggc taactagcac ctgcaacatc aactttatta tttttttaat ctgaaagtgt
     1981 tttgggaaaa gtttaaaaaa aaaatcaaca gaaatatgaa aatatttgac caacttca
//
