LOCUS       NP_080930                511 aa            linear   ROD 02-MAY-2024
DEFINITION  target of EGR1 protein 1 isoform 1 [Mus musculus].
ACCESSION   NP_080930
VERSION     NP_080930.1
DBSOURCE    REFSEQ: accession NM_026654.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 511)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 511)
  AUTHORS   Wang,H., Ming,X., Zhang,S., Chen,J., Liu,X., Wu,X., Zhang,S.,
            Zhang,Y., Cui,W., Li,W. and Liu,Y.
  TITLE     Knockdown of Toe1 causes developmental arrest during the
            morula-to-blastocyst transition in mice
  JOURNAL   Theriogenology 194, 154-161 (2022)
   PUBMED   36257135
  REMARK    GeneRIF: Knockdown of Toe1 causes developmental arrest during the
            morula-to-blastocyst transition in mice.
REFERENCE   3  (residues 1 to 511)
  AUTHORS   Lardelli,R.M., Schaffer,A.E., Eggens,V.R., Zaki,M.S., Grainger,S.,
            Sathe,S., Van Nostrand,E.L., Schlachetzki,Z., Rosti,B., Akizu,N.,
            Scott,E., Silhavy,J.L., Heckman,L.D., Rosti,R.O., Dikoglu,E.,
            Gregor,A., Guemez-Gamboa,A., Musaev,D., Mande,R., Widjaja,A.,
            Shaw,T.L., Markmiller,S., Marin-Valencia,I., Davies,J.H., de
            Meirleir,L., Kayserili,H., Altunoglu,U., Freckmann,M.L.,
            Warwick,L., Chitayat,D., Blaser,S., Caglayan,A.O., Bilguvar,K.,
            Per,H., Fagerberg,C., Christesen,H.T., Kibaek,M., Aldinger,K.A.,
            Manchester,D., Matsumoto,N., Muramatsu,K., Saitsu,H., Shiina,M.,
            Ogata,K., Foulds,N., Dobyns,W.B., Chi,N.C., Traver,D., Spaccini,L.,
            Bova,S.M., Gabriel,S.B., Gunel,M., Valente,E.M., Nassogne,M.C.,
            Bennett,E.J., Yeo,G.W., Baas,F., Lykke-Andersen,J. and Gleeson,J.G.
  TITLE     Biallelic mutations in the 3' exonuclease TOE1 cause
            pontocerebellar hypoplasia and uncover a role in snRNA processing
  JOURNAL   Nat Genet 49 (3), 457-464 (2017)
   PUBMED   28092684
REFERENCE   4  (residues 1 to 511)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (residues 1 to 511)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   6  (residues 1 to 511)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL683847.12.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023109.1, AK046576.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.33 cM"
     Protein         1..511
                     /product="target of EGR1 protein 1 isoform 1"
                     /note="target of EGR1 protein 1"
                     /calculated_mol_wt=56740
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D2E2.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q96GM8; propagated from
                     UniProtKB/Swiss-Prot (Q9D2E2.1)"
     Site            5
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96GM8; propagated from
                     UniProtKB/Swiss-Prot (Q9D2E2.1)"
     Region          41..279
                     /region_name="CAF1"
                     /note="CAF1 family ribonuclease; pfam04857"
                     /db_xref="CDD:461457"
     Region          334..410
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D2E2.1)"
     Region          336..348
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D2E2.1)"
     Site            349
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9D2E2.1)"
     Site            429
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96GM8; propagated from
                     UniProtKB/Swiss-Prot (Q9D2E2.1)"
     CDS             1..511
                     /gene="Toe1"
                     /gene_synonym="4930584N22Rik; 4933424D16Rik"
                     /coded_by="NM_026654.3:70..1605"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS18517.1"
                     /db_xref="GeneID:68276"
                     /db_xref="MGI:MGI:1915526"
ORIGIN      
        1 maadsdddvp pvptpsdggv nkntqpaeef vvrvpvvdvq sdnfkeiwps lllalktasf
       61 vavdtelsgl gdrksllnqc ieerykavch aartrsvlsl glacfrqqpd kgensylaqv
      121 fnltllciee yviepksvqf lvqhgfnfnr qyaqgipyhk gndkgdesqs qsvrtlflel
      181 irarrplvlh nglidlvfly qnfyahlpen lgtftadlce mfpagiydtk yaaefharfv
      241 asyleyafrk cerengkqra agsphlalef csypssmsgh idyrccmspg tcrrsrttgi
      301 cdkfsaygwc plgpqcpqsh didliidtde avaedkrrrr rrkdkrkrsl qsqpgtqtla
      361 eaedgpptkq vcedsletek meqkvaegea gdqpgsregh tsslemahrr tsaetadvat
      421 sellvnqast npvpgdglhr agfdafmtgy vmayvglsqg lqlcssepwl pechnkvyls
      481 gktvpltvtk sqfsrpskah nqkmklawgs s
//
