LOCUS       NM_020507               3994 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus transducer of ERBB2, 2 (Tob2), mRNA.
ACCESSION   NM_020507
VERSION     NM_020507.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3994)
  AUTHORS   Islam,M., Yang,Y., Simmons,A.J., Shah,V.M., Musale,K.P., Xu,Y.,
            Tasneem,N., Chen,Z., Trinh,L.T., Molina,P., Ramirez-Solano,M.A.,
            Sadien,I.D., Dou,J., Rolong,A., Chen,K., Magnuson,M.A.,
            Rathmell,J.C., Macara,I.G., Winton,D.J., Liu,Q., Zafar,H.,
            Kalhor,R., Church,G.M., Shrubsole,M.J., Coffey,R.J. and Lau,K.S.
  TITLE     Temporal recording of mammalian development and precancer
  JOURNAL   Nature 634 (8036), 1187-1195 (2024)
   PUBMED   39478207
REFERENCE   2  (bases 1 to 3994)
  AUTHORS   Perez,R.C., Yang,X., Familari,M., Martinez,G., Lovicu,F.J.,
            Hime,G.R. and de Iongh,R.U.
  TITLE     TOB1 and TOB2 mark distinct RNA processing granules in
            differentiating lens fiber cells
  JOURNAL   J Mol Histol 55 (1), 121-138 (2024)
   PUBMED   38165569
  REMARK    GeneRIF: TOB1 and TOB2 mark distinct RNA processing granules in
            differentiating lens fiber cells.
REFERENCE   3  (bases 1 to 3994)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3994)
  AUTHORS   Jiang,G., Gong,M., Song,H., Sun,W., Zhao,W. and Wang,L.
  TITLE     Tob2 Inhibits TLR-Induced Inflammatory Responses by Association
            with TRAF6 and MyD88
  JOURNAL   J Immunol 205 (4), 981-986 (2020)
   PUBMED   32611726
  REMARK    GeneRIF: Tob2 Inhibits TLR-Induced Inflammatory Responses by
            Association with TRAF6 and MyD88.
REFERENCE   5  (bases 1 to 3994)
  AUTHORS   Wang,H., Cui,Y., Luan,J., Zhou,X., Li,C., Li,H., Shi,L. and Han,J.
  TITLE     MiR-5100 promotes osteogenic differentiation by targeting Tob2
  JOURNAL   J Bone Miner Metab 35 (6), 608-615 (2017)
   PUBMED   27873073
  REMARK    GeneRIF: These results revealed a new molecular mechanism that
            fine-tunes osteoblast differentiation through miR-5100/Tob2/osterix
            networks.
REFERENCE   6  (bases 1 to 3994)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   7  (bases 1 to 3994)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   8  (bases 1 to 3994)
  AUTHORS   Matsuda,S., Rouault,J., Magaud,J. and Berthet,C.
  TITLE     In search of a function for the TIS21/PC3/BTG1/TOB family
  JOURNAL   FEBS Lett 497 (2-3), 67-72 (2001)
   PUBMED   11377414
  REMARK    Review article
REFERENCE   9  (bases 1 to 3994)
  AUTHORS   Ajima,R., Ikematsu,N., Ohsugi,M., Yoshida,Y. and Yamamoto,T.
  TITLE     Cloning and characterization of the mouse tob2 gene
  JOURNAL   Gene 253 (2), 215-220 (2000)
   PUBMED   10940559
REFERENCE   10 (bases 1 to 3994)
  AUTHORS   Lee,Y.J., Park,C.W., Hahn,Y., Park,J., Lee,J., Yun,J.H., Hyun,B.
            and Chung,J.H.
  TITLE     Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely
            linked to Peg1/Mest(1)
  JOURNAL   FEBS Lett 472 (2-3), 230-234 (2000)
   PUBMED   10788617
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK618657.1, AK143542.1, AK049766.1, DV644744.1 and AV220845.1.
            
            On Jun 12, 2006 this sequence version replaced NM_020507.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143542.1, BC094031.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                CK618657.1         113-136
            25-925              AK143542.1         2-902
            926-935             AK049766.1         873-882
            936-2265            AK143542.1         913-2242
            2266-2573           AK049766.1         2216-2523
            2574-3365           AK143542.1         2551-3342
            3366-3448           AK143542.1         3344-3426
            3449-3650           AK143542.1         3428-3629
            3651-3992           DV644744.1         164-505
            3993-3994           AV220845.1         293-294
FEATURES             Location/Qualifiers
     source          1..3994
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.26 cM"
     gene            1..3994
                     /gene="Tob2"
                     /gene_synonym="2900090N22Rik; 4930545K18Rik; mKIAA1663"
                     /note="transducer of ERBB2, 2"
                     /db_xref="GeneID:57259"
                     /db_xref="MGI:MGI:1888525"
     exon            1..391
                     /gene="Tob2"
                     /gene_synonym="2900090N22Rik; 4930545K18Rik; mKIAA1663"
                     /inference="alignment:Splign:2.1.0"
     exon            392..3994
                     /gene="Tob2"
                     /gene_synonym="2900090N22Rik; 4930545K18Rik; mKIAA1663"
                     /inference="alignment:Splign:2.1.0"
     CDS             498..1535
                     /gene="Tob2"
                     /gene_synonym="2900090N22Rik; 4930545K18Rik; mKIAA1663"
                     /note="transducer of erbB-2 2"
                     /codon_start=1
                     /product="protein Tob2"
                     /protein_id="NP_065253.1"
                     /db_xref="CCDS:CCDS27673.1"
                     /db_xref="GeneID:57259"
                     /db_xref="MGI:MGI:1888525"
                     /translation="MQLEIKVALNFIISYLYNKLPRRRADLFGEELERLLRKKYEGHW
                     YPEKPLKGSGFRCVHIGEVVDPVVELAAKRSGLAVEDVRANVPEELSVWIDPFEVSYQ
                     IGEKGVVKVLYLGDSEASGTPELDKEIKSSFNPDAQVFVPIGSQDSSLSSSPSPSFGQ
                     SPSPTFIPRSAQPITFTTASFAATKFGSTKMKKGGGASGGVSVGGSGAGGQQPPPQQP
                     RMARSPTKNLLKHKSLSLSMHSLNLIPANPAPQSQLSPNAKEFVYNGGGSPSLFFDGV
                     EGPSTSTTAPFGSGGASTCNSSSFDVSQVFGGGANSLFLEKSPFVEGLSYNLNTMQYP
                     NQPFQPVVLAN"
     regulatory      3971..3976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tob2"
                     /gene_synonym="2900090N22Rik; 4930545K18Rik; mKIAA1663"
                     /note="hexamer: ATTAAA"
     polyA_site      3992
                     /gene="Tob2"
                     /gene_synonym="2900090N22Rik; 4930545K18Rik; mKIAA1663"
                     /note="major polyA site"
ORIGIN      
        1 agcagattca tgcgcagggt tgctgagggt gaaacttttc attgactttg ctcacttcgg
       61 gcccaggcgc gggaaggtgc aggtcgttga gactgagtgt cgtgggaacc gagaggccag
      121 aaggacagga cctgccagac gagtacatcc agggctggcc tccatccacc gcgtgacggg
      181 tgccatcctc gggtccgcca tccccgcgcc gtcgccgccg agctcgacct ccaaaaacag
      241 cggaaagaat cacatgagct cggtcctcgt ccctctctac cctcaaacga cgtaaaagga
      301 caccgtggcc ctcagcctcg cggtgcccgg gaagctggga gagagacctc cgtcccgcgg
      361 cctgcagagc ggacccttcg tggagacccg agagcctctg gatcccagga tccctcgcct
      421 gttcctgccg ccgctctgct cttgggctgt gcacgtgtcc cgtgtgtgcg tgcgagatct
      481 cggcctagaa gagggccatg cagctggaga tcaaagtggc cctcaacttc atcatctcct
      541 acttatacaa caagctgccc cgccgcaggg cagacctgtt tggggaggag ctagagcggc
      601 ttctgagaaa gaaatatgag ggccactggt acccggagaa gccgttgaag ggttctggct
      661 tccgctgtgt ccacattggg gaagtggtag accctgtggt ggagctggct gccaagcgga
      721 gcggcctagc tgtggaggat gtgcgtgcca acgtgcccga agagctgagt gtctggattg
      781 accctttcga ggtatcctac cagattggcg agaagggagt cgtgaaggtc ctgtacctgg
      841 gtgacagtga ggcgagtggt accccagagc tggacaaaga gatcaagagc agcttcaacc
      901 ctgacgccca ggtgtttgtg cccatcggca gccaggacag ctctctgtcc agctctccct
      961 cgccgtcctt tggccagtca cccagcccca ccttcatccc ccggtctgcc cagcccatca
     1021 cctttactac tgcctctttt gctgccacca aatttggttc cactaagatg aagaagggtg
     1081 gtggggcatc tggcggtgtg agtgtgggtg gcagcggggc gggtggccag cagccgccgc
     1141 cacagcagcc tcgcatggcc cgctcaccca caaagaacct gctgaagcac aagagcctct
     1201 ctctatctat gcattcactg aacctcatcc cagccaatcc ggccccccag tcccagctct
     1261 cccccaatgc caaggagttt gtgtacaacg gtggtggctc acccagcctc ttcttcgatg
     1321 gggtggaagg cccgagcacc agcaccacgg cccccttcgg cagcggtgga gccagcactt
     1381 gcaacagcag cagctttgat gtgtcccagg tgttcggagg cggtgctaac agcctgttct
     1441 tggagaaatc gccctttgtg gaaggcctca gctacaacct gaataccatg cagtatccca
     1501 accagccctt ccagcctgtc gtgctggcca actgaccgtc ttcccatctg ccaggccagg
     1561 agcacacacg accacaggca agtgaaaaga aaggccaaac gcaagaggga aagaaaactg
     1621 tacagaaaga ttccagtctt ctcattctcc cagctaggaa aaggattcgc ccaggcacag
     1681 agtaggaggg gctcccaaag caacaagtgt tggactcagc ccctgactat tctgcctgcc
     1741 tctgatttca tttggttggt ttggattttg taattatttt ttttacatgt agttttctat
     1801 atgacaactt taattagtgg tttcctgtgc taagagtggt ccagatgtga attgctgctc
     1861 cccactccct ccctccgccc ctttgggatc agtgtgttga ggctcaccgg gaaggaagag
     1921 ctgaaacagg gagaggctga caccccccca ccctccaccc ccgtgtccac aacccccaac
     1981 ctagctgtct tctcagggcc tgccacccaa ataagtctgg ccctagcctc aactctctct
     2041 caggctgggc cacaggaagc tgctgactgg ccacttgaca ccctccccct aaagctaatg
     2101 tctgtgacta tagggaggtt agcacttttt ctaattggaa ttcttctctg tcctgtggcc
     2161 ccatccctca cccgctcttg gcctggacca gatacatgca gcctctttct ccagcacagc
     2221 ctttccctga gcctgaggtt agggcagagt ttagagggtg ggctaagtgt atgttttcat
     2281 gtatgcattc atgcctgtga gtgtgtggct tgctgtcgtg tcctctggga tcccaagcca
     2341 cgcgggtctt ccctctgtag atgggtcctg ggttctatca cctgcttatt tatgtacgag
     2401 gttggggggt ggacccaggg tgggttgatt gtctctttgt aaggaagtat gtgtcggggg
     2461 tgacacgagg ctaagcccga gaaaccccgg gggacagcac tgcataagaa actggtttcc
     2521 cagactgcag agggagctgc acttttgttt tgaccaaaaa caaaaaacaa aacaaaacaa
     2581 aaacaaaaca aaaataactc tgaagggcgg gaggataccc aagcctgatg cctgagagga
     2641 gtccctagac ttcagcaact ccgctgcgtg gcctgagccc agcgggaggg atggggagag
     2701 aattttttgg agtccgtgcc tgtggtgggc agtcctgagc cttcagctga agcagtgctt
     2761 tttggctgcc ctcacctcgc actacttgac cttgaggctc tgagtatctc ctgtgcacag
     2821 gagaagctcc tgcaccagaa agcaccaaag cccctggcac cccatcttac tccactctcc
     2881 ccagggactc ccaggtggga actgctgtgg cagtgagctc agcccggaca gacactgcca
     2941 accctgtctc ctggcattgg gctccggctc tacctcccca agcagggcga ggccccgcct
     3001 tctcagccta gcaccacctg tccccgagtc ttctccagct tgcccatcat tctcggcgcc
     3061 cacacaggtg acagtcccaa gtagataacc tccatgggac aagttgggtg ttgccttacc
     3121 cgcctgccca gcccctcctc ccacaggaac acaggtacca cctgcaccca cgacagcttc
     3181 ttttctcaca catggggaga ctggagccga gccccttgtg tcttttgaaa taggaagaaa
     3241 aatgagtgtt caggaacatg actcctggac tgggctcttg ggcccagttc agtgtctcat
     3301 cgcaaatcta ggcatttttg cttctatttt atttaatttt tttttttaag gaaaaaaaaa
     3361 aaaaacaaaa caagaaaact gcactaattt acctggtttc gtagaagaac ttttttttat
     3421 tttttacatt ttttggtgtc cgtttgtatt gaataatttg ctacatttgt aaaatgtaag
     3481 aggtatatat ataatatatg tatatttcta atgtaagaaa cgtaattttt ttcttttcaa
     3541 gattttttct taaaaagagg agagaaacca atattttttc aggaaaaaca aactttaaaa
     3601 aataggaaca taaaaccacc tccacccctc gccccatcct ctctatccct ctcacccagg
     3661 agcaaaacag aaggtggata agattgtcaa gaatgtcagc tgtcagtcac gctgtctctg
     3721 tcttgatgct gtagtctcta gagctccccc tagagatggg agcaggcact gaagcagcca
     3781 tagagaggag cccgggagcg gggcgacctt tttttctcta gcgaaggaag aatgcaatca
     3841 agacgttttg tattcagaac attgtgcaat attttggaat gagacattgg tgtgtttaga
     3901 gatttagttt caaaacaaag attgatcaaa tctgtacagt ttatattgtt ccagattttt
     3961 ttaagtttgt attaaaagca tgatatataa tagc
//
