LOCUS       NM_009427               2288 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus transducer of ErbB-2.1 (Tob1), mRNA.
ACCESSION   NM_009427
VERSION     NM_009427.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2288)
  AUTHORS   Kitajima,Y., Yoshioka,K., Mikumo,Y., Ohki,S., Maehara,K., Ohkawa,Y.
            and Ono,Y.
  TITLE     Loss of Tob1 promotes muscle regeneration through muscle stem cell
            expansion
  JOURNAL   J Cell Sci 137 (15) (2024)
   PUBMED   39037211
REFERENCE   2  (bases 1 to 2288)
  AUTHORS   Peng,G., Liu,T., Qi,X., Wang,Y., Ren,J., Peng,J., Du,X., Hu,S.,
            Wu,S., Zhao,Y., Li,D. and Zheng,H.
  TITLE     A genome-wide CRISPR screening uncovers that TOB1 acts as a key
            host factor for FMDV infection via both IFN and EGFR mediated
            pathways
  JOURNAL   PLoS Pathog 20 (3), e1012104 (2024)
   PUBMED   38512977
  REMARK    GeneRIF: A genome-wide CRISPR screening uncovers that TOB1 acts as
            a key host factor for FMDV infection via both IFN and EGFR mediated
            pathways.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2288)
  AUTHORS   Perez,R.C., Yang,X., Familari,M., Martinez,G., Lovicu,F.J.,
            Hime,G.R. and de Iongh,R.U.
  TITLE     TOB1 and TOB2 mark distinct RNA processing granules in
            differentiating lens fiber cells
  JOURNAL   J Mol Histol 55 (1), 121-138 (2024)
   PUBMED   38165569
  REMARK    GeneRIF: TOB1 and TOB2 mark distinct RNA processing granules in
            differentiating lens fiber cells.
REFERENCE   4  (bases 1 to 2288)
  AUTHORS   Yu,Z., Wang,L., Zhao,J., Song,H., Zhao,C., Zhao,W. and Jia,M.
  TITLE     TOB1 attenuates IRF3-directed antiviral responses by recruiting
            HDAC8 to specifically suppress IFN-beta expression
  JOURNAL   Commun Biol 5 (1), 943 (2022)
   PUBMED   36085336
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2288)
  AUTHORS   Youssef,M.M.M., Hamada,H.T., Lai,E.S.K., Kiyama,Y., El-Tabbal,M.,
            Kiyonari,H., Nakano,K., Kuhn,B. and Yamamoto,T.
  TITLE     TOB is an effector of the hippocampus-mediated acute stress
            response
  JOURNAL   Transl Psychiatry 12 (1), 302 (2022)
   PUBMED   35906220
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2288)
  AUTHORS   Suzuki,T., K-Tsuzuku,J., Ajima,R., Nakamura,T., Yoshida,Y. and
            Yamamoto,T.
  TITLE     Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2
            is required for Ras-mediated cell proliferation and transformation
  JOURNAL   Genes Dev 16 (11), 1356-1370 (2002)
   PUBMED   12050114
  REMARK    GeneRIF: Phosphorylation of three regulatory serines of Tob by Erk1
            and Erk2 is required for Ras-mediated cell proliferation and
            transformation
REFERENCE   7  (bases 1 to 2288)
  AUTHORS   Kannan,K., Kaminski,N., Rechavi,G., Jakob-Hirsch,J., Amariglio,N.
            and Givol,D.
  TITLE     DNA microarray analysis of genes involved in p53 mediated
            apoptosis: activation of Apaf-1
  JOURNAL   Oncogene 20 (26), 3449-3455 (2001)
   PUBMED   11423996
REFERENCE   8  (bases 1 to 2288)
  AUTHORS   Matsuda,S., Rouault,J., Magaud,J. and Berthet,C.
  TITLE     In search of a function for the TIS21/PC3/BTG1/TOB family
  JOURNAL   FEBS Lett 497 (2-3), 67-72 (2001)
   PUBMED   11377414
  REMARK    Review article
REFERENCE   9  (bases 1 to 2288)
  AUTHORS   Yoshida,Y., Tanaka,S., Umemori,H., Minowa,O., Usui,M., Ikematsu,N.,
            Hosoda,E., Imamura,T., Kuno,J., Yamashita,T., Miyazono,K., Noda,M.,
            Noda,T. and Yamamoto,T.
  TITLE     Negative regulation of BMP/Smad signaling by Tob in osteoblasts
  JOURNAL   Cell 103 (7), 1085-1097 (2000)
   PUBMED   11163184
REFERENCE   10 (bases 1 to 2288)
  AUTHORS   Yoshida,Y., Matsuda,S. and Yamamoto,T.
  TITLE     Cloning and characterization of the mouse tob gene
  JOURNAL   Gene 191 (1), 109-113 (1997)
   PUBMED   9210596
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF748516.1 and AL645846.12.
            
            On Mar 22, 2005 this sequence version replaced NM_009427.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082588.1, AK142667.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-530               CF748516.1         1-530
            531-2288            AL645846.12        83058-84815
FEATURES             Location/Qualifiers
     source          1..2288
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 58.9 cM"
     gene            1..2288
                     /gene="Tob1"
                     /gene_synonym="Tob; Trob"
                     /note="transducer of ErbB-2.1"
                     /db_xref="GeneID:22057"
                     /db_xref="MGI:MGI:1349721"
     exon            1..278
                     /gene="Tob1"
                     /gene_synonym="Tob; Trob"
                     /inference="alignment:Splign:2.1.0"
     exon            279..2288
                     /gene="Tob1"
                     /gene_synonym="Tob; Trob"
                     /inference="alignment:Splign:2.1.0"
     CDS             433..1521
                     /gene="Tob1"
                     /gene_synonym="Tob; Trob"
                     /note="transducer of erbB2"
                     /codon_start=1
                     /product="protein Tob1"
                     /protein_id="NP_033453.2"
                     /db_xref="CCDS:CCDS25250.1"
                     /db_xref="GeneID:22057"
                     /db_xref="MGI:MGI:1349721"
                     /translation="MQLEIQVALNFIISYLYNKLPRRRVNIFGEELERLLKKKYEGHW
                     YPEKPYKGSGFRCIHVGEKVDPVIEQASKESGLDIDDVRGNLPQDLSVWIDPFEVSYQ
                     IGEKGPVKVLYVDDSSETGCELDKEIKNSFNPEAQVFMPISDPASSVSSSPSPPFGHS
                     AAVSPTFMPRSTQPLTFTTATFAATKFGSTKMKNSGRSSKVARTSPINLGLTVNVNDL
                     LKQKAISSSVHSLYGLGLGSQQQPQPQPQQQQQQQPSSSQPPPPLPQQQQQQPQQQQQ
                     QQQQTSALSPNAKEFIFPNMQGQGSSTNGMFPGDSPLNLSPLQYSNAFDVFAAYGGLN
                     EKSFVDGLNFSLNNMQYSNQQFQPVMAN"
     regulatory      2281..2286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tob1"
                     /gene_synonym="Tob; Trob"
                     /note="hexamer: ATTAAA"
     polyA_site      2288
                     /gene="Tob1"
                     /gene_synonym="Tob; Trob"
                     /note="major polyA site"
ORIGIN      
        1 ctggcccggc gcgcagaggg cgctgtacgg ggacgcaggg ccgggccgcc gggctgtgta
       61 gagaagcgag cgcgctcgtg taagcttgcc gtccccgcca cccctgagcc agagcagcga
      121 gctcccggac ccgcccgagg cgtccgtcgc gtgtccggcg gtggcgacgt cttgcacccc
      181 gtcgcctcgc cgctcccgac ccacccgcgc ccccgcccgc tgccccttct cccccgccca
      241 gccgcggctc ggcggcggcc gcagctccgg agcagcttga acaagaccac gggaaggttg
      301 aaggataatc ttctaatacc agcactttga atgagaattt gtttctctgc cacaaactga
      361 tttttttttt taaaaaattt atttttctgg tggaggagtt gaaacaaagc taacttttgt
      421 ggcttcgcag ctatgcagct tgaaatccaa gtagcactca attttattat ttcttacttg
      481 tacaataagc ttcccaggag acgtgtcaac atttttggtg aagagcttga aagacttctt
      541 aagaagaaat atgaagggca ctggtatcct gaaaagccat acaaaggctc agggtttaga
      601 tgtatacacg tgggggagaa ggtagacccc gtgatcgagc aggcatccaa agagagtggt
      661 ttggacattg acgatgttcg tggcaatctg ccacaggatt tgagtgtctg gatcgacccg
      721 tttgaggttt cctaccagat cggcgaaaag ggaccagtga aggtgctgta cgtggacgac
      781 agtagtgaaa ccggctgtga gctggataag gagatcaaaa acagctttaa cccggaggcc
      841 caggtgttca tgcccataag cgacccggcc tcctccgtgt ccagctctcc ctcacctccc
      901 ttcggccact ctgctgctgt cagccctacc ttcatgcccc ggtccacgca gcctttaacc
      961 tttaccactg ccacttttgc tgccaccaag ttcggctcca ccaaaatgaa gaatagtggc
     1021 cgtagcagca aggtagctcg cacttctccg atcaacctgg gcctgactgt aaatgtgaac
     1081 gacctcctga agcagaaagc catctcttcc tcagtgcact ctctgtatgg gctgggcctg
     1141 ggcagccagc agcagccaca gccgcagcca cagcagcagc agcagcagca gccgtcatca
     1201 tcccagccgc cgcctccact accgcagcag cagcagcagc agccacagca gcagcagcag
     1261 cagcagcagc aaacctctgc tctttctccc aatgccaagg aatttatttt tcctaacatg
     1321 cagggtcaag gtagtagtac caatggaatg ttcccaggtg acagccccct caacctcagt
     1381 cccctccagt acagcaatgc ctttgatgtg tttgcggcct acggaggcct caacgagaag
     1441 tcttttgtag acggcttgaa ttttagctta aataacatgc agtattctaa ccagcaattc
     1501 cagcctgtta tggctaacta aaaaaacaaa acaaaggaga acatgtatcg tacaagttaa
     1561 aatgcatcgg cccaaggggg aacttttttt cttttttttt tttgcctcct tgagattttt
     1621 ttttttaaag cttatagtaa ggacacattc aggcttggtt acaaaataaa acacgcatca
     1681 tttttcattt gccaaccaag cacaaagtta ttttctactg actgtatatt ttaaagtata
     1741 ctttcagata tggcctctta cagtatttaa gatatagcaa ggacatggct gaattttttt
     1801 tttataaaaa attggcacta ataagtgggt ttattggtct tttctaattg tataatttaa
     1861 tttagtacaa agtttgtaaa atatcagagg atatatatat attgtttcta cgacatggta
     1921 ttgcatttct atctttttac tacagtgatc tgtgacagct tcatgttgta ttttttttac
     1981 tgaaattgta aaatatccat cttaaagaca tcagctattc tgaaaattgt gtacaggata
     2041 ttcctttagt ggtggaatta aaatgtacga atatttgctt tttcaaaaaa atgtattttc
     2101 tgttaaaggt ttaaagattt ttgctatata ttatggaaga aaatgtaatc gtaaatatta
     2161 attttgtacc tatattgtgc aatacttgaa aaaacggtat aaaagtattt tgagtcagtg
     2221 tcttacatgt taagagggac tgaaatagtt tatattaagt ttgtattaaa attctttaaa
     2281 attaaaaa
//
