LOCUS       NM_172564               4755 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus tensin 4 (Tns4), mRNA.
ACCESSION   NM_172564
VERSION     NM_172564.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4755)
  AUTHORS   Di-Luoffo,M., Pirenne,S., Saandi,T., Loriot,A., Gerard,C.,
            Dauguet,N., Manzano-Nunez,F., Alves Souza Carvalhais,N.,
            Lamoline,F., Cordi,S., Konobrocka,K., De Greef,V., Komuta,M.,
            Halder,G., Jacquemin,P. and Lemaigre,F.P.
  TITLE     A Mouse Model of Cholangiocarcinoma Uncovers a Role for Tensin-4 in
            Tumor Progression
  JOURNAL   Hepatology 74 (3), 1445-1460 (2021)
   PUBMED   33768568
  REMARK    GeneRIF: A Mouse Model of Cholangiocarcinoma Uncovers a Role for
            Tensin-4 in Tumor Progression.
REFERENCE   2  (bases 1 to 4755)
  AUTHORS   Dani,N., Herbst,R.H., McCabe,C., Green,G.S., Kaiser,K., Head,J.P.,
            Cui,J., Shipley,F.B., Jang,A., Dionne,D., Nguyen,L., Rodman,C.,
            Riesenfeld,S.J., Prochazka,J., Prochazkova,M., Sedlacek,R.,
            Zhang,F., Bryja,V., Rozenblatt-Rosen,O., Habib,N., Regev,A. and
            Lehtinen,M.K.
  TITLE     A cellular and spatial map of the choroid plexus across brain
            ventricles and ages
  JOURNAL   Cell 184 (11), 3056-3074 (2021)
   PUBMED   33932339
REFERENCE   3  (bases 1 to 4755)
  AUTHORS   Raposo,T.P., Alfahed,A., Nateri,A.S. and Ilyas,M.
  TITLE     Tensin4 (TNS4) is upregulated by Wnt signalling in adenomas in
            multiple intestinal neoplasia (Min) mice
  JOURNAL   Int J Exp Pathol 101 (3-4), 80-86 (2020)
   PUBMED   32567731
  REMARK    GeneRIF: Tensin4 (TNS4) is upregulated by Wnt signalling in
            adenomas in multiple intestinal neoplasia (Min) mice.
REFERENCE   4  (bases 1 to 4755)
  AUTHORS   Schneider,A.J., Gawdzik,J., Vezina,C.M., Baker,T.R. and
            Peterson,R.E.
  TITLE     Sox9 in mouse urogenital sinus epithelium mediates elongation of
            prostatic buds and expression of genes involved in epithelial cell
            migration
  JOURNAL   Gene Expr Patterns 34, 119075 (2019)
   PUBMED   31669249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY133848.1, AK036834.1 and AL591366.15.
            
            On May 29, 2009 this sequence version replaced NM_172564.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036834.1, BC055820.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BY133848.1         1-4
            5-940               AK036834.1         2-937
            941-964             AL591366.15        28213-28236         c
            965-3913            AK036834.1         962-3910
            3914-4755           AL591366.15        13811-14652         c
FEATURES             Location/Qualifiers
     source          1..4755
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.92 cM"
     gene            1..4755
                     /gene="Tns4"
                     /gene_synonym="9930017A07Rik; Cten"
                     /note="tensin 4"
                     /db_xref="GeneID:217169"
                     /db_xref="MGI:MGI:2144377"
     exon            1..68
                     /gene="Tns4"
                     /gene_synonym="9930017A07Rik; Cten"
                     /inference="alignment:Splign:2.1.0"
     exon            69..588
                     /gene="Tns4"
                     /gene_synonym="9930017A07Rik; Cten"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..2252
                     /gene="Tns4"
                     /gene_synonym="9930017A07Rik; Cten"
                     /codon_start=1
                     /product="tensin-4 precursor"
                     /protein_id="NP_766152.2"
                     /db_xref="CCDS:CCDS25372.1"
                     /db_xref="GeneID:217169"
                     /db_xref="MGI:MGI:2144377"
                     /translation="MSSSLLAGGHMVSLTPCEESRMALHPTPSPGLPALCPYYTTESW
                     GTQPLMAPTLRKGSSDRLQQAQQAEARAHCLLQGPGEQASGASQDLESCIDFSLEALN
                     QMILEIDPTFQLLPSGTAGPQAESTNSIMSRNKKEEPEALDIKYIEVTSTRSRYLDGP
                     QRCSSPCATPPFGSPRSGSLFLSRDIPRETRSSSNESLIFSGNQGRGPSPLTPSSLSN
                     AIPCRESRTSGSPLATPPGWEKGLRAPQRGSRVSILSASPVSDVSYVFGSNQSLPHSS
                     LSSYPSSSRSLGSPASSSSSLHSLDRGSQCGRPSDAQAPSNPILGMGQPQAVQSTPVA
                     KEQASSCPASVTNSMADIPIVLINGSPEPQSPPAQRTPGHQDSVQSRVTSPSHLCQAI
                     KSPSKTLPDVPLPASPDGPAKDMQPTMKFVMDTSKYWFKPSITREQAINLLRTEKPGA
                     FVIRDSSSYRGSFGLALKVQETSASAPNRPGEDSSDLIRHFLIESSAKGVHLKGADEE
                     PYFGSLSSFVCQHSIMALALPCKLTIPQKELGGAEPASDSPTHGQTSCLKISAGCHTL
                     YLSSVSVETLSGALAVQKAISVTLERDVLPTPTVVHFKVTEQGITLTDVQRKVFFRRH
                     YPLSALRFCGMDPEQRKWQKYCKPSRIFGFVAKSQTEPQENVCHLFAEYDAVQPASQV
                     ISLVTALLQDTERM"
     exon            589..964
                     /gene="Tns4"
                     /gene_synonym="9930017A07Rik; Cten"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1389
                     /gene="Tns4"
                     /gene_synonym="9930017A07Rik; Cten"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1476
                     /gene="Tns4"
                     /gene_synonym="9930017A07Rik; Cten"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1602
                     /gene="Tns4"
                     /gene_synonym="9930017A07Rik; Cten"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1695
                     /gene="Tns4"
                     /gene_synonym="9930017A07Rik; Cten"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1773
                     /gene="Tns4"
                     /gene_synonym="9930017A07Rik; Cten"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1845
                     /gene="Tns4"
                     /gene_synonym="9930017A07Rik; Cten"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..2014
                     /gene="Tns4"
                     /gene_synonym="9930017A07Rik; Cten"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2083
                     /gene="Tns4"
                     /gene_synonym="9930017A07Rik; Cten"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2110
                     /gene="Tns4"
                     /gene_synonym="9930017A07Rik; Cten"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..4755
                     /gene="Tns4"
                     /gene_synonym="9930017A07Rik; Cten"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4735..4740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tns4"
                     /gene_synonym="9930017A07Rik; Cten"
                     /note="hexamer: AATAAA"
     polyA_site      4755
                     /gene="Tns4"
                     /gene_synonym="9930017A07Rik; Cten"
                     /note="major polyA site"
ORIGIN      
        1 ttgcagttta cctggcctca gcacagttca atcctgagag tcttgagtgg aacagcggcc
       61 acgagcaggt ccttggagcc ctcgtgagca ggatctagct ccgaggcaga agtgaggctg
      121 cttggaagcc tggggtaaag ccctgggctc actgccccat catgtccagc tctctgctgg
      181 ctggaggtca catggtcagc ttgactccct gtgaggaatc caggatggcc ctgcacccaa
      241 cccccagccc tggcctccca gccctgtgtc cttactacac cacagagagc tggggaaccc
      301 agcctctgat ggcccccaca ctccgcaaag gcagctccga caggctccag caggcccagc
      361 aggctgaagc cagagctcac tgcctccttc agggccctgg ggagcaggcc tcaggggcct
      421 cgcaggatct ggaatcttgc attgacttct ccctggaggc cctcaaccag atgatcctag
      481 agatcgaccc tactttccag ttgcttccct ctgggactgc tggtccccag gctgagtcta
      541 ccaacagtat catgtcaagg aacaagaagg aggaacccga agccttagat ataaagtaca
      601 tcgaagtgac ctccaccaga tcaagatacc ttgacggtcc ccaacgctgc tccagcccgt
      661 gtgccacccc accatttggc tccccgcgca gtggcagcct cttcctctcc agggacatcc
      721 cccgagagac ccgcagcagc agcaacgaga gcctcatctt ctctgggaac cagggcaggg
      781 gtccctctcc tctcacccct tcttccctta gcaatgccat cccttgccga gaaagcagga
      841 cctccggctc tccactggca actcctccag gctgggagaa agggctcagg gccccacagc
      901 ggggcagcag ggtctctata ctgtcagcca gccctgtatc ggatgtcagc tatgtgtttg
      961 gaagcaatca gtccctcccc cactcaagcc tctccagcta tccgtcatct tctagatcct
     1021 tgggaagtcc agccagctca tcttccagcc tccacagcct ggaccgaggg tctcagtgtg
     1081 ggagacctag tgatgcccag gctcctagta accccatact gggcatgggc cagccccaag
     1141 cagtgcagtc tactccagtg gctaaggagc aggctagtag ctgccccgca tctgtcacca
     1201 actccatggc ggacataccc atagtgctca tcaatgggag cccagaacca cagtctcccc
     1261 cagcccagcg gacaccagga caccaggact ctgtccagtc tagggttaca tctcccagcc
     1321 acctctgtca agccattaag agccccagca agactctgcc agatgttcct ctccctgcat
     1381 ctccagatgg tcctgccaag gacatgcagc ccaccatgaa gttcgtgatg gacacatcaa
     1441 agtattggtt taagccaagc atcactcgag agcaagcaat caatctcctg aggacggaga
     1501 agccgggtgc ctttgtcatc agggacagtt cctcctacag aggctccttc ggccttgccc
     1561 tgaaggtaca ggagacttcc gcatctgctc caaaccgacc aggcgaggac agcagtgacc
     1621 ttatccgtca cttcctgatt gagtcttcgg ccaaaggagt acatctgaaa ggagcagatg
     1681 aggagcccta ctttgggagc ctctcttcct tcgtgtgcca gcactccatt atggccctgg
     1741 ccctgccctg caaactcacc atcccacaga aagaactggg aggtgcagag ccagcatcgg
     1801 actcccccac acacggccag acctcctgcc tgaagatatc agccggttgc cacacactgt
     1861 acctgagttc tgtgagtgtg gagaccctga gcggagccct ggctgtgcag aaggctatct
     1921 cagtcacctt ggagagggat gtcctcccca cacccactgt cgtccacttc aaagtcactg
     1981 aacagggcat tactctgaca gacgtccaaa ggaaggtgtt cttccgacgg cactacccac
     2041 tcagcgccct ccgcttctgt ggaatggacc ccgagcaacg gaagtggcag aagtactgca
     2101 agccttccag gatctttggg tttgtggcca agagccagac agaaccacaa gagaacgtgt
     2161 gccacctctt cgcagagtac gatgcggtcc agccagcttc ccaggtcatc agcctagtga
     2221 ctgctctgct tcaggacaca gaaaggatgt agaagggtgc catctgtgtg ccttctctga
     2281 catctcaagg gacttgccca ggacatggaa ctgtggcctc cttgacaaac ctatctcttg
     2341 gactcaagtt ggattgatca agttgaaccc tttgaacctg atgtgacttc agcaataacc
     2401 ttcacctgac tctggagcct ccgtctcttc gattataaag acacccgtcc ttaagacagc
     2461 cgctccttgg acactcggct ggaagtcttt agtgtgttcc tccatactac tgaagcccac
     2521 ccacatccaa gatcccttat gtaaaaactg tctgcaagga ccgtctggct tcatttccct
     2581 gagcactccc tacatggtag gttgtaccag agacctatga cccctgcctt gtggtaaaca
     2641 gcaggtgttg gatcagaacc atcgatttcc tggctggcac ctggtgttga ttcgcggagt
     2701 ttggggacag attctatttc cccacacctg ttccttttct cggtttgctg agggcctctt
     2761 ggatccactg gcccagagat ttaaaagttt ggggttgagg atgtgtgtag ctcagttggt
     2821 agactgattg ccctacatga acgggactga atttgatcac cagccccaca aaccattctc
     2881 aatggtcaat ggttgtaatc ccagcactac aaggcaggaa gatcataagt tcaaggtcat
     2941 tcttatctat ataatgagtt taaggcagtc taagctacat gagaccctgt tgagagaaag
     3001 agacagaaag gcatgcacgt gcgcgtgtgt gcacacgcac acacacacac acacacacac
     3061 acacacacac acacaatggg agtgggatta aggttttcat aaatctcagc caatggtctt
     3121 caaagccttt acctgaagag accacactcc aacacggagc tgggggcatc gctccacaaa
     3181 gacctgctgt gggaagaggg tactgaatgg gcaagagcct acaaggttca gtctatgatg
     3241 gagaggggac caggtcaagg gcctcagcca gagcagacca ggctgcctca gagcatacac
     3301 cttataatgc aacccacttc agctggcttt ggggaaaggg gcatcaaatt cagcctgccc
     3361 caaggttgtc agagtcaagt ctgggagcag aaaaggggtg agttttcaca tccctgcatc
     3421 ttctgctttg caatgaaggt tctgtcggtg aggccttctc taatgcagta ttcatgatgt
     3481 tctcattcat gttctcattc atgatgttca tgatcttgag atctatctgc tgcagttttt
     3541 tgactcctgt ctggtggaac atcctggatt tcttggattt ttaggtgtaa tttgccaagg
     3601 tcttggaatc tttttcccaa gagcatgata gaaagatccc tggactctgc tgttacaagc
     3661 gtggactctt gtctcacctc atcaattatt ctgtgatgtt gaatcaggat tctaaaggct
     3721 agcttttttc agtagaagac ccttgtaccc acgattagaa aagactcagc agggccaggc
     3781 agaggtggcg cacgccttta atcccagcac ttgggaggca ggcagaggca ggcagatttc
     3841 tgagttcaag gccagcctgg tctacagagt gagttccagg acagccagag ctatacagag
     3901 aaaccctgtc ttggaaaaaa aaaaaaaaga ctcagcaatg ttcacattct tcatgtctaa
     3961 tccctccttg cccacccatt acaaatgaac atcatcccaa actttgcttt cagtttcttg
     4021 gtaagcaaca gctgtctggc aatgctcaag gaatccacat ctggtgggta ggagaagaga
     4081 gaccctgttg ctatagtaca gagacaagta tatctctgcc ccagctccag tcttgctgga
     4141 tcctcctcca gctccaacac acacacacac acacacacac acacacacac acacactcat
     4201 aaccatgtgg catcaccaac cttacaacca caagggggaa gcagagagtc aagcatgcag
     4261 acaggcagct ttcccagctg gttaaagaag ctgggccctt ttcctcccac accctgccag
     4321 ccttgcataa gccatttgtt gcagcatttg ttgctcttgg tccagtccgc ctgcctcctt
     4381 aggagaccgt tccatgacat gcaaggggaa gctcacagaa gaagcccact gtaactcagt
     4441 gtgaagcaag tgtttgtccc tgcccgctat cagcctacag agcaacattg tcattggcca
     4501 aggtcagtcc tgagggatga tgatttcaat gtcagaaaag caaatcagac ccaagggtgg
     4561 gggtgggggg atgctaggtc agtggtacag gccaagaccg gccttcccag tgtgggatca
     4621 ggctctgtgc cactgccggg gtctgcaggg tgttagcaaa gttttcccag ttagtagtgc
     4681 cagttctagg ctgaatggga gagtcctcca caactccctg tgtgcctcat ggaaaataaa
     4741 gttttttgca ccata
//
