LOCUS       NM_001083587            7483 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus tensin 3 (Tns3), mRNA.
ACCESSION   NM_001083587 XM_001001602 XM_109868 XM_990368
VERSION     NM_001083587.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7483)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7483)
  AUTHORS   Juilland,M., Alouche,N., Ubezzi,I., Gonzalez,M., Rashid,H.O.,
            Scarpellino,L., Erdmann,T., Grau,M., Lenz,G., Luther,S.A. and
            Thome,M.
  TITLE     Identification of Tensin-3 as a MALT1 substrate that controls B
            cell adhesion and lymphoma dissemination
  JOURNAL   Proc Natl Acad Sci U S A 120 (52), e2301155120 (2023)
   PUBMED   38109544
  REMARK    GeneRIF: Identification of Tensin-3 as a MALT1 substrate that
            controls B cell adhesion and lymphoma dissemination.
REFERENCE   3  (bases 1 to 7483)
  AUTHORS   Merour,E., Hmidan,H., Marie,C., Helou,P.H., Lu,H., Potel,A.,
            Hure,J.B., Clavairoly,A., Shih,Y.P., Goudarzi,S., Dussaud,S.,
            Ravassard,P., Hafizi,S., Lo,S.H., Hassan,B.A. and Parras,C.
  TITLE     Transient regulation of focal adhesion via Tensin3 is required for
            nascent oligodendrocyte differentiation
  JOURNAL   Elife 11, e80273 (2022)
   PUBMED   36214451
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7483)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7483)
  AUTHORS   Piprek,R.P., Kolasa,M., Podkowa,D., Kloc,M. and Kubiak,J.Z.
  TITLE     Cell adhesion molecules expression pattern indicates that somatic
            cells arbitrate gonadal sex of differentiating bipotential fetal
            mouse gonad
  JOURNAL   Mech Dev 147, 17-27 (2017)
   PUBMED   28760667
REFERENCE   6  (bases 1 to 7483)
  AUTHORS   Touaitahuata,H., Morel,A., Urbach,S., Mateos-Langerak,J., de
            Rossi,S. and Blangy,A.
  TITLE     Tensin 3 is a new partner of Dock5 that controls osteoclast
            podosome organization and activity
  JOURNAL   J Cell Sci 129 (18), 3449-3461 (2016)
   PUBMED   27505886
  REMARK    GeneRIF: Dock5 and tensin 3 cooperate for osteoclast activity, to
            ensure the correct organization of podosomes.
REFERENCE   7  (bases 1 to 7483)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7483)
  AUTHORS   Qian,X., Li,G., Vass,W.C., Papageorge,A., Walker,R.C., Asnaghi,L.,
            Steinbach,P.J., Tosato,G., Hunter,K. and Lowy,D.R.
  TITLE     The Tensin-3 protein, including its SH2 domain, is phosphorylated
            by Src and contributes to tumorigenesis and metastasis
  JOURNAL   Cancer Cell 16 (3), 246-258 (2009)
   PUBMED   19732724
  REMARK    GeneRIF: Tns3 protein, including its SH2 domain, is phosphorylated
            by Src and contributes to tumorigenesis and metastasis.
REFERENCE   9  (bases 1 to 7483)
  AUTHORS   Chiang,M.K., Liao,Y.C., Kuwabara,Y. and Lo,S.H.
  TITLE     Inactivation of tensin3 in mice results in growth retardation and
            postnatal lethality
  JOURNAL   Dev Biol 279 (2), 368-377 (2005)
   PUBMED   15733665
  REMARK    GeneRIF: Results indicate that tensin3 is essential for normal
            development and functions of the small intestine, lung, and bone
            [tensin3].
REFERENCE   10 (bases 1 to 7483)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY154424.1, AK052680.1, AW259174.1, AL662881.10, BU056564.1,
            AK158101.1 and AL603845.11.
            
            On or before Mar 29, 2007 this sequence version replaced
            XM_109868.8, XM_001001602.1, XM_990368.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                BY154424.1         4-60
            58-468              AK052680.1         53-463
            469-623             AW259174.1         329-483
            624-642             AL662881.10        110231-110249       c
            643-707             AL662881.10        106169-106233       c
            708-791             AL662881.10        103005-103088       c
            792-904             AL662881.10        97399-97511         c
            905-965             AL662881.10        96706-96766         c
            966-1041            AL662881.10        95874-95949         c
            1042-1171           AL662881.10        84443-84572         c
            1172-1237           AL662881.10        84125-84190         c
            1238-1342           AL662881.10        83201-83305         c
            1343-2587           AL662881.10        57095-58339         c
            2588-2748           AL662881.10        44507-44667         c
            2749-3119           BU056564.1         96-466
            3120-3760           AL662881.10        15857-16497         c
            3761-4400           AK158101.1         892-1531
            4401-4469           AL603845.11        222339-222407       c
            4470-4496           AL603845.11        222209-222235       c
            4497-7483           AL603845.11        218145-221131       c
FEATURES             Location/Qualifiers
     source          1..7483
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 4.99 cM"
     gene            1..7483
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /note="tensin 3"
                     /db_xref="GeneID:319939"
                     /db_xref="MGI:MGI:2443012"
     exon            1..57
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            58..169
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            170..207
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            208..246
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            247..296
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..468
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..4641
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /note="tensin-like SH2 domain containing 1; tumor
                     endothelial marker 6; tensin-like SH2 domain-containing
                     protein 1"
                     /codon_start=1
                     /product="tensin-3"
                     /protein_id="NP_001077056.1"
                     /db_xref="CCDS:CCDS36109.1"
                     /db_xref="GeneID:319939"
                     /db_xref="MGI:MGI:2443012"
                     /translation="MEDSHELDLTYVTERIIAVSFPASCSEESYLHSLQEVTRMLKCK
                     HGDNYLVLNLSEKRYDLTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNNDPQHV
                     VVIHCRGGKGRIGVVISSYMHFTNVSASADQALDRFAMKKFYDDKISALMEPSQKRYV
                     QFLSGLLSGAMKMNTSPLFLHFVIMHGVPSFDTGGACRPFLKLYQAMQPVYTSGIYNV
                     GSENPSRIRIAIEPAQLLKGDIMVKCYHKKFRSATRDVIFRLQFHTGAVQGYGLLFGK
                     EELDSACKDDRFPDYGKIELVFSATPEKIQGSEHLYSDQGVTVDYNTADPLIRWDSYE
                     NMSADGEVLHTQGPVDGSLYAKVRKKSASDTGIPSSPQGMPATSSPDHGDHTLSVSSD
                     SGHSTASARTDKTEERLTPGARRGLSPQEKAELDQLLSGFGLEDSASSHKDMTDMRSK
                     YSGTRHVVPAQVHVNGDAALKDRETDILDDEMPHHDLHSVDSLGTLSSSEGPQSTHLG
                     PFTCLKSSQNSLLSDGFGNGVAEDHNGVLSPDLGLGVDTLYDRERMCGGREQKPLQPL
                     LRKPSAPTPVQAYGQSNYSTQTWVRQQQMVAAHQYSFASDGEARLGSRSTVDNTGLAQ
                     PPPHIPVTPNRGASSRVAVQRGISNGPNPPDTQQLCPGKALQPRFQDDRVTNGVHQEP
                     NTGSSPGSPTLDIDQSIEQLNRLILELDPTFEPIPTHLNALGISAVCPDGVGSGLRCS
                     GRLDSVDGPGRSPGRQGDDPIGGRLRKLSIGQYDNDAASQVTFSKCGWGKAGVDPAPS
                     LGSFSSPEDIKETVITAYPSDLNMIDGRIPNSKESSMCLTPSFPVSPETPYVKTSPRY
                     PPFSPPEPQLSSPASLHKGREPRGCPEIISHTVGMSESPVGPKPTMLRADMPATPNFQ
                     QVFASSCTVSSNGPGQRRESPPSAERQWVESSPKSTLTLLGNSHPSESPLGTHEFCSS
                     GKDSPGLPCFQSSELQASFHSHELSMSEPQGALPPAGSQTFLGFNTVTTATSVLPPGE
                     DAGTLLVNSHGTSPAPGTPLLTTGAADNGFLPHNFLTVSPGASSHHSPGLQNQNVSLP
                     GQPPLPEKKRASEGDRSLGSVSPSSSGFSSPHSGSTMSIPFPNVLPDFCKPSEVASPL
                     PDSPNDKLVIVKFVQDTSKFWYKADISREQAIAMLKDKAPGSFIVRDSHSFRGAYGLA
                     MKVATPPPSVLHLNKKAGDLSNELVRHFLIECTPKGVRLKGCSNEPYFGSLTALVCQH
                     SITPLALPCKLLIPERDPLEEIAENSPQTAANSAAELLKQGAACNVWYLNSVEMESLT
                     GHQAVQKALSMTLVQEPPPVSTVVHFKVSAQGITLTDNQRKLFFRRHYPVSSVIFCAL
                     DPQDRKWIKDGPSSKVFGFVARKQGSATDNVCHLFAEHDPEQPASAIVNFVSKVMIGS
                     PKKI"
     exon            469..519
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..642
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..707
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..791
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..904
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            905..965
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1041
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1171
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1237
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1342
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..2587
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2748
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2866
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..2947
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3119
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            3120..3760
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            3761..3847
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            3848..3979
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            3980..4075
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            4076..4153
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            4154..4231
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            4232..4400
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            4401..4469
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            4470..4496
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     exon            4497..7483
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7455..7460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /note="hexamer: AATAAA"
     polyA_site      7483
                     /gene="Tns3"
                     /gene_synonym="F830010I22Rik; TEM6; Tens1"
                     /note="major polyA site"
ORIGIN      
        1 ggagcccagc ttcgcttcgg ccatcgcccc gccggaccgc gctgcgggtt cgcccagccg
       61 ggagaattta ccacgtgtcc gcacaacttt aagaaaaagg actttaaaaa gcccagagtc
      121 tgtggagtgt gcagacagac cattgacggt caagggattg cttgccgagc ctgcaagtat
      181 tcctaccaca agagatgtga agcccaggtg gtgactccct gctctgtgca agtccacctg
      241 gaccaggctc ctgagagtcc cacacctgct gttctccgct gtgacaagcc ttcaaggacc
      301 gtggttctga gtccagccat ggaggacagc cacgaactgg accttacgta tgtcaccgag
      361 cgtatcatcg cagtgtcctt ccctgccagt tgttcagagg agtcctactt gcacagcctg
      421 caggaagtca cacgcatgct caagtgtaag catggagaca actacctggt attaaacctt
      481 tcagagaaga gatatgacct tacaaagctt aatccaaaga tcatggatgt gggctggccc
      541 gagctgcatg cacctcctct tgacaagatg tgcactatat gtaaggctca ggagtcctgg
      601 ctgaacaacg acccccagca tgtggtcgtc atccactgca ggggtggtaa aggacgcatt
      661 ggagtggtca tatcgtccta catgcacttc accaacgtct cagccagtgc tgaccaggca
      721 ctggacaggt ttgcaatgaa gaagttttat gatgacaaaa tttcagcttt aatggagccc
      781 tcccagaagc ggtacgtgca gtttctcagc gggctactgt ctggagccat gaagatgaac
      841 acctcacctc tgttcctaca cttcgtcatc atgcatggtg tccccagctt tgacactgga
      901 ggagcttgcc ggccctttct gaagctctac caagctatgc agcctgtgta cacatctgga
      961 atctacaatg tcggctctga aaaccccagc aggatccgca tcgccattga gccggcccag
     1021 ctgctgaagg gtgacatcat ggtgaaatgc tatcacaaga agttccgctc ggccacccgt
     1081 gatgtcattt tccgcctgca gttccacacc ggagctgtgc agggctacgg gcttctgttt
     1141 ggaaaggaag aactggacag cgcctgcaaa gatgaccgct ttcctgacta tggcaagatt
     1201 gagttggtct tctcggccac acctgagaag attcaaggat cggagcatct gtacagcgac
     1261 cagggagtga ccgtggacta taacacagca gacccgctga ttcgatggga ctcctatgag
     1321 aacatgagtg cggatggaga agtgctacac acacaggggc cagtggatgg cagcctgtat
     1381 gccaaggtga ggaagaagag tgcctcagat actggcatcc ctagtagccc ccagggcatg
     1441 ccagccacta gcagtccaga ccacggagac cacaccctgt cagtcagcag cgactcaggt
     1501 cattctactg cctccgccag gactgataag acagaagagc gcctgacccc cggagcacga
     1561 agaggcctga gccctcagga gaaggctgag ctggaccagc tgctcagtgg atttggcctg
     1621 gaagactctg caagctccca caaagacatg actgatatgc gcagcaagta cagtgggaca
     1681 cggcatgtgg taccagccca ggtccatgtg aatggagatg ctgccctaaa ggaccgggag
     1741 actgacattc tagatgatga gatgccccat catgatcttc acagtgtgga cagcctgggt
     1801 actctttcct cctctgaagg gccccagtcc acccacctgg gtcctttcac ctgtctcaag
     1861 agcagccaga actctctcct gtctgatggc tttggcaatg gtgttgctga agatcataat
     1921 ggtgtccttt ctccagacct gggccttggt gtagacaccc tttacgatcg ggagcggatg
     1981 tgtgggggcc gagagcaaaa accgctgcag cccctgttga ggaagccctc tgcacccacc
     2041 ccagtgcagg cctatgggca aagtaactat tccacccaga cttgggtacg tcagcagcag
     2101 atggtggctg ctcaccagta cagctttgcc tcagatgggg aggccaggct tggcagccgc
     2161 agcacagtgg acaatactgg ccttgcccag cccccacccc acatcccagt tactcccaac
     2221 cgtggagcca gcagcagagt ggctgttcag agaggcatca gcaatgggcc aaatcccccc
     2281 gacacacagc agctctgtcc tggtaaagct ctccagccca gatttcaaga tgacagagtc
     2341 acgaatggag tccatcagga gccgaacact ggctcctccc caggctctcc tactctggat
     2401 attgatcagt ccattgagca actcaacagg ctgatcctgg agctggaccc cacctttgag
     2461 cccatcccca cacacctgaa tgcccttggc atctcagctg tgtgtcctga cggtgtggga
     2521 agtgggctcc ggtgtagtgg ccggctggac tctgtggatg gccctggccg gagccctggc
     2581 cggcaaggtg atgaccccat tgggggacgg cttcgtaagc tgagcatcgg gcagtatgac
     2641 aatgatgctg cgagccaggt gaccttctct aagtgtggat ggggaaaggc tggagtggac
     2701 ccagccccaa gcctgggatc attttcctct cctgaagaca tcaaagagac ggtgatcact
     2761 gcatatccct ctgacctcaa tatgatcgat ggcaggattc caaacagcaa ggagtcatct
     2821 atgtgtctga ccccatcatt ccctgtgtct ccggaaacac catatgtgaa aacatcgcca
     2881 cgctaccctc cgttcagtcc acctgagccc cagctgagca gcccagccag tttgcacaaa
     2941 ggtcgagaac cacgaggctg cccagagatt attagccaca ctgtggggat gtcagagagc
     3001 cccgttggac ccaaacccac catgcttcgg gctgatatgc ctgcaacacc caactttcag
     3061 caggtgtttg catcatcctg cacggtttca agcaatggcc ctggccagag gagagagagc
     3121 ccgccttctg cagaacgcca gtgggtagag agcagcccga agtccaccct caccctactg
     3181 gggaacagcc acccttctga aagtcccctc ggcactcatg agttctgtag ctctggtaag
     3241 gactcaccag ggctgccctg cttccagtcc tcagagctcc aggcctcttt ccacagccat
     3301 gagctgtcca tgtcagagcc tcagggtgct ttgcctcctg cgggcagcca aaccttctta
     3361 ggtttcaaca cagtaaccac agcaacaagt gttcttccac ctggtgagga cgctggcacc
     3421 ttgctggtca attcccatgg aacatcacca gctcctggaa cccctctgct gacgacaggg
     3481 gctgctgaca acggctttct gccccacaac tttctcacgg tgtcacccgg agccagcagc
     3541 caccacagtc caggcctgca gaaccagaac gtgagcctgc ctgggcagcc acccctcccg
     3601 gagaagaaga gagcgtcgga gggtgatcgt tctttgggct cagtctcccc atcatccagt
     3661 ggcttctcca gcccccacag tggcagcacc atgagcatcc ccttcccgaa tgtccttcca
     3721 gacttctgca agccttcaga agtggcctca cctttgccag atagcccaaa tgataaactc
     3781 gtgattgtga aatttgttca agacacttcg aagttctggt acaaggcaga catctcaaga
     3841 gaacaagcca ttgccatgct gaaggacaaa gcccccgggt cattcatcgt gagggacagt
     3901 cactccttcc gaggggccta cggcctggcc atgaaggtgg ccacacctcc tccgtctgtc
     3961 ctgcacctca acaagaaagc tggagatttg tccaatgaac ttgtccggca tttcctgatt
     4021 gagtgtaccc caaagggagt gcggttgaaa gggtgctcaa atgaaccata ttttgggagc
     4081 ctgacggctt tggtgtgcca gcattccatt acgcccttgg ctttaccctg caagctgctc
     4141 attccggaga gagatccact ggaggaaata gcagaaaact ctccccagac agcagccaac
     4201 tctgcagccg agctgctgaa gcagggagca gcctgcaatg tttggtactt aaactctgtg
     4261 gaaatggagt ccctcactgg tcaccaggca gtccagaagg ccctgagtat gaccttggtt
     4321 caagaacctc ctccagtgtc tacagtggta cacttcaagg tgtcagccca gggcatcacc
     4381 ctgactgaca atcagagaaa gctcttcttc cggaggcatt acccggtcag cagtgtgatt
     4441 ttctgtgctt tggatccaca agacaggaag tggatcaaag atggcccttc ttctaaagtc
     4501 tttggatttg tggcccggaa acagggcagt gctacagaca acgtatgcca cctgtttgca
     4561 gagcatgacc ccgagcaacc tgccagtgcc attgtcaact ttgtgtcaaa ggtcatgatt
     4621 ggctccccta agaagatctg agcccttcct agccaaacct gccagatgcc tcatagggcc
     4681 ctcaacatgg cagtggggtg aggcagggcc cccattcgta ccagattgac aatcttcaca
     4741 ttccagactc aacaagagga gaagaatatg acaactcttc aaaccaagaa caaacaatgt
     4801 caccactgac tggccttaaa gaagctgctc ttccgacaca cctatatagt caggcgcatt
     4861 ttgagtggat ggatcttggc ccgggaaatg cctcatcagg gccccaagga caagggctgt
     4921 acaaggaggg agcatggaag acaaggctgt ccccagtccc tggctcatta gcatctgtgt
     4981 ggaggaagag catctgtcct gcttgacagg gactgagtag ccatggcacc cacttgtcag
     5041 cagaaatgct ccctcatctt gtctttctac atcagtgatg gaactgagga ggagatgcat
     5101 ggtcagtgaa ggtctgagca ggttggaaca tggcggggac ctaagtcagg ggcagcggaa
     5161 gggatgtgag gtgagggcag tggagaaagc ctctggggtc agggaggacc acgtggggtc
     5221 tgagagccac tgctgggggg taaggactct gtgattctgc tctcaggttg tcacctgggc
     5281 tgtggagagc ctagaggacc tggagaggaa aatgagaaga tggaatcaaa aatgccattt
     5341 tatataatat atattttact tatgccaaat tatttataac cgcttgccat tgccataccg
     5401 tacccatgtc aaatgctgca gccgactaag ctgtgattac taggaggctt gtccccttgt
     5461 agacacacca gagacagctg gcccgtcagc tggaagggga acagtggtct cagggtgatg
     5521 ccacgagatc cttctcctgt agtactgcca aatggatttg ccttaagcag cctccctacc
     5581 ctctgcctgg cgcagcaaca tgtcttgtcc agatgcagat ggttttgttc ctgatggaaa
     5641 cgtctgggag acgtggaaga ctaagacact gacgtcagtc tcagcctctt ctgcaggact
     5701 ggctgggcca tgtagaggtc tgcgtcatct aaagcacacg tggcctttta ccgtgatgct
     5761 cctgtggtac ctgcagcttc cgaggggaac ttctgtgggg tccagagggg gagaagggat
     5821 gaagggaaag atcaagaact ccagcactca cggctacgtt tgatttgctg agtcatctta
     5881 gttactgagt caggtgtgat ggttcttgct aagatgggca tccccctgct gcaggcttcc
     5941 tgtgcccaga gattcggaag aatgcggtaa gcccgtcctt cccagggtgg aggtggagga
     6001 gggctccggc tccgtggaga caaagccagg gtctcctcag tcagaacctt ctaccccagg
     6061 aaggctctga gaattcctgg cctggcctga aattcccact ctttgccttc taaaatccag
     6121 acctagcttc cacatttcac gtccaggaca ggctacagtt gttaagctgg gatttttgtg
     6181 gtgaattctg tttcaaaagg ggcagagatg taactatgtg tagaattggg atcaactgtc
     6241 aggatgagtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta caggtggact
     6301 attccatttt tgctcatgtg tatgtctgtg tgtatacagg tggaccattc cactttttgc
     6361 tcatgtatgt ctgtgtgtat acaggtggac cattccactt tttgctcatg tatgtctgtg
     6421 tgtatacagg tggactattc cactttttag ctcctattga tgcaccaaaa gcaagtgcct
     6481 catttctgtg ccaaatgttt gccttggtct ttaaggacct ccttcgtgga cactctgatg
     6541 tgcctgttag agggaatgtg ccaccattcc ctagaggccc catgtcttcc acagaggctt
     6601 ctagtgttcc agttactcat atgcagctaa actccagatg ggggcagggg tggggctgaa
     6661 gtttgtgctc taagaagtat cacatcctat gattataagt ttatatgcag atgtggccca
     6721 gagatcacag ccccgcactc ttttcctccc gctggagggg ggtgggggtg gggggagagg
     6781 gcctaattag aaatcagctg ggctctgctg aagcccagct ttccggtgaa ttgaatgcca
     6841 caaaggttgg catggaatgc atccaagaag ccacacgaat gtgctttcaa aactgaccgg
     6901 tgaggtatga tttttactca agataaaagt agtcaagggt atcaatggat ctgatctgag
     6961 gaaacacagg aagacagctc tacaactgtc tacaacagct ggtagggcaa ggctctgtct
     7021 tctgtgtgtg acgcgtgtat tgaacagaac aagaacagta tcatagacta taccgtgtgc
     7081 tcagaaacac tgcgaaagga gtattgccca ggcttttgct acaaggccat cggttgggca
     7141 caagttagta cattattcta tgagtaaatt caatgatgtc ccaccacttc caatagatag
     7201 ccagggtccc attaaccttc tcattaacgg tcttatagtt tccagtgttg ggctgtatcc
     7261 atgttaaaag ccacactgca tttatcttca gtgtcaaaga cattgtaatg ccgccatatc
     7321 tgtcttatct attagcgcag ttttcactat tctatattgt aaagaatata tatccagtat
     7381 gtaaatgagt gttctataaa ccttttgtat aggcatttcc tctgctcttt aaatatcagc
     7441 cttattcaga gtataataaa aattatgacc ttggtaagtc taa
//
