LOCUS       NM_001416206            4588 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus tensin 2 (Tns2), transcript variant 4, mRNA.
ACCESSION   NM_001416206 XM_006520694
VERSION     NM_001416206.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4588)
  AUTHORS   Mochida,Y., Ochiai,K., Nagase,T., Nonomura,K., Akimoto,Y.,
            Fukuhara,H., Sakai,T., Matsumura,G., Yamaguchi,Y. and Nagase,M.
  TITLE     Piezo2 expression and its alteration by mechanical forces in mouse
            mesangial cells and renin-producing cells
  JOURNAL   Sci Rep 12 (1), 4197 (2022)
   PUBMED   35273307
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4588)
  AUTHORS   Uchio-Yamada,K., Yasuda,K., Monobe,Y., Akagi,K.I., Suzuki,O. and
            Manabe,N.
  TITLE     Tensin2 is important for podocyte-glomerular basement membrane
            interaction and integrity of the glomerular filtration barrier
  JOURNAL   Am J Physiol Renal Physiol 318 (6), F1520-F1530 (2020)
   PUBMED   32390516
  REMARK    GeneRIF: Tensin2 is important for podocyte-glomerular basement
            membrane interaction and integrity of the glomerular filtration
            barrier.
REFERENCE   3  (bases 1 to 4588)
  AUTHORS   Sasaki,H., Takahashi,Y., Ogawa,T., Hiura,K., Nakano,K.,
            Sugiyama,M., Okamura,T. and Sasaki,N.
  TITLE     Deletion of the Tensin2 SH2-PTB domain, but not the loss of its
            PTPase activity, induces podocyte injury in FVB/N mouse strain
  JOURNAL   Exp Anim 69 (2), 135-143 (2020)
   PUBMED   31723089
REFERENCE   4  (bases 1 to 4588)
  AUTHORS   Marusugi,K., Nakano,K., Sasaki,H., Kimura,J., Yanobu-Takanashi,R.,
            Okamura,T. and Sasaki,N.
  TITLE     Functional validation of tensin2 SH2-PTB domain by
            CRISPR/Cas9-mediated genome editing
  JOURNAL   J Vet Med Sci 78 (9), 1413-1420 (2016)
   PUBMED   27246398
  REMARK    GeneRIF: deficiency causes alteration of actin remodeling and
            morphological changes in podocytes and subsequent proteinuria
REFERENCE   5  (bases 1 to 4588)
  AUTHORS   Sasaki,H., Kimura,J., Nagasaki,K., Marusugi,K., Agui,T. and
            Sasaki,N.
  TITLE     Mouse chromosome 2 harbors genetic determinants of resistance to
            podocyte injury and renal tubulointerstitial fibrosis
  JOURNAL   BMC Genet 17 (1), 69 (2016)
   PUBMED   27230548
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4588)
  AUTHORS   Ogura,A., Fujimura,H., Asano,T., Koura,M., Naito,I. and
            Kobayashi,Y.
  TITLE     Early ultrastructural glomerular alterations in neonatal nephrotic
            mice (ICGN strain)
  JOURNAL   Vet Pathol 32 (3), 321-323 (1995)
   PUBMED   7604502
REFERENCE   7  (bases 1 to 4588)
  AUTHORS   Ogura,A., Asano,T., Matsuda,J. and Fujimura,H.
  TITLE     Evolution of glomerular lesions in nephrotic ICGN mice: serial
            biopsy study with electron microscopy
  JOURNAL   J Vet Med Sci 53 (3), 513-515 (1991)
   PUBMED   1832041
REFERENCE   8  (bases 1 to 4588)
  AUTHORS   Ogura,A., Asano,T., Matsuda,J., Koura,M., Nakagawa,M., Kawaguchi,H.
            and Yamaguchi,Y.
  TITLE     An electron microscopic study of glomerular lesions in hereditary
            nephrotic mice (ICGN strain)
  JOURNAL   Virchows Arch A Pathol Anat Histopathol 417 (3), 223-228 (1990)
   PUBMED   2117311
REFERENCE   9  (bases 1 to 4588)
  AUTHORS   Ogura,A., Asano,T., Matsuda,J., Noguchi,Y., Yamamoto,Y., Takano,K.
            and Nakagawa,M.
  TITLE     Development of nephrotic ICGN mice--the origin, reproductive
            ability, and incidence of glomerulonephritis
  JOURNAL   Jikken Dobutsu 38 (4), 349-352 (1989)
   PUBMED   2806394
REFERENCE   10 (bases 1 to 4588)
  AUTHORS   Ogura,A., Asano,T., Matsuda,J., Takano,K., Nakagawa,M. and Fukui,M.
  TITLE     Characteristics of mutant mice (ICGN) with spontaneous renal
            lesions: a new model for human nephrotic syndrome
  JOURNAL   Lab Anim 23 (2), 169-174 (1989)
   PUBMED   2523501
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110512.13.
            
            On Jan 20, 2023 this sequence version replaced XM_006520694.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF424789.1, SRR17253012.2933863.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC110512.13        118531-118590
            61-169              AC110512.13        120847-120955
            170-207             AC110512.13        121656-121693
            208-246             AC110512.13        122561-122599
            247-285             AC110512.13        122908-122946
            286-335             AC110512.13        123106-123155
            336-507             AC110512.13        123332-123503
            508-558             AC110512.13        123799-123849
            559-681             AC110512.13        124119-124241
            682-746             AC110512.13        124328-124392
            747-830             AC110512.13        125172-125255
            831-943             AC110512.13        125638-125750
            944-1004            AC110512.13        125830-125890
            1005-1080           AC110512.13        126017-126092
            1081-1210           AC110512.13        126788-126917
            1211-1276           AC110512.13        126996-127061
            1277-1390           AC110512.13        127188-127301
            1391-2602           AC110512.13        127399-128610
            2603-2750           AC110512.13        128746-128893
            2751-3316           AC110512.13        128984-129549
            3317-3406           AC110512.13        129653-129742
            3407-3532           AC110512.13        130027-130152
            3533-3625           AC110512.13        130358-130450
            3626-3703           AC110512.13        130578-130655
            3704-3781           AC110512.13        130788-130865
            3782-3950           AC110512.13        131307-131475
            3951-4019           AC110512.13        131878-131946
            4020-4049           AC110512.13        132054-132083
            4050-4588           AC110512.13        132175-132713
FEATURES             Location/Qualifiers
     source          1..4588
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.29 cM"
     gene            1..4588
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /note="tensin 2"
                     /db_xref="GeneID:209039"
                     /db_xref="MGI:MGI:2387586"
     exon            1..60
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..4188
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /EC_number="3.1.3.48"
                     /note="isoform 4 is encoded by transcript variant 4; C1
                     domain-containing phosphatase and tensin-like protein;
                     tensin-like C1 domain-containing phosphatase; C1
                     domain-containing phosphatase and tensin homolog"
                     /codon_start=1
                     /product="tensin-2 isoform 4"
                     /protein_id="NP_001403135.1"
                     /db_xref="GeneID:209039"
                     /db_xref="MGI:MGI:2387586"
                     /translation="MKPRKAEPHSFREKVFRKKTPVCAVCKVTIDGTGVSCRVCKVAT
                     HRKCEAKVTSSCQALPPAELRRSTAPVRRIEHLGSTKSLNHSKQRSTLPRSFSLDPLM
                     ERRWDLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNLSEKRH
                     DLTRLNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLYCKGSKGKLGVI
                     VSAYMHYSKISAGADQALATLTMRKFCEDKVATELQPSQRRYVSYFSGLLSGSIRMNS
                     SPLFLHYVFVPVLPAFEPNTGFQPFLKIYQSMQLVYTSGVYRIAGPGPQQLCISLEPA
                     LLLKGDVMVTCYHKGGQGTDRTLVFRVQFHTCTIHGSRLTFPKDQLDEAWADERFPFQ
                     ASVEFVFSSSPEKVKGNTPRNDPSVSVDYNTTEPAVRWDSYENFNQHHEDSVDGALAH
                     TRGPLDGSPYAQVQRVPRQTPPAPSPELPPPPMLSVSSDSGHSSTLTTEHTAESPGRP
                     PPTAAERQELDRLLGGCGVASAGRGAGRETAILDDEEQPSVGGGLHLGMYSGHRPGLS
                     RRCSCRQGFREPCGVPNGSYYRPEGTLERRRPPYGGYEGHPQGYAEASVEKRRLCRSL
                     SEGPYPYAPELGKPANGDFGYRPAGYREVVILEDPGVPALCSCPACEEKLALPTAALY
                     GLRLEREAAEGWSSEVGKPLLHPVRPGHPLPLLVPACGHHHAPMPDYGCLKPPKVGEE
                     GHEGCSYAVCSEGRYGHSGYPALVTYGYGGAVPSYCPAYGRAPHSCGSPSEGRGYPSP
                     GAHSPRAGSVSPGSPPYLQPRKLGYEISAEDGRDKYPLSGHLASTGPLASTESPEPSW
                     RDGSSGHSTLPRSPRDPQCSASSELSGPSTPLHTSSPVQGKESNRRQDTTRSPSLAPT
                     QRLSPGEALPSVVQGVAEKTPELLTSSRPEQLDPSPFSQTSAPGSPNGWPQERSPGGH
                     TNSASPRSPVPTTLPGLRHAPWQGPRGTSDSPDGSPLTPVPTQMPWLVGSPEPPQSSP
                     TPAFPLATSYDANGPIQPPLPEKRHLPGSGQQPSPPARSTNQHVTFASPLPDVTQPPE
                     HPLQENQSNVKFVQDTSKFWYKPHLSRDQAIALLKDKDPGAFLIRDSHSFQGAYGLAL
                     KVATPPPSAQPWKGDPSEQLVRHFLIETGPKGVKIKGCPTEPYFGSLSALVSQHSISP
                     ISLPCCLRIPSKDPLEETPEAPVPTNMSTAADLLRQGAACSVLYLTSVETESLTGPQA
                     VAKASSAALSCSPVPVPAIVHFKVSAQGITLTDNQRKLFFRRHYPVNSITFSSTDPQD
                     RRWTNPDGATSKIFGFVAKKPGSPWENVCHLFAELDPDQPASAIVTFITKVLLGQRK"
     exon            61..169
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            170..207
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            208..246
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            247..285
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            286..335
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            336..507
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            508..558
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..681
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..746
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            747..830
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..943
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1004
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1080
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1210
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1276
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1390
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..2602
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2750
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..3316
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..3406
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3407..3532
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3533..3625
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3626..3703
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3704..3781
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3782..3950
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3951..4019
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4020..4049
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4050..4588
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4570..4575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /note="hexamer: AATAAA"
     polyA_site      4588
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /note="major polyA site"
ORIGIN      
        1 agtcctcggg tccagtgaca gccacagagg aaggagagac aggccagaag agccatgaag
       61 ccgaggaaag cagaaccaca cagcttccgg gagaaggttt tccggaagaa aactccagtg
      121 tgtgcagtgt gtaaggtgac catcgatggg accggtgtct cctgccgagt ctgcaaggtg
      181 gccacacaca gaaaatgtga agcaaaggtg acttcatcct gtcaggcctt gccccctgcg
      241 gagctgcgga gaagcacagc cccggtccgg cgcatagaac acctggggtc caccaagtct
      301 ctgaaccact caaagcaacg cagtactcta cccaggagct tcagcctaga tccgctcatg
      361 gagcgtcgct gggacttgga cctcacctat gtaacggagc ggatcttggc cgcagctttt
      421 cctgcacgac cggacgagca gcgacaccga ggccacttgc gcgagctagc ccatgtgctt
      481 caatccaagc acagagacaa gtacctgctc ttcaaccttt cagagaaacg gcatgacctc
      541 acccgcctga accccaaggt gcaagacttt ggttggcctg aactacatgc cccacctctg
      601 gacaagttgt gttccatctg caaagccatg gagacgtggc tcagtgccga ccctcagcac
      661 gtggttgtgt tgtactgcaa ggggagcaaa ggcaagcttg gggtcatcgt ctctgcttat
      721 atgcactaca gcaagatctc tgcaggggca gaccaggcgc tggcaaccct caccatgagg
      781 aaattctgtg aggacaaggt ggccacggaa ctgcagccct cccagcgccg ctatgtcagc
      841 tacttcagcg gactgctgtc tggctccatc agaatgaaca gcagcccact cttcctgcac
      901 tatgtgtttg ttcctgtgct gccagccttt gagcccaaca caggcttcca gcccttcctc
      961 aagatctacc agtctatgca gctggtctac acatctggag tctaccgcat agcaggtcca
     1021 gggcctcagc aactttgtat cagcctggag ccagcccttc tcctcaaagg cgacgtcatg
     1081 gtaacctgct accacaaggg tggccagggg acagaccgga ccctcgtgtt ccgagttcag
     1141 ttccacacat gcaccattca tggatcacgg ctcaccttcc caaaggacca actagatgag
     1201 gcctgggctg atgagcggtt tcctttccaa gcctcagtgg agtttgtttt ctcctccagc
     1261 cctgagaagg tcaaaggcaa caccccacgg aatgatccct ctgtctccgt ggattacaac
     1321 acgacagagc ctgctgtacg ctgggactcc tatgaaaact tcaatcagca ccatgaggat
     1381 agcgtggacg gcgccttggc ccacacaagg ggccccctgg atggcagtcc ttatgcccag
     1441 gtgcagcggg tcccccgcca gacaccacca gcaccttctc cagagcttcc cccacccccg
     1501 atgctctctg tcagcagcga ctctggccac tcatccacgc taaccacaga acacacagca
     1561 gaatcccccg gccggccgcc cccaactgct gctgaaagac aggagctgga tcgtctgctg
     1621 ggaggttgtg gagtggccag tgcgggccgt ggtgctgggc gagagaccgc catccttgat
     1681 gatgaagagc agccctctgt gggtggaggc ctgcaccttg ggatgtattc aggccacagg
     1741 cctggactca gtcgacgctg ctcctgccgt cagggcttcc gggagccttg tggggtccct
     1801 aatgggagct actaccggcc tgagggaacc ctagagagac gacgaccacc ctatgggggc
     1861 tatgagggac acccccaggg ctacgcagaa gcctctgtgg agaagagacg cctctgcagg
     1921 tcactgtcag aagggccgta cccctatgca cccgagctgg ggaaaccagc caatggggac
     1981 tttggctacc gtccagcagg ctaccgggag gtggtgatcc tggaggaccc tggggtgcct
     2041 gctttatgct catgccctgc ctgtgaagag aagctggcac tgcccaccgc agccctgtat
     2101 ggactgcgac tagagaggga ggctgcagag gggtggtcca gcgaggtagg caagcctctc
     2161 ctgcacccag tgaggcctgg acacccattg cctctgctgg tgcctgcctg tgggcatcat
     2221 catgccccaa tgcctgacta tggctgcctg aagccaccca aggtgggtga ggaagggcat
     2281 gagggctgct cctatgccgt gtgctctgaa ggcaggtatg ggcattcagg gtaccctgcc
     2341 ctggtaacct atggctatgg aggagcggtt cccagctact gcccagcata tggccgggca
     2401 cctcacagtt gcggatctcc aagtgaaggc cgagggtacc ccagccctgg tgcccactca
     2461 ccacgggctg gatctgtgtc cccggggagt ccaccctacc tgcagcccag gaagctgggt
     2521 tatgagattt ctgcggagga tgggagagac aagtacccac tttctggaca cctggcctca
     2581 acaggaccct tggcttctac agagtcacct gaaccatcct ggagggatgg ctccagtgga
     2641 cacagcacgc tacctcggtc tccccgagat cctcagtgca gtgcttcttc agagctgtct
     2701 ggtccctcca cacccttaca caccagcagc ccagttcagg gcaaggaaag caaccgacgg
     2761 caagacacca ccaggtctcc ctccttggca cccactcaga gactgagtcc tggcgaggcc
     2821 ttgccctctg ttgtacaggg agttgctgaa aagactcctg agctgttgac aagcagcagg
     2881 cctgagcaac tggaccctag ccccttctcc cagacctctg cacccggctc acccaatggc
     2941 tggcctcagg aaaggagccc aggaggccac accaacagtg ctagtcctcg gagccctgtg
     3001 ccaaccaccc tgcctggact tcgccatgcc ccgtggcagg gccctcgggg cacttcagat
     3061 agcccagatg gctcccctct tactcctgtg cctacccaga tgccctggct tgtgggcagc
     3121 ccagaaccac cccagagctc acccacccct gccttccccc tggctacctc ctatgatgcc
     3181 aatggtccca ttcagcctcc acttcctgaa aaacgacacc tgcctgggtc tgggcaacag
     3241 ccgtcgccac cagccagaag caccaatcaa catgtcacct ttgcatctcc tctcccagat
     3301 gtcacccaac ccccagaaca ccctttacaa gagaaccaaa gcaatgtcaa gtttgtccag
     3361 gatacatcaa agttctggta caagccacat ctttcccgag accaagccat tgccctgctg
     3421 aaagacaagg atcctggggc cttcctgatt agagacagcc attcattcca aggagcctat
     3481 gggctagccc tcaaggtggc tacacctcca cccagtgcgc agccctggaa aggggacccc
     3541 tcagaacagc tggtccgcca tttcctcatc gagactgggc ccaaaggcgt gaagatcaag
     3601 ggttgtccca ctgagcccta ttttggaagc ctgtctgccc tggtctccca gcactccatc
     3661 tctcccatct ccctgccctg ctgtctgaga attcctagca aagatcctct agaagaaacc
     3721 ccagaggccc cagtgcctac caacatgagc acagcagcag acctcctgcg tcaaggagca
     3781 gcctgcagtg tgctctacct gacctcggtg gagacagagt cattgactgg ccctcaggct
     3841 gtggccaagg ccagctctgc agctctgagc tgcagcccgg tcccagtgcc agccattgtc
     3901 catttcaagg tctcagctca aggcatcaca ctgacagaca accagagaaa gctcttcttt
     3961 cgccgccatt acccagtgaa cagcatcacc ttctctagca ctgaccccca ggaccgcaga
     4021 tggaccaacc cagatggagc cacctccaag atctttggtt tcgtggccaa gaagccagga
     4081 agtccctggg aaaatgtgtg tcacctcttt gcggagcttg acccggacca accggcaagt
     4141 gccattgtca ccttcatcac caaagttcta ctgggccaga ggaaatgaag gaaagccaca
     4201 agctccgagt gcacacccac actgcaccct cccagcatcc acagcgctca ctaccctggc
     4261 ctggcccctg tgaaagaggg agtggcagca tctgggccac tgctctttcc tgcccttgcc
     4321 tgctaagctg agtgagtggg cccctaaggt gacctggcat gtgagcagat ggcagagaca
     4381 ggtgtgaggg gggtgaggag gtgtcagtag tggagccctg gaggggaatg accctgccag
     4441 ctccacccag ctccagggcc catcatggag ggatgggaga agcttgaaag cttcctgcct
     4501 tccctccaca cagagaccag agtggggtca cataaacaga gggaaaaaga gagtctattt
     4561 ttgtgtaata ataaagaatt tctataaa
//
