LOCUS       NM_001355636            4755 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus tensin 2 (Tns2), transcript variant 2, mRNA.
ACCESSION   NM_001355636 XM_011245537
VERSION     NM_001355636.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4755)
  AUTHORS   Mochida,Y., Ochiai,K., Nagase,T., Nonomura,K., Akimoto,Y.,
            Fukuhara,H., Sakai,T., Matsumura,G., Yamaguchi,Y. and Nagase,M.
  TITLE     Piezo2 expression and its alteration by mechanical forces in mouse
            mesangial cells and renin-producing cells
  JOURNAL   Sci Rep 12 (1), 4197 (2022)
   PUBMED   35273307
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4755)
  AUTHORS   Uchio-Yamada,K., Yasuda,K., Monobe,Y., Akagi,K.I., Suzuki,O. and
            Manabe,N.
  TITLE     Tensin2 is important for podocyte-glomerular basement membrane
            interaction and integrity of the glomerular filtration barrier
  JOURNAL   Am J Physiol Renal Physiol 318 (6), F1520-F1530 (2020)
   PUBMED   32390516
  REMARK    GeneRIF: Tensin2 is important for podocyte-glomerular basement
            membrane interaction and integrity of the glomerular filtration
            barrier.
REFERENCE   3  (bases 1 to 4755)
  AUTHORS   Sasaki,H., Takahashi,Y., Ogawa,T., Hiura,K., Nakano,K.,
            Sugiyama,M., Okamura,T. and Sasaki,N.
  TITLE     Deletion of the Tensin2 SH2-PTB domain, but not the loss of its
            PTPase activity, induces podocyte injury in FVB/N mouse strain
  JOURNAL   Exp Anim 69 (2), 135-143 (2020)
   PUBMED   31723089
REFERENCE   4  (bases 1 to 4755)
  AUTHORS   Marusugi,K., Nakano,K., Sasaki,H., Kimura,J., Yanobu-Takanashi,R.,
            Okamura,T. and Sasaki,N.
  TITLE     Functional validation of tensin2 SH2-PTB domain by
            CRISPR/Cas9-mediated genome editing
  JOURNAL   J Vet Med Sci 78 (9), 1413-1420 (2016)
   PUBMED   27246398
  REMARK    GeneRIF: deficiency causes alteration of actin remodeling and
            morphological changes in podocytes and subsequent proteinuria
REFERENCE   5  (bases 1 to 4755)
  AUTHORS   Sasaki,H., Kimura,J., Nagasaki,K., Marusugi,K., Agui,T. and
            Sasaki,N.
  TITLE     Mouse chromosome 2 harbors genetic determinants of resistance to
            podocyte injury and renal tubulointerstitial fibrosis
  JOURNAL   BMC Genet 17 (1), 69 (2016)
   PUBMED   27230548
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4755)
  AUTHORS   Ogura,A., Fujimura,H., Asano,T., Koura,M., Naito,I. and
            Kobayashi,Y.
  TITLE     Early ultrastructural glomerular alterations in neonatal nephrotic
            mice (ICGN strain)
  JOURNAL   Vet Pathol 32 (3), 321-323 (1995)
   PUBMED   7604502
REFERENCE   7  (bases 1 to 4755)
  AUTHORS   Ogura,A., Asano,T., Matsuda,J. and Fujimura,H.
  TITLE     Evolution of glomerular lesions in nephrotic ICGN mice: serial
            biopsy study with electron microscopy
  JOURNAL   J Vet Med Sci 53 (3), 513-515 (1991)
   PUBMED   1832041
REFERENCE   8  (bases 1 to 4755)
  AUTHORS   Ogura,A., Asano,T., Matsuda,J., Koura,M., Nakagawa,M., Kawaguchi,H.
            and Yamaguchi,Y.
  TITLE     An electron microscopic study of glomerular lesions in hereditary
            nephrotic mice (ICGN strain)
  JOURNAL   Virchows Arch A Pathol Anat Histopathol 417 (3), 223-228 (1990)
   PUBMED   2117311
REFERENCE   9  (bases 1 to 4755)
  AUTHORS   Ogura,A., Asano,T., Matsuda,J., Noguchi,Y., Yamamoto,Y., Takano,K.
            and Nakagawa,M.
  TITLE     Development of nephrotic ICGN mice--the origin, reproductive
            ability, and incidence of glomerulonephritis
  JOURNAL   Jikken Dobutsu 38 (4), 349-352 (1989)
   PUBMED   2806394
REFERENCE   10 (bases 1 to 4755)
  AUTHORS   Ogura,A., Asano,T., Matsuda,J., Takano,K., Nakagawa,M. and Fukui,M.
  TITLE     Characteristics of mutant mice (ICGN) with spontaneous renal
            lesions: a new model for human nephrotic syndrome
  JOURNAL   Lab Anim 23 (2), 169-174 (1989)
   PUBMED   2523501
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110512.13.
            
            On Jan 20, 2023 this sequence version replaced NM_001355636.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               AC110512.13        119273-119478
            207-315             AC110512.13        120847-120955
            316-353             AC110512.13        121656-121693
            354-392             AC110512.13        122561-122599
            393-431             AC110512.13        122908-122946
            432-481             AC110512.13        123106-123155
            482-653             AC110512.13        123332-123503
            654-704             AC110512.13        123799-123849
            705-827             AC110512.13        124119-124241
            828-892             AC110512.13        124328-124392
            893-976             AC110512.13        125172-125255
            977-1089            AC110512.13        125638-125750
            1090-1150           AC110512.13        125830-125890
            1151-1226           AC110512.13        126017-126092
            1227-1356           AC110512.13        126788-126917
            1357-1422           AC110512.13        126996-127061
            1423-1536           AC110512.13        127188-127301
            1537-2748           AC110512.13        127399-128610
            2749-2917           AC110512.13        128725-128893
            2918-3483           AC110512.13        128984-129549
            3484-3573           AC110512.13        129653-129742
            3574-3699           AC110512.13        130027-130152
            3700-3792           AC110512.13        130358-130450
            3793-3870           AC110512.13        130578-130655
            3871-3948           AC110512.13        130788-130865
            3949-4117           AC110512.13        131307-131475
            4118-4186           AC110512.13        131878-131946
            4187-4216           AC110512.13        132054-132083
            4217-4755           AC110512.13        132175-132713
FEATURES             Location/Qualifiers
     source          1..4755
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.29 cM"
     gene            1..4755
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /note="tensin 2"
                     /db_xref="GeneID:209039"
                     /db_xref="MGI:MGI:2387586"
     exon            1..206
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..4355
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /EC_number="3.1.3.48"
                     /note="isoform 2 is encoded by transcript variant 2; C1
                     domain-containing phosphatase and tensin-like protein;
                     tensin-like C1 domain-containing phosphatase; C1
                     domain-containing phosphatase and tensin homolog"
                     /codon_start=1
                     /product="tensin-2 isoform 2"
                     /protein_id="NP_001342565.1"
                     /db_xref="CCDS:CCDS88852.1"
                     /db_xref="GeneID:209039"
                     /db_xref="MGI:MGI:2387586"
                     /translation="MKSSGPVERLLRALGRRDSSRATSRPRKAEPHSFREKVFRKKTP
                     VCAVCKVTIDGTGVSCRVCKVATHRKCEAKVTSSCQALPPAELRRSTAPVRRIEHLGS
                     TKSLNHSKQRSTLPRSFSLDPLMERRWDLDLTYVTERILAAAFPARPDEQRHRGHLRE
                     LAHVLQSKHRDKYLLFNLSEKRHDLTRLNPKVQDFGWPELHAPPLDKLCSICKAMETW
                     LSADPQHVVVLYCKGSKGKLGVIVSAYMHYSKISAGADQALATLTMRKFCEDKVATEL
                     QPSQRRYVSYFSGLLSGSIRMNSSPLFLHYVFVPVLPAFEPNTGFQPFLKIYQSMQLV
                     YTSGVYRIAGPGPQQLCISLEPALLLKGDVMVTCYHKGGQGTDRTLVFRVQFHTCTIH
                     GSRLTFPKDQLDEAWADERFPFQASVEFVFSSSPEKVKGNTPRNDPSVSVDYNTTEPA
                     VRWDSYENFNQHHEDSVDGALAHTRGPLDGSPYAQVQRVPRQTPPAPSPELPPPPMLS
                     VSSDSGHSSTLTTEHTAESPGRPPPTAAERQELDRLLGGCGVASAGRGAGRETAILDD
                     EEQPSVGGGLHLGMYSGHRPGLSRRCSCRQGFREPCGVPNGSYYRPEGTLERRRPPYG
                     GYEGHPQGYAEASVEKRRLCRSLSEGPYPYAPELGKPANGDFGYRPAGYREVVILEDP
                     GVPALCSCPACEEKLALPTAALYGLRLEREAAEGWSSEVGKPLLHPVRPGHPLPLLVP
                     ACGHHHAPMPDYGCLKPPKVGEEGHEGCSYAVCSEGRYGHSGYPALVTYGYGGAVPSY
                     CPAYGRAPHSCGSPSEGRGYPSPGAHSPRAGSVSPGSPPYLQPRKLGYEISAEDGRDK
                     YPLSGHLASTGPLASTELFPPVSESPEPSWRDGSSGHSTLPRSPRDPQCSASSELSGP
                     STPLHTSSPVQGKESNRRQDTTRSPSLAPTQRLSPGEALPSVVQGVAEKTPELLTSSR
                     PEQLDPSPFSQTSAPGSPNGWPQERSPGGHTNSASPRSPVPTTLPGLRHAPWQGPRGT
                     SDSPDGSPLTPVPTQMPWLVGSPEPPQSSPTPAFPLATSYDANGPIQPPLPEKRHLPG
                     SGQQPSPPARSTNQHVTFASPLPDVTQPPEHPLQENQSNVKFVQDTSKFWYKPHLSRD
                     QAIALLKDKDPGAFLIRDSHSFQGAYGLALKVATPPPSAQPWKGDPSEQLVRHFLIET
                     GPKGVKIKGCPTEPYFGSLSALVSQHSISPISLPCCLRIPSKDPLEETPEAPVPTNMS
                     TAADLLRQGAACSVLYLTSVETESLTGPQAVAKASSAALSCSPVPVPAIVHFKVSAQG
                     ITLTDNQRKLFFRRHYPVNSITFSSTDPQDRRWTNPDGATSKIFGFVAKKPGSPWENV
                     CHLFAELDPDQPASAIVTFITKVLLGQRK"
     exon            207..315
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            316..353
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            354..392
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..431
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..481
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..653
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            654..704
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..827
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..892
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..976
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1089
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1150
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1226
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1356
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1422
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1536
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..2748
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2917
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3483
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3484..3573
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3574..3699
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3700..3792
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3793..3870
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3871..3948
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3949..4117
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4118..4186
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4187..4216
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4217..4755
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4737..4742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /note="hexamer: AATAAA"
     polyA_site      4755
                     /gene="Tns2"
                     /gene_synonym="C1-ten; nep; nph; Tenc1"
                     /note="major polyA site"
ORIGIN      
        1 acacaccagc cagacagcct cccctccacc caagggaagc ggctgcctcg gcaggctgct
       61 tccaggaagc cccaggccag gccccagcat tgttcaggcc ctgcagccaa gagtccagcc
      121 agccagacac catgaagtcc agcggccctg tggaaaggtt gctcagagcc ctggggagga
      181 gggacagcag ccgggccacc agcaggccga ggaaagcaga accacacagc ttccgggaga
      241 aggttttccg gaagaaaact ccagtgtgtg cagtgtgtaa ggtgaccatc gatgggaccg
      301 gtgtctcctg ccgagtctgc aaggtggcca cacacagaaa atgtgaagca aaggtgactt
      361 catcctgtca ggccttgccc cctgcggagc tgcggagaag cacagccccg gtccggcgca
      421 tagaacacct ggggtccacc aagtctctga accactcaaa gcaacgcagt actctaccca
      481 ggagcttcag cctagatccg ctcatggagc gtcgctggga cttggacctc acctatgtaa
      541 cggagcggat cttggccgca gcttttcctg cacgaccgga cgagcagcga caccgaggcc
      601 acttgcgcga gctagcccat gtgcttcaat ccaagcacag agacaagtac ctgctcttca
      661 acctttcaga gaaacggcat gacctcaccc gcctgaaccc caaggtgcaa gactttggtt
      721 ggcctgaact acatgcccca cctctggaca agttgtgttc catctgcaaa gccatggaga
      781 cgtggctcag tgccgaccct cagcacgtgg ttgtgttgta ctgcaagggg agcaaaggca
      841 agcttggggt catcgtctct gcttatatgc actacagcaa gatctctgca ggggcagacc
      901 aggcgctggc aaccctcacc atgaggaaat tctgtgagga caaggtggcc acggaactgc
      961 agccctccca gcgccgctat gtcagctact tcagcggact gctgtctggc tccatcagaa
     1021 tgaacagcag cccactcttc ctgcactatg tgtttgttcc tgtgctgcca gcctttgagc
     1081 ccaacacagg cttccagccc ttcctcaaga tctaccagtc tatgcagctg gtctacacat
     1141 ctggagtcta ccgcatagca ggtccagggc ctcagcaact ttgtatcagc ctggagccag
     1201 cccttctcct caaaggcgac gtcatggtaa cctgctacca caagggtggc caggggacag
     1261 accggaccct cgtgttccga gttcagttcc acacatgcac cattcatgga tcacggctca
     1321 ccttcccaaa ggaccaacta gatgaggcct gggctgatga gcggtttcct ttccaagcct
     1381 cagtggagtt tgttttctcc tccagccctg agaaggtcaa aggcaacacc ccacggaatg
     1441 atccctctgt ctccgtggat tacaacacga cagagcctgc tgtacgctgg gactcctatg
     1501 aaaacttcaa tcagcaccat gaggatagcg tggacggcgc cttggcccac acaaggggcc
     1561 ccctggatgg cagtccttat gcccaggtgc agcgggtccc ccgccagaca ccaccagcac
     1621 cttctccaga gcttccccca cccccgatgc tctctgtcag cagcgactct ggccactcat
     1681 ccacgctaac cacagaacac acagcagaat cccccggccg gccgccccca actgctgctg
     1741 aaagacagga gctggatcgt ctgctgggag gttgtggagt ggccagtgcg ggccgtggtg
     1801 ctgggcgaga gaccgccatc cttgatgatg aagagcagcc ctctgtgggt ggaggcctgc
     1861 accttgggat gtattcaggc cacaggcctg gactcagtcg acgctgctcc tgccgtcagg
     1921 gcttccggga gccttgtggg gtccctaatg ggagctacta ccggcctgag ggaaccctag
     1981 agagacgacg accaccctat gggggctatg agggacaccc ccagggctac gcagaagcct
     2041 ctgtggagaa gagacgcctc tgcaggtcac tgtcagaagg gccgtacccc tatgcacccg
     2101 agctggggaa accagccaat ggggactttg gctaccgtcc agcaggctac cgggaggtgg
     2161 tgatcctgga ggaccctggg gtgcctgctt tatgctcatg ccctgcctgt gaagagaagc
     2221 tggcactgcc caccgcagcc ctgtatggac tgcgactaga gagggaggct gcagaggggt
     2281 ggtccagcga ggtaggcaag cctctcctgc acccagtgag gcctggacac ccattgcctc
     2341 tgctggtgcc tgcctgtggg catcatcatg ccccaatgcc tgactatggc tgcctgaagc
     2401 cacccaaggt gggtgaggaa gggcatgagg gctgctccta tgccgtgtgc tctgaaggca
     2461 ggtatgggca ttcagggtac cctgccctgg taacctatgg ctatggagga gcggttccca
     2521 gctactgccc agcatatggc cgggcacctc acagttgcgg atctccaagt gaaggccgag
     2581 ggtaccccag ccctggtgcc cactcaccac gggctggatc tgtgtccccg gggagtccac
     2641 cctacctgca gcccaggaag ctgggttatg agatttctgc ggaggatggg agagacaagt
     2701 acccactttc tggacacctg gcctcaacag gacccttggc ttctacagag ctcttccctc
     2761 ccgtctcaga gtcacctgaa ccatcctgga gggatggctc cagtggacac agcacgctac
     2821 ctcggtctcc ccgagatcct cagtgcagtg cttcttcaga gctgtctggt ccctccacac
     2881 ccttacacac cagcagccca gttcagggca aggaaagcaa ccgacggcaa gacaccacca
     2941 ggtctccctc cttggcaccc actcagagac tgagtcctgg cgaggccttg ccctctgttg
     3001 tacagggagt tgctgaaaag actcctgagc tgttgacaag cagcaggcct gagcaactgg
     3061 accctagccc cttctcccag acctctgcac ccggctcacc caatggctgg cctcaggaaa
     3121 ggagcccagg aggccacacc aacagtgcta gtcctcggag ccctgtgcca accaccctgc
     3181 ctggacttcg ccatgccccg tggcagggcc ctcggggcac ttcagatagc ccagatggct
     3241 cccctcttac tcctgtgcct acccagatgc cctggcttgt gggcagccca gaaccacccc
     3301 agagctcacc cacccctgcc ttccccctgg ctacctccta tgatgccaat ggtcccattc
     3361 agcctccact tcctgaaaaa cgacacctgc ctgggtctgg gcaacagccg tcgccaccag
     3421 ccagaagcac caatcaacat gtcacctttg catctcctct cccagatgtc acccaacccc
     3481 cagaacaccc tttacaagag aaccaaagca atgtcaagtt tgtccaggat acatcaaagt
     3541 tctggtacaa gccacatctt tcccgagacc aagccattgc cctgctgaaa gacaaggatc
     3601 ctggggcctt cctgattaga gacagccatt cattccaagg agcctatggg ctagccctca
     3661 aggtggctac acctccaccc agtgcgcagc cctggaaagg ggacccctca gaacagctgg
     3721 tccgccattt cctcatcgag actgggccca aaggcgtgaa gatcaagggt tgtcccactg
     3781 agccctattt tggaagcctg tctgccctgg tctcccagca ctccatctct cccatctccc
     3841 tgccctgctg tctgagaatt cctagcaaag atcctctaga agaaacccca gaggccccag
     3901 tgcctaccaa catgagcaca gcagcagacc tcctgcgtca aggagcagcc tgcagtgtgc
     3961 tctacctgac ctcggtggag acagagtcat tgactggccc tcaggctgtg gccaaggcca
     4021 gctctgcagc tctgagctgc agcccggtcc cagtgccagc cattgtccat ttcaaggtct
     4081 cagctcaagg catcacactg acagacaacc agagaaagct cttctttcgc cgccattacc
     4141 cagtgaacag catcaccttc tctagcactg acccccagga ccgcagatgg accaacccag
     4201 atggagccac ctccaagatc tttggtttcg tggccaagaa gccaggaagt ccctgggaaa
     4261 atgtgtgtca cctctttgcg gagcttgacc cggaccaacc ggcaagtgcc attgtcacct
     4321 tcatcaccaa agttctactg ggccagagga aatgaaggaa agccacaagc tccgagtgca
     4381 cacccacact gcaccctccc agcatccaca gcgctcacta ccctggcctg gcccctgtga
     4441 aagagggagt ggcagcatct gggccactgc tctttcctgc ccttgcctgc taagctgagt
     4501 gagtgggccc ctaaggtgac ctggcatgtg agcagatggc agagacaggt gtgagggggg
     4561 tgaggaggtg tcagtagtgg agccctggag gggaatgacc ctgccagctc cacccagctc
     4621 cagggcccat catggaggga tgggagaagc ttgaaagctt cctgccttcc ctccacacag
     4681 agaccagagt ggggtcacat aaacagaggg aaaaagagag tctatttttg tgtaataata
     4741 aagaatttct ataaa
//
