LOCUS       NM_001122730           10598 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus trinucleotide repeat containing 18 (Tnrc18),
            transcript variant A, mRNA.
ACCESSION   NM_001122730
VERSION     NM_001122730.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10598)
  AUTHORS   Chen,L.L., Li,Y.Q., Kang,Z.H., Zhang,X., Gu,S.Y., Wang,N. and
            Shen,X.Y.
  TITLE     Blocking the interaction between circTNRC18 and LIN28A promotes
            trophoblast epithelial-mesenchymal transformation and alleviates
            preeclampsia
  JOURNAL   Mol Cell Endocrinol 579, 112073 (2024)
   PUBMED   37774938
  REMARK    GeneRIF: Blocking the interaction between circTNRC18 and LIN28A
            promotes trophoblast epithelial-mesenchymal transformation and
            alleviates preeclampsia.
REFERENCE   2  (bases 1 to 10598)
  AUTHORS   Zhao,S., Lu,J., Pan,B., Fan,H., Byrum,S.D., Xu,C., Kim,A., Guo,Y.,
            Kanchi,K.L., Gong,W., Sun,T., Storey,A.J., Burkholder,N.T.,
            Mackintosh,S.G., Kuhlers,P.C., Edmondson,R.D., Strahl,B.D.,
            Diao,Y., Tackett,A.J., Raab,J.R., Cai,L., Song,J. and Wang,G.G.
  TITLE     TNRC18 engages H3K9me3 to mediate silencing of endogenous
            retrotransposons
  JOURNAL   Nature 623 (7987), 633-642 (2023)
   PUBMED   37938770
REFERENCE   3  (bases 1 to 10598)
  AUTHORS   Seedorf,H., Springer,I.N., Grundner-Culemann,E., Albers,H.K.,
            Reis,A., Fuchs,H., Hrabe de Angelis,M. and Acil,Y.
  TITLE     Amelogenesis imperfecta in a new animal model--a mutation in
            chromosome 5 (human 4q21)
  JOURNAL   J Dent Res 83 (8), 608-612 (2004)
   PUBMED   15271968
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY713750.1, AC144818.4, BC049818.1, AK141849.1, CB249572.1,
            CB244319.1, BC094365.1, AC240265.3 and AW491486.1.
            
            On May 19, 2018 this sequence version replaced NM_001122730.2.
            
            Transcript Variant: This variant (A) represents the longer
            transcript and encodes the longer isoform (A).
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               BY713750.1         2-199
            199-275             AC144818.4         161381-161457
            276-4954            BC049818.1         1-4679
            4955-5903           AK141849.1         3778-4726
            5904-6537           CB249572.1         50-683
            6538-7218           CB244319.1         18-698
            7219-8180           BC094365.1         473-1434
            8181-8240           AC240265.3         70855-70914
            8241-10579          BC094365.1         1435-3773
            10580-10598         AW491486.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..10598
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 81.73 cM"
     gene            1..10598
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /note="trinucleotide repeat containing 18"
                     /db_xref="GeneID:231861"
                     /db_xref="MGI:MGI:3648294"
     exon            1..391
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            392..822
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     CDS             636..9203
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /note="isoform A is encoded by transcript variant A;
                     trinucleotide repeat-containing gene 18 protein"
                     /codon_start=1
                     /product="trinucleotide repeat-containing gene 18 protein
                     isoform A"
                     /protein_id="NP_001116202.2"
                     /db_xref="GeneID:231861"
                     /db_xref="MGI:MGI:3648294"
                     /translation="MDGRDFGPQRSVHGPPPPLLSGLAMDSHRVGAATAGRLPSSGLP
                     GPPPPGKYMAGLNLHPHPGFSHLPSGLYPSYLHLNHLDPPSSGSPLLSQLGQPSIFDT
                     QKDGFYLPAPGTLHAHTPSSRTPSGHSSGGPAKGSSREGTGKDRAGRGGDPPPLFGKK
                     DPRAREEVSGPRGVVDLTQEARAEGRQDRGSSRLAERLSPFLAEVKAKGALQPSALSL
                     CNGVVDAGLVAELGRGGAKEVARQEENARLLRRAEALLPAARPCGSPLPPPPPLPPKG
                     PPAPPSSTPAGVYTVFREPGREHRVVAPTFVPSVEAFDERVGPIQIASQARDVRARER
                     EPGRPGVLQGPPGSPRLERPEVLREKSSVIRSLKRPPPSDGPPAARSSRSSPDARAYL
                     PPKELLKPEADPRPCERAPRGPSASAAQQAAKLFGLEPSRPPGPEHKWKPFELGNFAT
                     TQMAVLAAQHHHASRAEEEAAVATASKKAYLDPGGAMPRASATCGRPGADLHSAAHGP
                     GEASAMQSLIKYSGSFAREAVAVRPGGCGKKSPFGGLGTMKPEPTPTSAGPPRAQARL
                     THPGVPTAGGGRQLKRDPERPESAKAFGREGSGAQGEAEVRHPPVGIAVAVARQKDSG
                     SSSRLGPGLGDQERTLSLNNVKGHGRTDDECDRARHREDRLLGTRLDRDQEKLLRESK
                     ELADLARLHPTSCAPNGLNPNLMVTGGPTLAGSGRWSADPAAHLATNPWLPRSGSTSM
                     WLAGHPYGLGPPSLHQGMAPAFPPGLGGSLPSAYQFVRDPQSGQLVVIPSDHLPHFAE
                     LMERAAVPPLWPALYPPGRSPLHHAQQLQLFSQQHFLRQQELLYLQQQAAQALELQRS
                     AQLVERLKAQEHRTEMEEKISKRSLETTGKAGLSAAGPGLLPRKSAGLANGPAGSHGK
                     AVSPPPSPRASPVTSLKAKVIQKVEDVSKPPAYTYPATPSSHPSSPPPASPPPTPGLT
                     RKEEAPENVVEKKDLELEKETPSPFQALFTDIPPRYPFQALPPHYGRPYPFLLQPAAA
                     SDADGLAPDVPLPADGPERLALSPEDKPICLSPSKIPEPPRDSPEEEQLADREVKAEV
                     EDIEEGPTELPPLESPLALPVPETMVAVSPAGGCGGSPLEAQALSTAGPGCREPSEVS
                     DFAQVAEPQIELPSKTEHRMTALELGTQLTPEPLVETKEEPVEVPLDVPMEEPTTEAG
                     PEDSLPQPSLTEPQPSLELSDCDLPVPEGQCLNLEAQEAVPAPASTCYLEETHSESLL
                     PGLDDPLAGMNALAAAAELPQARPLPSLGPGVPAGEKLDTAPSLVLEHSFLQGITLLS
                     EIAELELDRRGQEAADPEPNLVVRPSLESLLAASSHMLKEVLESPFSDPLKNLRLPRE
                     LNSNKKYSWMQKKEERMFAMKSSLEDMDALELDFRMRLAEVQRRYKEKQRELVKLQRR
                     RDSGLSSKSLLTSDDYDLGAGIRKRHKGPEEEQEALMGMGKARSRNQSWDDHDSSSDF
                     MSQLKIKKKKMASDQEQLASKLDRALSLTKQDKLKSPFKFSDGPGGKPKTGGGCGRFL
                     TQYDSLLGKDRKALAKGLGLSLKPSREGKHKRASKARKMEGGFQARGQPKSVHSPFAS
                     EVSSQSYNTDSDEDEDFLKNEWSAQGPSSSKLTSSLLCGMVPKNSKPATGPKLTKRGL
                     AGPRTLKPKVVTSRKQSFCLLLREAEARSSFSDSSEEDSFDQDDSSEEEEEELEEEEE
                     DEEEEGIGSYRLGAGEQALSPSLEESGLGLLARFAASALPSPVVGPPLSVVQLEAEQK
                     ARKKEERQSLLGTEFEYTDSESEVKVPKQSAAGLLRTKKGVGEPGQSLAAPGPGSRAS
                     GPSSPDKAKLVSEKGRKARKIRGPKEPGFEAGPEASDDDLWTRRRSERIFLHDASAAV
                     QATSNTAPATKPSRCGRGGAPSPRKDTGRAKDRKDPRKKKRGKEAGSAATLPPPRVST
                     LPDSRAPHPGALATAKRSKAKARGKEAKKENRGKGGAVSKLMECMAAEEDFEANQDSS
                     FSEDEHLPRGGATERPLTPAPRSCIIDKEELKDGLRVLIPLDDKLLYAGHVQTVHSPD
                     IYRVVVEGERGNRPHIYCLEQLLQEAIIDVRPASTRFLPQGTRIAAYWSQQYRCLYPG
                     TVVRGLLDLEDDGDLITVEFDDGDTGRIPLSHIRLLPPDYKIQCAEPSPALLVPSAKR
                     RSRKTSKDTGEVKEGAATGPQEATGGKARGRGRKPSTKAKADRAVVLEEGAATNEVPS
                     APLALEPISTPNSKKSTPEPVDKRARAPKARSISAQPSPVPPTFSSCPAPEPFGELPT
                     PATAPLVTMPVTMPATRPKPKKARAAEGSGAKGPRRPGEDDELLVKLDHEGVMSPKSK
                     KAKEALLLREDPGPGGWPESTGLLSLGSYSPAVGSSEPKATWPKGLDGDLTQEPGPGL
                     PLEDPGNSKNPDKAQAEQDGAEESETTSSSSSSSSSSSSSSSSSSSSSSSSSGSETEG
                     EEDAEKNREDGRGAGGRTCSAASSRASSPASSSSSSSSSSSSSSSSSSSSSSSSSSSS
                     SSSSSSSSSSSSSSSSTTDEDSSCSSDEEAAPAPAAGPSTQPALPTKVSKPPSKARSS
                     AHSPGKKAPTTTQPPPQPPPQPQQTLQPKTQAGAGAKSRPKKREGVHLPTTKELAKRQ
                     RLPSVENRPKIAAFLPARQLWKWFGKPTQRRGMKGKARKLFYKAIVRGKEMIRIGDCA
                     VFLSAGRPNLPYIGRIQSMWESWGNNMVVRVKWFYHPEETSPGKQFHEGQHWDQKSGH
                     SLPAALRASSQRKDFMERALYQSSHVDENDVQTVSHKCLVVGLEQYEQMLKTKKYQDS
                     EGLYYLAGTYEPTTGMIFSTDGVPVLC"
     exon            823..948
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            949..2574
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2671
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2877
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..3024
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3215
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3642
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            3643..4641
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            4642..4817
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            4818..4954
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            4955..5126
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            5127..5487
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            5488..5766
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            5767..6021
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            6022..6449
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            6450..6599
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            6600..6741
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            6742..6859
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            6860..6935
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            6936..7044
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            7045..7161
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            7162..7329
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            7330..8684
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            8685..8921
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            8922..8996
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            8997..10582
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10555..10560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /note="hexamer: AAGAAA"
     polyA_site      10579
                     /gene="Tnrc18"
                     /gene_synonym="EG381742; Zfp469"
                     /note="major polyA site"
ORIGIN      
        1 agatccagcg agaggaactt gaaagggggg ttgtgtaatg taccttttcc aatcccgggc
       61 tgtatatgga gatttgggat tctttaaacc ggcgctacct ggattttatt aaaaagcggg
      121 gagctcggcg ggaggaaagc tggcttttcc gggggctgcg ggagcggggc cgcgggaggg
      181 cggaggagtt ggcgcgccgc gcgcccggcc cggggagcgg ttttctacca aaaaaaggaa
      241 aggcgggcaa aaagtgtgag gcggctgcgg gtggcggagg ggagcggcgg ccgagggatg
      301 gcgggcagta cgggcgccta gccgcgccag gaaccgcggc ggttgccgga gtcgccgtcg
      361 gagcctggag cccggagccc cgccgcgcca gataccgtgt acgcctcctt cctcatctcc
      421 gctcagccgc ccggagggga ctcaccgcgg gcggttcatg cgccccgggc cgcgggcccg
      481 tggttgagcg caagccccgc tggccgccgc catgcacgcc gcggagcgcc cgccacccga
      541 ggacactagg actacatcga ggccgaactt ttaagtccca ctgaagcagg ccggcgggcc
      601 gggtggggag gctgatcgcg gcactcccgc ggaggatgga tggccgagat ttcgggcccc
      661 agcggtccgt ccacggcccc ccgccgccgc tgctgtccgg cttggccatg gacagccacc
      721 gcgtgggcgc ggccaccgcc ggacgcttgc cctcctcggg cttgccaggt cccccgccgc
      781 ccgggaaata catggccggt ctcaaccttc acccgcaccc gggcttctcc cacctgccca
      841 gtgggctata tccatcctac ctccacctga accacctgga cccccccagc agtgggagcc
      901 ccctcctcag ccagctgggt cagcccagca tcttcgatac ccagaaagat ggcttctacc
      961 tgcccgcacc ggggaccctg catgctcaca cgccctcgtc cagaactccc agtggccact
     1021 cctcaggtgg tccagccaaa ggctcctccc gggaaggtac agggaaggat cgtgcaggcc
     1081 gtggtggaga ccctcctccg ttgtttggca agaaagaccc tcgggcacgt gaggaggtgt
     1141 ccgggccccg aggtgtggtg gacttgaccc aggaggcccg agcggagggc cgccaggacc
     1201 gaggatcctc acgcctggct gagcgcctgt ctccctttct ggcagaggtc aaagccaagg
     1261 gtgcactgca gccgtcggcc ctgagcctgt gcaatggtgt ggtggacgcg gggctggtgg
     1321 ccgagttggg ccgtggaggt gccaaggagg tagccaggca ggaggagaat gctcggctgc
     1381 tgaggcgggc tgaggccctg ctgcccgctg caaggccctg tgggtcccca ctaccgccgc
     1441 cacctccact gccccccaag ggtccccctg cacccccttc ctctacacca gccggtgtgt
     1501 acaccgtgtt ccgtgaacca ggccgtgagc accgcgtggt ggcacccacc tttgtgcctt
     1561 ctgtggaggc ctttgatgag cgggtgggac ccatccagat agcatcccag gctcgcgatg
     1621 tccgggccag ggagcgtgag ccgggccgtc ctggggtcct gcaaggtcca cccggatctc
     1681 cacgcctgga gcggccagag gttctgcggg agaaaagctc ggtcatccgc tccctcaagc
     1741 gtccgcctcc atccgatgga cccccagcag cccgctcctc ccgctcctcc ccggatgcgc
     1801 gagcctacct gccccccaag gaactactca agcccgaggc tgatccgagg ccttgcgagc
     1861 gcgcaccccg aggcccgagc gcttctgctg cccagcaggc tgctaagctc tttggcctgg
     1921 aaccatcccg accccccggg ccggagcata agtggaaacc ctttgaactg ggcaacttcg
     1981 ccaccacgca gatggctgtc ctggcagccc agcaccacca tgccagcaga gccgaagagg
     2041 aagcagctgt cgccacagca tccaaaaagg cctacctgga ccccgggggc gcaatgcccc
     2101 gtgcctcggc cacctgcggc aggccaggtg ctgacctcca ctcggcagcc cacggacccg
     2161 gagaggcctc tgctatgcag agcctcatca aatacagcgg tagctttgct cgggaggcgg
     2221 tggcagtgcg ccctggtggc tgtgggaaga agagcccctt tggaggcctg ggcaccatga
     2281 aacctgaacc tacgcccacg tcggcgggtc cccctagagc ccaggcccgg ctcacacacc
     2341 ccggggtccc tacagccgga gggggccggc agctgaaacg ggacccagag agacctgaga
     2401 gcgccaaggc ctttgggaga gagggctctg gtgcccaggg ggaagccgaa gtaagacacc
     2461 cgcctgttgg cattgctgtg gctgtggccc ggcagaagga cagtggaagc agtagccggc
     2521 tggggcctgg gctgggagac caggaacgca ctttgtcact gaacaatgtc aaagggcatg
     2581 gccggactga tgatgagtgt gatcgagcca ggcatcggga ggatcggctg ctagggacac
     2641 ggctggaccg ggaccaggag aagttgctcc gagaaagtaa ggagctggct gacctggccc
     2701 gtctacaccc caccagctgc gctcccaatg gcctgaaccc caaccttatg gtgactggtg
     2761 gcccaacgct ggcaggctcg ggacgctggt ctgctgatcc tgctgctcat ttggccacga
     2821 acccctggct gccacgctcg ggtagtacat ccatgtggct tgccggacac ccttatggcc
     2881 tgggaccccc ctctttgcac cagggcatgg cccctgcatt tccacctggc ttagggggct
     2941 ccttgccgtc agcttaccag ttcgtcaggg acccccagtc tggccagctg gtggttatcc
     3001 ctagtgatca cctgcctcat tttgccgagc tgatggagcg cgcggcggtg ccgcccctct
     3061 ggccggccct gtacccacca ggccgcagcc cactgcacca cgctcagcag ctgcagctct
     3121 tctctcagca gcactttttg aggcagcaag aactgctcta cctgcaacag caggcggccc
     3181 aggccctgga gctgcagcgg agcgcacagc tggtggagcg gttgaaagca caagagcatc
     3241 gaacggagat ggaggagaag attagcaaga ggagcctgga gaccacgggc aaggccggcc
     3301 tgagtgccgc aggccctggg ctcctgcctc gaaagtctgc cggcctggcc aacggcccgg
     3361 caggcagcca cggcaaggcc gtgagcccac ccccgtctcc ccgagcctcc cccgtgacct
     3421 ctctgaaggc caaggtcatc cagaaggtgg aagatgtgtc taagcctcca gcctatacct
     3481 accccgccac acctagctcg caccccagca gcccaccacc tgcctcccca cctcctaccc
     3541 ctgggctcac ccgaaaggaa gaggctcccg agaacgtggt ggagaagaaa gacctggagt
     3601 tggagaagga gacgcccagt ccgttccagg ccctgttcac agatattcct cccaggtatc
     3661 cattccaagc cctgccgccg cactacgggc gaccctaccc cttcctgctg caacccgctg
     3721 cggcctctga tgccgatggc ctcgccccag atgtgccact cccagctgat gggcccgagc
     3781 gcctggcact gtctcctgaa gataagccca tctgcctgtc accctccaag atcccagagc
     3841 cacctcggga cagcccagag gaggagcagc tggctgaccg ggaggtgaag gctgaagttg
     3901 aggatatcga agagggcccc acagaactgc ctccccttga gtcaccattg gccctgcccg
     3961 tcccagagac catggtggcc gtgagccccg caggtggctg tggaggtagt cctctcgagg
     4021 cccaggcgtt gagcacagca ggtccgggct gccgggagcc ctctgaagtt tcagactttg
     4081 cacaggttgc cgagccgcag atagaactac cgagtaagac agagcaccgc atgactgccc
     4141 tggagttggg gacacagctg acacccgagc cactggtaga gactaaggaa gagccggtgg
     4201 aggtgcccct ggatgtgccg atggaggagc ccaccacaga ggcagggcct gaggacagtc
     4261 tgccccagcc atctttgact gagcctcagc ccagccttga gctctcagac tgtgatttgc
     4321 ctgtcccaga gggccagtgt ctcaacctgg aggcccagga ggctgtgcct gctcctgcca
     4381 gtacctgtta tctggaagag acccactccg aatccctcct gcctggcctg gatgacccac
     4441 tggccggcat gaatgcactg gcagctgcag ccgagctgcc ccaagccagg cctctgccct
     4501 ccttgggtcc tggagtccca gccggggaga agctggatac agcccccagc ctcgtcctgg
     4561 aacacagctt tctgcagggc atcaccctct tgagtgagat agctgagctg gagctggacc
     4621 ggaggggcca ggaggctgca gatccagagc caaacctggt ggtgcgaccc tccctcgaaa
     4681 gcctgctggc agccagcagc cacatgttga aggaggtgct ggagagcccc ttctcagacc
     4741 cgctcaagaa cttgcggctt ccgcgtgaac tgaactccaa taagaaatat agctggatgc
     4801 agaagaagga agagcggatg tttgctatga aatcttcctt ggaggacatg gatgcgctag
     4861 agctggactt ccggatgcgg ctggcagagg tccagcgaag gtacaaagag aaacagcggg
     4921 agttggtcaa gctccagaga cgccgggact cggggctgag cagcaagtcc ttgctgacat
     4981 cagacgacta tgatctggga gcggggataa ggaagagaca caaggggccc gaggaggagc
     5041 aagaggccct catgggcatg gggaaagccc gcagcaggaa ccagagctgg gacgatcacg
     5101 actcctcatc tgattttatg agtcagctaa agattaagaa aaaaaagatg gcaagcgacc
     5161 aggagcagtt ggcaagcaag ctagacagag ccctctccct cacaaaacaa gacaagctga
     5221 agtcaccctt caagttttcc gacggccccg ggggaaaacc gaaaaccggt gggggctgtg
     5281 gcaggttctt gacacagtat gacagcctgc tgggcaagga caggaaagca ctggccaaag
     5341 gactcggctt gtctctgaaa ccctccagag aaggtaaaca caaaagagct tccaaagcca
     5401 ggaagatgga ggggggcttc caggccagag gccagcccaa gtctgtccat tctccatttg
     5461 cctcggaagt cagcagtcag tcttacaata cggactctga cgaagacgaa gacttcctga
     5521 agaatgagtg gtctgcccag ggcccctcca gctccaaact gacctcgtcc ctcctgtgtg
     5581 gcatggtgcc caagaacagc aagccagcca caggccctaa gctgaccaag aggggcctgg
     5641 caggcccccg gactttgaaa cccaaggtgg tcaccagcag gaagcagtcc ttctgtttgc
     5701 tgctccgaga ggctgaggcc cgctcctcct tcagcgactc ttccgaggag gactcctttg
     5761 accaagatga cagctcagaa gaggaggagg aagagctaga ggaagaggag gaagacgagg
     5821 aagaggaagg cattggtagc tataggctgg gtgctgggga acaggccctg tcgccaagcc
     5881 tggaggagag tggactgggg ctgctggccc gctttgcggc cagcgctctc cccagccctg
     5941 tcgtggggcc gcccttgtct gtggtacagc tggaagctga gcagaaggcc cggaagaagg
     6001 aagagcgaca gagcttgctg ggcacagagt tcgagtacac agactcagag agtgaagtga
     6061 aggttcccaa gcagtcagct gctgggctgc tgcggaccaa gaaaggggtg ggggagcccg
     6121 gacagtctct ggctgcaccc ggacctggca gccgggcctc tggtccctcc agcccagaca
     6181 aggccaagct ggtctcagag aagggacgca aagcccggaa gattcgaggc cccaaggaac
     6241 ctggctttga ggcggggcca gaggccagtg atgatgacct gtggacgcga cgcagaagcg
     6301 agcgcatctt cttacacgat gcctccgctg cagtccaggc aaccagcaac acggcgccag
     6361 caaccaagcc tagccgctgt ggcaggggtg gtgccccaag cccacggaag gacaccgggc
     6421 gagccaagga caggaaggac cccaggaaga agaagagagg gaaggaggct gggtcagcag
     6481 ccacactgcc accaccccgt gtttctaccc tgcctgactc cagggcaccc cacccagggg
     6541 ccctggcgac tgccaaacgc agcaaggcca aggccagagg gaaggaagca aagaaggaga
     6601 accgaggaaa agggggtgcc gtgagtaagc tgatggagtg catggctgca gaggaagact
     6661 tcgaagccaa ccaggactca agcttctctg aggatgagca tctgccgcgg ggcggggcca
     6721 cagagagacc tctgacccca gccccccgct cctgcatcat tgacaaggaa gagctgaagg
     6781 atggcctgcg tgtgctcatc cctctggatg acaagctgct gtatgccggg cacgtgcaga
     6841 ccgtgcattc acctgacata taccgtgtgg tggttgaagg tgagcgtggg aaccgacccc
     6901 acatctactg cctggagcag ctactgcagg aggcgattat agatgtgagg ccggcctcta
     6961 cacgcttctt gccccagggg accaggatcg ctgcctactg gagccaacaa taccgctgcc
     7021 tgtatccagg cactgtggtc cgagggctgc tggacctgga agacgacgga gacctgatca
     7081 ccgtggagtt tgatgacgga gatacaggca ggattcccct ctcacacatc cgcctcttgc
     7141 cacctgacta taaaatccaa tgtgctgagc cctccccagc actcctagtg cccagcgcaa
     7201 aacgccgtag caggaagacc agtaaagaca cgggggaagt caaagaaggg gctgccacag
     7261 ggcctcagga ggctacaggg ggcaaggctc gagggcgagg acggaaacct agcaccaaag
     7321 ccaaggctga cagagctgtt gtcctggagg aaggggctgc caccaatgag gtccccagtg
     7381 ctcccttggc tctggaaccc atcagcactc caaattctaa gaagagtacc ccagaaccag
     7441 tggacaagcg ggcccgagcc cccaaagcac gctcaatctc tgcacagccc agccccgtac
     7501 cacccacctt ctctagctgc ccagctcctg agccctttgg ggagcttcca acccccgcta
     7561 cagccccgct cgtcaccatg cctgtcacca tgcctgccac tcgccctaaa cccaagaagg
     7621 ctcgggccgc tgaggggtcc ggtgccaaag gtccccggag gccaggggaa gatgacgaac
     7681 tgcttgtcaa actggaccat gagggggtca tgtctcccaa aagcaagaag gccaaagagg
     7741 ccctcctcct gcgggaagat ccagggccgg ggggttggcc agagtccaca gggctgctca
     7801 gcctgggcag ctactcacca gctgttggca gcagtgagcc caaggccacc tggcccaagg
     7861 gtctggatgg agacctcact caggagcccg ggccaggtct tcctttagaa gatcctggca
     7921 actccaaaaa cccagacaag gcccaggctg aacaagatgg ggcagaggag tcagagacca
     7981 cttccagcag cagcagcagt agcagcagta gcagtagcag cagcagcagc agcagcagca
     8041 gtagcagcag cagcagtggt tcggagacag aaggcgagga ggatgctgag aagaacaggg
     8101 aggatggccg gggtgcaggg ggccggacct gcagtgctgc gagctccagg gcctcttctc
     8161 ctgcctcctc ctcttcttcc tcctcctcct cttcttcctc ctcttcttcc tcttcctcct
     8221 cctcttcttc ctcctcctct tcctcctcct cttcctcctc ttcttcctct tcctcctctt
     8281 cctcctcttc ctcttctacc acagacgagg actcttcttg cagctcagat gaggaagcag
     8341 cccctgcacc cgccgctggt ccctctaccc agccagcgct ccccacgaag gtatccaagc
     8401 cacctagcaa ggcacgttcc tcagcccact ccccaggcaa gaaggcaccc accaccaccc
     8461 agccaccgcc ccagccccca ccccagcccc agcagactct tcagcccaag acccaggctg
     8521 gggctggggc caagagccga cccaagaaga gagaaggcgt acacctgcct accaccaagg
     8581 agctggccaa gcggcagcgg ctgccgtctg tggagaacag gcctaagatc gcggccttct
     8641 tacctgcccg gcagctttgg aagtggtttg gcaagcccac ccagcggcga ggcatgaaag
     8701 gcaaggctcg caagctcttc tacaaggcca tcgtccgagg caaggagatg atccgaatcg
     8761 gtgactgcgc agtcttcctg tcagccggcc gccccaacct gccctatatt ggccggatcc
     8821 agagcatgtg ggagtcctgg ggcaacaata tggtggttcg tgtcaagtgg ttctaccatc
     8881 cggaggagac cagcccgggc aagcagttcc atgagggcca gcactgggac cagaagtcag
     8941 ggcatagcct ccctgcagcc ctgcgggcct ccagccagag gaaggacttc atggagcgcg
     9001 ccctgtacca gtcctcccac gtggatgaga acgatgtgca gacagtgtcc cacaagtgcc
     9061 tggtggtggg cctggagcag tacgaacaga tgctgaagac caagaaatac caggacagcg
     9121 agggcctcta ctacctcgcg ggcacctatg agcccaccac aggcatgatc ttctccacgg
     9181 acggcgtgcc tgtgctctgt tgagcgccgc ccacccagcg gggcccacag agaccccccc
     9241 tccccaccac tgccatggcg cgggaccacg tgtgttgtgt gcatgccagt gtgcttgtgg
     9301 gcgtgtgcat gtggccaggt ggacgcccca ggcaagtgtg agtgtgtaca tgtgtgtgcc
     9361 cgtatgcatg cacgtgtgtg cacacatgtg cacacatttc cagacccttt ctggtcatcc
     9421 cctggtgccc tcatgctgag attccccccc ccccccacct cagctatcag ggtccggctc
     9481 tgctgtcccc tcagggtcac ctcagcgagg aggacttccc tccggcactt tgtctgcgct
     9541 caatgaggct gccctctgtg ctctgggcct gtgtagactc tttgattctg tggatggggt
     9601 aagggagagt tccaaggacc caaactggtg tttggtgtag agttcagcca cacccagcac
     9661 ggagcccatc caagacctcc taccatgggg cggggggggg tggggggggt gcccaacgcc
     9721 agccagcttc accaatcacc cggggcatcc gggtgtccgt atgcccggcc tccaccctct
     9781 caggacagcc tggaattggg gaacagggag ggcagcccag gagcgtcacc ataccccgtg
     9841 ggccccccca gcccagaccc ttacactaca gaaatcccca atggtgctga aatccgcgcc
     9901 cacgcccggc acggcccgcc cggcacggcc cgcccggcac ggcccgcccg gcccctccac
     9961 caggaggatc cgaaaggtta cctgtacagt ttcctgtagc ctgcccctgt atcatacacc
    10021 tttaaatgga gtcaactttt taattatata tataaagata aatatatata aatatatata
    10081 taaacttttt aaaactgtga aaaatagcta tgaaattata aaaaaaaaca cattctgacg
    10141 tgcagaatat tattttttat ttcctgttag atcgtgaatg tctagcaccg gctttatgcc
    10201 tctcccccac tcccctgtac ccgcacccct gcccatgtgt actgtatgtg cccccaaatg
    10261 gatgagagat ggaaatagaa agagggggcc cgagcccagc ccccagctca gcccgaagca
    10321 cttaaccagt ccccctgtgc ctgccagacc ccagtggggt ccccggaggc tttgagcaga
    10381 caatcttgaa ggaaggaaaa gccagatttc ggttttgttt tttcttttct ttttggggtg
    10441 ggggtaatta ctgtttcctg attttttttt ttaagtttct tttggaattt tgtttgttgg
    10501 caaattctgt gtgatctttt ttcataaaaa aaaaaaaagg aaagaaaaag agaaaagaaa
    10561 aaatttaatt ggaaaaatac taaaaaaaaa aaaaaaaa
//
