LOCUS       NM_177296               4213 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus transportin 3 (Tnpo3), transcript variant 1, mRNA.
ACCESSION   NM_177296 XM_485736
VERSION     NM_177296.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4213)
  AUTHORS   Iwanami,N., Richter,A.S., Sikora,K. and Boehm,T.
  TITLE     Tnpo3 controls splicing of the pre-mRNA encoding the canonical TCR
            alpha chain of iNKT cells
  JOURNAL   Nat Commun 14 (1), 3645 (2023)
   PUBMED   37339974
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4213)
  AUTHORS   Bayer,M., Boller,S., Ramamoothy,S., Zolotarev,N., Cauchy,P.,
            Iwanami,N., Mittler,G., Boehm,T. and Grosschedl,R.
  TITLE     Tnpo3 enables EBF1 function in conditions of antagonistic Notch
            signaling
  JOURNAL   Genes Dev 36 (15-16), 901-915 (2022)
   PUBMED   36167471
  REMARK    GeneRIF: Tnpo3 enables EBF1 function in conditions of antagonistic
            Notch signaling.
REFERENCE   3  (bases 1 to 4213)
  AUTHORS   Costa,R., Rodia,M.T., Zini,N., Pegoraro,V., Marozzo,R., Capanni,C.,
            Angelini,C., Lattanzi,G., Santi,S. and Cenacchi,G.
  TITLE     Morphological study of TNPO3 and SRSF1 interaction during
            myogenesis by combining confocal, structured illumination and
            electron microscopy analysis
  JOURNAL   Mol Cell Biochem 476 (4), 1797-1811 (2021)
   PUBMED   33452620
  REMARK    GeneRIF: Morphological study of TNPO3 and SRSF1 interaction during
            myogenesis by combining confocal, structured illumination and
            electron microscopy analysis.
REFERENCE   4  (bases 1 to 4213)
  AUTHORS   Iwanami,N., Sikora,K., Richter,A.S., Monnich,M., Guerri,L.,
            Soza-Ried,C., Lawir,D.F., Mateos,F., Hess,I., O'Meara,C.P.,
            Schorpp,M. and Boehm,T.
  TITLE     Forward Genetic Screens in Zebrafish Identify Pre-mRNA-Processing
            Pathways Regulating Early T Cell Development
  JOURNAL   Cell Rep 17 (9), 2259-2270 (2016)
   PUBMED   27880902
REFERENCE   5  (bases 1 to 4213)
  AUTHORS   Cerasoli,D.M., Riley,M.P., Shih,F.F. and Caton,A.J.
  TITLE     Genetic basis for T cell recognition of a major histocompatibility
            complex class II-restricted neo-self peptide
  JOURNAL   J Exp Med 182 (5), 1327-1336 (1995)
   PUBMED   7595203
REFERENCE   6  (bases 1 to 4213)
  AUTHORS   Stenzel-Poore,M.P. and Rittenberg,M.B.
  TITLE     Clonal diversity, somatic mutation, and immune memory to
            phosphocholine-keyhole limpet hemocyanin
  JOURNAL   J Immunol 143 (12), 4123-4133 (1989)
   PUBMED   2512351
REFERENCE   7  (bases 1 to 4213)
  AUTHORS   Blier,P.R. and Bothwell,A.
  TITLE     A limited number of B cell lineages generates the heterogeneity of
            a secondary immune response
  JOURNAL   J Immunol 139 (12), 3996-4006 (1987)
   PUBMED   3500977
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079276.4.
            
            On Mar 19, 2018 this sequence version replaced NM_177296.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064646.1, SRR1660813.268267.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-484               AC079276.4         177740-178223       c
            485-685             AC079276.4         157403-157603       c
            686-759             AC079276.4         156397-156470       c
            760-916             AC079276.4         154412-154568       c
            917-1060            AC079276.4         150540-150683       c
            1061-1236           AC079276.4         147895-148070       c
            1237-1375           AC079276.4         146837-146975       c
            1376-1522           AC079276.4         143380-143526       c
            1523-1630           AC079276.4         140960-141067       c
            1631-1722           AC079276.4         139410-139501       c
            1723-1862           AC079276.4         137228-137367       c
            1863-2054           AC079276.4         134038-134229       c
            2055-2146           AC079276.4         133545-133636       c
            2147-2223           AC079276.4         131232-131308       c
            2224-2284           AC079276.4         129734-129794       c
            2285-2425           AC079276.4         128456-128596       c
            2426-2542           AC079276.4         127126-127242       c
            2543-2637           AC079276.4         125352-125446       c
            2638-2794           AC079276.4         123527-123683       c
            2795-2962           AC079276.4         123169-123336       c
            2963-3075           AC079276.4         120226-120338       c
            3076-3173           AC079276.4         111637-111734       c
            3174-4213           AC079276.4         109201-110240       c
FEATURES             Location/Qualifiers
     source          1..4213
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.36 cM"
     gene            1..4213
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /note="transportin 3"
                     /db_xref="GeneID:320938"
                     /db_xref="MGI:MGI:1196412"
     exon            1..484
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     CDS             365..3136
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transportin-SR"
                     /codon_start=1
                     /product="transportin-3 isoform 1"
                     /protein_id="NP_796270.2"
                     /db_xref="CCDS:CCDS19963.1"
                     /db_xref="GeneID:320938"
                     /db_xref="MGI:MGI:1196412"
                     /translation="MEGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAW
                     EISDQLLQIRQDVESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSP
                     VIVTQLALAIADLALQMPSWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLR
                     IGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTDEKMLMKVFRCLGSWFNLGVLDSNF
                     MANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIENVETNLPLAMQLFQGVLTL
                     ETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGLGDLRTLELLLICAGHP
                     QYEVVEISFNFWYRLGEHLYKTNDEVIHSIFKAYIQRLLHALARHCQLEPDHEGVPEE
                     TDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAIAKS
                     VDPENNPTLVEVLEGVVHLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMK
                     GLCEKPLASAAAKAIHNICSVCRDHMAQHFNGLLEIAHSLDSFMLSPEAAVGLLKGTA
                     LVLARLPLDKITECLSELCSVQVMALKKLLSQEPSNGISSDPTVFLDRLAVIFRHTNP
                     IVENGQTHPCQKVIQEIWPVLSETLNKHRADNRIVERCCRCLRFAVRCVGKGSAALLQ
                     PLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEEGCRQGLLDMLQALCIPTFQLLEQQN
                     GLQNHPDTVDDLFRLATRFIQRSPVTLLRSQVVIPILQWAIASTTLDHRDANSSVMRF
                     LRDLIHTGVANDHEEDFELRKELIGQVMSQLGQQLVSQLLHTCCFCLPPYTLPDVAEV
                     LWEIMQVDRPTFCRWLENSLKGLPKETTVGAVTVTHKQLTDFHKQVTSAEECKQVCWA
                     LRDFTRLFR"
     exon            485..685
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     exon            686..759
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     exon            760..916
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1060
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1236
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1375
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1522
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1630
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1722
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1862
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..2054
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2146
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2223
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2284
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2425
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2542
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2637
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2794
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2962
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3075
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..3173
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     exon            3174..4213
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3444..3449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
                     /note="hexamer: AAGAAA"
     polyA_site      3460
                     /gene="Tnpo3"
                     /gene_synonym="5730544L10Rik; C430013M08Rik; D6Ertd313e;
                     mKIAA4133; Trn-SR"
ORIGIN      
        1 acttccggcc cggggaagcc ctgcttcggc tcgctgcgtg gttcgtgtca tgcggaggta
       61 ggcctctgcg agcaaggcgg gaggtgcaga agccagaacc cgtgtccgga ctcgagagtc
      121 tgcgattctg gcgggaagac aagacaaaaa ggaggcagga acctgaaagc gacctctccg
      181 ctgtttccga gggggcaact tccacgagga accccccttc cctggtaacg gccagaaagg
      241 aggagatggc gccagtcagg gagcggctgt ggccgagaca gtgaggacgc ttgaaggcag
      301 agcaagcgga agcctaggga ggagtatcgg gctctttgct gtcatcgccg ccgctcccgc
      361 cagcatggag ggagccaagc caaccttgca gctcgtgtac caggcggtgc aagcgcttta
      421 ccacgacccg gatcccagcg gaaaggagcg cgcctcgttt tggcttgggg agctgcagcg
      481 ttcggttcac gcttgggaga tttctgatca attgttacag atccgacagg atgtggaatc
      541 atgctatttc gctgcccaga ccatgaaaat gaagattcag acctcatttt atgagctccc
      601 cacagactct catgcttctt taagggactc attgctaact cacattcaga acttgaaaga
      661 cttgtcgcct gtcattgtaa cacagctggc tttagcaata gcagacctcg ccctacagat
      721 gccttcttgg aaaggatgcg tacaaacatt ggtagaaaaa tatagcaatg acgtaacttc
      781 tttacctttt ttgctggaaa tccttacagt gttacccgaa gaagtacata gtcgttcctt
      841 gcggattggg gccaacaggc ggacagaaat tatagaagac ttagccttct actctagtac
      901 cgtggtatct ttattgatga catgtgtaga gaaagcagga accgatgaga agatgcttat
      961 gaaggtcttc cgatgtttgg gaagttggtt taacttgggg gttttggaca gtaacttcat
     1021 ggctaataat aagttattag cactcctttt tgaggtcttg caacaagata agacctcatc
     1081 taacctacac gaagctgctt cagactgtgt atgctcagct ctctatgcta ttgaaaatgt
     1141 agagactaac ttgccattgg ccatgcagct ttttcaggga gtcctgacat tggagactgc
     1201 atatcatatg gctgtggcac gggaagattt ggacaaagtt ctgaattact gccgaatttt
     1261 caccgaacta tgtgaaactt tcctggaaaa aattgtctgt actccaggcc aaggtctggg
     1321 agatcttcga actttggaat tgcttcttat ctgtgcaggc caccctcagt atgaggtagt
     1381 agaaatttcc tttaactttt ggtaccgact aggagaacat ttatacaaaa ccaatgatga
     1441 agttattcac agcatcttca aagcgtacat tcagaggctg cttcatgcct tggctcgaca
     1501 ctgccagttg gaaccagacc atgagggagt tcctgaagag accgatgact ttggggagtt
     1561 tcgaatgaga gtgtcagacc tggtgaagga cttgatcttc ctgattggat ctatggagtg
     1621 ttttgctcag ttgtattcta ctctgaagga aggcaaccca ccctgggagg tgacagaagc
     1681 ggttctcttt atcatggctg ctatagcaaa gagtgtggat ccggagaaca accctacact
     1741 tgtggaggta ctagagggag ttgtccatct cccagagacc gtgcatacag ctgtgcggta
     1801 cactagcatt gagttggttg gtgagatgag tgaagtggtg gaccggaatc cccagttcct
     1861 ggaccctgta ttgggctatt tgatgaaagg cctgtgtgaa aagcctctgg cttctgctgc
     1921 agccaaagcc attcataaca tttgttccgt ttgtcgcgat catatggctc agcactttaa
     1981 tggactccta gaaattgccc actcccttga ttctttcatg ttgtctcccg aagctgctgt
     2041 gggtttgcta aaaggaacag ctcttgtcct agcaagacta cctttggata agattacaga
     2101 atgtctaagt gagttatgtt ctgttcaggt tatggcattg aaaaagctgt tgtctcagga
     2161 gcccagcaat ggcatttctt cagatcccac tgtcttctta gatcgcctgg cagtaatatt
     2221 tagacacacc aatcctattg tagaaaatgg acagactcat ccatgccaaa aagtcatcca
     2281 ggaaatatgg ccagttttgt ctgagactct aaataagcac cgagccgaca atcgaattgt
     2341 agagcgttgt tgtagatgcc tgcgctttgc ggttcgttgt gtaggcaaag gatctgcagc
     2401 actgctacag ccactagtta cacagatggt gaatgtgtac catgtacatc agcattcctg
     2461 tttcctctac cttggcagta tccttgtgga tgagtacggc atggaagaag gctgtcggca
     2521 ggggttatta gacatgctcc aggcgctatg cattcccacc tttcagctcc tagaacagca
     2581 gaatggcctc caaaatcacc ctgacactgt agatgaccta ttcaggttag ccacccgatt
     2641 tattcagcga agccctgtca ccttgctgag gagccaggtt gtcatcccaa tcttacagtg
     2701 ggccattgca tcaaccactt tggaccaccg agatgccaat tccagtgtca tgagatttct
     2761 gcgagacctc atccacacag gagtagccaa tgatcatgaa gaagattttg aattgcggaa
     2821 ggaactaatt ggacaggtga tgagccagct tggccagcaa cttgtcagcc agctgctcca
     2881 cacatgctgc ttttgtcttc ccccctacac cctacccgac gtggctgaag tgctctggga
     2941 gatcatgcag gttgacagac cgactttctg tcggtggcta gagaattcct tgaaaggttt
     3001 gccaaaagag accacagtgg gagctgtcac agtgacacat aaacaactta cagatttcca
     3061 caagcaagtc actagtgccg aggaatgtaa gcaagtttgc tgggccttga gagacttcac
     3121 caggttgttt cgatagctca agctcacact cctgcactgt gcctgtcatc caggaatgtc
     3181 tttttttatt agaagacagg aagaaaacaa cccagactgt gtcccacaat cagaaacctc
     3241 tgttgtggca gaggggcctt cactaccacc agaccatccc gccacacagg gagagacttc
     3301 accctccaag gcatcctaag gagtccctgt ttgggatgtg agggagaaac agcgcggttt
     3361 ttaaggatgg ctggagcctg tccgacgtgg tgggagggga actagtttcc tggtgaactt
     3421 ctttctaaaa ggaaaaataa tttaagaaaa gttaaaaaaa gaaagaaaat ttttaaaaag
     3481 gaaagctgag atgacaccag aactgaaata tgcacctggt agcagatgat gcacacacat
     3541 gatagacaca caccagcatg cagtgcacac actgagacac gacagtgaga cagacacatt
     3601 accttaggga agcgcgggga tgcgagtagg taacatagtt acagttggaa ttaaagaggt
     3661 agggtcacct cctctgctct ccttccttta aacacaggtg aatagaggaa acaccccccc
     3721 ccccaactgt tcacctttag aaatgtccag acaaggagcc tggtctgctt atatcatggt
     3781 tagggatgat agtccggact agccagggtc aaagttgctt ttaatgtaga gcccaaccct
     3841 gatcctattg agttgctaag tccaatccag ttcatgggcc tttgtcatca gccttgggga
     3901 gaaaagccaa aactggtggg tggagaggac aaatatggat taaaccttgc tctctctctc
     3961 ttttagtgaa ttattcatcc acaaacatgg ggtgggaagg gataaaaaag agggtgagag
     4021 tctggaggga atgtatttac agggctacct gtattttgct aaaaaaaaaa aaaaagtgtg
     4081 aaaattaatt gccttcaagg gcactgttct gtcctgtggt gtagccatct tatgaataaa
     4141 tcaacagcac caaaaaaaaa aaaaaaaaaa aaaaccagaa aaaagaaaaa aataaaacca
     4201 atttttaaaa ttt
//
