LOCUS       NM_013694                724 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus transition protein 2 (Tnp2), mRNA.
ACCESSION   NM_013694
VERSION     NM_013694.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 724)
  AUTHORS   Dura,M., Teissandier,A., Armand,M., Barau,J., Lapoujade,C.,
            Fouchet,P., Bonneville,L., Schulz,M., Weber,M., Baudrin,L.G.,
            Lameiras,S. and Bourc'his,D.
  TITLE     DNMT3A-dependent DNA methylation is required for spermatogonial
            stem cells to commit to spermatogenesis
  JOURNAL   Nat Genet 54 (4), 469-480 (2022)
   PUBMED   35410378
REFERENCE   2  (bases 1 to 724)
  AUTHORS   Gustafson,E.A., Seymour,K.A., Sigrist,K., Rooij,D.G.D.E. and
            Freiman,R.N.
  TITLE     ZFP628 Is a TAF4b-Interacting Transcription Factor Required for
            Mouse Spermiogenesis
  JOURNAL   Mol Cell Biol 40 (7), e00228-19 (2020)
   PUBMED   31932482
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 724)
  AUTHORS   Malla,A.B. and Bhandari,R.
  TITLE     IP6K1 is essential for chromatoid body formation and temporal
            regulation of Tnp2 and Prm2 expression in mouse spermatids
  JOURNAL   J Cell Sci 130 (17), 2854-2866 (2017)
   PUBMED   28743739
  REMARK    GeneRIF: juvenile spermatids from Ip6k1(-/-) mice display premature
            expression of the transition protein TNP2 and the protamine PRM2
            due to translational derepression.
REFERENCE   4  (bases 1 to 724)
  AUTHORS   Barral,S., Morozumi,Y., Tanaka,H., Montellier,E., Govin,J., de
            Dieuleveult,M., Charbonnier,G., Coute,Y., Puthier,D., Buchou,T.,
            Boussouar,F., Urahama,T., Fenaille,F., Curtet,S., Hery,P.,
            Fernandez-Nunez,N., Shiota,H., Gerard,M., Rousseaux,S.,
            Kurumizaka,H. and Khochbin,S.
  TITLE     Histone Variant H2A.L.2 Guides Transition Protein-Dependent
            Protamine Assembly in Male Germ Cells
  JOURNAL   Mol Cell 66 (1), 89-101 (2017)
   PUBMED   28366643
REFERENCE   5  (bases 1 to 724)
  AUTHORS   Nakajima,R., Okano,H. and Noce,T.
  TITLE     JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during
            Spermatogenesis
  JOURNAL   PLoS One 11 (9), e0163466 (2016)
   PUBMED   27649575
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 724)
  AUTHORS   Nelson,J.E. and Krawetz,S.A.
  TITLE     Linkage of human spermatid-specific basic nuclear protein genes.
            Definition and evolution of the P1-->P2-->TP2 locus
  JOURNAL   J Biol Chem 268 (4), 2932-2936 (1993)
   PUBMED   8428967
REFERENCE   7  (bases 1 to 724)
  AUTHORS   Keime,S., Heitland,K., Kumm,S., Schlosser,M., Hroch,N., Holtz,W.
            and Engel,W.
  TITLE     Characterization of four genes encoding basic proteins of the
            porcine spermatid nucleus and close linkage of three of them
  JOURNAL   Biol Chem Hoppe Seyler 373 (5), 261-270 (1992)
   PUBMED   1627265
REFERENCE   8  (bases 1 to 724)
  AUTHORS   Engel,W., Keime,S., Kremling,H., Hameister,H. and Schluter,G.
  TITLE     The genes for protamine 1 and 2 (PRM1 and PRM2) and transition
            protein 2 (TNP2) are closely linked in the mammalian genome
  JOURNAL   Cytogenet Cell Genet 61 (2), 158-159 (1992)
   PUBMED   1395729
REFERENCE   9  (bases 1 to 724)
  AUTHORS   Kleene,K.C., Gerstel,J. and Shih,D.
  TITLE     Nucleotide sequence of the gene encoding mouse transition protein 2
  JOURNAL   Gene 95 (2), 301-302 (1990)
   PUBMED   2249785
REFERENCE   10 (bases 1 to 724)
  AUTHORS   Kleene,K.C. and Flynn,J.F.
  TITLE     Characterization of a cDNA clone encoding a basic protein, TP2,
            involved in chromatin condensation during spermiogenesis in the
            mouse
  JOURNAL   J Biol Chem 262 (36), 17272-17277 (1987)
   PUBMED   3693351
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC092529.1.
            
            On Apr 11, 2005 this sequence version replaced NM_013694.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092529.1, CN839027.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..724
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 5.83 cM"
     gene            1..724
                     /gene="Tnp2"
                     /gene_synonym="Tp-2; TP2"
                     /note="transition protein 2"
                     /db_xref="GeneID:21959"
                     /db_xref="MGI:MGI:98785"
     exon            1..391
                     /gene="Tnp2"
                     /gene_synonym="Tp-2; TP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..408
                     /gene="Tnp2"
                     /gene_synonym="Tp-2; TP2"
                     /note="transition protein 2 (alt.)"
                     /codon_start=1
                     /product="nuclear transition protein 2"
                     /protein_id="NP_038722.3"
                     /db_xref="CCDS:CCDS27953.1"
                     /db_xref="GeneID:21959"
                     /db_xref="MGI:MGI:98785"
                     /translation="MDTKMQSLPTTHPHPHSSSRPQSHTSNQCNQCTCSHHCRSCSQA
                     GHAGSSSSPSPGPPMKHPKPSVHSRHSPARPSHRGSCPKNRKTFEGKVSKRKAVRRRK
                     RTHRAKRRSSGRRYK"
     exon            392..550
                     /gene="Tnp2"
                     /gene_synonym="Tp-2; TP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      525..530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnp2"
                     /gene_synonym="Tp-2; TP2"
                     /note="hexamer: ATTAAA"
     polyA_site      550
                     /gene="Tnp2"
                     /gene_synonym="Tp-2; TP2"
                     /note="major polyA site"
ORIGIN      
        1 gggcctgctg ggaggaggag gaggaggaag tctctgcccc gagtgtggcc tcccatggac
       61 accaagatgc agagccttcc caccactcat ccccaccccc acagctcctc gcggcctcaa
      121 agtcacacca gtaaccagtg caatcagtgc acctgcagcc accactgccg gagctgcagc
      181 caggcaggcc acgcgggctc tagctccagc cccagccctg gcccgcccat gaagcacccc
      241 aagccatccg tgcactctcg acactcacct gcaagaccca gccaccgcgg gagctgcccc
      301 aagaacagga agacctttga agggaaagtg agcaagagaa aggccgtcag gaggcggaaa
      361 cggactcaca gagctaagag gcgtagctca gggcgaagat acaagtgacg cactccagga
      421 tgttcctgtg tccatttgat cccaaaatga gatagccatc actaggggac tgttgggatg
      481 atgtcacagg aacatgtcac tgcagcaatt tctatgcaac atggattaaa gcttgtaccc
      541 tggaagacta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
      601 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
      661 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
      721 aaaa
//
