LOCUS       NM_001347550            1008 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus troponin T3, skeletal, fast (Tnnt3), transcript
            variant 13, mRNA.
ACCESSION   NM_001347550 XM_006508594
VERSION     NM_001347550.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1008)
  AUTHORS   Doll,C.F., Pereira,N.J., Hashimi,M.S., Grindrod,T.J.,
            Alkassis,F.F., Cai,L.X., Milovanovic,U., Sandino,A.I. and
            Kasahara,H.
  TITLE     Gestational intermittent hyperoxia rescues murine genetic
            congenital heart disease in part
  JOURNAL   Sci Rep 11 (1), 6608 (2021)
   PUBMED   33758249
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1008)
  AUTHORS   Mu,Y., Yu,H., Wu,T., Zhang,J., Evans,S.M. and Chen,J.
  TITLE     O-linked beta-N-acetylglucosamine transferase plays an essential
            role in heart development through regulating angiopoietin-1
  JOURNAL   PLoS Genet 16 (4), e1008730 (2020)
   PUBMED   32251422
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1008)
  AUTHORS   Comai,G., Heude,E., Mella,S., Paisant,S., Pala,F., Gallardo,M.,
            Langa,F., Kardon,G., Gopalakrishnan,S. and Tajbakhsh,S.
  TITLE     A distinct cardiopharyngeal mesoderm genetic hierarchy establishes
            antero-posterior patterning of esophagus striated muscle
  JOURNAL   Elife 8, e47460 (2019)
   PUBMED   31535973
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1008)
  AUTHORS   Narboux-Neme,N., Ekker,M., Levi,G. and Heude,E.
  TITLE     Posterior axis formation requires Dlx5/Dlx6 expression at the
            neural plate border
  JOURNAL   PLoS One 14 (3), e0214063 (2019)
   PUBMED   30889190
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1008)
  AUTHORS   Wilczewski,C.M., Hepperla,A.J., Shimbo,T., Wasson,L., Robbe,Z.L.,
            Davis,I.J., Wade,P.A. and Conlon,F.L.
  TITLE     CHD4 and the NuRD complex directly control cardiac sarcomere
            formation
  JOURNAL   Proc Natl Acad Sci U S A 115 (26), 6727-6732 (2018)
   PUBMED   29891665
REFERENCE   6  (bases 1 to 1008)
  AUTHORS   Mohri,K., Takano-Ohmuro,H., Nakashima,H., Hayakawa,K., Endo,T.,
            Hanaoka,K. and Obinata,T.
  TITLE     Expression of cofilin isoforms during development of mouse striated
            muscles
  JOURNAL   J Muscle Res Cell Motil 21 (1), 49-57 (2000)
   PUBMED   10813634
REFERENCE   7  (bases 1 to 1008)
  AUTHORS   Kato,R., Shirohzu,H., Yokomine,T., Mizuno,S., Mukai,T. and
            Sasaki,H.
  TITLE     Sequence-ready 1-Mb YAC, BAC and cosmid contigs covering the distal
            imprinted region of mouse chromosome 7
  JOURNAL   DNA Res 6 (6), 401-405 (1999)
   PUBMED   10691133
REFERENCE   8  (bases 1 to 1008)
  AUTHORS   Misener,V.L., Wielowieyski,A., Brennan,L.A., Beebakhee,G. and
            Jongstra,J.
  TITLE     The mouse Lsp1 and Tnnt3 genes are 4.3 kb apart on distal mouse
            chromosome 7
  JOURNAL   Mamm Genome 9 (10), 846-848 (1998)
   PUBMED   9745043
REFERENCE   9  (bases 1 to 1008)
  AUTHORS   Wang,J. and Jin,J.P.
  TITLE     Primary structure and developmental acidic to basic transition of
            13 alternatively spliced mouse fast skeletal muscle troponin T
            isoforms
  JOURNAL   Gene 193 (1), 105-114 (1997)
   PUBMED   9249073
REFERENCE   10 (bases 1 to 1008)
  AUTHORS   Koch,A., Juan,T.S., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.,
            McNiece,I.K. and Fletcher,F.A.
  TITLE     cDNA cloning and chromosomal mapping of mouse fast skeletal muscle
            troponin T
  JOURNAL   Mamm Genome 8 (5), 346-348 (1997)
   PUBMED   9107680
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603651.14.
            
            On Dec 1, 2016 this sequence version replaced XM_006508594.1.
            
            Transcript Variant: This variant (13) lacks four alternate exons
            and contains another alternate exon compared to variant 1. The
            resulting isoform (13) has the same N- and C-termini but is shorter
            compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: L48991.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849375, SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AL603651.14        36494-36557         c
            65-99               AL603651.14        33739-33773         c
            100-113             AL603651.14        33551-33564         c
            114-131             AL603651.14        31328-31345         c
            132-146             AL603651.14        31129-31143         c
            147-158             AL603651.14        30094-30105         c
            159-177             AL603651.14        27040-27058         c
            178-223             AL603651.14        24684-24729         c
            224-340             AL603651.14        24020-24136         c
            341-418             AL603651.14        23851-23928         c
            419-532             AL603651.14        23244-23357         c
            533-642             AL603651.14        23028-23137         c
            643-733             AL603651.14        22771-22861         c
            734-774             AL603651.14        21688-21728         c
            775-1008            AL603651.14        19384-19617         c
FEATURES             Location/Qualifiers
     source          1..1008
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 87.94 cM"
     gene            1..1008
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /note="troponin T3, skeletal, fast"
                     /db_xref="GeneID:21957"
                     /db_xref="MGI:MGI:109550"
     exon            1..64
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            65..99
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..829
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /note="isoform 13 is encoded by transcript variant 13;
                     fast skeletal muscle troponin T3; troponin T, fast
                     skeletal muscle; tnTf; skeletal muscle fast-twitch TnT"
                     /codon_start=1
                     /product="troponin T, fast skeletal muscle isoform 13"
                     /protein_id="NP_001334479.1"
                     /db_xref="CCDS:CCDS85474.1"
                     /db_xref="GeneID:21957"
                     /db_xref="MGI:MGI:109550"
                     /translation="MSDEETEQVEEEAQEEEVQEEAPEPEEKPRPKLTAPKIPEGEKV
                     DFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELIALKERIEKRRAERAEQQRIRAE
                     KERERQNRLAEEKARREEEDAKRRAEDDMKKKKALSSMGANYSSYLAKADQKRGKKQT
                     AREMKKKILAERRKPLNIDHLSDDKLRDKAKELWDTLYQLETDKFEFGEKLKRQKYDI
                     MTVRARVEMLAKFSKKAGATAKGKVGGRWK"
     exon            100..113
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            114..131
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            132..146
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            147..158
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            159..177
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            178..223
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            224..340
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            341..418
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            419..532
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            533..642
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            643..733
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            734..774
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            775..1008
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      984..989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /note="hexamer: AATAAA"
     polyA_site      1008
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /note="major polyA site"
ORIGIN      
        1 ggacagtgcc tgctgctggt cctgtccaca aggagccccc agcctttctc agactcaact
       61 acagatacaa cccaccgcca ctatgtctga cgaggaaact gaacaagttg aggaggaggc
      121 ccaagaggaa gaagtccagg aggaagcccc cgaaccagag gagaaaccaa gacccaaact
      181 tactgctcct aagatcccgg aaggggagaa agtagacttt gatgacatcc agaagaagcg
      241 tcaaaacaag gacctcatgg agctccaagc cctcattgac agccactttg aagctagaaa
      301 gaaagaagaa gaggagctaa tcgcacttaa agaaagaatt gagaagcgcc gtgcagagag
      361 ggctgagcag caaagaattc gcgctgagaa ggagcgggaa cgccagaaca gattggcgga
      421 ggagaaggcc agaagagagg aggaggatgc caagaggaga gctgaagatg acatgaagaa
      481 gaaaaaggct ctgtcctcca tgggtgccaa ctacagcagc tacctggcca aggctgacca
      541 gaagagaggc aagaaacaga cagcccggga aatgaaaaag aagattcttg ccgaaaggcg
      601 caagcctctg aacattgacc atcttagcga tgacaagctg agggacaagg ccaaggaact
      661 ctgggatacc ttgtaccaac tggagactga caaattcgag tttggggaga agctgaaacg
      721 tcagaaatat gatatcatga ctgtccgggc cagagtggag atgctggcca agttcagcaa
      781 gaaggccggt gccacagcca agggcaaagt cggtgggcgc tggaagtaaa agagcagaga
      841 ggtgcactgc agcagagacc atcaaccctg actcctgcca gggcccctta ttccagctct
      901 gcactctcca gccttcacgc ccaggcatct ttgggaactc aggacccacc ctgctgcaat
      961 gccctcacct tctggggtct aggaataaag ttatcagact cccctcta
//
