LOCUS       NM_001163669            1069 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus troponin T3, skeletal, fast (Tnnt3), transcript
            variant 5, mRNA.
ACCESSION   NM_001163669
VERSION     NM_001163669.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1069)
  AUTHORS   Doll,C.F., Pereira,N.J., Hashimi,M.S., Grindrod,T.J.,
            Alkassis,F.F., Cai,L.X., Milovanovic,U., Sandino,A.I. and
            Kasahara,H.
  TITLE     Gestational intermittent hyperoxia rescues murine genetic
            congenital heart disease in part
  JOURNAL   Sci Rep 11 (1), 6608 (2021)
   PUBMED   33758249
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1069)
  AUTHORS   Mu,Y., Yu,H., Wu,T., Zhang,J., Evans,S.M. and Chen,J.
  TITLE     O-linked beta-N-acetylglucosamine transferase plays an essential
            role in heart development through regulating angiopoietin-1
  JOURNAL   PLoS Genet 16 (4), e1008730 (2020)
   PUBMED   32251422
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1069)
  AUTHORS   Comai,G., Heude,E., Mella,S., Paisant,S., Pala,F., Gallardo,M.,
            Langa,F., Kardon,G., Gopalakrishnan,S. and Tajbakhsh,S.
  TITLE     A distinct cardiopharyngeal mesoderm genetic hierarchy establishes
            antero-posterior patterning of esophagus striated muscle
  JOURNAL   Elife 8, e47460 (2019)
   PUBMED   31535973
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1069)
  AUTHORS   Narboux-Neme,N., Ekker,M., Levi,G. and Heude,E.
  TITLE     Posterior axis formation requires Dlx5/Dlx6 expression at the
            neural plate border
  JOURNAL   PLoS One 14 (3), e0214063 (2019)
   PUBMED   30889190
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1069)
  AUTHORS   Wilczewski,C.M., Hepperla,A.J., Shimbo,T., Wasson,L., Robbe,Z.L.,
            Davis,I.J., Wade,P.A. and Conlon,F.L.
  TITLE     CHD4 and the NuRD complex directly control cardiac sarcomere
            formation
  JOURNAL   Proc Natl Acad Sci U S A 115 (26), 6727-6732 (2018)
   PUBMED   29891665
REFERENCE   6  (bases 1 to 1069)
  AUTHORS   Mohri,K., Takano-Ohmuro,H., Nakashima,H., Hayakawa,K., Endo,T.,
            Hanaoka,K. and Obinata,T.
  TITLE     Expression of cofilin isoforms during development of mouse striated
            muscles
  JOURNAL   J Muscle Res Cell Motil 21 (1), 49-57 (2000)
   PUBMED   10813634
REFERENCE   7  (bases 1 to 1069)
  AUTHORS   Kato,R., Shirohzu,H., Yokomine,T., Mizuno,S., Mukai,T. and
            Sasaki,H.
  TITLE     Sequence-ready 1-Mb YAC, BAC and cosmid contigs covering the distal
            imprinted region of mouse chromosome 7
  JOURNAL   DNA Res 6 (6), 401-405 (1999)
   PUBMED   10691133
REFERENCE   8  (bases 1 to 1069)
  AUTHORS   Misener,V.L., Wielowieyski,A., Brennan,L.A., Beebakhee,G. and
            Jongstra,J.
  TITLE     The mouse Lsp1 and Tnnt3 genes are 4.3 kb apart on distal mouse
            chromosome 7
  JOURNAL   Mamm Genome 9 (10), 846-848 (1998)
   PUBMED   9745043
REFERENCE   9  (bases 1 to 1069)
  AUTHORS   Wang,J. and Jin,J.P.
  TITLE     Primary structure and developmental acidic to basic transition of
            13 alternatively spliced mouse fast skeletal muscle troponin T
            isoforms
  JOURNAL   Gene 193 (1), 105-114 (1997)
   PUBMED   9249073
REFERENCE   10 (bases 1 to 1069)
  AUTHORS   Koch,A., Juan,T.S., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.,
            McNiece,I.K. and Fletcher,F.A.
  TITLE     cDNA cloning and chromosomal mapping of mouse fast skeletal muscle
            troponin T
  JOURNAL   Mamm Genome 8 (5), 346-348 (1997)
   PUBMED   9107680
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV049834.1, AA028290.1, CK791812.1 and AI037743.1.
            
            Transcript Variant: This variant (5) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (5) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L49470.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DV049834.1         48-67
            21-436              AA028290.1         1-416
            437-969             CK791812.1         114-646
            970-1069            AI037743.1         331-430
FEATURES             Location/Qualifiers
     source          1..1069
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 87.94 cM"
     gene            1..1069
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /note="troponin T3, skeletal, fast"
                     /db_xref="GeneID:21957"
                     /db_xref="MGI:MGI:109550"
     exon            1..64
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            65..99
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..862
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /note="isoform 5 is encoded by transcript variant 5; fast
                     skeletal muscle troponin T3; troponin T, fast skeletal
                     muscle; tnTf; skeletal muscle fast-twitch TnT"
                     /codon_start=1
                     /product="troponin T, fast skeletal muscle isoform 5"
                     /protein_id="NP_001157141.1"
                     /db_xref="CCDS:CCDS52453.1"
                     /db_xref="GeneID:21957"
                     /db_xref="MGI:MGI:109550"
                     /translation="MSDEETEQVEEQYEEEEEAQEEEVQEEAPEPEEVQEEEKPRPKL
                     TAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELIALKERIEKRRA
                     ERAEQQRIRAEKERERQNRLAEEKARREEEDAKRRAEDDMKKKKALSSMGANYSSYLA
                     KADQKRGKKQTAREMKKKILAERRKPLNIDHLSDDKLRDKAKELWDTLYQLETDKFEF
                     GEKLKRQKYDITTLRSRIDQAQKHSKKAGATAKGKVGGRWK"
     exon            100..113
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            114..131
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            132..149
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            150..164
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            165..176
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            177..191
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            192..210
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            211..256
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            257..373
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            374..451
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            452..565
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            566..675
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            676..766
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            767..807
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1041
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1017..1022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /note="hexamer: AATAAA"
     polyA_site      1041
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /note="major polyA site"
ORIGIN      
        1 ggacagtgcc tgctgctggt cctgtccaca aggagccccc agcctttctc agactcaact
       61 acagatacaa cccaccgcca ctatgtctga cgaggaaact gaacaagttg aggaacaata
      121 cgaagaggaa gaggaggccc aagaggaaga agtccaggag gaagcccccg aaccagagga
      181 agtccaagaa gaggagaaac caagacccaa acttactgct cctaagatcc cggaagggga
      241 gaaagtagac tttgatgaca tccagaagaa gcgtcaaaac aaggacctca tggagctcca
      301 agccctcatt gacagccact ttgaagctag aaagaaagaa gaagaggagc taatcgcact
      361 taaagaaaga attgagaagc gccgtgcaga gagggctgag cagcaaagaa ttcgcgctga
      421 gaaggagcgg gaacgccaga acagattggc ggaggagaag gccagaagag aggaggagga
      481 tgccaagagg agagctgaag atgacatgaa gaagaaaaag gctctgtcct ccatgggtgc
      541 caactacagc agctacctgg ccaaggctga ccagaagaga ggcaagaaac agacagcccg
      601 ggaaatgaaa aagaagattc ttgccgaaag gcgcaagcct ctgaacattg accatcttag
      661 cgatgacaag ctgagggaca aggccaagga actctgggat accttgtacc aactggagac
      721 tgacaaattc gagtttgggg agaagctgaa acgtcagaaa tatgatatca ccaccctcag
      781 gagccgcatt gaccaagccc agaagcacag caagaaggcc ggtgccacag ccaagggcaa
      841 agtcggtggg cgctggaagt aaaagagcag agaggtgcac tgcagcagag accatcaacc
      901 ctgactcctg ccagggcccc ttattccagc tctgcactct ccagccttca cgcccaggca
      961 tctttgggaa ctcaggaccc accctgctgc aatgccctca ccttctgggg tctaggaata
     1021 aagttatcag actcccctct aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
