LOCUS       NM_001163666            1081 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus troponin T3, skeletal, fast (Tnnt3), transcript
            variant 4, mRNA.
ACCESSION   NM_001163666
VERSION     NM_001163666.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1081)
  AUTHORS   Doll,C.F., Pereira,N.J., Hashimi,M.S., Grindrod,T.J.,
            Alkassis,F.F., Cai,L.X., Milovanovic,U., Sandino,A.I. and
            Kasahara,H.
  TITLE     Gestational intermittent hyperoxia rescues murine genetic
            congenital heart disease in part
  JOURNAL   Sci Rep 11 (1), 6608 (2021)
   PUBMED   33758249
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1081)
  AUTHORS   Mu,Y., Yu,H., Wu,T., Zhang,J., Evans,S.M. and Chen,J.
  TITLE     O-linked beta-N-acetylglucosamine transferase plays an essential
            role in heart development through regulating angiopoietin-1
  JOURNAL   PLoS Genet 16 (4), e1008730 (2020)
   PUBMED   32251422
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1081)
  AUTHORS   Comai,G., Heude,E., Mella,S., Paisant,S., Pala,F., Gallardo,M.,
            Langa,F., Kardon,G., Gopalakrishnan,S. and Tajbakhsh,S.
  TITLE     A distinct cardiopharyngeal mesoderm genetic hierarchy establishes
            antero-posterior patterning of esophagus striated muscle
  JOURNAL   Elife 8, e47460 (2019)
   PUBMED   31535973
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1081)
  AUTHORS   Narboux-Neme,N., Ekker,M., Levi,G. and Heude,E.
  TITLE     Posterior axis formation requires Dlx5/Dlx6 expression at the
            neural plate border
  JOURNAL   PLoS One 14 (3), e0214063 (2019)
   PUBMED   30889190
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1081)
  AUTHORS   Wilczewski,C.M., Hepperla,A.J., Shimbo,T., Wasson,L., Robbe,Z.L.,
            Davis,I.J., Wade,P.A. and Conlon,F.L.
  TITLE     CHD4 and the NuRD complex directly control cardiac sarcomere
            formation
  JOURNAL   Proc Natl Acad Sci U S A 115 (26), 6727-6732 (2018)
   PUBMED   29891665
REFERENCE   6  (bases 1 to 1081)
  AUTHORS   Mohri,K., Takano-Ohmuro,H., Nakashima,H., Hayakawa,K., Endo,T.,
            Hanaoka,K. and Obinata,T.
  TITLE     Expression of cofilin isoforms during development of mouse striated
            muscles
  JOURNAL   J Muscle Res Cell Motil 21 (1), 49-57 (2000)
   PUBMED   10813634
REFERENCE   7  (bases 1 to 1081)
  AUTHORS   Kato,R., Shirohzu,H., Yokomine,T., Mizuno,S., Mukai,T. and
            Sasaki,H.
  TITLE     Sequence-ready 1-Mb YAC, BAC and cosmid contigs covering the distal
            imprinted region of mouse chromosome 7
  JOURNAL   DNA Res 6 (6), 401-405 (1999)
   PUBMED   10691133
REFERENCE   8  (bases 1 to 1081)
  AUTHORS   Misener,V.L., Wielowieyski,A., Brennan,L.A., Beebakhee,G. and
            Jongstra,J.
  TITLE     The mouse Lsp1 and Tnnt3 genes are 4.3 kb apart on distal mouse
            chromosome 7
  JOURNAL   Mamm Genome 9 (10), 846-848 (1998)
   PUBMED   9745043
REFERENCE   9  (bases 1 to 1081)
  AUTHORS   Wang,J. and Jin,J.P.
  TITLE     Primary structure and developmental acidic to basic transition of
            13 alternatively spliced mouse fast skeletal muscle troponin T
            isoforms
  JOURNAL   Gene 193 (1), 105-114 (1997)
   PUBMED   9249073
REFERENCE   10 (bases 1 to 1081)
  AUTHORS   Koch,A., Juan,T.S., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.,
            McNiece,I.K. and Fletcher,F.A.
  TITLE     cDNA cloning and chromosomal mapping of mouse fast skeletal muscle
            troponin T
  JOURNAL   Mamm Genome 8 (5), 346-348 (1997)
   PUBMED   9107680
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV049834.1, AI746973.1, CK791812.1 and AI037743.1.
            
            Transcript Variant: This variant (4) lacks two alternate in-frame
            exons compared to variant 1. The resulting isoform (4) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L49468.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 DV049834.1         48-52
            6-611               AI746973.1         1-606
            612-981             CK791812.1         277-646
            982-1081            AI037743.1         331-430
FEATURES             Location/Qualifiers
     source          1..1081
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 87.94 cM"
     gene            1..1081
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /note="troponin T3, skeletal, fast"
                     /db_xref="GeneID:21957"
                     /db_xref="MGI:MGI:109550"
     exon            1..64
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            65..99
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..874
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /note="isoform 4 is encoded by transcript variant 4; fast
                     skeletal muscle troponin T3; troponin T, fast skeletal
                     muscle; tnTf; skeletal muscle fast-twitch TnT"
                     /codon_start=1
                     /product="troponin T, fast skeletal muscle isoform 4"
                     /protein_id="NP_001157138.1"
                     /db_xref="CCDS:CCDS52456.1"
                     /db_xref="GeneID:21957"
                     /db_xref="MGI:MGI:109550"
                     /translation="MSDEETEQVEEQYEEEEEAQEEEEVQEDAVAEEEREEDEEEEKP
                     RPKLTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELIALKERIE
                     KRRAERAEQQRIRAEKERERQNRLAEEKARREEEDAKRRAEDDMKKKKALSSMGANYS
                     SYLAKADQKRGKKQTAREMKKKILAERRKPLNIDHLSDDKLRDKAKELWDTLYQLETD
                     KFEFGEKLKRQKYDITTLRSRIDQAQKHSKKAGATAKGKVGGRWK"
     exon            100..113
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            114..131
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            132..149
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            150..164
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            165..203
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            204..222
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            223..268
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            269..385
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            386..463
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            464..577
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            578..687
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            688..778
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            779..819
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1053
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1029..1034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /note="hexamer: AATAAA"
     polyA_site      1053
                     /gene="Tnnt3"
                     /gene_synonym="fTnT"
                     /note="major polyA site"
ORIGIN      
        1 ggacagtgcc tgctgctggt cctgtccaca aggagccccc agcctttctc agactcaact
       61 acagatacaa cccaccgcca ctatgtctga cgaggaaact gaacaagttg aggaacaata
      121 cgaagaggaa gaggaggccc aagaggaaga ggaagtccaa gaagatgctg tcgccgagga
      181 ggagcgggag gaggacgagg aagaggagaa accaagaccc aaacttactg ctcctaagat
      241 cccggaaggg gagaaagtag actttgatga catccagaag aagcgtcaaa acaaggacct
      301 catggagctc caagccctca ttgacagcca ctttgaagct agaaagaaag aagaagagga
      361 gctaatcgca cttaaagaaa gaattgagaa gcgccgtgca gagagggctg agcagcaaag
      421 aattcgcgct gagaaggagc gggaacgcca gaacagattg gcggaggaga aggccagaag
      481 agaggaggag gatgccaaga ggagagctga agatgacatg aagaagaaaa aggctctgtc
      541 ctccatgggt gccaactaca gcagctacct ggccaaggct gaccagaaga gaggcaagaa
      601 acagacagcc cgggaaatga aaaagaagat tcttgccgaa aggcgcaagc ctctgaacat
      661 tgaccatctt agcgatgaca agctgaggga caaggccaag gaactctggg ataccttgta
      721 ccaactggag actgacaaat tcgagtttgg ggagaagctg aaacgtcaga aatatgatat
      781 caccaccctc aggagccgca ttgaccaagc ccagaagcac agcaagaagg ccggtgccac
      841 agccaagggc aaagtcggtg ggcgctggaa gtaaaagagc agagaggtgc actgcagcag
      901 agaccatcaa ccctgactcc tgccagggcc ccttattcca gctctgcact ctccagcctt
      961 cacgcccagg catctttggg aactcaggac ccaccctgct gcaatgccct caccttctgg
     1021 ggtctaggaa taaagttatc agactcccct ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1081 a
//
