LOCUS       NM_001130181            1195 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus troponin T2, cardiac (Tnnt2), transcript variant 8,
            mRNA.
ACCESSION   NM_001130181
VERSION     NM_001130181.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1195)
  AUTHORS   Fujiwara,K., Inoue,T., Kimoto,A., Zixian,J., Tokuhiro,K.,
            Yasukochi,Y., Akama,T.O., Cai,C.L., Shiojima,I., Kimura,H.,
            Yoshimura,S.H., Nakamura,T. and Hirai,M.
  TITLE     Spatial organizations of heterochromatin underpin nuclear
            structural integrity of ventricular cardiomyocytes against
            mechanical stress
  JOURNAL   Cell Rep 43 (12), 115048 (2024)
   PUBMED   39656588
REFERENCE   2  (bases 1 to 1195)
  AUTHORS   Cano-Carrillo,S., Garcia-Padilla,C., Aranega,A.E.,
            Lozano-Velasco,E. and Franco,D.
  TITLE     Mef2c- and Nkx2-5-Divergent Transcriptional Regulation of Chick
            WT1_76127 and Mouse Gm14014 lncRNAs and Their Implication in
            Epicardial Cell Migration
  JOURNAL   Int J Mol Sci 25 (23), 12904 (2024)
   PUBMED   39684625
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1195)
  AUTHORS   Argiro,L., Chevalier,C., Choquet,C., Nandkishore,N., Ghata,A.,
            Baudot,A., Zaffran,S. and Lescroart,F.
  TITLE     Gastruloids are competent to specify both cardiac and skeletal
            muscle lineages
  JOURNAL   Nat Commun 15 (1), 10172 (2024)
   PUBMED   39580459
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1195)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   5  (bases 1 to 1195)
  AUTHORS   Jeyarajah,M.J., Patterson,V.S., Jaju Bhattad,G., Zhao,L.,
            Whitehead,S.N. and Renaud,S.J.
  TITLE     Placental extracellular vesicles promote cardiomyocyte maturation
            and fetal heart development
  JOURNAL   Commun Biol 7 (1), 1254 (2024)
   PUBMED   39363116
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1195)
  AUTHORS   Wang,D.Z., Reiter,R.S., Lin,J.L., Wang,Q., Williams,H.S.,
            Krob,S.L., Schultheiss,T.M., Evans,S. and Lin,J.J.
  TITLE     Requirement of a novel gene, Xin, in cardiac morphogenesis
  JOURNAL   Development 126 (6), 1281-1294 (1999)
   PUBMED   10021346
REFERENCE   7  (bases 1 to 1195)
  AUTHORS   Tardiff,J.C., Factor,S.M., Tompkins,B.D., Hewett,T.E., Palmer,B.M.,
            Moore,R.L., Schwartz,S., Robbins,J. and Leinwand,L.A.
  TITLE     A truncated cardiac troponin T molecule in transgenic mice suggests
            multiple cellular mechanisms for familial hypertrophic
            cardiomyopathy
  JOURNAL   J Clin Invest 101 (12), 2800-2811 (1998)
   PUBMED   9637714
REFERENCE   8  (bases 1 to 1195)
  AUTHORS   Jin,J.P., Wang,J. and Zhang,J.
  TITLE     Expression of cDNAs encoding mouse cardiac troponin T isoforms:
            characterization of a large sample of independent clones
  JOURNAL   Gene 168 (2), 217-221 (1996)
   PUBMED   8654947
REFERENCE   9  (bases 1 to 1195)
  AUTHORS   Jin,J.P., Zhang,J. and Wang,J.
  TITLE     An embryonic alternative transcription initiation site and the
            5'-upstream structure of mouse cardiac troponin T gene
  JOURNAL   Biochem Biophys Res Commun 214 (3), 1168-1174 (1995)
   PUBMED   7575526
REFERENCE   10 (bases 1 to 1195)
  AUTHORS   Chen,Z., Friedrich,G.A. and Soriano,P.
  TITLE     Transcriptional enhancer factor 1 disruption by a retroviral gene
            trap leads to heart defects and embryonic lethality in mice
  JOURNAL   Genes Dev 8 (19), 2293-2301 (1994)
   PUBMED   7958896
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162441.11 and L47551.1.
            
            On Jun 16, 2012 this sequence version replaced NM_001130181.1.
            
            Transcript Variant: This variant (8) has multiple differences in
            the coding region, compared to variant 1. The encoded isoform (i)
            is longer than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849383,
                              SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AC162441.11        41560-41643         c
            85-1187             L47551.1           1-1103
            1188-1195           AC162441.11        25709-25716         c
FEATURES             Location/Qualifiers
     source          1..1195
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 59.32 cM"
     gene            1..1195
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /note="troponin T2, cardiac"
                     /db_xref="GeneID:21956"
                     /db_xref="MGI:MGI:104597"
     exon            1..113
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..999
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /note="isoform i is encoded by transcript variant 8;
                     troponin T, cardiac muscle; tnTc; cardiac muscle troponin
                     T; cardiac TnT"
                     /codon_start=1
                     /product="troponin T, cardiac muscle isoform i"
                     /protein_id="NP_001123653.4"
                     /db_xref="GeneID:21956"
                     /db_xref="MGI:MGI:104597"
                     /translation="MPCPQPVPAEAEQIPQDLCAVPVQRAESMSDAEEVVEEYEEEQE
                     EQEEAVEEEEAGGAEPEPEGEAETEEANVEEVGPDEEAKDAEEGPVEDTKPKPSRLFM
                     PNLVPPKIPDGERVDFDDIHRKRVEKDLNELQTLIEAHFENRKKEEEELISLKDRIEK
                     RRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGY
                     IQKQAQTERKSGKRQTEREKKKKILAERRKALAIDHLNEDQLREKAKELWQSIHNLEA
                     EKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK"
     exon            114..161
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            162..172
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            173..262
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            263..298
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            299..332
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            333..396
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            397..513
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            514..591
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            592..702
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            703..711
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            712..821
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            822..912
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            913..953
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1195
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1167..1172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /note="hexamer: AATAAA"
     polyA_site      1188
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /note="major polyA site"
ORIGIN      
        1 acaaggcccc agcccacatg cctgcttaaa gctctcccca tgccctgccc tcagccagtc
       61 cctgctgagg ctgaacagat acctcaagac ctgtgtgcag tccctgttca gagagccgag
      121 agcatgtctg acgccgagga ggtggtggag gagtacgagg aggaacagga agagcaagag
      181 gaggcagtgg aggaggagga ggctggtggg gctgaacctg agcctgaggg tgaggctgag
      241 acagaggagg ccaacgtaga agaggttggt cctgatgaag aagccaaaga tgctgaagaa
      301 ggtccagtag aggacaccaa acccaagccc agcaggctct tcatgcccaa cttggtgcca
      361 cccaagatcc ccgatggaga gagagtggac tttgatgaca tccacaggaa gcgcgtggag
      421 aaggacctga atgagctaca gactctgatc gaggctcact tcgagaacag gaagaaggag
      481 gaagaggagc tgatttccct caaagacagg atcgaaaagc gtcgggcaga gcgggccgag
      541 cagcagcgta ttcgcaatga gcgggagaag gaaaggcaga accgcctggc tgaagagagg
      601 gcccggcgtg aggaggagga gaacaggagg aaggctgagg atgaggcccg gaagaagaag
      661 gctctgtcca acatgatgca ctttggaggg tacatccaga agcaagctca gacagagcgg
      721 aagagtggga agagacagac agagagagag aagaagaaga agatcctggc agagaggagg
      781 aaggcgctgg ccatcgacca cctgaatgaa gaccaactga gagagaaggc caaggagctg
      841 tggcagagta ttcacaacct ggaggctgag aagttcgacc tgcaggaaaa gttcaagcag
      901 cagaaatacg aaatcaacgt tctgcgaaac cggatcaatg acaaccagaa agtctccaaa
      961 actcgtggga aggccaaagt caccgggcgt tggaaataga tgaaactgtt ctcgtcaaag
     1021 ctgtgccccc tgcttgtgtc cttgccccgt gcatcccagc tctgggtcct ccttggcacc
     1081 caatgcagac tcctgtttgg atagtgggag ctggcttagc tagaagccag tactctgcct
     1141 gacccctatg cccgcactat gccagcaata aaaagccaac acactgcaca tatgg
//
