LOCUS       NM_001130178            1211 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus troponin T2, cardiac (Tnnt2), transcript variant 5,
            mRNA.
ACCESSION   NM_001130178 NM_001136083
VERSION     NM_001130178.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1211)
  AUTHORS   Fujiwara,K., Inoue,T., Kimoto,A., Zixian,J., Tokuhiro,K.,
            Yasukochi,Y., Akama,T.O., Cai,C.L., Shiojima,I., Kimura,H.,
            Yoshimura,S.H., Nakamura,T. and Hirai,M.
  TITLE     Spatial organizations of heterochromatin underpin nuclear
            structural integrity of ventricular cardiomyocytes against
            mechanical stress
  JOURNAL   Cell Rep 43 (12), 115048 (2024)
   PUBMED   39656588
REFERENCE   2  (bases 1 to 1211)
  AUTHORS   Cano-Carrillo,S., Garcia-Padilla,C., Aranega,A.E.,
            Lozano-Velasco,E. and Franco,D.
  TITLE     Mef2c- and Nkx2-5-Divergent Transcriptional Regulation of Chick
            WT1_76127 and Mouse Gm14014 lncRNAs and Their Implication in
            Epicardial Cell Migration
  JOURNAL   Int J Mol Sci 25 (23), 12904 (2024)
   PUBMED   39684625
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1211)
  AUTHORS   Argiro,L., Chevalier,C., Choquet,C., Nandkishore,N., Ghata,A.,
            Baudot,A., Zaffran,S. and Lescroart,F.
  TITLE     Gastruloids are competent to specify both cardiac and skeletal
            muscle lineages
  JOURNAL   Nat Commun 15 (1), 10172 (2024)
   PUBMED   39580459
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1211)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   5  (bases 1 to 1211)
  AUTHORS   Jeyarajah,M.J., Patterson,V.S., Jaju Bhattad,G., Zhao,L.,
            Whitehead,S.N. and Renaud,S.J.
  TITLE     Placental extracellular vesicles promote cardiomyocyte maturation
            and fetal heart development
  JOURNAL   Commun Biol 7 (1), 1254 (2024)
   PUBMED   39363116
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1211)
  AUTHORS   Wang,D.Z., Reiter,R.S., Lin,J.L., Wang,Q., Williams,H.S.,
            Krob,S.L., Schultheiss,T.M., Evans,S. and Lin,J.J.
  TITLE     Requirement of a novel gene, Xin, in cardiac morphogenesis
  JOURNAL   Development 126 (6), 1281-1294 (1999)
   PUBMED   10021346
REFERENCE   7  (bases 1 to 1211)
  AUTHORS   Tardiff,J.C., Factor,S.M., Tompkins,B.D., Hewett,T.E., Palmer,B.M.,
            Moore,R.L., Schwartz,S., Robbins,J. and Leinwand,L.A.
  TITLE     A truncated cardiac troponin T molecule in transgenic mice suggests
            multiple cellular mechanisms for familial hypertrophic
            cardiomyopathy
  JOURNAL   J Clin Invest 101 (12), 2800-2811 (1998)
   PUBMED   9637714
REFERENCE   8  (bases 1 to 1211)
  AUTHORS   Jin,J.P., Wang,J. and Zhang,J.
  TITLE     Expression of cDNAs encoding mouse cardiac troponin T isoforms:
            characterization of a large sample of independent clones
  JOURNAL   Gene 168 (2), 217-221 (1996)
   PUBMED   8654947
REFERENCE   9  (bases 1 to 1211)
  AUTHORS   Jin,J.P., Zhang,J. and Wang,J.
  TITLE     An embryonic alternative transcription initiation site and the
            5'-upstream structure of mouse cardiac troponin T gene
  JOURNAL   Biochem Biophys Res Commun 214 (3), 1168-1174 (1995)
   PUBMED   7575526
REFERENCE   10 (bases 1 to 1211)
  AUTHORS   Chen,Z., Friedrich,G.A. and Soriano,P.
  TITLE     Transcriptional enhancer factor 1 disruption by a retroviral gene
            trap leads to heart defects and embryonic lethality in mice
  JOURNAL   Genes Dev 8 (19), 2293-2301 (1994)
   PUBMED   7958896
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162441.11, BQ554639.1 and AK169061.1.
            
            On or before Jun 16, 2012 this sequence version replaced
            NM_001136083.1, NM_001130178.1.
            
            Transcript Variant: This variant (5) lacks an alternate in-frame
            exon in the 5' coding region, and includes an alternate in-frame
            exon in the 3' coding region, compared to variant 1. The encoded
            isoform (d) is shorter than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169061.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AC162441.11        41575-41643         c
            70-668              BQ554639.1         6-604
            669-1203            AK169061.1         615-1149
            1204-1211           AC162441.11        25709-25716         c
FEATURES             Location/Qualifiers
     source          1..1211
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 59.32 cM"
     gene            1..1211
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /note="troponin T2, cardiac"
                     /db_xref="GeneID:21956"
                     /db_xref="MGI:MGI:104597"
     exon            1..113
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            114..165
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1015
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /note="isoform d is encoded by transcript variant 5;
                     troponin T, cardiac muscle; tnTc; cardiac muscle troponin
                     T; cardiac TnT"
                     /codon_start=1
                     /product="troponin T, cardiac muscle isoform d"
                     /protein_id="NP_001123650.1"
                     /db_xref="CCDS:CCDS48376.1"
                     /db_xref="GeneID:21956"
                     /db_xref="MGI:MGI:104597"
                     /translation="MSDAEEVVEEYEEEQEEAVEEQEEAVEEEEAGGAEPEPEGEAET
                     EEANVEEVGPDEEAKDAEEGPVEDTKPKPSRLFMPNLVPPKIPDGERVDFDDIHRKRV
                     EKDLNELQTLIEAHFENRKKEEEELISLKDRIEKRRAERAEQQRIRNEREKERQNRLA
                     EERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKI
                     LAERRKALAIDHLNEDQLREKAKELWQSIHNLEAEKFDLQEKFKQQKYEINVLRNRIN
                     DNQKVSKTRGKAKVTGRWK"
     exon            166..176
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            177..188
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            189..278
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            279..314
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            315..348
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            349..412
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            413..529
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            530..607
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            608..718
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            719..727
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            728..837
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            838..928
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            929..969
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1211
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1183..1188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /note="hexamer: AATAAA"
     polyA_site      1204
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /note="major polyA site"
ORIGIN      
        1 acaaggcccc agcccacatg cctgcttaaa gctctcccca tgccctgccc tcagccagtc
       61 cctgctgagg ctgaacagat acctcaagac ctgtgtgcag tccctgttca gagggagagc
      121 cgagagcatg tctgacgccg aggaggtggt ggaggagtac gaggaggaac aggaagaagc
      181 tgtggaagag caagaggagg cagtggagga ggaggaggct ggtggggctg aacctgagcc
      241 tgagggtgag gctgagacag aggaggccaa cgtagaagag gttggtcctg atgaagaagc
      301 caaagatgct gaagaaggtc cagtagagga caccaaaccc aagcccagca ggctcttcat
      361 gcccaacttg gtgccaccca agatccccga tggagagaga gtggactttg atgacatcca
      421 caggaagcgc gtggagaagg acctgaatga gctacagact ctgatcgagg ctcacttcga
      481 gaacaggaag aaggaggaag aggagctgat ttccctcaaa gacaggatcg aaaagcgtcg
      541 ggcagagcgg gccgagcagc agcgtattcg caatgagcgg gagaaggaaa ggcagaaccg
      601 cctggctgaa gagagggccc ggcgtgagga ggaggagaac aggaggaagg ctgaggatga
      661 ggcccggaag aagaaggctc tgtccaacat gatgcacttt ggagggtaca tccagaagca
      721 agctcagaca gagcggaaga gtgggaagag acagacagag agagagaaga agaagaagat
      781 cctggcagag aggaggaagg cgctggccat cgaccacctg aatgaagacc aactgagaga
      841 gaaggccaag gagctgtggc agagtattca caacctggag gctgagaagt tcgacctgca
      901 ggaaaagttc aagcagcaga aatacgaaat caacgttctg cgaaaccgga tcaatgacaa
      961 ccagaaagtc tccaaaactc gtgggaaggc caaagtcacc gggcgttgga aatagatgaa
     1021 actgttctcg tcaaagctgt gccccctgct tgtgtccttg ccccgtgcat cccagctctg
     1081 ggtcctcctt ggcacccaat gcagactcct gtttggatag tgggagctgg cttagctaga
     1141 agccagtact ctgcctgacc cctatgcccg cactatgcca gcaataaaaa gccaacacac
     1201 tgcacatatg g
//
