LOCUS       NM_001417402             958 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus troponin T1, skeletal, slow (Tnnt1), transcript
            variant 6, mRNA.
ACCESSION   NM_001417402
VERSION     NM_001417402.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 958)
  AUTHORS   Hashimoto,K., Ohira,M., Kodama,A., Kimoto,M., Inoue,M., Tone,S.,
            Usui,Y., Hanashima,A., Goto,T., Ogura,Y., Ujihara,Y. and Mohri,S.
  TITLE     Loss of connectin novex-3 leads to heart dysfunction associated
            with impaired cardiomyocyte proliferation and abnormal nuclear
            mechanics
  JOURNAL   Sci Rep 14 (1), 13727 (2024)
   PUBMED   38877142
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 958)
  AUTHORS   Robbe,Z.L., Shi,W., Wasson,L.K., Scialdone,A.P., Wilczewski,C.M.,
            Sheng,X., Hepperla,A.J., Akerberg,B.N., Pu,W.T., Cristea,I.M.,
            Davis,I.J. and Conlon,F.L.
  TITLE     CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene
            programs in the developing heart
  JOURNAL   Genes Dev 36 (7-8), 468-482 (2022)
   PUBMED   35450884
REFERENCE   3  (bases 1 to 958)
  AUTHORS   Wu,T., Liang,Z., Zhang,Z., Liu,C., Zhang,L., Gu,Y., Peterson,K.L.,
            Evans,S.M., Fu,X.D. and Chen,J.
  TITLE     PRDM16 Is a Compact Myocardium-Enriched Transcription Factor
            Required to Maintain Compact Myocardial Cardiomyocyte Identity in
            Left Ventricle
  JOURNAL   Circulation 145 (8), 586-602 (2022)
   PUBMED   34915728
REFERENCE   4  (bases 1 to 958)
  AUTHORS   Doll,C.F., Pereira,N.J., Hashimi,M.S., Grindrod,T.J.,
            Alkassis,F.F., Cai,L.X., Milovanovic,U., Sandino,A.I. and
            Kasahara,H.
  TITLE     Gestational intermittent hyperoxia rescues murine genetic
            congenital heart disease in part
  JOURNAL   Sci Rep 11 (1), 6608 (2021)
   PUBMED   33758249
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 958)
  AUTHORS   Barton,P.J., Mullen,A.J., Cullen,M.E., Dhoot,G.K.,
            Simon-Chazottes,D. and Guenet,J.L.
  TITLE     Genes encoding troponin I and troponin T are organized as three
            paralogous pairs in the mouse genome
  JOURNAL   Mamm Genome 11 (10), 926-929 (2000)
   PUBMED   11003710
REFERENCE   6  (bases 1 to 958)
  AUTHORS   Huang,Q.Q. and Jin,J.P.
  TITLE     Preserved close linkage between the genes encoding troponin I and
            troponin T, reflecting an evolution of adapter proteins coupling
            the Ca(2+) signaling of contractility
  JOURNAL   J Mol Evol 49 (6), 780-788 (1999)
   PUBMED   10594179
REFERENCE   7  (bases 1 to 958)
  AUTHORS   Tardiff,J.C., Hewett,T.E., Palmer,B.M., Olsson,C., Factor,S.M.,
            Moore,R.L., Robbins,J. and Leinwand,L.A.
  TITLE     Cardiac troponin T mutations result in allele-specific phenotypes
            in a mouse model for hypertrophic cardiomyopathy
  JOURNAL   J Clin Invest 104 (4), 469-481 (1999)
   PUBMED   10449439
REFERENCE   8  (bases 1 to 958)
  AUTHORS   Huang,Q.Q., Chen,A. and Jin,J.P.
  TITLE     Genomic sequence and structural organization of mouse slow skeletal
            muscle troponin T gene
  JOURNAL   Gene 229 (1-2), 1-10 (1999)
   PUBMED   10095098
REFERENCE   9  (bases 1 to 958)
  AUTHORS   Jin,J.P., Chen,A. and Huang,Q.Q.
  TITLE     Three alternatively spliced mouse slow skeletal muscle troponin T
            isoforms: conserved primary structure and regulated expression
            during postnatal development
  JOURNAL   Gene 214 (1-2), 121-129 (1998)
   PUBMED   9651500
REFERENCE   10 (bases 1 to 958)
  AUTHORS   Koch,A., Juan,T.S., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.,
            McNiece,I.K. and Fletcher,F.A.
  TITLE     cDNA cloning and chromosomal mapping of mouse fast skeletal muscle
            troponin T
  JOURNAL   Mamm Genome 8 (5), 346-348 (1997)
   PUBMED   9107680
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC161218.10.
            
            Summary: This gene encodes the slow skeletal tropomyosin-binding
            subunit of the troponin complex and plays an essential role in the
            regulation of striated muscle contraction. In humans, mutations in
            this gene are associated with nemaline myopathy type 5. Alternative
            splicing of this gene results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Apr 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB587978.1, AK003317.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-370               AC161218.10        124914-125283       c
            371-484             AC161218.10        124367-124480       c
            485-594             AC161218.10        123830-123939       c
            595-685             AC161218.10        122878-122968       c
            686-726             AC161218.10        122739-122779       c
            727-958             AC161218.10        119925-120156       c
FEATURES             Location/Qualifiers
     source          1..958
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.6 cM"
     gene            1..958
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /note="troponin T1, skeletal, slow"
                     /db_xref="GeneID:21955"
                     /db_xref="MGI:MGI:1333868"
     exon            1..370
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            371..484
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     CDS             380..772
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /note="isoform 6 is encoded by transcript variant 6;
                     troponin T, slow skeletal muscle; skeletal muscle
                     slow-twitch TnT"
                     /codon_start=1
                     /product="troponin T, slow skeletal muscle isoform 6"
                     /protein_id="NP_001404331.1"
                     /db_xref="GeneID:21955"
                     /db_xref="MGI:MGI:1333868"
                     /translation="MRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQ
                     TGREMKLRILSERKKPLNIDYMGEDQLREKAQELSEWIHQLESEKFDLMEKLKQQKYE
                     INVLYNRISHAQKFRKGAGKGRVGGRWK"
     exon            485..594
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            595..685
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            686..726
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            727..958
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      938..943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /note="hexamer: ATTAAA"
     polyA_site      958
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /note="major polyA site"
ORIGIN      
        1 agttacatct atctcccgtt ccctccctcc atgtagtgct ttggggtctc tgggagaaac
       61 agcggggaca ttgggcgggt ccactccagt atccatttct accaggagtg cattttggag
      121 gcggaggcag gaagattacc atgagttcga gagactgtct caaaaaggac aattaaataa
      181 aagaaactat ccttatttcg ttcgtctact ggtggaggga caacttgtgg gaggggatag
      241 cctccaagaa cccccacatt ccctgcccca atcttcccct taatacccct aggagaggcg
      301 acgcgcagag agagctgagc aacagcgctt cagaacggaa aaggagcgag aacgccaggc
      361 caagctggcg gaggagaaga tgcggaagga ggaggaggag gcaaagaaga gagcagagga
      421 tgacgccaag aagaagaaag ttctgtccaa catgggagct cattttgggg gctacctggt
      481 caaggcagaa cagaagcgtg ggaagcgaca gactggtcgg gagatgaaac tccggattct
      541 gtctgagagg aaaaagccct tgaacatcga ctacatgggg gaggaccagc tccgggaaaa
      601 ggcccaggag ctgtcagaat ggatccacca gctggaatca gaaaaatttg acctgatgga
      661 gaagttgaag caacagaaat atgagatcaa tgtgctctac aaccgcatca gccacgccca
      721 gaaattccga aagggggctg ggaagggtcg agttggaggc cgctggaagt gagactgcca
      781 ggacatgacc tgctgtgtgg agcccaggag ccactggagc gtgtcccatc tgtaactcaa
      841 aataaagtgc ccccaggcat ctgcttaagt tcttcagggt tgttattatg tgggttgatc
      901 gacatctcca tactgcctgg gagagccatc aactgtcatt aaagagagtt caagttca
//
