LOCUS       NM_001360154             997 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus troponin T1, skeletal, slow (Tnnt1), transcript
            variant 4, mRNA.
ACCESSION   NM_001360154 XM_006539726
VERSION     NM_001360154.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 997)
  AUTHORS   Hashimoto,K., Ohira,M., Kodama,A., Kimoto,M., Inoue,M., Tone,S.,
            Usui,Y., Hanashima,A., Goto,T., Ogura,Y., Ujihara,Y. and Mohri,S.
  TITLE     Loss of connectin novex-3 leads to heart dysfunction associated
            with impaired cardiomyocyte proliferation and abnormal nuclear
            mechanics
  JOURNAL   Sci Rep 14 (1), 13727 (2024)
   PUBMED   38877142
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 997)
  AUTHORS   Robbe,Z.L., Shi,W., Wasson,L.K., Scialdone,A.P., Wilczewski,C.M.,
            Sheng,X., Hepperla,A.J., Akerberg,B.N., Pu,W.T., Cristea,I.M.,
            Davis,I.J. and Conlon,F.L.
  TITLE     CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene
            programs in the developing heart
  JOURNAL   Genes Dev 36 (7-8), 468-482 (2022)
   PUBMED   35450884
REFERENCE   3  (bases 1 to 997)
  AUTHORS   Wu,T., Liang,Z., Zhang,Z., Liu,C., Zhang,L., Gu,Y., Peterson,K.L.,
            Evans,S.M., Fu,X.D. and Chen,J.
  TITLE     PRDM16 Is a Compact Myocardium-Enriched Transcription Factor
            Required to Maintain Compact Myocardial Cardiomyocyte Identity in
            Left Ventricle
  JOURNAL   Circulation 145 (8), 586-602 (2022)
   PUBMED   34915728
REFERENCE   4  (bases 1 to 997)
  AUTHORS   Doll,C.F., Pereira,N.J., Hashimi,M.S., Grindrod,T.J.,
            Alkassis,F.F., Cai,L.X., Milovanovic,U., Sandino,A.I. and
            Kasahara,H.
  TITLE     Gestational intermittent hyperoxia rescues murine genetic
            congenital heart disease in part
  JOURNAL   Sci Rep 11 (1), 6608 (2021)
   PUBMED   33758249
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 997)
  AUTHORS   Barton,P.J., Mullen,A.J., Cullen,M.E., Dhoot,G.K.,
            Simon-Chazottes,D. and Guenet,J.L.
  TITLE     Genes encoding troponin I and troponin T are organized as three
            paralogous pairs in the mouse genome
  JOURNAL   Mamm Genome 11 (10), 926-929 (2000)
   PUBMED   11003710
REFERENCE   6  (bases 1 to 997)
  AUTHORS   Huang,Q.Q. and Jin,J.P.
  TITLE     Preserved close linkage between the genes encoding troponin I and
            troponin T, reflecting an evolution of adapter proteins coupling
            the Ca(2+) signaling of contractility
  JOURNAL   J Mol Evol 49 (6), 780-788 (1999)
   PUBMED   10594179
REFERENCE   7  (bases 1 to 997)
  AUTHORS   Tardiff,J.C., Hewett,T.E., Palmer,B.M., Olsson,C., Factor,S.M.,
            Moore,R.L., Robbins,J. and Leinwand,L.A.
  TITLE     Cardiac troponin T mutations result in allele-specific phenotypes
            in a mouse model for hypertrophic cardiomyopathy
  JOURNAL   J Clin Invest 104 (4), 469-481 (1999)
   PUBMED   10449439
REFERENCE   8  (bases 1 to 997)
  AUTHORS   Huang,Q.Q., Chen,A. and Jin,J.P.
  TITLE     Genomic sequence and structural organization of mouse slow skeletal
            muscle troponin T gene
  JOURNAL   Gene 229 (1-2), 1-10 (1999)
   PUBMED   10095098
REFERENCE   9  (bases 1 to 997)
  AUTHORS   Jin,J.P., Chen,A. and Huang,Q.Q.
  TITLE     Three alternatively spliced mouse slow skeletal muscle troponin T
            isoforms: conserved primary structure and regulated expression
            during postnatal development
  JOURNAL   Gene 214 (1-2), 121-129 (1998)
   PUBMED   9651500
REFERENCE   10 (bases 1 to 997)
  AUTHORS   Koch,A., Juan,T.S., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.,
            McNiece,I.K. and Fletcher,F.A.
  TITLE     cDNA cloning and chromosomal mapping of mouse fast skeletal muscle
            troponin T
  JOURNAL   Mamm Genome 8 (5), 346-348 (1997)
   PUBMED   9107680
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC161218.10.
            
            On Jan 27, 2018 this sequence version replaced XM_006539726.3.
            
            Summary: This gene encodes the slow skeletal tropomyosin-binding
            subunit of the troponin complex and plays an essential role in the
            regulation of striated muscle contraction. In humans, mutations in
            this gene are associated with nemaline myopathy type 5. Alternative
            splicing of this gene results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Apr 2013].
            
            Transcript Variant: This variant (4) lacks an alternate in-frame
            exon in the 5' coding region compared to variant 1. This results in
            a shorter protein (isoform 4), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164137,
                              SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC161218.10        131287-131331       c
            46-88               AC161218.10        129693-129735       c
            89-102              AC161218.10        129569-129582       c
            103-129             AC161218.10        129167-129193       c
            130-151             AC161218.10        127621-127642       c
            152-215             AC161218.10        125673-125736       c
            216-332             AC161218.10        125308-125424       c
            333-410             AC161218.10        124914-124991       c
            411-524             AC161218.10        124367-124480       c
            525-634             AC161218.10        123830-123939       c
            635-725             AC161218.10        122878-122968       c
            726-766             AC161218.10        122739-122779       c
            767-997             AC161218.10        119926-120156       c
FEATURES             Location/Qualifiers
     source          1..997
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.6 cM"
     gene            1..997
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /note="troponin T1, skeletal, slow"
                     /db_xref="GeneID:21955"
                     /db_xref="MGI:MGI:1333868"
     exon            1..45
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            46..88
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..812
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /note="isoform 4 is encoded by transcript variant 4;
                     troponin T, slow skeletal muscle; skeletal muscle
                     slow-twitch TnT"
                     /codon_start=1
                     /product="troponin T, slow skeletal muscle isoform 4"
                     /protein_id="NP_001347083.1"
                     /db_xref="GeneID:21955"
                     /db_xref="MGI:MGI:1333868"
                     /translation="MSDTEEQEYEEEQAEDEEAVEEEEEEERPKPSRPVVPPLIPPKI
                     PEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELIALKDRIERRRAERAEQ
                     QRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQK
                     RGKRQTGREMKLRILSERKKPLNIDYMGEDQLREKAQELSEWIHQLESEKFDLMEKLK
                     QQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK"
     exon            89..102
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            103..129
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            130..151
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            152..215
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            216..332
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            333..410
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            411..524
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            525..634
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            635..725
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            726..766
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            767..997
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagcctca gactccctct acagcatctg tggacccagc cttaggtctc tccaggatgt
       61 cagacaccga agaacaagaa tatgaggagg agcaggcaga agatgaggaa gcggtggagg
      121 aggaggaaga agaagagcgc cccaaaccca gccgtcctgt ggtgcctcct ttgattcccc
      181 cgaagattcc agaaggggag cgtgtggatt ttgatgacat ccaccggaag cgcatggaga
      241 aagacttact ggagctgcag acgctcatcg acgtgcactt tgaacagcgg aaaaaggagg
      301 aggaagagct cattgcacta aaagaccgca ttgagaggcg acgcgcagag agagctgagc
      361 aacagcgctt cagaacggaa aaggagcgag aacgccaggc caagctggcg gaggagaaga
      421 tgcggaagga ggaggaggag gcaaagaaga gagcagagga tgacgccaag aagaagaaag
      481 ttctgtccaa catgggagct cattttgggg gctacctggt caaggcagaa cagaagcgtg
      541 ggaagcgaca gactggtcgg gagatgaaac tccggattct gtctgagagg aaaaagccct
      601 tgaacatcga ctacatgggg gaggaccagc tccgggaaaa ggcccaggag ctgtcagaat
      661 ggatccacca gctggaatca gaaaaatttg acctgatgga gaagttgaag caacagaaat
      721 atgagatcaa tgtgctctac aaccgcatca gccacgccca gaaattccga aagggggctg
      781 ggaagggtcg agttggaggc cgctggaagt gagactgcca ggacatgacc tgctgtgtgg
      841 agcccaggag ccactggagc gtgtcccatc tgtaactcaa aataaagtgc ccccaggcat
      901 ctgcttaagt tcttcagggt tgttattatg tgggttgatc gacatctcca tactgcctgg
      961 gagagccatc aactgtcatt aaagagagtt caagttc
//
