LOCUS       NM_001277904             994 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus troponin T1, skeletal, slow (Tnnt1), transcript
            variant 3, mRNA.
ACCESSION   NM_001277904
VERSION     NM_001277904.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 994)
  AUTHORS   Hashimoto,K., Ohira,M., Kodama,A., Kimoto,M., Inoue,M., Tone,S.,
            Usui,Y., Hanashima,A., Goto,T., Ogura,Y., Ujihara,Y. and Mohri,S.
  TITLE     Loss of connectin novex-3 leads to heart dysfunction associated
            with impaired cardiomyocyte proliferation and abnormal nuclear
            mechanics
  JOURNAL   Sci Rep 14 (1), 13727 (2024)
   PUBMED   38877142
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 994)
  AUTHORS   Robbe,Z.L., Shi,W., Wasson,L.K., Scialdone,A.P., Wilczewski,C.M.,
            Sheng,X., Hepperla,A.J., Akerberg,B.N., Pu,W.T., Cristea,I.M.,
            Davis,I.J. and Conlon,F.L.
  TITLE     CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene
            programs in the developing heart
  JOURNAL   Genes Dev 36 (7-8), 468-482 (2022)
   PUBMED   35450884
REFERENCE   3  (bases 1 to 994)
  AUTHORS   Wu,T., Liang,Z., Zhang,Z., Liu,C., Zhang,L., Gu,Y., Peterson,K.L.,
            Evans,S.M., Fu,X.D. and Chen,J.
  TITLE     PRDM16 Is a Compact Myocardium-Enriched Transcription Factor
            Required to Maintain Compact Myocardial Cardiomyocyte Identity in
            Left Ventricle
  JOURNAL   Circulation 145 (8), 586-602 (2022)
   PUBMED   34915728
REFERENCE   4  (bases 1 to 994)
  AUTHORS   Doll,C.F., Pereira,N.J., Hashimi,M.S., Grindrod,T.J.,
            Alkassis,F.F., Cai,L.X., Milovanovic,U., Sandino,A.I. and
            Kasahara,H.
  TITLE     Gestational intermittent hyperoxia rescues murine genetic
            congenital heart disease in part
  JOURNAL   Sci Rep 11 (1), 6608 (2021)
   PUBMED   33758249
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 994)
  AUTHORS   Barton,P.J., Mullen,A.J., Cullen,M.E., Dhoot,G.K.,
            Simon-Chazottes,D. and Guenet,J.L.
  TITLE     Genes encoding troponin I and troponin T are organized as three
            paralogous pairs in the mouse genome
  JOURNAL   Mamm Genome 11 (10), 926-929 (2000)
   PUBMED   11003710
REFERENCE   6  (bases 1 to 994)
  AUTHORS   Huang,Q.Q. and Jin,J.P.
  TITLE     Preserved close linkage between the genes encoding troponin I and
            troponin T, reflecting an evolution of adapter proteins coupling
            the Ca(2+) signaling of contractility
  JOURNAL   J Mol Evol 49 (6), 780-788 (1999)
   PUBMED   10594179
REFERENCE   7  (bases 1 to 994)
  AUTHORS   Tardiff,J.C., Hewett,T.E., Palmer,B.M., Olsson,C., Factor,S.M.,
            Moore,R.L., Robbins,J. and Leinwand,L.A.
  TITLE     Cardiac troponin T mutations result in allele-specific phenotypes
            in a mouse model for hypertrophic cardiomyopathy
  JOURNAL   J Clin Invest 104 (4), 469-481 (1999)
   PUBMED   10449439
REFERENCE   8  (bases 1 to 994)
  AUTHORS   Huang,Q.Q., Chen,A. and Jin,J.P.
  TITLE     Genomic sequence and structural organization of mouse slow skeletal
            muscle troponin T gene
  JOURNAL   Gene 229 (1-2), 1-10 (1999)
   PUBMED   10095098
REFERENCE   9  (bases 1 to 994)
  AUTHORS   Jin,J.P., Chen,A. and Huang,Q.Q.
  TITLE     Three alternatively spliced mouse slow skeletal muscle troponin T
            isoforms: conserved primary structure and regulated expression
            during postnatal development
  JOURNAL   Gene 214 (1-2), 121-129 (1998)
   PUBMED   9651500
REFERENCE   10 (bases 1 to 994)
  AUTHORS   Koch,A., Juan,T.S., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.,
            McNiece,I.K. and Fletcher,F.A.
  TITLE     cDNA cloning and chromosomal mapping of mouse fast skeletal muscle
            troponin T
  JOURNAL   Mamm Genome 8 (5), 346-348 (1997)
   PUBMED   9107680
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC161218.10.
            
            Summary: This gene encodes the slow skeletal tropomyosin-binding
            subunit of the troponin complex and plays an essential role in the
            regulation of striated muscle contraction. In humans, mutations in
            this gene are associated with nemaline myopathy type 5. Alternative
            splicing of this gene results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Apr 2013].
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon and uses an alternate in-frame splice site in the 5' coding
            region compared to variant 1. This results in a shorter protein
            (isoform 3, also known as low Mr isoform), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U92884.1, BC145450.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC161218.10        131287-131331       c
            46-88               AC161218.10        129693-129735       c
            89-102              AC161218.10        129569-129582       c
            103-129             AC161218.10        129167-129193       c
            130-148             AC161218.10        127621-127639       c
            149-212             AC161218.10        125673-125736       c
            213-329             AC161218.10        125308-125424       c
            330-407             AC161218.10        124914-124991       c
            408-521             AC161218.10        124367-124480       c
            522-631             AC161218.10        123830-123939       c
            632-722             AC161218.10        122878-122968       c
            723-763             AC161218.10        122739-122779       c
            764-994             AC161218.10        119926-120156       c
FEATURES             Location/Qualifiers
     source          1..994
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.6 cM"
     gene            1..994
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /note="troponin T1, skeletal, slow"
                     /db_xref="GeneID:21955"
                     /db_xref="MGI:MGI:1333868"
     exon            1..45
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            46..88
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..809
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /note="isoform 3 is encoded by transcript variant 3;
                     troponin T, slow skeletal muscle; skeletal muscle
                     slow-twitch TnT"
                     /codon_start=1
                     /product="troponin T, slow skeletal muscle isoform 3"
                     /protein_id="NP_001264833.1"
                     /db_xref="CCDS:CCDS71879.1"
                     /db_xref="GeneID:21955"
                     /db_xref="MGI:MGI:1333868"
                     /translation="MSDTEEQEYEEEQAEDEEAVEEEEEERPKPSRPVVPPLIPPKIP
                     EGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELIALKDRIERRRAERAEQQ
                     RFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKR
                     GKRQTGREMKLRILSERKKPLNIDYMGEDQLREKAQELSEWIHQLESEKFDLMEKLKQ
                     QKYEINVLYNRISHAQKFRKGAGKGRVGGRWK"
     exon            89..102
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            103..129
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            130..148
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            149..212
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            213..329
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            330..407
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            408..521
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            522..631
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            632..722
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            723..763
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            764..994
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagcctca gactccctct acagcatctg tggacccagc cttaggtctc tccaggatgt
       61 cagacaccga agaacaagaa tatgaggagg agcaggcaga agatgaggaa gcggtggagg
      121 aggaggaaga agagcgcccc aaacccagcc gtcctgtggt gcctcctttg attcccccga
      181 agattccaga aggggagcgt gtggattttg atgacatcca ccggaagcgc atggagaaag
      241 acttactgga gctgcagacg ctcatcgacg tgcactttga acagcggaaa aaggaggagg
      301 aagagctcat tgcactaaaa gaccgcattg agaggcgacg cgcagagaga gctgagcaac
      361 agcgcttcag aacggaaaag gagcgagaac gccaggccaa gctggcggag gagaagatgc
      421 ggaaggagga ggaggaggca aagaagagag cagaggatga cgccaagaag aagaaagttc
      481 tgtccaacat gggagctcat tttgggggct acctggtcaa ggcagaacag aagcgtggga
      541 agcgacagac tggtcgggag atgaaactcc ggattctgtc tgagaggaaa aagcccttga
      601 acatcgacta catgggggag gaccagctcc gggaaaaggc ccaggagctg tcagaatgga
      661 tccaccagct ggaatcagaa aaatttgacc tgatggagaa gttgaagcaa cagaaatatg
      721 agatcaatgt gctctacaac cgcatcagcc acgcccagaa attccgaaag ggggctggga
      781 agggtcgagt tggaggccgc tggaagtgag actgccagga catgacctgc tgtgtggagc
      841 ccaggagcca ctggagcgtg tcccatctgt aactcaaaat aaagtgcccc caggcatctg
      901 cttaagttct tcagggttgt tattatgtgg gttgatcgac atctccatac tgcctgggag
      961 agccatcaac tgtcattaaa gagagttcaa gttc
//
