LOCUS       NM_001277903            1030 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus troponin T1, skeletal, slow (Tnnt1), transcript
            variant 1, mRNA.
ACCESSION   NM_001277903
VERSION     NM_001277903.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1030)
  AUTHORS   Hashimoto,K., Ohira,M., Kodama,A., Kimoto,M., Inoue,M., Tone,S.,
            Usui,Y., Hanashima,A., Goto,T., Ogura,Y., Ujihara,Y. and Mohri,S.
  TITLE     Loss of connectin novex-3 leads to heart dysfunction associated
            with impaired cardiomyocyte proliferation and abnormal nuclear
            mechanics
  JOURNAL   Sci Rep 14 (1), 13727 (2024)
   PUBMED   38877142
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1030)
  AUTHORS   Robbe,Z.L., Shi,W., Wasson,L.K., Scialdone,A.P., Wilczewski,C.M.,
            Sheng,X., Hepperla,A.J., Akerberg,B.N., Pu,W.T., Cristea,I.M.,
            Davis,I.J. and Conlon,F.L.
  TITLE     CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene
            programs in the developing heart
  JOURNAL   Genes Dev 36 (7-8), 468-482 (2022)
   PUBMED   35450884
REFERENCE   3  (bases 1 to 1030)
  AUTHORS   Wu,T., Liang,Z., Zhang,Z., Liu,C., Zhang,L., Gu,Y., Peterson,K.L.,
            Evans,S.M., Fu,X.D. and Chen,J.
  TITLE     PRDM16 Is a Compact Myocardium-Enriched Transcription Factor
            Required to Maintain Compact Myocardial Cardiomyocyte Identity in
            Left Ventricle
  JOURNAL   Circulation 145 (8), 586-602 (2022)
   PUBMED   34915728
REFERENCE   4  (bases 1 to 1030)
  AUTHORS   Doll,C.F., Pereira,N.J., Hashimi,M.S., Grindrod,T.J.,
            Alkassis,F.F., Cai,L.X., Milovanovic,U., Sandino,A.I. and
            Kasahara,H.
  TITLE     Gestational intermittent hyperoxia rescues murine genetic
            congenital heart disease in part
  JOURNAL   Sci Rep 11 (1), 6608 (2021)
   PUBMED   33758249
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1030)
  AUTHORS   Barton,P.J., Mullen,A.J., Cullen,M.E., Dhoot,G.K.,
            Simon-Chazottes,D. and Guenet,J.L.
  TITLE     Genes encoding troponin I and troponin T are organized as three
            paralogous pairs in the mouse genome
  JOURNAL   Mamm Genome 11 (10), 926-929 (2000)
   PUBMED   11003710
REFERENCE   6  (bases 1 to 1030)
  AUTHORS   Huang,Q.Q. and Jin,J.P.
  TITLE     Preserved close linkage between the genes encoding troponin I and
            troponin T, reflecting an evolution of adapter proteins coupling
            the Ca(2+) signaling of contractility
  JOURNAL   J Mol Evol 49 (6), 780-788 (1999)
   PUBMED   10594179
REFERENCE   7  (bases 1 to 1030)
  AUTHORS   Tardiff,J.C., Hewett,T.E., Palmer,B.M., Olsson,C., Factor,S.M.,
            Moore,R.L., Robbins,J. and Leinwand,L.A.
  TITLE     Cardiac troponin T mutations result in allele-specific phenotypes
            in a mouse model for hypertrophic cardiomyopathy
  JOURNAL   J Clin Invest 104 (4), 469-481 (1999)
   PUBMED   10449439
REFERENCE   8  (bases 1 to 1030)
  AUTHORS   Huang,Q.Q., Chen,A. and Jin,J.P.
  TITLE     Genomic sequence and structural organization of mouse slow skeletal
            muscle troponin T gene
  JOURNAL   Gene 229 (1-2), 1-10 (1999)
   PUBMED   10095098
REFERENCE   9  (bases 1 to 1030)
  AUTHORS   Jin,J.P., Chen,A. and Huang,Q.Q.
  TITLE     Three alternatively spliced mouse slow skeletal muscle troponin T
            isoforms: conserved primary structure and regulated expression
            during postnatal development
  JOURNAL   Gene 214 (1-2), 121-129 (1998)
   PUBMED   9651500
REFERENCE   10 (bases 1 to 1030)
  AUTHORS   Koch,A., Juan,T.S., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.,
            McNiece,I.K. and Fletcher,F.A.
  TITLE     cDNA cloning and chromosomal mapping of mouse fast skeletal muscle
            troponin T
  JOURNAL   Mamm Genome 8 (5), 346-348 (1997)
   PUBMED   9107680
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC161218.10.
            
            Summary: This gene encodes the slow skeletal tropomyosin-binding
            subunit of the troponin complex and plays an essential role in the
            regulation of striated muscle contraction. In humans, mutations in
            this gene are associated with nemaline myopathy type 5. Alternative
            splicing of this gene results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Apr 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF020946.1, BC141142.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC161218.10        131287-131331       c
            46-88               AC161218.10        129693-129735       c
            89-102              AC161218.10        129569-129582       c
            103-129             AC161218.10        129167-129193       c
            130-162             AC161218.10        128937-128969       c
            163-184             AC161218.10        127621-127642       c
            185-248             AC161218.10        125673-125736       c
            249-365             AC161218.10        125308-125424       c
            366-443             AC161218.10        124914-124991       c
            444-557             AC161218.10        124367-124480       c
            558-667             AC161218.10        123830-123939       c
            668-758             AC161218.10        122878-122968       c
            759-799             AC161218.10        122739-122779       c
            800-1030            AC161218.10        119926-120156       c
FEATURES             Location/Qualifiers
     source          1..1030
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.6 cM"
     gene            1..1030
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /note="troponin T1, skeletal, slow"
                     /db_xref="GeneID:21955"
                     /db_xref="MGI:MGI:1333868"
     exon            1..45
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            46..88
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..845
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /note="isoform 1 is encoded by transcript variant 1;
                     troponin T, slow skeletal muscle; skeletal muscle
                     slow-twitch TnT"
                     /codon_start=1
                     /product="troponin T, slow skeletal muscle isoform 1"
                     /protein_id="NP_001264832.1"
                     /db_xref="CCDS:CCDS71880.1"
                     /db_xref="GeneID:21955"
                     /db_xref="MGI:MGI:1333868"
                     /translation="MSDTEEQEYEEEQAEDEEAVEEEEAPEEPEPVAEREEERPKPSR
                     PVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELIALKDR
                     IERRRAERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAH
                     FGGYLVKAEQKRGKRQTGREMKLRILSERKKPLNIDYMGEDQLREKAQELSEWIHQLE
                     SEKFDLMEKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK"
     exon            89..102
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            103..129
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            130..162
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            163..184
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            185..248
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            249..365
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            366..443
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            444..557
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            558..667
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            668..758
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            759..799
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
     exon            800..1030
                     /gene="Tnnt1"
                     /gene_synonym="ssTnT; sTnT; Tnt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagcctca gactccctct acagcatctg tggacccagc cttaggtctc tccaggatgt
       61 cagacaccga agaacaagaa tatgaggagg agcaggcaga agatgaggaa gcggtggagg
      121 aggaggaagc ccccgaggag ccggagccgg tggcagagcg agaagaagag cgccccaaac
      181 ccagccgtcc tgtggtgcct cctttgattc ccccgaagat tccagaaggg gagcgtgtgg
      241 attttgatga catccaccgg aagcgcatgg agaaagactt actggagctg cagacgctca
      301 tcgacgtgca ctttgaacag cggaaaaagg aggaggaaga gctcattgca ctaaaagacc
      361 gcattgagag gcgacgcgca gagagagctg agcaacagcg cttcagaacg gaaaaggagc
      421 gagaacgcca ggccaagctg gcggaggaga agatgcggaa ggaggaggag gaggcaaaga
      481 agagagcaga ggatgacgcc aagaagaaga aagttctgtc caacatggga gctcattttg
      541 ggggctacct ggtcaaggca gaacagaagc gtgggaagcg acagactggt cgggagatga
      601 aactccggat tctgtctgag aggaaaaagc ccttgaacat cgactacatg ggggaggacc
      661 agctccggga aaaggcccag gagctgtcag aatggatcca ccagctggaa tcagaaaaat
      721 ttgacctgat ggagaagttg aagcaacaga aatatgagat caatgtgctc tacaaccgca
      781 tcagccacgc ccagaaattc cgaaaggggg ctgggaaggg tcgagttgga ggccgctgga
      841 agtgagactg ccaggacatg acctgctgtg tggagcccag gagccactgg agcgtgtccc
      901 atctgtaact caaaataaag tgcccccagg catctgctta agttcttcag ggttgttatt
      961 atgtgggttg atcgacatct ccatactgcc tgggagagcc atcaactgtc attaaagaga
     1021 gttcaagttc
//
