LOCUS       NM_177066               3042 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus TNNI3 interacting kinase (Tnni3k), mRNA.
ACCESSION   NM_177066 XM_487772
VERSION     NM_177066.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3042)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3042)
  AUTHORS   Liu,L., Li,R.G. and Martin,J.F.
  TITLE     An improved method reveals the dual role of Tnni3k in promoting
            S-phase entry while suppressing cell division in cardiomyocytes
  JOURNAL   J Mol Cell Cardiol 183, 100-101 (2023)
   PUBMED   37769962
  REMARK    GeneRIF: An improved method reveals the dual role of Tnni3k in
            promoting S-phase entry while suppressing cell division in
            cardiomyocytes.
REFERENCE   3  (bases 1 to 3042)
  AUTHORS   Purdy,A.L., Swift,S.K., Sucov,H.M. and Patterson,M.
  TITLE     Tnni3k influences cardiomyocyte S-phase activity and proliferation
  JOURNAL   J Mol Cell Cardiol 183, 22-26 (2023)
   PUBMED   37597489
  REMARK    GeneRIF: Tnni3k influences cardiomyocyte S-phase activity and
            proliferation.
REFERENCE   4  (bases 1 to 3042)
  AUTHORS   Gu,Q., Orgil,B.O., Bajpai,A.K., Chen,Y., Ashbrook,D.G.,
            Starlard-Davenport,A., Towbin,J.A., Lebeche,D., Purevjav,E.,
            Sheng,H. and Lu,L.
  TITLE     Expression Levels of the Tnni3k Gene in the Heart Are Highly
            Associated with Cardiac and Glucose Metabolism-Related Phenotypes
            and Functional Pathways
  JOURNAL   Int J Mol Sci 24 (16), 12759 (2023)
   PUBMED   37628941
  REMARK    GeneRIF: Expression Levels of the Tnni3k Gene in the Heart Are
            Highly Associated with Cardiac and Glucose Metabolism-Related
            Phenotypes and Functional Pathways.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3042)
  AUTHORS   Swift,S.K., Purdy,A.L., Kolell,M.E., Andresen,K.G., Lahue,C.,
            Buddell,T., Akins,K.A., Rau,C.D., O'Meara,C.C. and Patterson,M.
  TITLE     Cardiomyocyte ploidy is dynamic during postnatal development and
            varies across genetic backgrounds
  JOURNAL   Development 150 (7) (2023)
   PUBMED   36912240
REFERENCE   6  (bases 1 to 3042)
  AUTHORS   Wiltshire,S.A., Leiva-Torres,G.A. and Vidal,S.M.
  TITLE     Quantitative trait locus analysis, pathway analysis, and consomic
            mapping show genetic variants of Tnni3k, Fpgt, or H28 control
            susceptibility to viral myocarditis
  JOURNAL   J Immunol 186 (11), 6398-6405 (2011)
   PUBMED   21525387
  REMARK    GeneRIF: Data identified Tnni3k, Fpgt and H28 as likely likely
            candidates for Vms1.
REFERENCE   7  (bases 1 to 3042)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 3042)
  AUTHORS   Wheeler,F.C., Tang,H., Marks,O.A., Hadnott,T.N., Chu,P.L., Mao,L.,
            Rockman,H.A. and Marchuk,D.A.
  TITLE     Tnni3k modifies disease progression in murine models of
            cardiomyopathy
  JOURNAL   PLoS Genet 5 (9), e1000647 (2009)
   PUBMED   19763165
  REMARK    GeneRIF: Tnni3k plays a critical role in the modulation of
            different forms of heart disease, and this protein may provide a
            novel target for therapeutic intervention.
REFERENCE   9  (bases 1 to 3042)
  AUTHORS   Aly,M., Wiltshire,S., Chahrour,G., Osti,J.C. and Vidal,S.M.
  TITLE     Complex genetic control of host susceptibility to coxsackievirus
            B3-induced myocarditis
  JOURNAL   Genes Immun 8 (3), 193-204 (2007)
   PUBMED   17287827
REFERENCE   10 (bases 1 to 3042)
  AUTHORS   Wheeler,F.C., Fernandez,L., Carlson,K.M., Wolf,M.J., Rockman,H.A.
            and Marchuk,D.A.
  TITLE     QTL mapping in a mouse model of cardiomyopathy reveals an ancestral
            modifier allele affecting heart function and survival
  JOURNAL   Mamm Genome 16 (6), 414-423 (2005)
   PUBMED   16075368
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC144762.3, AC124174.4, AC125097.3 and BY452372.1.
            
            On Oct 1, 2009 this sequence version replaced NM_177066.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY526095.1, BC139394.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AC144762.3         106465-106605
            142-250             AC144762.3         107216-107324
            251-336             AC144762.3         123308-123393
            337-434             AC144762.3         124387-124484
            435-545             AC144762.3         131501-131611
            546-644             AC124174.4         188155-188253       c
            645-780             AC124174.4         178214-178349       c
            781-925             AC124174.4         170957-171101       c
            926-1030            AC124174.4         170779-170883       c
            1031-1125           AC124174.4         166696-166790       c
            1126-1275           AC124174.4         165946-166095       c
            1276-1362           AC124174.4         150614-150700       c
            1363-1419           AC124174.4         150038-150094       c
            1420-1512           AC124174.4         149031-149123       c
            1513-1570           AC124174.4         148880-148937       c
            1571-1765           AC124174.4         148589-148783       c
            1766-1870           AC124174.4         147757-147861       c
            1871-1923           AC124174.4         84497-84549         c
            1924-1976           AC124174.4         84138-84190         c
            1977-2109           AC124174.4         81099-81231         c
            2110-2219           AC124174.4         65527-65636         c
            2220-2279           AC124174.4         42652-42711         c
            2280-2449           AC124174.4         36487-36656         c
            2450-2529           AC125097.3         162170-162249       c
            2530-3031           AC125097.3         155699-156200       c
            3032-3042           BY452372.1         433-443
FEATURES             Location/Qualifiers
     source          1..3042
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 79.32 cM"
     gene            1..3042
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /note="TNNI3 interacting kinase"
                     /db_xref="GeneID:435766"
                     /db_xref="MGI:MGI:2443276"
     exon            1..141
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..2606
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /EC_number="2.7.11.1"
                     /note="cardiac ankyrin repeat kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase TNNI3K"
                     /protein_id="NP_796040.3"
                     /db_xref="CCDS:CCDS17928.1"
                     /db_xref="GeneID:435766"
                     /db_xref="MGI:MGI:2443276"
                     /translation="MGNYKSRPTQTCSDEWKKKVSESYAIIIERLEDDLQIKENEFQE
                     LRHIFGSDEAFSEVSLNYRTERGLSLLHLCCACGGNKSHIRALMLKGLRPSRLTRNGF
                     PALHLAVYKDSLELITSLLHSGADVQQAGYGGLTALHIAAIAGHPEAVEVLLQHGANV
                     NVQDAVFFTPLHIAAYYGHEQVTSVLLKFGADVNVSGEVGDRPLHLASAKGFFNIVKL
                     LVEGNKADVNAQDNEDHVPLHFCSRFGHHNIVSYLLQSDLEVQPHVINIYGDTPLHLA
                     CYNGNFEVAKEIVHVTGTESLTKENIFSETAFHSACTYGKNIDLVKFLLDQNAVNINH
                     RGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKG
                     HDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADVLLLRAE
                     LPSRFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCRE
                     VSILCQLNHPCVVQFVGACLDDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIA
                     VDVAKGMEYLHSLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQP
                     GNLRWMAPEVFTQCTRYTIKADVFSYALCLWELLTGEIPFAHLKPAAAAADMAYHHIR
                     PPIGYSIPKPISSLLMRGWNACPEGRPEFSEVVRKLEECLCNVELMSPASSNSSGSLS
                     PSSSSDCLLSRGGPGRSHVAALRSRFELEYALNARSYTGWPQSVGTHTNPGLSLEEMN
                     RGAQYSAVDKYGYVSDPMSPMHLHSRRNSGSFEDGN"
     exon            142..250
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            251..336
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            337..434
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            435..545
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            546..644
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            645..780
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            781..925
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1030
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1125
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1275
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1362
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1419
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1512
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1570
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1765
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1870
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..1923
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..1976
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2109
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2219
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2279
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2449
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2529
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..3042
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3013..3018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3036
                     /gene="Tnni3k"
                     /gene_synonym="Cark; D830019J24Rik"
                     /note="major polyA site"
ORIGIN      
        1 agaaagacta tcaacatatt ttcaactggt ctgtttcagc gctagaactt ggaatcttat
       61 atcgtgaagg gcagcacagg aggaaagcag acttctttaa aatggggaat tacaaatcca
      121 gaccgacaca gacttgttct gatgaatgga agaagaaagt tagtgaatct tatgctatta
      181 taatagaaag gctggaagat gacctgcaga tcaaagaaaa tgaatttcaa gaactaagac
      241 acatctttgg ctctgacgaa gccttcagtg aagtcagttt aaattaccgc acagagcgtg
      301 gcctgtccct actgcacctc tgctgtgcct gcggtggcaa caagtcgcat atccgtgccc
      361 ttatgttaaa agggctccgt ccatccagac tgacaagaaa tgggtttcca gctctgcact
      421 tggctgttta caaggatagc ctggaactta tcacttcact gttgcatagc ggagcagatg
      481 ttcagcaagc gggatatggc ggcctcacag ccctccacat cgctgcaata gctgggcacc
      541 cagaggccgt ggaagtgctg ctgcagcatg gagccaatgt gaacgttcaa gatgcagtct
      601 tcttcacccc actgcacatc gcagcctatt acgggcacga gcaggtaacc agtgtccttt
      661 tgaagtttgg agctgatgtc aatgtaagcg gtgaagttgg agacaggcct ctgcacctgg
      721 cctctgcaaa agggttcttc aacattgtga aactcctggt agaagggaac aaagccgacg
      781 tgaacgctca ggacaatgaa gaccatgtcc ctctgcactt ctgttctcga tttggacacc
      841 acaatatagt gagctacttg ctccagagtg acttggaggt tcagcctcac gtcattaaca
      901 tctatggtga cactcctttg cacctggcgt gctacaatgg aaattttgaa gttgccaagg
      961 aaattgtcca cgtaacagga actgaaagtc tgactaagga aaacatcttc agtgagacag
     1021 cttttcacag tgcttgtacc tatggcaaga acattgacct ggtcaaattc cttcttgatc
     1081 agaatgctgt gaacattaac catcgaggaa gagatgggca cacaggatta cactctgctt
     1141 gctaccatgg ccacatacgc ctggttcagt tcctactgga taatggtgca gatatgaatc
     1201 tagttgcttg tgatcccagc aggtctagtg gtgaaaaaga tgagcagaca tgtttgatgt
     1261 gggcttatga gaaaggacat gatgccattg ttacactcct gaagcactat aagagacccc
     1321 aggatgagct gccatgtaac gaatattctc agcctggagg agatggctcc tatgtgtctg
     1381 tcccatcccc cttggggaag attaaaagca tgacaaaaga gaaggcagat gttctcctcc
     1441 tgagggctga attaccctcc cgtttccatc tgcagctctc ggaaattgaa ttccatgaga
     1501 ttatcggctc aggttctttt gggaaagtct ataaagggcg atgcagaaat aaaatagtgg
     1561 caatcaaacg ataccgagcc aacacctact gctccaagtc agacgtggat atgttttgcc
     1621 gagaagtgtc catcctctgc cagctcaatc acccctgcgt ggttcagttt gtgggtgcct
     1681 gcctggatga ccccagccag tttgccattg tcacacaata catttcagga ggctctctgt
     1741 tctccctgct tcatgaacag aagagaattc ttgacttgca gtctaaatta atcattgcag
     1801 tagacgttgc caagggcatg gagtacctgc acagcttgac ccagccaatc atacaccgcg
     1861 acctgaacag tcacaatatt cttctctatg aggacggcca tgctgtggtg gcagattttg
     1921 gagaatcaag atttctgcag tccctggatg aagacaacat gacaaagcag ccagggaacc
     1981 tgcgctggat ggcccccgag gtgttcacac agtgcacgcg ctacaccatc aaggctgatg
     2041 tcttcagtta cgccctgtgt ctgtgggagc tcctcactgg agaaattcca ttcgctcatc
     2101 tgaagccagc cgctgcagca gcagatatgg cgtaccacca catcagacct cccatcggct
     2161 actccatccc caagccaatc tcatctctgc tgatgcgggg ctggaatgca tgtcccgaag
     2221 gaagacccga gttctctgaa gtcgttagga agctggagga gtgcctgtgt aacgtggagc
     2281 tcatgtctcc tgcatcaagt aacagcagtg gctctctgtc accttcctct tcttctgatt
     2341 gcctactgag ccgaggaggg cctggccgga gccatgtggc agctttacgg agtcgttttg
     2401 agttggaata cgccctaaat gcaaggtcct acactgggtg gcctcaaagt gtcgggacac
     2461 acactaatcc aggcctgtct ttggaggaaa tgaacagagg tgcccagtat tcagctgttg
     2521 acaaatatgg ctacgtgtct gatcccatga gcccgatgca cctccactcc cgccggaaca
     2581 gtggcagctt tgaggacggc aactgacagg tctgacatac acctaagggg agttttccca
     2641 tcagactgac agcagtgatt ttatccatgg caggctcact tccaattata atgctctgcc
     2701 ctctgaggtc tcttcaagtc gtcttgctta ttctgcgctc acgtaattcc cttctacagg
     2761 gtaggctttc aattgctcag agcatgaagt accaaggagc agatatagac cgtgcatgag
     2821 gaactgttct tagtttgata tttaaagtcc ttaattgcct gggggtgggg ttcaagtctg
     2881 tgtagatggc tgggctgatc cttatgtatt cgtagacgga actatgtggg cttgtgtttg
     2941 agcgtctccg gttgggttat ttaaaatatg ttcactgcct tatctcctgt tacctctgtt
     3001 gttaattcta tgattaaaga ctctggtggt ctagaacatg gt
//
