LOCUS       NM_009406                925 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus troponin I, cardiac 3 (Tnni3), mRNA.
ACCESSION   NM_009406 XM_975686
VERSION     NM_009406.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 925)
  AUTHORS   Mah,S.Y.Y., Vanyai,H.K., Li-Wai-Suen,C.S.N., Garnham,A.L., Wynn,J.,
            Bergamasco,M.I., Malelang,S., Wilcox,S., Biben,C., Smyth,G.K.,
            Thomas,T. and Voss,A.K.
  TITLE     ING4 and ING5 are essential for histone H3 lysine 14 acetylation
            and epicardial cell lineage development
  JOURNAL   Development 151 (5) (2024)
   PUBMED   38446206
REFERENCE   2  (bases 1 to 925)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   3  (bases 1 to 925)
  AUTHORS   Beutner,G., Burris,J.R., Collins,M.P., Kulkarni,C.A.,
            Nadtochiy,S.M., de Mesy Bentley,K.L., Cohen,E.D., Brookes,P.S. and
            Porter,G.A. Jr.
  TITLE     Coordinated metabolic responses to cyclophilin D deletion in the
            developing heart
  JOURNAL   iScience 27 (3), 109157 (2024)
   PUBMED   38414851
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 925)
  AUTHORS   Salyer,L.G., Salhi,H.E., Brundage,E.A., Shettigar,V.,
            Sturgill,S.L., Zanella,H., Templeton,B., Abay,E., Emmer,K.M.,
            Lowe,J., Rafael-Fortney,J.A., Parinandi,N., Foster,D.B.,
            McKinsey,T.A., Woulfe,K.C., Ziolo,M.T. and Biesiadecki,B.J.
  TITLE     Troponin I Tyrosine Phosphorylation Beneficially Accelerates
            Diastolic Function
  JOURNAL   Circ Res 134 (1), 33-45 (2024)
   PUBMED   38095088
  REMARK    GeneRIF: Troponin I Tyrosine Phosphorylation Beneficially
            Accelerates Diastolic Function.
REFERENCE   5  (bases 1 to 925)
  AUTHORS   Eley,L., Richardson,R.V., Alqahtani,A., Chaudhry,B. and
            Henderson,D.J.
  TITLE     eNOS plays essential roles in the developing heart and aorta linked
            to disruption of Notch signalling
  JOURNAL   Dis Model Mech 17 (1) (2024)
   PUBMED   38111957
REFERENCE   6  (bases 1 to 925)
  AUTHORS   Lyons,I., Parsons,L.M., Hartley,L., Li,R., Andrews,J.E., Robb,L.
            and Harvey,R.P.
  TITLE     Myogenic and morphogenetic defects in the heart tubes of murine
            embryos lacking the homeo box gene Nkx2-5
  JOURNAL   Genes Dev 9 (13), 1654-1666 (1995)
   PUBMED   7628699
REFERENCE   7  (bases 1 to 925)
  AUTHORS   Zhu,L., Lyons,G.E., Juhasz,O., Joya,J.E., Hardeman,E.C. and Wade,R.
  TITLE     Developmental regulation of troponin I isoform genes in striated
            muscles of transgenic mice
  JOURNAL   Dev Biol 169 (2), 487-503 (1995)
   PUBMED   7781893
REFERENCE   8  (bases 1 to 925)
  AUTHORS   Chen,Z., Friedrich,G.A. and Soriano,P.
  TITLE     Transcriptional enhancer factor 1 disruption by a retroviral gene
            trap leads to heart defects and embryonic lethality in mice
  JOURNAL   Genes Dev 8 (19), 2293-2301 (1994)
   PUBMED   7958896
REFERENCE   9  (bases 1 to 925)
  AUTHORS   Guo,X., Wattanapermpool,J., Palmiter,K.A., Murphy,A.M. and
            Solaro,R.J.
  TITLE     Mutagenesis of cardiac troponin I. Role of the unique NH2-terminal
            peptide in myofilament activation
  JOURNAL   J Biol Chem 269 (21), 15210-15216 (1994)
   PUBMED   8195157
REFERENCE   10 (bases 1 to 925)
  AUTHORS   Ausoni,S., Campione,M., Picard,A., Moretti,P., Vitadello,M., De
            Nardi,C. and Schiaffino,S.
  TITLE     Structure and regulation of the mouse cardiac troponin I gene
  JOURNAL   J Biol Chem 269 (1), 339-346 (1994)
   PUBMED   8276817
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY115313.1, BC061171.1 and AI843419.1.
            
            On Jan 24, 2017 this sequence version replaced NM_009406.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061171.1, AK169223.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                BY115313.1         1-85
            86-909              BC061171.1         1-824
            910-925             AI843419.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..925
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.61 cM"
     gene            1..925
                     /gene="Tnni3"
                     /gene_synonym="cTnI; Tn1"
                     /note="troponin I, cardiac 3"
                     /db_xref="GeneID:21954"
                     /db_xref="MGI:MGI:98783"
     exon            1..224
                     /gene="Tnni3"
                     /gene_synonym="cTnI; Tn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..849
                     /gene="Tnni3"
                     /gene_synonym="cTnI; Tn1"
                     /note="cardiac troponin I"
                     /codon_start=1
                     /product="troponin I, cardiac muscle"
                     /protein_id="NP_033432.1"
                     /db_xref="CCDS:CCDS39736.1"
                     /db_xref="GeneID:21954"
                     /db_xref="MGI:MGI:98783"
                     /translation="MADESSDAAGEPQPAPAPVRRRSSANYRAYATEPHAKKKSKISA
                     SRKLQLKTLMLQIAKQEMEREAEERRGEKGRVLRTRCQPLELDGLGFEELQDLCRQLH
                     ARVDKVDEERYDVEAKVTKNITEIADLTQKIYDLRGKFKRPTLRRVRISADAMMQALL
                     GTRAKESLDLRAHLKQVKKEDIEKENREVGDWRKNIDALSGMEGRKKKFEG"
     exon            225..237
                     /gene="Tnni3"
                     /gene_synonym="cTnI; Tn1"
                     /inference="alignment:Splign:2.1.0"
     exon            238..324
                     /gene="Tnni3"
                     /gene_synonym="cTnI; Tn1"
                     /inference="alignment:Splign:2.1.0"
     exon            325..366
                     /gene="Tnni3"
                     /gene_synonym="cTnI; Tn1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..498
                     /gene="Tnni3"
                     /gene_synonym="cTnI; Tn1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..588
                     /gene="Tnni3"
                     /gene_synonym="cTnI; Tn1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..765
                     /gene="Tnni3"
                     /gene_synonym="cTnI; Tn1"
                     /inference="alignment:Splign:2.1.0"
     exon            766..912
                     /gene="Tnni3"
                     /gene_synonym="cTnI; Tn1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      891..896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnni3"
                     /gene_synonym="cTnI; Tn1"
                     /note="hexamer: AATAAA"
     polyA_site      912
                     /gene="Tnni3"
                     /gene_synonym="cTnI; Tn1"
                     /note="major polyA site"
ORIGIN      
        1 ggctcccctc acaccctgtt atcgcttatc ctgggcaggg gaggagacag cagtatattt
       61 agtctttgtc ctcgcccctt atctcagtgt cctcagtgag gcttgagcag cccagaggaa
      121 acccaacctc tagagacctc caaggtcacc agggacaccc ttccaggacc ctccaggaat
      181 ctccgatcct gttctctgcc tctggagatc atcatggctg atgagagcag cgatgcggct
      241 ggggaaccgc agcctgcgcc tgctcctgtc cgacgccgct cctctgccaa ctaccgagcc
      301 tatgccaccg agccacacgc caagaaaaag tctaagatct ccgcctccag aaaacttcag
      361 ttgaagactc tgatgctgca gattgcgaag caggagatgg aacgagaggc agaagagcga
      421 cgtggagaga aggggcgcgt tctgaggact cgttgccagc ctttggagtt ggatgggctg
      481 ggctttgaag agcttcagga cttatgccga cagcttcacg ctcgggtgga caaagtggat
      541 gaagagagat atgacgtgga agcaaaagtc accaagaaca tcactgagat tgcagatctg
      601 acccagaaga tctatgacct ccgtggcaag tttaagcggc ccaccctccg aagagtgagg
      661 atctctgcag atgccatgat gcaggcgctg ctggggaccc gggccaagga atccttggac
      721 ctgagggccc acctcaagca ggtgaagaag gaggacattg agaaggaaaa ccgggaggtg
      781 ggagactggc gcaagaatat cgatgcactg agtggcatgg aaggccgcaa gaaaaagttt
      841 gagggctgag ccatggctcc cacactgtgc tctgaaggac gtccctgcag aataaacctc
      901 tccaaaccag aaaaaaaaaa aaaaa
//
