LOCUS       NM_021467               1086 bp    mRNA    linear   ROD 21-MAY-2024
DEFINITION  Mus musculus troponin I, skeletal, slow 1 (Tnni1), transcript
            variant 1, mRNA.
ACCESSION   NM_021467
VERSION     NM_021467.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1086)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1086)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   3  (bases 1 to 1086)
  AUTHORS   Beutner,G., Burris,J.R., Collins,M.P., Kulkarni,C.A.,
            Nadtochiy,S.M., de Mesy Bentley,K.L., Cohen,E.D., Brookes,P.S. and
            Porter,G.A. Jr.
  TITLE     Coordinated metabolic responses to cyclophilin D deletion in the
            developing heart
  JOURNAL   iScience 27 (3), 109157 (2024)
   PUBMED   38414851
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1086)
  AUTHORS   Ferdous,A., Singh,S., Luo,Y., Abedin,M.J., Jiang,N., Perry,C.E.,
            Evers,B.M., Gillette,T.G., Kyba,M., Trojanowska,M. and Hill,J.A.
  TITLE     Fli1 Promotes Vascular Morphogenesis by Regulating Endothelial
            Potential of Multipotent Myogenic Progenitors
  JOURNAL   Circ Res 129 (10), 949-964 (2021)
   PUBMED   34544261
REFERENCE   5  (bases 1 to 1086)
  AUTHORS   Hornos,F., Feng,H.Z., Rizzuti,B., Palomino-Schatzlein,M.,
            Wieczorek,D., Neira,J.L. and Jin,J.P.
  TITLE     The muscle-relaxing C-terminal peptide from troponin I populates a
            nascent helix, facilitating binding to tropomyosin with a potent
            therapeutic effect
  JOURNAL   J Biol Chem 296, 100228 (2021)
   PUBMED   33814345
  REMARK    GeneRIF: The muscle-relaxing C-terminal peptide from troponin I
            populates a nascent helix, facilitating binding to tropomyosin with
            a potent therapeutic effect.
REFERENCE   6  (bases 1 to 1086)
  AUTHORS   Zhang,W., Behringer,R.R. and Olson,E.N.
  TITLE     Inactivation of the myogenic bHLH gene MRF4 results in
            up-regulation of myogenin and rib anomalies
  JOURNAL   Genes Dev 9 (11), 1388-1399 (1995)
   PUBMED   7797078
REFERENCE   7  (bases 1 to 1086)
  AUTHORS   Zhu,L., Lyons,G.E., Juhasz,O., Joya,J.E., Hardeman,E.C. and Wade,R.
  TITLE     Developmental regulation of troponin I isoform genes in striated
            muscles of transgenic mice
  JOURNAL   Dev Biol 169 (2), 487-503 (1995)
   PUBMED   7781893
REFERENCE   8  (bases 1 to 1086)
  AUTHORS   Braun,T. and Arnold,H.H.
  TITLE     Inactivation of Myf-6 and Myf-5 genes in mice leads to alterations
            in skeletal muscle development
  JOURNAL   EMBO J 14 (6), 1176-1186 (1995)
   PUBMED   7720708
REFERENCE   9  (bases 1 to 1086)
  AUTHORS   Chen,Z., Friedrich,G.A. and Soriano,P.
  TITLE     Transcriptional enhancer factor 1 disruption by a retroviral gene
            trap leads to heart defects and embryonic lethality in mice
  JOURNAL   Genes Dev 8 (19), 2293-2301 (1994)
   PUBMED   7958896
REFERENCE   10 (bases 1 to 1086)
  AUTHORS   Koppe,R.I., Hallauer,P.L., Karpati,G. and Hastings,K.E.
  TITLE     cDNA clone and expression analysis of rodent fast and slow skeletal
            muscle troponin I mRNAs
  JOURNAL   J Biol Chem 264 (24), 14327-14333 (1989)
   PUBMED   2760067
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA230582.1, AK012258.1, CR521220.1 and AV124377.1.
            
            On Dec 18, 2007 this sequence version replaced NM_021467.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012258.1, BY711428.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AA230582.1         1-18
            19-1006             AK012258.1         2-989
            1007-1075           CR521220.1         4-72                c
            1076-1086           AV124377.1         232-242
FEATURES             Location/Qualifiers
     source          1..1086
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 59.28 cM"
     gene            1..1086
                     /gene="Tnni1"
                     /gene_synonym="2700018B22Rik; ssTnI"
                     /note="troponin I, skeletal, slow 1"
                     /db_xref="GeneID:21952"
                     /db_xref="MGI:MGI:105073"
     exon            1..76
                     /gene="Tnni1"
                     /gene_synonym="2700018B22Rik; ssTnI"
                     /inference="alignment:Splign:2.1.0"
     exon            77..124
                     /gene="Tnni1"
                     /gene_synonym="2700018B22Rik; ssTnI"
                     /inference="alignment:Splign:2.1.0"
     exon            125..154
                     /gene="Tnni1"
                     /gene_synonym="2700018B22Rik; ssTnI"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..707
                     /gene="Tnni1"
                     /gene_synonym="2700018B22Rik; ssTnI"
                     /codon_start=1
                     /product="troponin I, slow skeletal muscle"
                     /protein_id="NP_067442.1"
                     /db_xref="CCDS:CCDS48374.1"
                     /db_xref="GeneID:21952"
                     /db_xref="MGI:MGI:105073"
                     /translation="MPEVERKSKITASRKLMLKSLMLAKAKECWEQEHEEREAEKVRY
                     LSERIPTLQTRGLSLSALQDLCRELHAKVEVVDEERYDIEAKCLHNTREIKDLKLKVL
                     DLRGKFKRPPLRRVRVSADAMLRALLGSKHKVSMDLRANLKSVKKEDTEKERPVEVGD
                     WRKNVEAMSGMEGRKKMFDAAKSPTSQ"
     exon            155..158
                     /gene="Tnni1"
                     /gene_synonym="2700018B22Rik; ssTnI"
                     /inference="alignment:Splign:2.1.0"
     exon            159..200
                     /gene="Tnni1"
                     /gene_synonym="2700018B22Rik; ssTnI"
                     /inference="alignment:Splign:2.1.0"
     exon            201..332
                     /gene="Tnni1"
                     /gene_synonym="2700018B22Rik; ssTnI"
                     /inference="alignment:Splign:2.1.0"
     exon            333..422
                     /gene="Tnni1"
                     /gene_synonym="2700018B22Rik; ssTnI"
                     /inference="alignment:Splign:2.1.0"
     exon            423..599
                     /gene="Tnni1"
                     /gene_synonym="2700018B22Rik; ssTnI"
                     /inference="alignment:Splign:2.1.0"
     exon            600..709
                     /gene="Tnni1"
                     /gene_synonym="2700018B22Rik; ssTnI"
                     /inference="alignment:Splign:2.1.0"
     exon            710..1086
                     /gene="Tnni1"
                     /gene_synonym="2700018B22Rik; ssTnI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccctcagct ctgcccccac actctgcagt ctgtggtgag gctcaggcca gcctagctcc
       61 acgaggacta aactaggcac tttgagccct cttcacctgt ctcacctgca caggacacga
      121 acaggtgcag ccttgccacc accatgccgg aagttgagag gaaatccaag atcactgcct
      181 cccgtaaact catgctgaag agcctgatgc tagccaaggc caaggagtgt tgggagcagg
      241 aacacgagga gcgagaggct gagaaggtgc gttacctctc ggagcgcatt cccacactgc
      301 agacccgcgg tctgtctctc agtgcccttc aggacttgtg ccgagagctc catgccaagg
      361 tagaggtggt ggatgaggag cgctatgata ttgaagccaa atgcctccac aacaccagag
      421 agatcaagga cctgaagctg aaggtgctgg acctccgtgg gaagttcaag cgtcctcccc
      481 tgcgccgggt ccgtgtctca gccgatgcca tgctccgagc cctactgggc tctaagcaca
      541 aggtgtccat ggatctgcgg gccaacctca agtctgtgaa gaaagaagac acagaaaagg
      601 agcggccagt cgaggtagga gactggagga agaatgtgga ggctatgtct ggcatggaag
      661 gccgcaagaa gatgttcgac gctgctaagt ccccgacctc ccagtagagg ttggcttgct
      721 gtatgacact ctgtgtcatg ctttggtccc tttccagccc cactcaccta tctttctgct
      781 cgtgcctgga acatccctaa tatgcgctcc ctccctccag cctatgcaca cacctttgga
      841 gccaggatga aatggcgcac aaaggggaag agagatgcca gtgcctggga cctcatccca
      901 gcagtgtggg cttatggtac ccgctgggca tgctggggtt atccagtcac cccaaggggc
      961 cctaggctga ggagggaggc agagagaact gcctctcagc agccccgtgt tgcttccctc
     1021 catctctgtt gctacctgca gtattcacaa gttctccatt aaaaaaaaaa aaagatccag
     1081 gtttcc
//
