LOCUS       NM_009394                705 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus troponin C2, fast (Tnnc2), mRNA.
ACCESSION   NM_009394
VERSION     NM_009394.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 705)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 705)
  AUTHORS   Kurz,J., Weiss,A.C., Thiesler,H., Qasrawi,F., Deuper,L., Kaur,J.,
            Rudat,C., Ludtke,T.H., Wojahn,I., Hildebrandt,H., Trowe,M.O. and
            Kispert,A.
  TITLE     Notch signaling is a novel regulator of visceral smooth muscle cell
            differentiation in the murine ureter
  JOURNAL   Development 149 (4) (2022)
   PUBMED   35103284
REFERENCE   3  (bases 1 to 705)
  AUTHORS   Sun,S.C., Ma,D., Li,M.Y., Zhang,R.X., Huang,C., Huang,H.J.,
            Xie,Y.Z., Wang,Z.J., Liu,J., Cai,D.C., Liu,C.X., Yang,Q., Bao,F.X.,
            Gong,X.L., Li,J.R., Hui,Z., Wei,X.F., Zhong,J.M., Zhou,W.J.,
            Shang,X., Zhang,C., Liu,X.G., Tang,B.S., Xiong,F. and Xu,X.M.
  TITLE     Mutations in C1orf194, encoding a calcium regulator, cause dominant
            Charcot-Marie-Tooth disease
  JOURNAL   Brain 142 (8), 2215-2229 (2019)
   PUBMED   31199454
  REMARK    Erratum:[Brain. 2019 Oct 1;142(10):e56. doi: 10.1093/brain/awz237..
            PMID: 31359062]
REFERENCE   4  (bases 1 to 705)
  AUTHORS   Wilczewski,C.M., Hepperla,A.J., Shimbo,T., Wasson,L., Robbe,Z.L.,
            Davis,I.J., Wade,P.A. and Conlon,F.L.
  TITLE     CHD4 and the NuRD complex directly control cardiac sarcomere
            formation
  JOURNAL   Proc Natl Acad Sci U S A 115 (26), 6727-6732 (2018)
   PUBMED   29891665
REFERENCE   5  (bases 1 to 705)
  AUTHORS   Zoupa,M., Xavier,G.M., Bryan,S., Theologidis,I., Arno,M. and
            Cobourne,M.T.
  TITLE     Gene expression profiling in the developing secondary palate in the
            absence of Tbx1 function
  JOURNAL   BMC Genomics 19 (1), 429 (2018)
   PUBMED   29866044
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 705)
  AUTHORS   Yamane,A., Mayo,M., Shuler,C., Crowe,D., Ohnuki,Y., Dalrymple,K.
            and Saeki,Y.
  TITLE     Expression of myogenic regulatory factors during the development of
            mouse tongue striated muscle
  JOURNAL   Arch Oral Biol 45 (1), 71-78 (2000)
   PUBMED   10669094
REFERENCE   7  (bases 1 to 705)
  AUTHORS   Farah,C.S. and Reinach,F.C.
  TITLE     The troponin complex and regulation of muscle contraction
  JOURNAL   FASEB J 9 (9), 755-767 (1995)
   PUBMED   7601340
  REMARK    Review article
REFERENCE   8  (bases 1 to 705)
  AUTHORS   Schleef,M., Zuhlke,C., Schoffl,F. and Jockusch,H.
  TITLE     Subtractive cDNA cloning as a tool to analyse secondary effects of
            a muscle disease. Characterization of affected genes in the
            myotonic ADR mouse
  JOURNAL   Neuromuscul Disord 4 (3), 205-217 (1994)
   PUBMED   7522680
REFERENCE   9  (bases 1 to 705)
  AUTHORS   Parmacek,M.S., Bengur,A.R., Vora,A.J. and Leiden,J.M.
  TITLE     The structure and regulation of expression of the murine fast
            skeletal troponin C gene. Identification of a developmentally
            regulated, muscle-specific transcriptional enhancer
  JOURNAL   J Biol Chem 265 (26), 15970-15976 (1990)
   PUBMED   2394755
REFERENCE   10 (bases 1 to 705)
  AUTHORS   Parmacek,M.S. and Leiden,J.M.
  TITLE     Structure and expression of the murine slow/cardiac troponin C gene
  JOURNAL   J Biol Chem 264 (22), 13217-13225 (1989)
   PUBMED   2753913
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB566378.1 and BC024390.1.
            
            On Apr 29, 2004 this sequence version replaced NM_009394.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024390.1, DV048890.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               CB566378.1         36-418
            384-705             BC024390.1         383-704
FEATURES             Location/Qualifiers
     source          1..705
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.27 cM"
     gene            1..705
                     /gene="Tnnc2"
                     /gene_synonym="Tncs"
                     /note="troponin C2, fast"
                     /db_xref="GeneID:21925"
                     /db_xref="MGI:MGI:98780"
     exon            1..72
                     /gene="Tnnc2"
                     /gene_synonym="Tncs"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..552
                     /gene="Tnnc2"
                     /gene_synonym="Tncs"
                     /note="STNC; troponin C, fast skeletal"
                     /codon_start=1
                     /product="troponin C, skeletal muscle"
                     /protein_id="NP_033420.1"
                     /db_xref="CCDS:CCDS17056.1"
                     /db_xref="GeneID:21925"
                     /db_xref="MGI:MGI:98780"
                     /translation="MTDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVM
                     RMLGQTPTKEELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRI
                     FDRNADGYIDAEELAEIFRASGEHVTEEEIESLMKDGDKNNDGRIDFDEFLKMMEGVQ
                     "
     exon            73..124
                     /gene="Tnnc2"
                     /gene_synonym="Tncs"
                     /inference="alignment:Splign:2.1.0"
     exon            125..268
                     /gene="Tnnc2"
                     /gene_synonym="Tncs"
                     /inference="alignment:Splign:2.1.0"
     exon            269..383
                     /gene="Tnnc2"
                     /gene_synonym="Tncs"
                     /inference="alignment:Splign:2.1.0"
     exon            384..520
                     /gene="Tnnc2"
                     /gene_synonym="Tncs"
                     /inference="alignment:Splign:2.1.0"
     exon            521..693
                     /gene="Tnnc2"
                     /gene_synonym="Tncs"
                     /inference="alignment:Splign:2.1.0"
     regulatory      673..678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnnc2"
                     /gene_synonym="Tncs"
                     /note="hexamer: AATAAA"
     polyA_site      693
                     /gene="Tnnc2"
                     /gene_synonym="Tncs"
                     /note="major polyA site"
ORIGIN      
        1 ggggcacctt tgggtggtgg agtgcggagg agacaaccca cagcggagga gtcccagtcg
       61 ccagcaacca tgacggacca acaggctgag gccaggtcct acctcagcga ggagatgatc
      121 gctgagttca aggctgcctt tgacatgttc gatgctgatg gcggtgggga catcagcgtt
      181 aaagagttgg gcaccgtgat gaggatgcta gggcagacac ccaccaaaga ggaattggat
      241 gccatcatcg aggaggtgga cgaggatggc agcggtacta tcgactttga agagttcttg
      301 gtcatgatgg tgcgccagat gaaagaggat gcgaagggga agagcgaaga ggaactggct
      361 gagtgcttcc gcatctttga caggaacgca gacggctaca ttgatgctga ggagctagct
      421 gagattttcc gggcttctgg ggagcatgtg acagaagagg agatcgaatc cctgatgaag
      481 gatggtgata aaaacaacga cggccgcatt gactttgatg agtttctgaa gatgatggag
      541 ggcgttcagt aaggagacgg tctttgttcg tgtccatcca gactgcaggt cccctgggcg
      601 tgggcagctc cacctttgct ttccctgcct cacacgggaa aggctgctcc tttgggctct
      661 gtgactggaa ggaataaaag ttgacaatgt aaaaaaaaaa aaaaa
//
