LOCUS       NM_009393                701 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus troponin C, cardiac/slow skeletal (Tnnc1), mRNA.
ACCESSION   NM_009393
VERSION     NM_009393.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 701)
  AUTHORS   Rehmani,T., Dias,A.P., Kamal,M., Salih,M. and Tuana,B.S.
  TITLE     Deletion of Sarcolemmal Membrane-Associated Protein Isoform 3
            (SLMAP3) in Cardiac Progenitors Delays Embryonic Growth of
            Myocardium without Affecting Hippo Pathway
  JOURNAL   Int J Mol Sci 25 (5), 2888 (2024)
   PUBMED   38474134
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 701)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 701)
  AUTHORS   Sandovici,I., Georgopoulou,A., Perez-Garcia,V., Hufnagel,A.,
            Lopez-Tello,J., Lam,B.Y.H., Schiefer,S.N., Gaudreau,C., Santos,F.,
            Hoelle,K., Yeo,G.S.H., Burling,K., Reiterer,M., Fowden,A.L.,
            Burton,G.J., Branco,C.M., Sferruzzi-Perri,A.N. and Constancia,M.
  TITLE     The imprinted Igf2-Igf2r axis is critical for matching placental
            microvasculature expansion to fetal growth
  JOURNAL   Dev Cell 57 (1), 63-79 (2022)
   PUBMED   34963058
REFERENCE   4  (bases 1 to 701)
  AUTHORS   Christ,A., Marczenke,M. and Willnow,T.E.
  TITLE     LRP2 controls sonic hedgehog-dependent differentiation of cardiac
            progenitor cells during outflow tract formation
  JOURNAL   Hum Mol Genet 29 (19), 3183-3196 (2020)
   PUBMED   32901292
REFERENCE   5  (bases 1 to 701)
  AUTHORS   Powers,J.D., Kooiker,K.B., Mason,A.B., Teitgen,A.E., Flint,G.V.,
            Tardiff,J.C., Schwartz,S.D., McCulloch,A.D., Regnier,M., Davis,J.
            and Moussavi-Harami,F.
  TITLE     Modulating the tension-time integral of the cardiac twitch prevents
            dilated cardiomyopathy in murine hearts
  JOURNAL   JCI Insight 5 (20), 142446 (2020)
   PUBMED   32931484
  REMARK    GeneRIF: Modulating the tension-time integral of the cardiac twitch
            prevents dilated cardiomyopathy in murine hearts.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 701)
  AUTHORS   Farah,C.S. and Reinach,F.C.
  TITLE     The troponin complex and regulation of muscle contraction
  JOURNAL   FASEB J 9 (9), 755-767 (1995)
   PUBMED   7601340
  REMARK    Review article
REFERENCE   7  (bases 1 to 701)
  AUTHORS   Chen,Z., Friedrich,G.A. and Soriano,P.
  TITLE     Transcriptional enhancer factor 1 disruption by a retroviral gene
            trap leads to heart defects and embryonic lethality in mice
  JOURNAL   Genes Dev 8 (19), 2293-2301 (1994)
   PUBMED   7958896
REFERENCE   8  (bases 1 to 701)
  AUTHORS   Parmacek,M.S., Vora,A.J., Shen,T., Barr,E., Jung,F. and Leiden,J.M.
  TITLE     Identification and characterization of a cardiac-specific
            transcriptional regulatory element in the slow/cardiac troponin C
            gene
  JOURNAL   Mol Cell Biol 12 (5), 1967-1976 (1992)
   PUBMED   1569934
REFERENCE   9  (bases 1 to 701)
  AUTHORS   Parmacek,M.S., Bengur,A.R., Vora,A.J. and Leiden,J.M.
  TITLE     The structure and regulation of expression of the murine fast
            skeletal troponin C gene. Identification of a developmentally
            regulated, muscle-specific transcriptional enhancer
  JOURNAL   J Biol Chem 265 (26), 15970-15976 (1990)
   PUBMED   2394755
REFERENCE   10 (bases 1 to 701)
  AUTHORS   Parmacek,M.S. and Leiden,J.M.
  TITLE     Structure and expression of the murine slow/cardiac troponin C gene
  JOURNAL   J Biol Chem 264 (22), 13217-13225 (1989)
   PUBMED   2753913
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108416.5.
            
            On Aug 30, 2022 this sequence version replaced NM_009393.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA459998.1, CB596418.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AC108416.5         51496-51557
            63-93               AC108416.5         52982-53012
            94-240              AC108416.5         53239-53385
            241-355             AC108416.5         53743-53857
            356-492             AC108416.5         54459-54595
            493-701             AC108416.5         54685-54893
FEATURES             Location/Qualifiers
     source          1..701
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.09 cM"
     gene            1..701
                     /gene="Tnnc1"
                     /gene_synonym="cTnC; cTnI; TnC; tncc"
                     /note="troponin C, cardiac/slow skeletal"
                     /db_xref="GeneID:21924"
                     /db_xref="MGI:MGI:98779"
     exon            1..62
                     /gene="Tnnc1"
                     /gene_synonym="cTnC; cTnI; TnC; tncc"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..524
                     /gene="Tnnc1"
                     /gene_synonym="cTnC; cTnI; TnC; tncc"
                     /codon_start=1
                     /product="troponin C, slow skeletal and cardiac muscles"
                     /protein_id="NP_033419.1"
                     /db_xref="CCDS:CCDS36854.1"
                     /db_xref="GeneID:21924"
                     /db_xref="MGI:MGI:98779"
                     /translation="MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKV
                     MRMLGQNPTPEELQEMIDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKSEEELSDLFR
                     MFDKNADGYIDLDELKMMLQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGV
                     E"
     exon            63..93
                     /gene="Tnnc1"
                     /gene_synonym="cTnC; cTnI; TnC; tncc"
                     /inference="alignment:Splign:2.1.0"
     exon            94..240
                     /gene="Tnnc1"
                     /gene_synonym="cTnC; cTnI; TnC; tncc"
                     /inference="alignment:Splign:2.1.0"
     exon            241..355
                     /gene="Tnnc1"
                     /gene_synonym="cTnC; cTnI; TnC; tncc"
                     /inference="alignment:Splign:2.1.0"
     exon            356..492
                     /gene="Tnnc1"
                     /gene_synonym="cTnC; cTnI; TnC; tncc"
                     /inference="alignment:Splign:2.1.0"
     exon            493..701
                     /gene="Tnnc1"
                     /gene_synonym="cTnC; cTnI; TnC; tncc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      681..686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnnc1"
                     /gene_synonym="cTnC; cTnI; TnC; tncc"
                     /note="hexamer: AATAAA"
     polyA_site      701
                     /gene="Tnnc1"
                     /gene_synonym="cTnC; cTnI; TnC; tncc"
                     /note="major polyA site"
ORIGIN      
        1 ggcaacccca gtagcctgtc ctgtgagctg tcgccagaat ggatgacatc tacaaagctg
       61 cggtagaaca gttgacagag gagcagaaga atgagttcaa ggctgccttt gatatctttg
      121 tcctgggcgc ggaggatggc tgcatcagca ccaaggagct gggcaaggtg atgaggatgc
      181 tgggccagaa ccccacacct gaggagctgc aggagatgat tgacgaagta gacgaggatg
      241 gcagtggcac agtggacttc gatgagtttc ttgtcatgat ggttcggtgc atgaaggacg
      301 acagcaaagg gaagtctgag gaggagctgt cggatctctt ccgcatgttt gacaaaaacg
      361 ctgatggcta cattgactta gatgagctga agatgatgct gcaggccaca ggtgagacca
      421 ttacggaaga tgacattgaa gagctcatga aggacggtga caagaacaac gatggccgaa
      481 ttgactatga cgagttcctg gaattcatga agggtgtgga gtagatgctg gtcttgcacg
      541 gttgcctgcg cctgttctcc ccctccaccc agaccccgtg gtaggagtgc agctgggctc
      601 tctagactct gagcctgcct gtgtccttga accttggccc ttccggactt tctctcccca
      661 ttcctgtcct ggggaacgca aataaatcct tgctccccag a
//
