LOCUS       NM_022322               1338 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus tenomodulin (Tnmd), mRNA.
ACCESSION   NM_022322
VERSION     NM_022322.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1338)
  AUTHORS   Bobzin,L., Nickle,A., Ko,S., Ince,M., Huang,A., Bhojwani,A.,
            Roberts,R. and Merrill,A.E.
  TITLE     FGFR2 directs inhibition of WNT signaling to regulate anterior
            fontanelle closure during skull development
  JOURNAL   Development 152 (2) (2025)
   PUBMED   39775862
REFERENCE   2  (bases 1 to 1338)
  AUTHORS   Wada,S., Ideno,H., Nakashima,K., Komatsu,K., Demura,N.,
            Tomonari,H., Kimura,H., Tachibana,M. and Nifuji,A.
  TITLE     The histone H3K9 methyltransferase G9a regulates tendon formation
            during development
  JOURNAL   Sci Rep 14 (1), 20771 (2024)
   PUBMED   39237663
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1338)
  AUTHORS   Li,H., Korcari,A., Ciufo,D., Mendias,C.L., Rodeo,S.A.,
            Buckley,M.R., Loiselle,A.E., Pitt,G.S. and Cao,C.
  TITLE     Increased Ca2+ signaling through CaV 1.2 induces tendon hypertrophy
            with increased collagen fibrillogenesis and biomechanical
            properties
  JOURNAL   FASEB J 37 (7), e23007 (2023)
   PUBMED   37261735
REFERENCE   4  (bases 1 to 1338)
  AUTHORS   Ono,Y., Schlesinger,S., Fukunaga,K., Yambe,S., Sato,T., Sasaki,T.,
            Shukunami,C., Asahara,H. and Inui,M.
  TITLE     Scleraxis-lineage cells are required for correct muscle patterning
  JOURNAL   Development 150 (10) (2023)
   PUBMED   37246520
REFERENCE   5  (bases 1 to 1338)
  AUTHORS   Fuiten,A.M., Yoshimoto,Y., Shukunami,C. and Stadler,H.S.
  TITLE     Digits in a dish: An in vitro system to assess the molecular
            genetics of hand/foot development at single-cell resolution
  JOURNAL   Front Cell Dev Biol 11, 1135025 (2023)
   PUBMED   36994104
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1338)
  AUTHORS   Oshima,Y., Shukunami,C., Honda,J., Nishida,K., Tashiro,F.,
            Miyazaki,J., Hiraki,Y. and Tano,Y.
  TITLE     Expression and localization of tenomodulin, a transmembrane type
            chondromodulin-I-related angiogenesis inhibitor, in mouse eyes
  JOURNAL   Invest Ophthalmol Vis Sci 44 (5), 1814-1823 (2003)
   PUBMED   12714610
REFERENCE   7  (bases 1 to 1338)
  AUTHORS   Brandau,O., Aszodi,A., Hunziker,E.B., Neame,P.J., Vestweber,D. and
            Fassler,R.
  TITLE     Chondromodulin I is dispensable during enchondral ossification and
            eye development
  JOURNAL   Mol Cell Biol 22 (18), 6627-6635 (2002)
   PUBMED   12192060
REFERENCE   8  (bases 1 to 1338)
  AUTHORS   Brandau,O., Meindl,A., Fassler,R. and Aszodi,A.
  TITLE     A novel gene, tendin, is strongly expressed in tendons and
            ligaments and shows high homology with chondromodulin-I
  JOURNAL   Dev Dyn 221 (1), 72-80 (2001)
   PUBMED   11357195
REFERENCE   9  (bases 1 to 1338)
  AUTHORS   Shukunami,C., Oshima,Y. and Hiraki,Y.
  TITLE     Molecular cloning of tenomodulin, a novel chondromodulin-I related
            gene
  JOURNAL   Biochem Biophys Res Commun 280 (5), 1323-1327 (2001)
   PUBMED   11162673
REFERENCE   10 (bases 1 to 1338)
  AUTHORS   Yamana,K., Wada,H., Takahashi,Y., Sato,H., Kasahara,Y. and
            Kiyoki,M.
  TITLE     Molecular cloning and characterization of CHM1L, a novel membrane
            molecule similar to chondromodulin-I
  JOURNAL   Biochem Biophys Res Commun 280 (4), 1101-1106 (2001)
   PUBMED   11162640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC049944.1.
            
            On Jun 19, 2003 this sequence version replaced NM_022322.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049944.1, AF191768.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1338
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 55.47 cM"
     gene            1..1338
                     /gene="Tnmd"
                     /gene_synonym="1110017I01Rik; Bricd4; ChM1L; TeM"
                     /note="tenomodulin"
                     /db_xref="GeneID:64103"
                     /db_xref="MGI:MGI:1929885"
     exon            1..247
                     /gene="Tnmd"
                     /gene_synonym="1110017I01Rik; Bricd4; ChM1L; TeM"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1153
                     /gene="Tnmd"
                     /gene_synonym="1110017I01Rik; Bricd4; ChM1L; TeM"
                     /note="myodulin; tendin; mTeM; mChM1L;
                     chondromodulin-1-like protein; chondromodulin-I-like
                     protein"
                     /codon_start=1
                     /product="tenomodulin"
                     /protein_id="NP_071717.1"
                     /db_xref="CCDS:CCDS30386.1"
                     /db_xref="GeneID:64103"
                     /db_xref="MGI:MGI:1929885"
                     /translation="MAKNPPENCEGCHILNAEALKSKKICKSLKICGLVFGILALTLI
                     VLFWGSKHFWPEVSKKTYDMEHTFYSNGEKKKIYMEIDPITRTEIFRSGNGTDETLEV
                     HDFKNGYTGIYFVGLQKCFIKTQIKVIPEFSEPEEEIDENEEITTTFFEQSVIWVPAE
                     KPIENRDFLKNSKILEICDNVTMYWINPTLIAVSELQDFEEDGEDLHFPTSEKKGIDQ
                     NEQWVVPQVKVEKTRHTRQASEEDLPINDYTENGIEFDPMLDERGYCCIYCRRGNRYC
                     RRVCEPLLGYYPYPYCYQGGRVICRVIMPCNWWVARMLGRV"
     exon            248..379
                     /gene="Tnmd"
                     /gene_synonym="1110017I01Rik; Bricd4; ChM1L; TeM"
                     /inference="alignment:Splign:2.1.0"
     exon            380..520
                     /gene="Tnmd"
                     /gene_synonym="1110017I01Rik; Bricd4; ChM1L; TeM"
                     /inference="alignment:Splign:2.1.0"
     exon            521..622
                     /gene="Tnmd"
                     /gene_synonym="1110017I01Rik; Bricd4; ChM1L; TeM"
                     /inference="alignment:Splign:2.1.0"
     exon            623..776
                     /gene="Tnmd"
                     /gene_synonym="1110017I01Rik; Bricd4; ChM1L; TeM"
                     /inference="alignment:Splign:2.1.0"
     exon            777..943
                     /gene="Tnmd"
                     /gene_synonym="1110017I01Rik; Bricd4; ChM1L; TeM"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1325
                     /gene="Tnmd"
                     /gene_synonym="1110017I01Rik; Bricd4; ChM1L; TeM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1302..1307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnmd"
                     /gene_synonym="1110017I01Rik; Bricd4; ChM1L; TeM"
                     /note="hexamer: AATAAA"
     polyA_site      1325
                     /gene="Tnmd"
                     /gene_synonym="1110017I01Rik; Bricd4; ChM1L; TeM"
                     /note="major polyA site"
ORIGIN      
        1 catatatggg tatatctatg taacaaatcg tagcacggga gccccctggg ctccctccgg
       61 ctctggtatg acatatttga gccatataaa ttcagcttct cctccggcat ctggtagccg
      121 actcacttgc aactccacct cagcagtagt cctctcagtc ctctcaaagc agggaaagag
      181 caccgtgtgc tgggagacca tggcaaagaa tcctccagag aactgtgagg gctgtcacat
      241 tctaaatgca gaagctctga aatctaagaa gatatgtaaa tcactgaaga tttgtggact
      301 agtgtttggt atcctggcct taactctaat tgtcctgttt tgggggagca aacacttctg
      361 gcccgaggta tccaagaaaa cctatgacat ggagcacact ttctacagca acggcgagaa
      421 gaagaagatt tacatggaaa ttgatcccat aaccagaaca gaaatattca gaagtggaaa
      481 tggcactgat gaaacattgg aagtccatga ctttaaaaat ggatacactg gcatctactt
      541 tgtaggtctt caaaaatgct ttattaaaac tcaaatcaaa gtgattcctg aattttctga
      601 accagaggaa gaaatagatg agaatgaaga aattactaca actttctttg aacagtcagt
      661 gatttgggtt cccgcagaaa agcctattga aaacagagac ttcctgaaaa attctaaaat
      721 tctggagatt tgcgataatg tgaccatgta ctggatcaat cccactctaa tagcagtttc
      781 agaattacag gactttgagg aggacggtga agatcttcac tttcctacca gtgaaaaaaa
      841 ggggattgac cagaatgagc aatgggtggt cccgcaagtg aaggtggaga agacccgcca
      901 caccagacaa gcaagcgagg aagaccttcc tataaatgac tatactgaaa atggaattga
      961 atttgaccca atgctggatg agagaggtta ctgttgtatt tactgtcgtc gaggcaaccg
     1021 ttactgccgc cgtgtctgtg aacctttact aggctactac ccatacccct actgctacca
     1081 aggaggtcga gtcatctgtc gtgtcatcat gccttgcaac tggtgggtgg cccgcatgct
     1141 tgggagagtc taataggaag attgagttca aacgcttaac cttctgttag ccaatatata
     1201 attaatgcat gctactccat gaatttctgc ctatgaggca tttgcctcca agtagcctat
     1261 ccttcagaat tacttgtagg atattcctct cttcatgttc taataaactt ctacatcatc
     1321 atcaaaaaaa aaaaaaaa
//
