LOCUS       NM_001163635            6503 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tankyrase, TRF1-interacting ankyrin-related ADP-ribose
            polymerase 2 (Tnks2), mRNA.
ACCESSION   NM_001163635 XM_001000101 XM_917270
VERSION     NM_001163635.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6503)
  AUTHORS   Hou,S., Zhang,J., Jiang,X., Yang,Y., Shan,B., Zhang,M., Liu,C.,
            Yuan,J. and Xu,D.
  TITLE     PARP5A and RNF146 phase separation restrains RIPK1-dependent
            necroptosis
  JOURNAL   Mol Cell 84 (5), 938-954 (2024)
   PUBMED   38272024
REFERENCE   2  (bases 1 to 6503)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6503)
  AUTHORS   Xu,Y.R., Shi,M.L., Zhang,Y., Kong,N., Wang,C., Xiao,Y.F., Du,S.S.,
            Zhu,Q.Y. and Lei,C.Q.
  TITLE     Tankyrases inhibit innate antiviral response by PARylating
            VISA/MAVS and priming it for RNF146-mediated ubiquitination and
            degradation
  JOURNAL   Proc Natl Acad Sci U S A 119 (26), e2122805119 (2022)
   PUBMED   35733260
REFERENCE   4  (bases 1 to 6503)
  AUTHORS   Matsumoto,Y., Dimitriou,I.D., La Rose,J., Lim,M., Camilleri,S.,
            Law,N., Adissu,H.A., Tong,J., Moran,M.F., Chruscinski,A., He,F.,
            Asano,Y., Katsuyama,T., Sada,K.E., Wada,J. and Rottapel,R.
  TITLE     Tankyrase represses autoinflammation through the attenuation of
            TLR2 signaling
  JOURNAL   J Clin Invest 132 (7) (2022)
   PUBMED   35362478
REFERENCE   5  (bases 1 to 6503)
  AUTHORS   Gambini,A., Stein,P., Savy,V., Grow,E.J., Papas,B.N., Zhang,Y.,
            Kenan,A.C., Padilla-Banks,E., Cairns,B.R. and Williams,C.J.
  TITLE     Developmentally Programmed Tankyrase Activity Upregulates
            beta-Catenin and Licenses Progression of Embryonic Genome
            Activation
  JOURNAL   Dev Cell 53 (5), 545-560 (2020)
   PUBMED   32442396
  REMARK    GeneRIF: Developmentally Programmed Tankyrase Activity Upregulates
            beta-Catenin and Licenses Progression of Embryonic Genome
            Activation.
REFERENCE   6  (bases 1 to 6503)
  AUTHORS   Levaot,N., Voytyuk,O., Dimitriou,I., Sircoulomb,F.,
            Chandrakumar,A., Deckert,M., Krzyzanowski,P.M., Scotter,A., Gu,S.,
            Janmohamed,S., Cong,F., Simoncic,P.D., Ueki,Y., La Rose,J. and
            Rottapel,R.
  TITLE     Loss of Tankyrase-mediated destruction of 3BP2 is the underlying
            pathogenic mechanism of cherubism
  JOURNAL   Cell 147 (6), 1324-1339 (2011)
   PUBMED   22153076
  REMARK    GeneRIF: Study shows that TNKS2, regulates 3BP2 stability through
            ADP-ribosylation and subsequent ubiquitylation in osteoclasts;
            cherubism mutations uncouple 3BP2 from Tankyrase-mediated protein
            destruction.
REFERENCE   7  (bases 1 to 6503)
  AUTHORS   Karner,C.M., Merkel,C.E., Dodge,M., Ma,Z., Lu,J., Chen,C., Lum,L.
            and Carroll,T.J.
  TITLE     Tankyrase is necessary for canonical Wnt signaling during kidney
            development
  JOURNAL   Dev Dyn 239 (7), 2014-2023 (2010)
   PUBMED   20549720
  REMARK    GeneRIF: Data show that Tnks1 and 2 are broadly expressed during
            mouse development and are essential during kidney and lung
            development. In the kidney, blockage of tankyrase activity
            phenocopies the effect of blocking production of all Wnt ligands.
REFERENCE   8  (bases 1 to 6503)
  AUTHORS   Chiang,Y.J., Hsiao,S.J., Yver,D., Cushman,S.W., Tessarollo,L.,
            Smith,S. and Hodes,R.J.
  TITLE     Tankyrase 1 and tankyrase 2 are essential but redundant for mouse
            embryonic development
  JOURNAL   PLoS One 3 (7), e2639 (2008)
   PUBMED   18612384
  REMARK    GeneRIF: tankyrase 2is essential but redundant for mouse embryonic
            development
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6503)
  AUTHORS   Hsiao,S.J., Poitras,M.F., Cook,B.D., Liu,Y. and Smith,S.
  TITLE     Tankyrase 2 poly(ADP-ribose) polymerase domain-deleted mice exhibit
            growth defects but have normal telomere length and capping
  JOURNAL   Mol Cell Biol 26 (6), 2044-2054 (2006)
   PUBMED   16507985
  REMARK    GeneRIF: Tnks2 has a role in normal growth and development but is
            not essential for telomere length maintenance or telomere capping
            in mice.
REFERENCE   10 (bases 1 to 6503)
  AUTHORS   Chiang,Y.J., Nguyen,M.L., Gurunathan,S., Kaminker,P.,
            Tessarollo,L., Campisi,J. and Hodes,R.J.
  TITLE     Generation and characterization of telomere length maintenance in
            tankyrase 2-deficient mice
  JOURNAL   Mol Cell Biol 26 (6), 2037-2043 (2006)
   PUBMED   16507984
  REMARK    GeneRIF: inactivation of tankyrase 2 does not result in the
            alteration in telomere length when monitored through multiple
            generations of breeding, tankyrase 2 functions in potentially
            telomerase-independent pathways to affect overall development
            and/or metabolism.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY710137.1, AK047094.1, AK163335.1, AK149368.1, BC063101.1 and
            CN531910.1.
            
            On or before Jul 29, 2009 this sequence version replaced
            XM_917270.3, XM_001000101.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               BY710137.1         1-142
            143-651             AK047094.1         2-510
            652-965             AK163335.1         480-793
            966-2108            AK047094.1         825-1967
            2109-2730           AK149368.1         74-695
            2731-5884           BC063101.1         151-3304
            5885-6503           CN531910.1         38-656              c
FEATURES             Location/Qualifiers
     source          1..6503
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 31.96 cM"
     gene            1..6503
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /note="tankyrase, TRF1-interacting ankyrin-related
                     ADP-ribose polymerase 2"
                     /db_xref="GeneID:74493"
                     /db_xref="MGI:MGI:1921743"
     exon            1..505
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..3807
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /EC_number="2.4.2.30"
                     /note="tankyrase-like protein; tankyrase-related protein;
                     tankyrase-2; tankyrase II; TRF1-interacting
                     ankyrin-related ADP-ribose polymerase 2;
                     ADP-ribosyltransferase diphtheria toxin-like 6; protein
                     poly-ADP-ribosyltransferase tankyrase-2"
                     /codon_start=1
                     /product="poly [ADP-ribose] polymerase tankyrase-2"
                     /protein_id="NP_001157107.1"
                     /db_xref="CCDS:CCDS50426.1"
                     /db_xref="GeneID:74493"
                     /db_xref="MGI:MGI:1921743"
                     /translation="MSGRRCAGGGAACASAGAEAVEPSARELFEACRNGDVERVKRLV
                     TPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFG
                     HAEVVNLLLQHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTA
                     LDLADPSAKAVLTGDYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLA
                     AGYNRVKIVQLLLHHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLW
                     QFTPLHEAASKNRIEVCSLLLSYGADPTLLNCHNKSAIDLAPTAQLKERLSYEFKGHS
                     LLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGAN
                     TNEKTKEFLTPLHVASENAHNDVVEVVVKHEAKVNALDSLGQTSLHRAAHCGHLQTCR
                     LLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGASLGHSEADRQLLEAAKAGDVETV
                     KKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNA
                     CSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRD
                     GNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTP
                     LHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA
                     TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAM
                     PPSALPTCYKPQVLSGVRGPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSAVVS
                     SSAAEGATGLQRKEDSGIDFSITQFIRNLGLEHLMDIFEREQITLDVLVEMGHKELKE
                     IGINAYGHRHKLIKGVERLISGQQGLNPYLTLNNSGSGTILIDLSPDDKEFQSVEEEM
                     QSTVREHRDGGHAGGVFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLF
                     HGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPIHKDRS
                     CYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQ
                     AYPEYLITYQIVRPEGMVDG"
     exon            506..730
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            731..826
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            827..863
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            864..939
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1034
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1101
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1288
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1410
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1502
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1581
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1753
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1833
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1979
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2145
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2365
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2475
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2664
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2917
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3000
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3121
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3219
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3220..3294
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..3400
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3401..3587
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3588..3744
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3745..6481
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5866..5871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /note="hexamer: AATAAA"
     polyA_site      5893
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /note="major polyA site"
     regulatory      6455..6460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /note="hexamer: AATAAA"
     polyA_site      6477
                     /gene="Tnks2"
                     /gene_synonym="5430432P15Rik; ARTD6; Parp5b; Tank2;
                     TNKS-2"
                     /note="major polyA site"
ORIGIN      
        1 tcccaggacc cgaccgagct ggcaggagtg gtctcggccg cttccgccgt cgcgtcgctt
       61 cggggctcgg cgagcgggtt cgcgctgcct ccaccgcggt ggggcagccg gggctcacgg
      121 agccgagccg ggggcgcgcg gcgacgcggc catgggaccg tgccgactct ggtgacagcg
      181 gggagcggag cggcccgggc cctgagcgcg tctcctgcgg ggggcctcgc cctcctgctc
      241 gcggggcccg ggctcctgct gcctttgctg gcgctgctgc tggcggcggc ggcggcggcc
      301 cggatcatgt ctggccgccg ctgcgccggc gggggcgcgg cctgcgcgag cgccggggcc
      361 gaggccgtgg agccgtccgc ccgcgagctg ttcgaggctt gccgcaacgg ggacgtggag
      421 cgagtcaaga ggctggtgac gcccgagaag gtgaacagcc gcgacacggc gggcaggaag
      481 tccaccccgc tccacttcgc cgcaggtttt ggacggaagg atgtagttga atatcttctt
      541 cagaacggtg caaatgtgca agcgcgtgat gatgggggtc ttattcctct tcataacgca
      601 tgctcttttg gtcatgctga agtagtcaat cttcttttac aacacggtgc agacccaaat
      661 gctcgggata attggaatta tactcctctc catgaagctg caattaaagg aaaaattgat
      721 gtttgcattg tgcttttaca gcatggagct gagccaacca tccgaaatac agatggaagg
      781 acagcattgg atttagcaga cccatctgcc aaagctgttc tgactggtga ctataagaaa
      841 gatgaacttc tggaaagtgc caggagtggc aatgaggaaa aaatgatggc cctgcttaca
      901 ccattgaatg tcaactgcca tgcaagtgat ggcagaaagt caactccatt gcatttggca
      961 gcaggataca acagagtaaa aattgtacaa ctgttactgc accatggggc tgatgtccat
     1021 gctaaagata aaggggatct ggtaccacta cacaatgcct gctcttacgg tcattatgaa
     1081 gtaactgaac ttctggtcaa gcacggtgcc tgtgtgaatg caatggacct gtggcagttc
     1141 actcctcttc atgaggcagc ttctaagaac aggattgaag tatgttctct cctcctaagt
     1201 tacggggcag atccaaccct gctgaactgt cacaataaaa gtgctataga cctggccccc
     1261 acggcacagc tgaaggaaag attatcgtat gaatttaaag gccattcatt gctgcaagct
     1321 gcacgagaag ctgatgttac aagaatcaaa aaacatcttt ctctggaaat ggtgaatttc
     1381 aaacatcctc agacacatga aacagcactg cattgtgctg ctgcatctcc atatcccaaa
     1441 agaaagcaga tatgtgaact gctgctcaga aagggagcaa acaccaacga aaagactaaa
     1501 gaattcttga ctcctctgca cgtggcttct gagaacgctc acaatgatgt tgttgaagta
     1561 gtggtgaaac atgaagcaaa ggttaatgct ttggatagtc ttggacagac gtcattacac
     1621 agagctgcac actgtggtca cctgcagacc tgccgcctgc tcctgagcta tgggtgtgat
     1681 ccaaacatca tatcccttca gggtttcacc gccttgcaaa tgggaaatga aaatgtgcag
     1741 cagctgctcc aagagggcgc ctcactaggt cactcagagg cggacagaca gctgctggaa
     1801 gctgcaaagg ctggtgacgt tgaaactgta aaaaaactct gtactgttca gagtgtcaac
     1861 tgcagagaca ttgaaggacg ccagtcaacc ccactccact ttgcagctgg gtacaacaga
     1921 gtgtctgtgg tagaatatct gctgcaacat ggagctgatg ttcatgctaa agacaaagga
     1981 ggtcttgtac ctttacacaa tgcatgttct tatggacact atgaagttgc agaacttctt
     2041 gtcaagcatg gagcagtagt caatgtcgct gacttgtgga agttcacacc tttacatgaa
     2101 gctgcagcaa aaggaaaata tgaaatatgc aaacttctac tccagcatgg tgcagaccct
     2161 acaaagaaaa acagagatgg taatactcct ctggatcttg ttaaagatgg agatacagat
     2221 attcaagatc tacttagagg tgatgcagct ttgctggatg ctgccaagaa gggttgttta
     2281 gccagagtga agaaattgtc ttctcctgat aatgtaaatt gccgtgatac ccaaggtcgg
     2341 cattctacac ctttacattt ggcagctggt tataataact tggaagttgc tgagtattta
     2401 ttgcaacatg gagctgatgt gaatgcccag gacaaaggag gactcattcc tttacataac
     2461 gcagcatcgt atggacatgt agatgtagca gctttgctga taaagtacaa tgcgtgtgtc
     2521 aatgccacgg acaaatgggc tttcacaccg ttacatgaag cagcccaaaa gggacggaca
     2581 cagctttgtg ctttattgtt ggcccatgga gctgatccta ctcttaaaaa tcaagaagga
     2641 caaacacctt tagatttagt ttcagcagat gatgtcagtg cactcttgac agcagccatg
     2701 cccccctctg ctctgcctac gtgctacaaa cctcaagtgc tcagtggcgt gaggggcccc
     2761 ggagccactg cagatgctct gtcttcaggt ccgtccagcc catccagcct ctctgcagcc
     2821 agcagcctcg acaacttatc tggcagcttc tcggaactgt ccgcagtggt tagttcaagt
     2881 gcagcagaag gtgctactgg tttgcaaaga aaagaggatt caggaatcga ttttagtata
     2941 actcagttca taaggaacct tggacttgag cacttgatgg atatatttga gagagaacag
     3001 attaccttag atgtcctagt tgaaatgggc cacaaggaac tgaaagagat tggaatcaat
     3061 gcctatggac atcgacacaa gctgattaaa ggagttgaaa ggctgatctc tggacaacaa
     3121 ggtcttaatc catatttaac tctaaacaac tctggtagtg gaacaattct catagatctg
     3181 tctcctgatg ataaagaatt tcagtctgtg gaagaagaga tgcagagtac tgtgcgggag
     3241 cacagagatg gtggtcacgc aggcggcgtc ttcaacagat acaacattct caagattcag
     3301 aaggtttgta acaagaaatt gtgggaaaga tatacacacc ggagaaaaga agtttctgaa
     3361 gaaaaccaca accatgcaaa cgaaaggatg ttatttcatg ggtctccttt tgtgaatgcg
     3421 attatccata agggctttga tgaaaggcat gcatacatag gtggcatgtt tggagctgga
     3481 atttattttg ctgagaactc ttccaaaagc aatcaatatg tgtatggaat tggaggtggc
     3541 accggatgtc caattcacaa agacagatcg tgttacattt gtcacaggca gctgctgttt
     3601 tgtcgagtaa ccttgggaaa gtctttcttg cagttcagcg caatgaaaat ggcacattct
     3661 cctcccggcc atcactcggt cactggccgg cccagtgtaa atggcctagc attagctgaa
     3721 tatgttattt acagaggaga acaggcttat cctgaatatc taattactta ccagattgta
     3781 aggcctgaag gtatggttga tggctgaaac cagttccccc agacgaaatg tcctgaagca
     3841 gctgacggcc tcttaagttt cactccttgg caggaaaaca attcatgctg actacaggcc
     3901 tgtggcacaa atgataaaat gtgaacgaag cccagcgttg tgacttgatg aagctttaac
     3961 agtgtacagt gtttctgagt gtttcctgtt ctcagcactt taacagatgc cattccaggt
     4021 tcaactgggt ttgtctgtcc taaattataa acagttaact tgaatctttt atacgtcgtg
     4081 cattggttct aacaaaaatg gtaatccctc aacagaactc attttactaa tcagtactgt
     4141 gttctttaaa acacagcatt tacactgaat acaatttcat ttgtaaaatg taaataagag
     4201 cttttgtact agcccgatat ttatttacat cgctttgtac tataaactgt tctagagctg
     4261 cagcggttca cagagtattt tcatatgtgt tgctcatccg tgtttcatct gtcgtcgcct
     4321 gactgatcgc tacgtttgat tccagaggct gctcggttgc taatagagag ttagtgggga
     4381 aacattgact taacaaattt aatttactga tggaagcatt tctctattaa tagaaatctt
     4441 tctaatttaa gaattttatg aatactcttg gaatttaatt ggtgatgcct ttgtgtctag
     4501 aaggcacaca tcccagagag ctctggtgtg acgtgatggg gacttgtggc tagagaagat
     4561 cttcaatggc cttaagctct gggtcttgct ctagagaggt ctctgatgtc ctcgacctca
     4621 gagcagaact ctcttcaagt tttgaagatg ctaagcccca gcttctgaac tcttagtgct
     4681 ctgatcgtga actgtaagtg gacacgggga aggcaatggt ggataatttc ccaatcaggt
     4741 ctaattacct taaatctaaa acggaggaat aacaagtgga aatggatagg ttttttaaat
     4801 ttaagttttt cttgatctta tggatatatt atagccagtg tatttatcat gagtaaatac
     4861 aacctaaaac cataggtgtg agtgtctgtg tctgtggcag cctctggaat gggcaagcct
     4921 agtgcttcct acttctgtca aggcattctg cccagttgga aaaacactgt cacaggctca
     4981 agttcagtat ggcagctgtg gaagaaatta ctttccatga aaggctattt ttactattct
     5041 ctaatgtaag ccttacactt agcatcttgc attgcacaga gacctgccgt actgcatggc
     5101 ggtacactca gaaatcaagg agagattttt atccacctaa gtttttgtaa atgaggatgt
     5161 cctcttcact ctctgtacac tttctctttg ttttacattt tatttggtct cttaattacc
     5221 tacctggtcc tttatagaat cttgtacata gagttgcttg aaagttaagt ttcccatcct
     5281 gtgagttaag agaaatgtat gtctggagtt gttcctaaga tgtgaattgt ggtcaagggt
     5341 taagaggtca aatcctgacc tagaaatgct tttatacagc tctctgctaa ctacaaatat
     5401 cctaaaatca tttcttgaac ataaaaggag tatgccaaat tttatataaa tttttcaggt
     5461 tctgtaagct tctgggtttt atagttaaaa gataatgaag ttaattagtg gggtttatat
     5521 ttacgtactt ttcaaagttt ggcctatgtt actctgtgtg gatctggaat tgtttttcat
     5581 gtagaatcat ggtctggtta tgacccgtgt tacctcctaa cccattgctt atgtgtgttc
     5641 ccattgtggt caatacgctg gcatggcaat gtttattggg agctgggagt ttgggggtgt
     5701 ggtttagtgc tttgcatgaa atacctttat aataatggaa ttgctttttc ttttgccttg
     5761 tgattttttt ttgaggtgaa atttaatttg tgtatgtgtg tgtgtgtagt gttctgccca
     5821 tctgagtgtc tacttgtatc acattccatg cctcacttaa ttcttaataa actgtttact
     5881 tgttttctgg gtagcatggt aattcattga aattacagta aatcgtaatt gcaagagaac
     5941 agtgtagttt tgagtctaat cgtgacaggg tgcagcataa atgtaagatg tagaatgtgg
     6001 tggccatact tgctcagatg cttcatgatg aaggtaagat gtgtttggcg tccacaccat
     6061 ccagtatgac tttggtagtc cttaaaattc attcacgaaa atcagtctgc ttaacttaca
     6121 aagagaaata tatttttgtt ttctatgtca taaaaacatt cttgataagt ttccaaatcc
     6181 cagttagtca tattttttct ctaaaaggaa aaaaaagtag tgtattttat atttccatat
     6241 gctaatgaca tgtctgtaat tagtcttcag tgttccataa gaagagagtg atggtacaag
     6301 tatccctaag tatcactttg aagtctacat aaactgcttt atcttcctgc ttcttttaag
     6361 atgatactga agtgtttgct tgctgtttgc tgagcgtgca tgcccacgta tgatgtgatc
     6421 cagttgtttg aagattgagg caagaaaaca tgcaaataaa cttcccaaag ctattaacta
     6481 aaaaaaaaaa aaaaaaaaaa aaa
//
