LOCUS       NM_175091               6444 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tankyrase, TRF1-interacting ankyrin-related ADP-ribose
            polymerase (Tnks), mRNA.
ACCESSION   NM_175091 NM_175322
VERSION     NM_175091.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6444)
  AUTHORS   Hou,S., Zhang,J., Jiang,X., Yang,Y., Shan,B., Zhang,M., Liu,C.,
            Yuan,J. and Xu,D.
  TITLE     PARP5A and RNF146 phase separation restrains RIPK1-dependent
            necroptosis
  JOURNAL   Mol Cell 84 (5), 938-954 (2024)
   PUBMED   38272024
REFERENCE   2  (bases 1 to 6444)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6444)
  AUTHORS   Bamunuarachchi,G., Vaddadi,K., Yang,X., Dang,Q., Zhu,Z.,
            Hewawasam,S., Huang,C., Liang,Y., Guo,Y. and Liu,L.
  TITLE     MicroRNA-9-1 Attenuates Influenza A Virus Replication via Targeting
            Tankyrase 1
  JOURNAL   J Innate Immun 15 (1), 647-664 (2023)
   PUBMED   37607510
  REMARK    GeneRIF: MicroRNA-9-1 Attenuates Influenza A Virus Replication via
            Targeting Tankyrase 1.
REFERENCE   4  (bases 1 to 6444)
  AUTHORS   Xu,Y.R., Shi,M.L., Zhang,Y., Kong,N., Wang,C., Xiao,Y.F., Du,S.S.,
            Zhu,Q.Y. and Lei,C.Q.
  TITLE     Tankyrases inhibit innate antiviral response by PARylating
            VISA/MAVS and priming it for RNF146-mediated ubiquitination and
            degradation
  JOURNAL   Proc Natl Acad Sci U S A 119 (26), e2122805119 (2022)
   PUBMED   35733260
REFERENCE   5  (bases 1 to 6444)
  AUTHORS   Matsumoto,Y., Dimitriou,I.D., La Rose,J., Lim,M., Camilleri,S.,
            Law,N., Adissu,H.A., Tong,J., Moran,M.F., Chruscinski,A., He,F.,
            Asano,Y., Katsuyama,T., Sada,K.E., Wada,J. and Rottapel,R.
  TITLE     Tankyrase represses autoinflammation through the attenuation of
            TLR2 signaling
  JOURNAL   J Clin Invest 132 (7) (2022)
   PUBMED   35362478
  REMARK    GeneRIF: Tankyrase represses autoinflammation through the
            attenuation of TLR2 signaling.
REFERENCE   6  (bases 1 to 6444)
  AUTHORS   Yeh,T.Y., Sbodio,J.I., Tsun,Z.Y., Luo,B. and Chi,N.W.
  TITLE     Insulin-stimulated exocytosis of GLUT4 is enhanced by IRAP and its
            partner tankyrase
  JOURNAL   Biochem J 402 (2), 279-290 (2007)
   PUBMED   17059388
  REMARK    GeneRIF: insulin-stimulated insulin-responsive aminopeptidase
            translocation remained intact despite substantial GLUT4 knockdown
REFERENCE   7  (bases 1 to 6444)
  AUTHORS   Yeh,T.Y., Sbodio,J.I. and Chi,N.W.
  TITLE     Mitotic phosphorylation of tankyrase, a PARP that promotes spindle
            assembly, by GSK3
  JOURNAL   Biochem Biophys Res Commun 350 (3), 574-579 (2006)
   PUBMED   17026964
  REMARK    GeneRIF: Collectively, our data suggest that GSK3 contributes to
            mitotic tankyrase phosphorylation.
REFERENCE   8  (bases 1 to 6444)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 6444)
  AUTHORS   Seldin,M.F., Hirohata,S. and Apte,S.S.
  TITLE     Chromosomal mapping of Adam9, Adam15 and Adam21
  JOURNAL   Matrix Biol 19 (2), 185-187 (2000)
   PUBMED   10842103
REFERENCE   10 (bases 1 to 6444)
  AUTHORS   Zhu,L., Smith,S., de Lange,T. and Seldin,M.F.
  TITLE     Chromosomal mapping of the tankyrase gene in human and mouse
  JOURNAL   Genomics 57 (2), 320-321 (1999)
   PUBMED   10198177
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK080913.1, BC057370.1 and AC122458.3.
            
            On or before Feb 16, 2006 this sequence version replaced
            NM_175322.2, NM_175091.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057370.1, SRR10223969.8176.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-355               AK080913.1         2-356
            356-4061            BC057370.1         337-4042
            4062-6444           AC122458.3         101549-103931       c
FEATURES             Location/Qualifiers
     source          1..6444
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 21.16 cM"
     gene            1..6444
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /note="tankyrase, TRF1-interacting ankyrin-related
                     ADP-ribose polymerase"
                     /db_xref="GeneID:21951"
                     /db_xref="MGI:MGI:1341087"
     exon            1..677
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..3988
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /EC_number="2.4.2.30"
                     /note="tankyrase-1; tankyrase I; TRF1-interacting
                     ankyrin-related ADP-ribose polymerase 1;
                     ADP-ribosyltransferase diphtheria toxin-like 5; protein
                     poly-ADP-ribosyltransferase tankyrase-1"
                     /codon_start=1
                     /product="poly [ADP-ribose] polymerase tankyrase-1"
                     /protein_id="NP_780300.2"
                     /db_xref="CCDS:CCDS22242.1"
                     /db_xref="GeneID:21951"
                     /db_xref="MGI:MGI:1341087"
                     /translation="MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGPT
                     PASPTAGGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGAVCTVAAPAAVPAASA
                     AVGVAPTPAGGGGGGGNNSASSASSPTSSSSSSPSSPGSSLAESPEAAGVGSTATLGA
                     GAAGLGPGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAG
                     FGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNY
                     TPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLE
                     AARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKD
                     KGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH
                     GADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIIN
                     FKQPQSHETALHCAVASLHPKRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHNDV
                     MEVLHKHGAKMNALDSLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMG
                     NEAVQQILSESTPMRTSDVDYRLLEASKAGDLETVKQLCSPQNVNCRDLEGRHSTPLH
                     FAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVAD
                     LWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDA
                     ALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADV
                     NAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCAL
                     LLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISP
                     ASTPSCLSAASSIDNLTGPLTDLAVGGASNAGDGAAGAERKEGEVAGLDMNISQFLKS
                     LGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNP
                     YLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKV
                     VNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAG
                     IYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMA
                     HAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQKT
                     "
     exon            678..902
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            903..998
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1035
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1111
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1206
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1273
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1460
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1582
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1674
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1753
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1925
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2005
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2151
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2317
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2537
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2647
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2836
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2837..3074
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3157
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3158..3278
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3279..3376
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3377..3451
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3452..3557
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3558..3744
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3745..3901
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3902..6444
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4553..4558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /note="hexamer: CATAAA"
     polyA_site      4573
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /note="major polyA site"
     regulatory      5443..5448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /note="hexamer: ATTAAA"
     polyA_site      5460
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
     regulatory      6132..6137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
                     /note="hexamer: AATAAA"
     polyA_site      6153
                     /gene="Tnks"
                     /gene_synonym="4930554K12Rik; ARTD5; D130072O21Rik;
                     mTNKS1; Parp5a; TANK1"
ORIGIN      
        1 agtgacagta cgggggagtg ggaagatggc ggcgtcgcgt cgctctcagc atcatcacca
       61 ccatcatcag caacagctcc agcccgcccc aggggcttcg gctccgccac cgccacctcc
      121 cccgccgctc agcccgggct tggccccggg acccacccct gcctcgccta cggccggcgg
      181 cctggcgccc ttcgcctccc cgcggcacgg cctggcgctg ccggaggggg atggcagccg
      241 ggacccgccc gacaggccgc gatctcccga cccggtggac ggcgccgtct gcaccgtggc
      301 tgctccggcc gcggtcccgg cagcttccgc cgccgtcggg gtcgctccca ccccagccgg
      361 cggcggcggc ggcggcggga acaactccgc gtcgtccgct tcttccccga cttcgtcttc
      421 gtcttcctcc ccgtcctccc ctggctcgag cttagcggag agtcccgagg cggccggagt
      481 tggctccacg gcaactttgg gagccggggc ggcgggcctc ggcccggggg tcccagccgt
      541 gagtggggcc ctgcgggagc tgctcgaggc ctgtcggaat ggggacgtgt cccgggtgaa
      601 gaggttggtg gacgccgcga acgtgaatgc caaggacatg gccggccgaa agtcttctcc
      661 cctgcacttc gcagcaggtt ttggaaggaa ggatgttgta gaacacttgc tgcagatggg
      721 tgctaatgtc cacgcccgtg atgacggggg tctcatccca cttcataatg cctgctcttt
      781 cggccatgct gaggttgtga gtctgttact gtgtcaagga gcagatccga atgccagaga
      841 taactggaac tatacaccac tgcatgaagc tgccattaaa gggaaaattg atgtctgtat
      901 tgtgctgctg cagcacggag ccgatccaaa catccggaac accgatggga aatcagctct
      961 ggacctggca gatccttcag caaaagctgt cctcacaggt gaatacaaaa aagacgaact
     1021 cctagaagct gctaggagtg gtaatgaaga aaaactaatg gctttactga ctcctctaaa
     1081 tgtgaattgc catgcaagtg atggacgaaa gtctactccg ttacacctgg cagcaggcta
     1141 caacagagtt cggatagttc agctgcttct acagcatggt gctgatgtcc acgcgaaaga
     1201 caaaggtgga cttgtacctc ttcataatgc atgctcatac ggacactatg aggtcacaga
     1261 actgctgcta aagcatggag cttgtgtcaa cgctatggat ctgtggcagt tcacaccgct
     1321 gcatgaagct gcttcaaaga accgggtaga agtctgttct ctgttactta gtcacggtgc
     1381 cgatccaacc ttggtcaatt gccatggcaa aagtgctgtc gacatggctc caactcctga
     1441 gctccgggaa agactgacat atgaatttaa aggccattct ttactccaag ccgccagaga
     1501 agcagacctg gccaaagtta aaaaaacgct tgctttggaa atcattaact tcaagcagcc
     1561 acagtctcat gaaactgcat tgcactgtgc tgtggcctcc ttgcatccca aacgaaagca
     1621 ggtggcagag ctgttactga ggaagggagc caacgtcaac gaaaagaaca aggatttcat
     1681 gacccctctg catgttgcag ctgaaagagc tcataatgat gtcatggaag ttctgcataa
     1741 gcacggagca aagatgaatg cactggatag tcttggtcag actgctttgc acagagctgc
     1801 cttagcgggc cacctgcaga cctgccgcct cctgctgagt tatggctctg atccttccat
     1861 catctccctg caaggcttca cggcagcgca gatggggaat gaagcagtgc aacagattct
     1921 gagcgagagt actcctatgc gcacttcgga cgtggactat cgtctcttag aggcatcgaa
     1981 agctggtgac ttggaaactg tgaagcaact ctgcagcccg cagaatgtga actgcagaga
     2041 cctggagggc cggcactcta cacccttaca cttcgctgca ggctataacc gtgtgtctgt
     2101 cgttgagtac cttctacatc atggagctga tgtccatgcc aaagacaaag gtggcttggt
     2161 tccccttcac aatgcctgct cctatggaca ctatgaggtc gccgagctct tggtgaggca
     2221 cggggcttca gtcaatgtgg ccgacctgtg gaaattcacc cctctccatg aagcggcagc
     2281 caagggaaaa tacgaaatct gcaaactcct tctaaaacat ggagcagatc caactaagaa
     2341 gaacagagat ggaaatacac ccctagatct ggtcaaagaa ggagacacgg atattcagga
     2401 cctgctgagg ggcgatgctg ccctgttgga tgctgccaag aagggctgcc tagccagagt
     2461 gcagaagctt tgtactccag agaatatcaa ctgccgagac acccagggca gaaattcaac
     2521 ccctctccac ctggcagcag gctacaataa cctggaagta gctgagtacc ttctagagca
     2581 cggggctgat gtcaatgccc aggacaaagg agggctaatc ccacttcaca acgctgcgtc
     2641 ttatgggcat gttgacatag cagcgttact gataaaatac aacacgtgtg taaacgcaac
     2701 ggataagtgg gcctttactc cccttcacga agctgcccag aaaggaagga cgcagttatg
     2761 tgccctgctc ctagcacatg gcgcagaccc aaccatgaag aaccaggaag gtcagacacc
     2821 tttagatctg gcgacggctg atgacatccg ggctctgctg atagatgcca tgccccctga
     2881 ggccttacct acctgtttta aacctcaggc aactgtagtt agtgcctctc tgatctcacc
     2941 agcgtccacc ccctcctgcc tctctgctgc cagcagcata gataacctca ctggcccgtt
     3001 aacggatctg gctgtaggag gggcctccaa tgcaggggat ggcgctgcgg gtgcagaaag
     3061 gaaggaagga gaagttgcgg gtcttgacat gaacatcagc cagttcctta agagccttgg
     3121 ccttgagcac ctgagggaca tttttgaaac agagcagatt acgctagatg tgttggctga
     3181 tatgggtcat gaagaattga aagaaatagg catcaatgca tatggacacc gccacaagtt
     3241 gatcaagggt gttgaaagac ttttaggtgg acaacaagga accaatccat atttgacttt
     3301 tcactgtgtg aatcagggaa ctattttgct agatcttgct ccagaagata aagaatatca
     3361 atcagtagaa gaagagatgc agagcactat tcgagagcac agagacggtg ggaacgctgg
     3421 cggcatcttc aacagataca acgtcattcg aattcagaaa gttgtgaata agaagctgag
     3481 ggagcgattc tgccacagac aaaaggaggt gtctgaggag aaccacaacc atcacaatga
     3541 gcgcatgctg ttccacggtt ctcctttcat taatgcaatt attcataaag ggtttgatga
     3601 gcgacatgcg tacattggag ggatgtttgg agctggaatt tactttgctg aaaactcctc
     3661 aaaaagcaat cagtatgttt atggaattgg aggaggaaca ggctgtccca cacacaaaga
     3721 cagatcatgt tatatatgtc acagacaaat gcttttctgt agagtgaccc ttggaaagtc
     3781 cttcctgcaa ttcagcacca tgaaaatggc ccatgcaccc ccaggccatc actcagtcat
     3841 cggtagacca agtgtcaatg ggctggcata tgctgaatat gtcatctaca gaggggaaca
     3901 ggcatatcca gaatatctca tcacctacca gatcatgaag ccagaagccc cttcacagac
     3961 cgcaacggca gcagagcaga agacctagtg accacccctg gtaaaggcca gagtgattca
     4021 aacctgcaac tggagtacag tggattgctt ccaacaaaaa atcaatattc tctaaatccc
     4081 aacagccaag aaataagctg tcttttataa agcattgcta gagtgacagt gcagagtggg
     4141 tcccaagcac actcacctgc cctggtccct ttgaggaaat ggctgccggg cggtcttgaa
     4201 catgtctcag gccattttca ttgcagttac ccatttctga agcaagatgc tttgctcgag
     4261 atgtagagat gggaaagaga atgtgctggc tcacacgttc ttggttcata cactacattt
     4321 tcttggttat gtttggcaca tgaataacag acacatgtgg tgtgctcatt ttttaatttt
     4381 gccaagcata tttgttgatg cttcttgttg tcgttgttac tttgaaaatg agccagtctt
     4441 cctggaatat tttgcacaga gtcacactga ctaaaatcat tagcaatgca gccgagcaag
     4501 acactgttcc catgtccctg ttgtttgatt ttgtatctct gcttcttgtg aacataaagg
     4561 aaaatcagca atatttagtt tccttttata aactgcccta tctttccatc ttaaaaggaa
     4621 gggcacaaac gtctctttga cctaaagagc cagagccggg tggaccattt gctctctgct
     4681 gtcctcaggg ctcttgggac catgctgcag atgtcaaaag tgtcagggaa aggtttaatg
     4741 gaggtggtta gaaatttgct tccctggtgg aatggctaga gagccgggag ggaggagccc
     4801 agggctctgg ctgcagccag cgaacccagg atgtctcagc caacgcttcc ctctctgcac
     4861 ctccagaatt gtttcctggc attatctgta attccagagt cagggtccca gcattctcct
     4921 ctcctctcct ctcctctcct tgtagattag aaagccagga ttcaagccgt actgataaat
     4981 atgcacaatt gcaaggacgt tttgtttact cctgatctgg cctttatttt gagtagtatt
     5041 catcaaatac tttagaaaga tcccttctct ctgtttttga accatttctt caaagttctt
     5101 aatatagtta gacaaagaaa acagaagttg aaaccaaagg cagtttgacc tattttttta
     5161 gacgccactg atagagaaac atttctttgt gaaagtgctg cttgtaatgg cattcgccaa
     5221 gtgcacgcca ccgagcagag ccaccccact ttgcagagcc acgcttcctt ctgtcccctg
     5281 tggaccttaa ctgagtactg aattaaatgc attgctctgt ataggttctg ctcagctctg
     5341 aagcagaagt cacataaaca gagggaagct atgtgacaca cttaatcatt tcaattggaa
     5401 ggctgaaaac agttcttttg actttttttt taatgcaagc atattaaaac tgtgactgtc
     5461 tttgtttctc tggttcttga aatacacatt tctctcttta tttattaaat ttttgttagc
     5521 ttgagcccag tgctaggact aggcatccag tctagtgtga atgaatatta tagttatatc
     5581 ttgaatgagt tcctcaaaat gaagtcaaga attagcctca gttttcactt ttgttgaagt
     5641 ttcaatggcc tgagctgggt gcttgtggat ttggctgcgt gtttaatagc aactcgacta
     5701 ccatacagag cttcagaatg ggatgttggc tcgagagctc ttccccttcc ctctcttttc
     5761 ctttctgtta acaaagggtt gaagaaatgg gcatctgtat agttttagta gctataatat
     5821 ttggcccaac tgaaattagt ttaacatgct aaacacggct gtgattttaa tttagtaacg
     5881 agctactgtg gtatagtaaa acaaactgaa ccgtgaacct ccatcccaca gctggattaa
     5941 cctggccctt accttgagga gtctaccttg gttccctcaa ccaccagggc tgtggctcat
     6001 gttctgagct gagtagagac aatgtgtaag gaagcctgct gtagtgctag tggtctcgtg
     6061 gtgacccacc tatgacaaaa tgcacatgaa cgagctgttt aaaaagaaca agtcctggaa
     6121 aaaaaattaa aaataaatgg tccatagagc taatagatat tttcagaact tgaaaaccaa
     6181 aggtatcagg agtgtattca agttggcaaa aaggtggttg cttaggattt ccttgtacag
     6241 cagcatagac tgtagaagag ccctctggac tagacaagcc tggcattcgg ctgacagctg
     6301 tttaccttct tgtatgtgca ttatgtagaa ctcctggcag gtgtggaacc aactcctgct
     6361 tcccaacaga gctgcagaga gaaggcaggt ggctccaagc tcttcttcaa ggcctttccc
     6421 agagacccca cagtgccact ttac
//
