LOCUS       NM_016788               4454 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tyrosine kinase, non-receptor, 2 (Tnk2), transcript
            variant 1, mRNA.
ACCESSION   NM_016788
VERSION     NM_016788.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4454)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4454)
  AUTHORS   Sridaran,D., Chouhan,S., Mahajan,K., Renganathan,A., Weimholt,C.,
            Bhagwat,S., Reimers,M., Kim,E.H., Thakur,M.K., Saeed,M.A.,
            Pachynski,R.K., Seeliger,M.A., Miller,W.T., Feng,F.Y. and
            Mahajan,N.P.
  TITLE     Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase
            counteracts prostate cancer immune checkpoint blockade resistance
  JOURNAL   Nat Commun 13 (1), 6929 (2022)
   PUBMED   36376335
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4454)
  AUTHORS   Jing,L., Zhang,X., Liu,D., Yang,Y., Xiong,H. and Dong,G.
  TITLE     ACK1 Contributes to the Pathogenesis of Inflammation and
            Autoimmunity by Promoting the Activation of TLR Signaling Pathways
  JOURNAL   Front Immunol 13, 864995 (2022)
   PUBMED   35669783
  REMARK    GeneRIF: ACK1 Contributes to the Pathogenesis of Inflammation and
            Autoimmunity by Promoting the Activation of TLR Signaling Pathways.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4454)
  AUTHORS   Brandao,R., Kwa,M.Q., Yarden,Y. and Brakebusch,C.
  TITLE     ACK1 is dispensable for development, skin tumor formation, and
            breast cancer cell proliferation
  JOURNAL   FEBS Open Bio 11 (6), 1579-1592 (2021)
   PUBMED   33730447
  REMARK    GeneRIF: ACK1 is dispensable for development, skin tumor formation,
            and breast cancer cell proliferation.
REFERENCE   5  (bases 1 to 4454)
  AUTHORS   Fritz,K.R., Zhang,Y. and Ruest,L.B.
  TITLE     Cdc42 activation by endothelin regulates neural crest cell
            migration in the cardiac outflow tract
  JOURNAL   Dev Dyn 248 (9), 795-812 (2019)
   PUBMED   31219639
REFERENCE   6  (bases 1 to 4454)
  AUTHORS   La Torre,A., del Rio,J.A., Soriano,E. and Urena,J.M.
  TITLE     Expression pattern of ACK1 tyrosine kinase during brain development
            in the mouse
  JOURNAL   Gene Expr Patterns 6 (8), 886-892 (2006)
   PUBMED   16750431
  REMARK    GeneRIF: Ack1 is up-regulated during development and is expressed
            in proliferative areas and in migratory pathways in the developing
            brain.
REFERENCE   7  (bases 1 to 4454)
  AUTHORS   Galisteo,M.L., Yang,Y., Urena,J. and Schlessinger,J.
  TITLE     Activation of the nonreceptor protein tyrosine kinase Ack by
            multiple extracellular stimuli
  JOURNAL   Proc Natl Acad Sci U S A 103 (26), 9796-9801 (2006)
   PUBMED   16777958
  REMARK    GeneRIF: These experiments suggest a functional role for Ack as an
            early transducer of multiple extracellular stimuli.
REFERENCE   8  (bases 1 to 4454)
  AUTHORS   Urena,J.M., La Torre,A., Martinez,A., Lowenstein,E., Franco,N.,
            Winsky-Sommerer,R., Fontana,X., Casaroli-Marano,R.,
            Ibanez-Sabio,M.A., Pascual,M., Del Rio,J.A., de Lecea,L. and
            Soriano,E.
  TITLE     Expression, synaptic localization, and developmental regulation of
            Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the
            developing and adult brain
  JOURNAL   J Comp Neurol 490 (2), 119-132 (2005)
   PUBMED   16052498
  REMARK    GeneRIF: Ack1/Pyk1 tyrosine kinase may be involved both in adult
            synaptic function and plasticity and in brain development.
REFERENCE   9  (bases 1 to 4454)
  AUTHORS   Robinson,D.R., Wu,Y.M. and Lin,S.F.
  TITLE     The protein tyrosine kinase family of the human genome
  JOURNAL   Oncogene 19 (49), 5548-5557 (2000)
   PUBMED   11114734
  REMARK    Review article
REFERENCE   10 (bases 1 to 4454)
  AUTHORS   Gertler,F.B., Niebuhr,K., Reinhard,M., Wehland,J. and Soriano,P.
  TITLE     Mena, a relative of VASP and Drosophila Enabled, is implicated in
            the control of microfilament dynamics
  JOURNAL   Cell 87 (2), 227-239 (1996)
   PUBMED   8861907
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ770866.1, DQ666696.1, BU702226.1 and AC161755.3.
            
            On Oct 26, 2007 this sequence version replaced NM_016788.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ666696.1, AF037260.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               BQ770866.1         1-189
            190-1386            DQ666696.1         1-1197
            1387-1692           BU702226.1         355-660
            1693-2203           DQ666696.1         1504-2014
            2204-3347           AC161755.3         63933-65076         c
            3348-3645           DQ666696.1         3159-3456
            3646-4454           AC161755.3         61173-61981         c
FEATURES             Location/Qualifiers
     source          1..4454
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 23.16 cM"
     gene            1..4454
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /note="tyrosine kinase, non-receptor, 2"
                     /db_xref="GeneID:51789"
                     /db_xref="MGI:MGI:1858308"
     exon            1..466
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     exon            467..647
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             485..3652
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 1; Cdc42
                     GTPase-inhibiting protein; activated CDC42 kinase 1;
                     P21cdc42Hs kinase; non-receptor protein tyrosine kinase
                     ACK; tyrosine kinase non-receptor protein 2"
                     /codon_start=1
                     /product="activated CDC42 kinase 1 isoform 1"
                     /protein_id="NP_058068.2"
                     /db_xref="CCDS:CCDS37313.1"
                     /db_xref="GeneID:51789"
                     /db_xref="MGI:MGI:1858308"
                     /translation="MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNITRLSHFEYVKNE
                     DLEKIGMGRPGQRRLWEAVKRRKAMCKRKSWMSKVFSGKRLEAEFPSQHSQSTFRKPS
                     PTPGSLPGEGTLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPAGKTVSVAVKCL
                     KPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTLPMKMVTELAPLGSLLDRLR
                     KHQGHFLLGTLSRYAVQVAEGMAYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRA
                     LPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGL
                     NGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTD
                     MRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCVGPFPRNVVTSVAGLS
                     AQDISQPLQNSFIHTGHGDSDPRHCWGFPDRIDELYLGNPMDPPDLLSVELSTSRPTQ
                     HLGRVKREPPPRPPQPAIFTQKPTYDPVSEDPDPLSSDFKRLGLRKPALPRGLWLAKP
                     SARVPGTKADRSSGGEVTLIDFGEEPVVPTPRPCAPSLAQLAMDACSLLDKTPPQSPT
                     RALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEVCSINSTLVGAGLPAGPSQGE
                     TNYAFVPEQAQMPPALEDNLFLPPQGGGKPPSSVQTAEIFQALQQECMRQLQVPTGQL
                     TPSPTPGGDDKPQVPPRVPIPPRPTRPRVELSPAPSGEEETSRWPGPASPPRVPPREP
                     LSPQGSRTPSPLVPPGSSPLPHRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAG
                     PCILPIVRDGRKVSSTHYYLLPERPPYLERYQRFLREAQSPEEPAALPVPPLLPPPST
                     PAPAAPTATVRPMPQAAPDPKANFSTNNSNPGARPPSLRATARLPQRGCPGDGQEAAR
                     PADKVQMLQAMVHGVTTEECQAALQSHSWSVQRAAQYLKVEQLFGLGLRPRVECHKVL
                     EMFDWNLEQAGCHLLGSCGPAHHKR"
     exon            648..718
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     exon            719..940
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1093
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1371
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1498
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1645
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1740
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1935
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2027
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2072
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..3421
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     exon            3422..3517
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     exon            3518..3645
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     exon            3646..4454
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4428..4433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /note="hexamer: AATAAA"
     polyA_site      4454
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /note="major polyA site"
ORIGIN      
        1 ggtccttgga gcatccctag cgagtgggga cagactcgag ctgctgggga gagccaggcc
       61 tgtagggccc cgagggcctg aaggagaggg gcgcctgggg gtgcaggaag caaattggct
      121 gcccggggtg caagagggcc aggtagtgtg ggctgttcag gagacgtatc tgaacggtaa
      181 agggtcctca gggggagagg gattccaaga gggacacagg acccgcaggc gcagacggcg
      241 aaggaggtgg taatcggcaa gctgccttcc ttgctggcat cagggttgct ctagtgccaa
      301 gagtaatgca ggaagatgta ggggattggg gagcagaaga gcgctgtgaa cctgaccttt
      361 ggaagatatt gctggagggt aggcactggc ctgcaagatc ctttctgcta cctcaagtct
      421 gagcatcctc gaagcagtgt ctgcctgggg acagctggaa actcagaggc tggggagcag
      481 cagcatgcag ccggaggagg gaacgggctg gctgttggag ctgctgtccg aggtgcagct
      541 acaacagtat ttcctgaggc ttcgagatga cctcaacatt acccgcctat ctcattttga
      601 atatgtcaaa aatgaagacc tggaaaagat tggcatgggc cggcctggcc agaggcggct
      661 gtgggaggcc gtgaagagga ggaaggccat gtgcaaacgc aagtcatgga tgagcaaggt
      721 gttcagtgga aagcggttgg aggccgagtt cccttcccag cactctcaga gcaccttccg
      781 gaagccctcc cccaccccag ggagcctgcc aggggagggg accctgcaga gcctcacctg
      841 cctcattggg gagaaagacc tacgcctgct ggagaagctg ggggatggct cctttggcgt
      901 ggtgcgcagg ggtgaatggg acgcccccgc agggaagacg gtgagtgtgg ccgtcaagtg
      961 cctgaagcct gacgtgctga gccagccaga ggccatggac gacttcatcc gggaggtcaa
     1021 tgccatgcat tcactagacc accgaaacct cattcgcttg tatggtgtgg tgctcacact
     1081 acccatgaag atggtgacag agctggcacc tctgggatct ttgttggacc gcctacgtaa
     1141 acaccaaggt catttcctct tggggacgct gagtcgctac gctgtgcagg tggctgaggg
     1201 tatggcctac ctggagtcca agcgcttcat tcaccgggat ctggctgctc gaaacctgct
     1261 tttggctacc cgggacctgg tcaagattgg ggacttcgga ctgatgcgag ctctgcccca
     1321 gaatgatgac cactatgtca tgcaagaaca ccgcaaggtg ccctttgcct ggtgtgcccc
     1381 tgagagcctg aagacacgga ctttctccca tgccagtgac acctggatgt ttggggtcac
     1441 actgtgggag atgttcacct atggccagga gccctggatt ggcctcaatg gcagccagat
     1501 cctgcataag atcgacaagg aaggggagcg cctgccccgg ccggaggact gccctcaaga
     1561 catctacaat gtcatggtcc agtgctgggc ccacaagcca gaggacagac ccacatttgt
     1621 ggctcttcgg gacttcctgc tggaggctca gcccactgac atgcgggctc ttcaggactt
     1681 tgaggagcca gataaactgc acatccagat gaatgacgtc atcactgtca tcgagggaag
     1741 ggctgagaac tactggtggc gtgggcagaa tacgcggacc ctgtgtgtag gacccttccc
     1801 tcgaaatgtc gtgacctccg tggctggcct gtcagcccag gacatcagcc agcctctaca
     1861 gaatagcttc attcacacag gacatggtga cagtgacccc cgccactgct gggggttccc
     1921 tgacaggatc gatgaactgt acctgggaaa ccccatggac cctcctgacc tgctgagtgt
     1981 ggaactgagc acctcccgac ccacccagca cctaggacgg gtgaaaaggg agcctccacc
     2041 tcgcccacct cagcctgcca tcttcactca gaagccaaca tacgaccctg tgagtgagga
     2101 cccagacccc ctgtccagcg acttcaagag gcttggcctg aggaagccag ccctgcctcg
     2161 agggctgtgg ctggcaaagc cctcagcccg agtgccaggc accaaggcag accgcagcag
     2221 tgggggtgag gtcacactca tcgacttcgg tgaggagcct gtggtcccaa cccctcggcc
     2281 ctgtgcaccc tccttggcac agttggccat ggatgcctgc tccttgctgg acaagacacc
     2341 accacagagc cccacacggg cactgccacg acctttacac cccacccctg tggtagactg
     2401 ggacgcgcgt ccgctgcccc cgccccctgc ctatgacgac gtggcccagg atgaggatga
     2461 ctttgaggtc tgctccatca acagcacgct agtaggtgca ggcctccctg ctgggcctag
     2521 ccaaggcgag accaattacg cctttgtacc tgagcaggcg cagatgcccc ctgccctgga
     2581 ggataacctg ttccttccac cccagggcgg aggcaagccg cccagctcag tgcagactgc
     2641 agagattttc caggcactgc agcaggagtg tatgcggcag ctacaggtcc ccactggcca
     2701 gctgaccccc tccccgaccc caggaggtga tgacaagccc caggtgccac cccgggtacc
     2761 tattccccct cggcccacgc gtccacgtgt ggagctatct ccagctccct cgggtgagga
     2821 agagacaagc cggtggcctg gacctgcctc gcccccccga gtgcctcccc gggaacctct
     2881 gtctcctcaa ggttcaagga ccccaagccc cctagtgcca cctggcagct ctccactacc
     2941 gcatcggctc tctagctcac ctggaaagac catgcccacc actcaaagct ttgcctcaga
     3001 ccctaagtat gccactccac aagtgatcca ggctcctggc ccacgggcag gcccctgcat
     3061 cctgcccatt gtccgcgatg gcaggaaggt cagcagcact cattactacc tgctgcctga
     3121 gcgccctcct tacctggaac gctatcagcg cttcctgcgg gaggcccaga gcccggaaga
     3181 gccggccgcc ctgcctgtgc ccccgctgtt gcccccgccc agtactccag cccctgctgc
     3241 ccccactgcc accgtcagac ctatgcctca ggccgcccca gacccaaagg ccaacttctc
     3301 caccaataac agcaacccag gggcacggcc accatccctg agggccacgg ctcggctgcc
     3361 acagaggggc tgcccagggg acgggcaaga ggctgctcgg ccagcagaca aggtccagat
     3421 gctgcaggcc atggtgcatg gggtgaccac agaggagtgc caggcggccc tgcagagcca
     3481 cagctggagt gttcagaggg ctgcccagta tctgaaggtg gagcagctct ttgggctggg
     3541 tcttcggcca cgggtggagt gccacaaggt cctagagatg ttcgactgga acctagagca
     3601 agccggctgt caccttctgg gctcctgtgg ccctgctcat cacaaacgct gatggttgac
     3661 tggagagcag tggtctgccc taaaagaacc tcttgaacct gtctgtggga caagggtggg
     3721 ggagctgccc tgcctcaggc ccgaaggacc cacaactgcc tgcggctccc aggggacagt
     3781 gagacccagg cagcaggagg ctgggagcct caccttgccc acctcgctca cccacccagc
     3841 gctgttctgc acaccttggt tcagccctca gtgccccaag aggtgggacg ttcccagcct
     3901 tgtgaaggca agacaggaag ctgcctggca ggctctgtgt ggcctgcctc tggctccaga
     3961 tcaaggctgg gctggtggct agagtgtgcc ccaggctttc ctctggggga ttagactgac
     4021 aggaagccag gcttgacatg gacaagaagg atgtgttggc cacacagcag ggcgagccag
     4081 caaccaacag gccctcctca gggctaggcc ccttcccagg gaacccctgt aggagtgtgg
     4141 agtgttggac agaatgtgac ctgtagcttc actgtgaact tgtgggcttg gctggtctta
     4201 ggaacttgta cctataaaca gcctgaagtg gctcagaaac agaaaaggtg ccaggatctt
     4261 ctctggcagg gaccagggcc caaggccccg gatgtggaag gagaccccag tggcaccagt
     4321 actttcctgt ttgacctgtt cctcccctgt tgctatctga tgtgttccca tcagcctctg
     4381 ttgccaaagt cgtggcccca gctatggata tctgcttctt ccagagaaat aaagcttgtt
     4441 tctattttat gtta
//
