LOCUS       NM_001289443            2721 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tyrosine kinase, non-receptor, 2 (Tnk2), transcript
            variant 3, mRNA.
ACCESSION   NM_001289443
VERSION     NM_001289443.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2721)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2721)
  AUTHORS   Sridaran,D., Chouhan,S., Mahajan,K., Renganathan,A., Weimholt,C.,
            Bhagwat,S., Reimers,M., Kim,E.H., Thakur,M.K., Saeed,M.A.,
            Pachynski,R.K., Seeliger,M.A., Miller,W.T., Feng,F.Y. and
            Mahajan,N.P.
  TITLE     Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase
            counteracts prostate cancer immune checkpoint blockade resistance
  JOURNAL   Nat Commun 13 (1), 6929 (2022)
   PUBMED   36376335
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2721)
  AUTHORS   Jing,L., Zhang,X., Liu,D., Yang,Y., Xiong,H. and Dong,G.
  TITLE     ACK1 Contributes to the Pathogenesis of Inflammation and
            Autoimmunity by Promoting the Activation of TLR Signaling Pathways
  JOURNAL   Front Immunol 13, 864995 (2022)
   PUBMED   35669783
  REMARK    GeneRIF: ACK1 Contributes to the Pathogenesis of Inflammation and
            Autoimmunity by Promoting the Activation of TLR Signaling Pathways.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2721)
  AUTHORS   Brandao,R., Kwa,M.Q., Yarden,Y. and Brakebusch,C.
  TITLE     ACK1 is dispensable for development, skin tumor formation, and
            breast cancer cell proliferation
  JOURNAL   FEBS Open Bio 11 (6), 1579-1592 (2021)
   PUBMED   33730447
  REMARK    GeneRIF: ACK1 is dispensable for development, skin tumor formation,
            and breast cancer cell proliferation.
REFERENCE   5  (bases 1 to 2721)
  AUTHORS   Fritz,K.R., Zhang,Y. and Ruest,L.B.
  TITLE     Cdc42 activation by endothelin regulates neural crest cell
            migration in the cardiac outflow tract
  JOURNAL   Dev Dyn 248 (9), 795-812 (2019)
   PUBMED   31219639
REFERENCE   6  (bases 1 to 2721)
  AUTHORS   La Torre,A., del Rio,J.A., Soriano,E. and Urena,J.M.
  TITLE     Expression pattern of ACK1 tyrosine kinase during brain development
            in the mouse
  JOURNAL   Gene Expr Patterns 6 (8), 886-892 (2006)
   PUBMED   16750431
  REMARK    GeneRIF: Ack1 is up-regulated during development and is expressed
            in proliferative areas and in migratory pathways in the developing
            brain.
REFERENCE   7  (bases 1 to 2721)
  AUTHORS   Galisteo,M.L., Yang,Y., Urena,J. and Schlessinger,J.
  TITLE     Activation of the nonreceptor protein tyrosine kinase Ack by
            multiple extracellular stimuli
  JOURNAL   Proc Natl Acad Sci U S A 103 (26), 9796-9801 (2006)
   PUBMED   16777958
  REMARK    GeneRIF: These experiments suggest a functional role for Ack as an
            early transducer of multiple extracellular stimuli.
REFERENCE   8  (bases 1 to 2721)
  AUTHORS   Urena,J.M., La Torre,A., Martinez,A., Lowenstein,E., Franco,N.,
            Winsky-Sommerer,R., Fontana,X., Casaroli-Marano,R.,
            Ibanez-Sabio,M.A., Pascual,M., Del Rio,J.A., de Lecea,L. and
            Soriano,E.
  TITLE     Expression, synaptic localization, and developmental regulation of
            Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the
            developing and adult brain
  JOURNAL   J Comp Neurol 490 (2), 119-132 (2005)
   PUBMED   16052498
  REMARK    GeneRIF: Ack1/Pyk1 tyrosine kinase may be involved both in adult
            synaptic function and plasticity and in brain development.
REFERENCE   9  (bases 1 to 2721)
  AUTHORS   Robinson,D.R., Wu,Y.M. and Lin,S.F.
  TITLE     The protein tyrosine kinase family of the human genome
  JOURNAL   Oncogene 19 (49), 5548-5557 (2000)
   PUBMED   11114734
  REMARK    Review article
REFERENCE   10 (bases 1 to 2721)
  AUTHORS   Gertler,F.B., Niebuhr,K., Reinhard,M., Wehland,J. and Soriano,P.
  TITLE     Mena, a relative of VASP and Drosophila Enabled, is implicated in
            the control of microfilament dynamics
  JOURNAL   Cell 87 (2), 227-239 (1996)
   PUBMED   8861907
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB583500.1, AC161755.3 and BC052421.1.
            
            Transcript Variant: This variant (3) differs in its 5' UTR, lacks
            part of the 5' coding region, lacks two in-frame exons in the
            central coding region, and uses a downstream in-frame start codon,
            compared to variant 1. The encoded isoform (3) is shorter, compared
            to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR11927937.5044296.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BB583500.1         2-48
            48-127              AC161755.3         71386-71465         c
            128-2721            BC052421.1         1741-4334
FEATURES             Location/Qualifiers
     source          1..2721
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 23.16 cM"
     gene            1..2721
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /note="tyrosine kinase, non-receptor, 2"
                     /db_xref="GeneID:51789"
                     /db_xref="MGI:MGI:1858308"
     exon            1..127
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     exon            128..322
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     exon            323..414
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             342..1898
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.10.2"
                     /note="isoform 3 is encoded by transcript variant 3; Cdc42
                     GTPase-inhibiting protein; activated CDC42 kinase 1;
                     P21cdc42Hs kinase; non-receptor protein tyrosine kinase
                     ACK; tyrosine kinase non-receptor protein 2"
                     /codon_start=1
                     /product="activated CDC42 kinase 1 isoform 3"
                     /protein_id="NP_001276372.1"
                     /db_xref="GeneID:51789"
                     /db_xref="MGI:MGI:1858308"
                     /translation="MDPPDLLSVELSTSRPTQHLGRVKKPTYDPVSEDPDPLSSDFKR
                     LGLRKPALPRGLWLAKPSARVPGTKADRSSGGEVTLIDFGEEPVVPTPRPCAPSLAQL
                     AMDACSLLDKTPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEVCSI
                     NSTLVGAGLPAGPSQGETNYAFVPEQAQMPPALEDNLFLPPQGGGKPPSSVQTAEIFQ
                     ALQQECMRQLQVPTGQLTPSPTPGGDDKPQVPPRVPIPPRPTRPRVELSPAPSGEEET
                     SRWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPLPHRLSSSPGKTMPTTQSFASD
                     PKYATPQVIQAPGPRAGPCILPIVRDGRKVSSTHYYLLPERPPYLERYQRFLREAQSP
                     EEPAALPVPPLLPPPSTPAPAAPTATVRPMPQAAPDPKANFSTNNSNPGARPPSLRAT
                     ARLPQRGCPGDGQEAARPADKVQMVEQLFGLGLRPRVECHKVLEMFDWNLEQAGCHLL
                     GSCGPAHHKR"
     exon            415..1763
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1891
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2700
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2674..2679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /note="hexamer: AATAAA"
     polyA_site      2700
                     /gene="Tnk2"
                     /gene_synonym="Ack; Ack-1; Ack1; Cdgip; Pyk1"
                     /note="major polyA site"
ORIGIN      
        1 cttccgcccc aggctcctgc tggcttcagc tgctaatact gccacagcgg atgggtcaac
       61 ttctagactg ccttcttctg aggtgccagc ttttactcgg tccctagaac tgctcaggag
      121 gtgggagggc tgagaactac tggtggcgtg ggcagaatac gcggaccctg tgtgtaggac
      181 ccttccctcg aaatgtcgtg acctccgtgg ctggcctgtc agcccaggac atcagccagc
      241 ctctacagaa tagcttcatt cacacaggac atggtgacag tgacccccgc cactgctggg
      301 ggttccctga caggatcgat gaactgtacc tgggaaaccc catggaccct cctgacctgc
      361 tgagtgtgga actgagcacc tcccgaccca cccagcacct aggacgggtg aaaaagccaa
      421 catacgaccc tgtgagtgag gacccagacc ccctgtccag cgacttcaag aggcttggcc
      481 tgaggaagcc agccctgcct cgagggctgt ggctggcaaa gccctcagcc cgagtgccag
      541 gcaccaaggc agaccgcagc agtgggggtg aggtcacact catcgacttc ggtgaggagc
      601 ctgtggtccc aacccctcgg ccctgtgcac cctccttggc acagttggcc atggatgcct
      661 gctccttgct ggacaagaca ccaccacaga gccccacacg ggcactgcca cgacctttac
      721 accccacccc tgtggtagac tgggacgcgc gtccgctgcc cccgccccct gcctatgacg
      781 acgtggccca ggatgaggat gactttgagg tctgctccat caacagcacg ctagtaggtg
      841 caggcctccc tgctgggcct agccaaggcg agaccaatta cgcctttgta cctgagcagg
      901 cgcagatgcc ccctgccctg gaggataacc tgttccttcc accccagggc ggaggcaagc
      961 cgcccagctc agtgcagact gcagagattt tccaggcact gcagcaggag tgtatgcggc
     1021 agctacaggt ccccactggc cagctgaccc cctccccgac cccaggaggt gatgacaagc
     1081 cccaggtgcc accccgggta cctattcccc ctcggcccac gcgtccacgt gtggagctat
     1141 ctccagctcc ctcgggtgag gaagagacaa gccggtggcc tggacctgcc tcgccccccc
     1201 gagtgcctcc ccgggaacct ctgtctcctc aaggttcaag gaccccaagc cccctagtgc
     1261 cacctggcag ctctccacta ccgcatcggc tctctagctc acctggaaag accatgccca
     1321 ccactcaaag ctttgcctca gaccctaagt atgccactcc acaagtgatc caggctcctg
     1381 gcccacgggc aggcccctgc atcctgccca ttgtccgcga tggcaggaag gtcagcagca
     1441 ctcattacta cctgctgcct gagcgccctc cttacctgga acgctatcag cgcttcctgc
     1501 gggaggccca gagcccggaa gagccggccg ccctgcctgt gcccccgctg ttgcccccgc
     1561 ccagtactcc agcccctgct gcccccactg ccaccgtcag acctatgcct caggccgccc
     1621 cagacccaaa ggccaacttc tccaccaata acagcaaccc aggggcacgg ccaccatccc
     1681 tgagggccac ggctcggctg ccacagaggg gctgcccagg ggacgggcaa gaggctgctc
     1741 ggccagcaga caaggtccag atggtggagc agctctttgg gctgggtctt cggccacggg
     1801 tggagtgcca caaggtccta gagatgttcg actggaacct agagcaagcc ggctgtcacc
     1861 ttctgggctc ctgtggccct gctcatcaca aacgctgatg gttgactgga gagcagtggt
     1921 ctgccctaaa agaacctctt gaacctgtct gtgggacaag ggtgggggag ctgccctgcc
     1981 tcaggcccga aggacccaca actgcctgcg gctcccaggg gacagtgaga cccaggcagc
     2041 aggaggctgg gagcctcacc ttgcccacct cgctcaccca cccagcgctg ttctgcacac
     2101 cttggttcag ccctcagtgc cccaagaggt gggacgttcc cagccttgtg aaggcaagac
     2161 aggaagctgc ctggcaggct ctgtgtggcc tgcctctggc tccagatcaa ggctgggctg
     2221 gtggctagag tgtgccccag gctttcctct gggggattag actgacagga agccaggctt
     2281 gacatggaca agaaggatgt gttggccaca cagcagggcg agccagcaac caacaggccc
     2341 tcctcagggc taggcccctt cccagggaac ccctgtagga gtgtggagtg ttggacagaa
     2401 tgtgacctgt agcttcactg tgaacttgtg ggcttggctg gtcttaggaa cttgtaccta
     2461 taaacagcct gaagtggctc agaaacagaa aaggtgccag gatcttctct ggcagggacc
     2521 agggcccaag gccccggatg tggaaggaga ccccagtggc accagtactt tcctgtttga
     2581 cctgttcctc ccctgttgct atctgatgtg ttcccatcag cctctgttgc caaagtcgtg
     2641 gccccagcta tggatatctg cttcttccag agaaataaag cttgtttcta ttttatgtta
     2701 aaaaaaaaaa aaaaaaaaaa a
//
