LOCUS       NM_031880               3220 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tyrosine kinase, non-receptor, 1 (Tnk1), mRNA.
ACCESSION   NM_031880
VERSION     NM_031880.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3220)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3220)
  AUTHORS   Bao,M.H., Lv,Q.L., Li,H.G., Zhang,Y.W., Xu,B.F. and He,B.S.
  TITLE     A Novel Putative Role of TNK1 in Atherosclerotic Inflammation
            Implicating the Tyk2/STAT1 Pathway
  JOURNAL   Mediators Inflamm 2020, 6268514 (2020)
   PUBMED   32694928
  REMARK    GeneRIF: A Novel Putative Role of TNK1 in Atherosclerotic
            Inflammation Implicating the Tyk2/STAT1 Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3220)
  AUTHORS   Armacki,M., Trugenberger,A.K., Ellwanger,A.K., Eiseler,T.,
            Schwerdt,C., Bettac,L., Langgartner,D., Azoitei,N., Halbgebauer,R.,
            Gross,R., Barth,T., Lechel,A., Walter,B.M., Kraus,J.M.,
            Wiegreffe,C., Grimm,J., Scheffold,A., Schneider,M.R., Peuker,K.,
            Zeissig,S., Britsch,S., Rose-John,S., Vettorazzi,S., Wolf,E.,
            Tannapfel,A., Steinestel,K., Reber,S.O., Walther,P., Kestler,H.A.,
            Radermacher,P., Barth,T.F., Huber-Lang,M., Kleger,A. and
            Seufferlein,T.
  TITLE     Thirty-eight-negative kinase 1 mediates trauma-induced intestinal
            injury and multi-organ failure
  JOURNAL   J Clin Invest 128 (11), 5056-5072 (2018)
   PUBMED   30320600
  REMARK    GeneRIF: TNK1 was found to be deregulated in the gut in murine and
            porcine trauma models and human inflammatory bowel disease. Thus,
            TNK1 might be a target during MODS to prevent damage in several
            organs, notably the gut.
REFERENCE   4  (bases 1 to 3220)
  AUTHORS   Walentin,K., Hinze,C., Werth,M., Haase,N., Varma,S., Morell,R.,
            Aue,A., Potschke,E., Warburton,D., Qiu,A., Barasch,J., Purfurst,B.,
            Dieterich,C., Popova,E., Bader,M., Dechend,R., Staff,A.C.,
            Yurtdas,Z.Y., Kilic,E. and Schmidt-Ott,K.M.
  TITLE     A Grhl2-dependent gene network controls trophoblast branching
            morphogenesis
  JOURNAL   Development 142 (6), 1125-1136 (2015)
   PUBMED   25758223
REFERENCE   5  (bases 1 to 3220)
  AUTHORS   Ooi,E.L., Chan,S.T., Cho,N.E., Wilkins,C., Woodward,J., Li,M.,
            Kikkawa,U., Tellinghuisen,T., Gale,M. Jr. and Saito,T.
  TITLE     Novel antiviral host factor, TNK1, regulates IFN signaling through
            serine phosphorylation of STAT1
  JOURNAL   Proc Natl Acad Sci U S A 111 (5), 1909-1914 (2014)
   PUBMED   24449862
  REMARK    GeneRIF: The activated TNK1 potentiates JAK-STAT signaling through
            dual phosphorylation of STAT1 at tyrosine 701 and serine 727 amino
            acid positions.
REFERENCE   6  (bases 1 to 3220)
  AUTHORS   Hoare,S., Hoare,K., Reinhard,M.K., Flagg,T.O. and May,W.S. Jr.
  TITLE     Functional characterization of the murine Tnk1 promoter
  JOURNAL   Gene 444 (1-2), 1-9 (2009)
   PUBMED   19481140
  REMARK    GeneRIF: cellular stress reverses the repression of Tnk1/Kos1 and
            induces its expression through increased high affinity interactions
            between nuclear proteins Sp1, Sp3, AP2 and MED1 for the m-Tnk1
            promoter
REFERENCE   7  (bases 1 to 3220)
  AUTHORS   Hoare,S., Hoare,K., Reinhard,M.K., Lee,Y.J., Oh,S.P. and May,W.S.
            Jr.
  TITLE     Tnk1/Kos1 knockout mice develop spontaneous tumors
  JOURNAL   Cancer Res 68 (21), 8723-8732 (2008)
   PUBMED   18974114
  REMARK    GeneRIF: Tnk1/Kos1 is a tumor suppressor that functions to
            down-regulate Ras activity
REFERENCE   8  (bases 1 to 3220)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   9  (bases 1 to 3220)
  AUTHORS   Hoare,K., Hoare,S., Smith,O.M., Kalmaz,G., Small,D. and Stratford
            May,W.
  TITLE     Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling
  JOURNAL   Oncogene 22 (23), 3562-3577 (2003)
   PUBMED   12789265
  REMARK    GeneRIF: data support a negative regulatory role for Kos1 in
            regulating the Ras-Raf1-MAPK growth pathway by a mechanism that
            requires its autotyrosine kinase activity
REFERENCE   10 (bases 1 to 3220)
  AUTHORS   Robinson,D.R., Wu,Y.M. and Lin,S.F.
  TITLE     The protein tyrosine kinase family of the human genome
  JOURNAL   Oncogene 19 (49), 5548-5557 (2000)
   PUBMED   11114734
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK167292.1, AK033440.1, BB676903.1 and BX528991.1.
            
            On Nov 10, 2009 this sequence version replaced NM_031880.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029623.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-630               AK167292.1         2-631
            631-2631            AK033440.1         2-2002
            2632-2780           BB676903.1         275-423
            2781-3220           BX528991.1         1-440               c
FEATURES             Location/Qualifiers
     source          1..3220
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.9 cM"
     gene            1..3220
                     /gene="Tnk1"
                     /gene_synonym="Kos1; Tnk1a; Tnk1b"
                     /note="tyrosine kinase, non-receptor, 1"
                     /db_xref="GeneID:83813"
                     /db_xref="MGI:MGI:1930958"
     exon            1..24
                     /gene="Tnk1"
                     /gene_synonym="Kos1; Tnk1a; Tnk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            25..129
                     /gene="Tnk1"
                     /gene_synonym="Kos1; Tnk1a; Tnk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            130..343
                     /gene="Tnk1"
                     /gene_synonym="Kos1; Tnk1a; Tnk1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..2181
                     /gene="Tnk1"
                     /gene_synonym="Kos1; Tnk1a; Tnk1b"
                     /EC_number="2.7.10.2"
                     /note="non-receptor tyrosine kinase; kinase of embryonic
                     stem cells"
                     /codon_start=1
                     /product="non-receptor tyrosine-protein kinase TNK1"
                     /protein_id="NP_114086.3"
                     /db_xref="CCDS:CCDS24917.1"
                     /db_xref="GeneID:83813"
                     /db_xref="MGI:MGI:1930958"
                     /translation="MLPEASSLWLLRLLRDVQLAQFYRPILEELNVTRPEHFDFVRPE
                     DLDNIGMGRPAQRRLNEALKRYRSGVKSKNWVYKILGGFAPEQKEIPPRSDSPLCFHE
                     PEGGLKCLIPEGAVRRGELLGSGCFGVVHRGLWTLPSGQSIPVAVKSLRVGPEGPMGT
                     ELGDFLREVSVMMKLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLP
                     VALLCLFLRQLAGAMAYLGSCGLVHRDLATRNLLLASPRMIKVADFGLVRPLGGARGR
                     YVMGGPRPIPYAWCAPESLRQGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQ
                     RLEKDRARLPKPPLCSRALYSLALRCWAPHPADRPSFSNLEGLLQEAWLSEGRCVREV
                     TEPGALRMEPGDPITIIEGSLDTATWKGQNGRTLKVGNFPASAVTLADLGGSPVTHPA
                     HRGSPAHGEKCRGGTDGDREKATLQDLPPARSHRTKMPLQRMRGISKSLESVLSLGPR
                     PTGGGSSPPELRRTRAMPQRLPDLPPRPPDLPPRPPIICNSSQPTQPHKARPKRESSH
                     NHRTGAPGASKATVPSGGPLSDPEWQRKVVEVELSVHGVTYQECQVALRTTGGDVASA
                     IRNLKVDQLFHLSNRSRADCRRILEHHQWDLSAASRYILARS"
     exon            344..414
                     /gene="Tnk1"
                     /gene_synonym="Kos1; Tnk1a; Tnk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            415..606
                     /gene="Tnk1"
                     /gene_synonym="Kos1; Tnk1a; Tnk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            607..762
                     /gene="Tnk1"
                     /gene_synonym="Kos1; Tnk1a; Tnk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            763..1046
                     /gene="Tnk1"
                     /gene_synonym="Kos1; Tnk1a; Tnk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1320
                     /gene="Tnk1"
                     /gene_synonym="Kos1; Tnk1a; Tnk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1415
                     /gene="Tnk1"
                     /gene_synonym="Kos1; Tnk1a; Tnk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1580
                     /gene="Tnk1"
                     /gene_synonym="Kos1; Tnk1a; Tnk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1660
                     /gene="Tnk1"
                     /gene_synonym="Kos1; Tnk1a; Tnk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1971
                     /gene="Tnk1"
                     /gene_synonym="Kos1; Tnk1a; Tnk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2067
                     /gene="Tnk1"
                     /gene_synonym="Kos1; Tnk1a; Tnk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..3220
                     /gene="Tnk1"
                     /gene_synonym="Kos1; Tnk1a; Tnk1b"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2621
                     /gene="Tnk1"
                     /gene_synonym="Kos1; Tnk1a; Tnk1b"
                     /note="major polyA site"
     polyA_site      2635
                     /gene="Tnk1"
                     /gene_synonym="Kos1; Tnk1a; Tnk1b"
                     /note="major polyA site"
     regulatory      2667..2672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnk1"
                     /gene_synonym="Kos1; Tnk1a; Tnk1b"
                     /note="hexamer: ATTATA"
     polyA_site      2703
                     /gene="Tnk1"
                     /gene_synonym="Kos1; Tnk1a; Tnk1b"
     polyA_site      2783
                     /gene="Tnk1"
                     /gene_synonym="Kos1; Tnk1a; Tnk1b"
ORIGIN      
        1 agctgcctct tccgccttcg ccagttctca ggccgcctgg ggtgaccaac tccccacgct
       61 ccccacctcc acctcccacc tcagacctcc gatctaggac ttcctcgtgg tataactaca
      121 gagagacagg ccatccattt aaagcagtcg gccatcctcc tgagacatct gaccccagac
      181 atgctccctg aagccagttc cctgtggctc cttcggctac tccgggatgt tcaactggcc
      241 cagttttacc ggcccatcct tgaggaactc aacgtcactc ggccagaaca ttttgacttt
      301 gtaaggcctg aggacctgga caacataggc atgggcaggc ctgcccagcg cagacttaat
      361 gaagccctga agaggtaccg gtcaggggtc aagtccaaga attgggtgta caagatactt
      421 gggggctttg ctcccgaaca gaaggagatc cctccacgct cagacagtcc tctgtgcttc
      481 catgagccag aggggggact caagtgtctg attccagagg gtgctgtgcg cagaggggag
      541 ctgctgggtt caggctgctt tggtgttgta catcgagggt tatggacact acccagtggg
      601 cagagtatcc cagtggcggt caagtccctc cgtgtgggtc ccgagggtcc gatgggcaca
      661 gaactgggcg acttcctgcg ggaagtatct gtcatgatga agctagagca cccacacgtg
      721 ctgcgcctgc atggcctcgt actgggccag cctctacaga tggtgatgga acttgcgcca
      781 ctgggctccc tgcatgcgcg cctgactgcc ccagcaccga cacccccact gcctgtggcc
      841 ctgctgtgcc tttttctgcg tcagttggca ggagccatgg cgtacttggg gtcctgtggg
      901 ttagtgcacc gggatctcgc cacccgcaac ctgctgctgg cctcacctcg aatgatcaag
      961 gtggcggatt ttggactggt tcggccactg ggaggcgccc ggggacgcta cgtcatgggc
     1021 gggccccgtc ctatccccta tgcctggtgt gccccagaga gcctacgcca gggagccttc
     1081 tcgtctgcct ctgatgtgtg gatgtttggc gtgacactct gggaaatgtt ttctggaggt
     1141 gaggaaccct gggcaggtgt cccaccatat ctcatcctac agcgactgga gaaggaccga
     1201 gccaggctgc caaagcctcc cctgtgttcc agggccctct actccctcgc cttgcgctgc
     1261 tgggccccac accctgcaga ccggcctagc ttttccaacc tggaagggct gcttcaagag
     1321 gcttggcttt ctgagggacg ctgtgtgagg gaggtcacag agccaggtgc tttgcggatg
     1381 gaacccggtg accccatcac tatcattgag ggcagcctgg acactgcaac ctggaaaggc
     1441 cagaatggcc ggaccctcaa agtgggcaac tttccggctt ccgcagtgac actagcagac
     1501 ttggggggtt caccagtcac ccatccagcc cacagaggtt cccctgccca tggagagaaa
     1561 tgcagagggg gcacagatgg ggacagagag aaggcaacgt tacaagacct acccccagca
     1621 cggagccaca gaacgaagat gcccctgcag aggatgcgag gcatttccaa gagtctggaa
     1681 tcagttctgt ccctgggccc tagacccaca ggaggtggtt caagtcctcc agaacttcgg
     1741 cgtacaagag ctatgccgca aagactccca gacctacctc cacgcccacc agacctgcct
     1801 ccacgcccac ctattatctg caactcttct cagcccaccc agccccacaa agcccggccc
     1861 aaaagagaat cctcacataa tcaccgcact ggagcacctg gagccagcaa agccactgtc
     1921 ccctctggag gtcccttgtc agaccccgag tggcagagga aggttgtaga ggtagagctg
     1981 agtgtgcatg gtgtcaccta ccaggagtgc caagtggcac tcagaaccac tgggggagat
     2041 gtggcttctg ctatccggaa cctcaaggta gaccagctct tccaccttag taaccggtcc
     2101 cgagcagact gtcgtcgcat cctggagcat caccagtggg acctgtcagc agccagtcgc
     2161 tacatcctag cccggtcctg aactctgtat cctcagggat ggacaccagc atgggttacc
     2221 tggtccactt agggcttggc cttacggact aatcagaaca tgaggtcttg acggaggcac
     2281 gctgagggag atttacctgc tgtgaggagt gacaggaagt gtatagggca ctcaggtact
     2341 ggctaatgct tcctccgagc cctgctcctt ggcctctgaa gggaccaaga ccaagtccac
     2401 tctgcctact atattcccaa ttgaacagga cttgaaagaa aaagctttgg aggaggcctc
     2461 tactcactac agacaaggat caagtagcaa taccggatca ctgaccaacc gtcggaactg
     2521 tcattagcta cttccctaaa ctctatgggg cacccaactt agatattgac ttgggagctg
     2581 ctctggtttg gtccagaatc actatgggtg atgaaaacta actttttgga ctcaaggact
     2641 tttttccttt aatccaaata gtgtagatta tacaggctgg ctgacgccgc tccctttgtg
     2701 ttatccggta tctaccctct cccatcacat ccggcttcta ctgtttaaaa agtttcaaag
     2761 tttatatgag tacaacatac aaagacacag cctccttcct acagtagggg aaggaagggg
     2821 ttaacggtta aataaggcac aggaagctgc agaaagcacc cgcagggccc aggggcttag
     2881 ggagttggca ctggggccca accgctacag ctattagtga ggaggcaagg atcccctcag
     2941 agtgccacaa tcggaagcta aactaattgg ctaaagtgcc ataagggaag ggtggtgtct
     3001 gccatctttg gtactgcttg ccttttaccc acaagccctg gggtaaaact tgagtccagg
     3061 attccagatg cccctgccta tgcagaggcc ccagaggaag gctggaagga gtgtgcaagg
     3121 aagtttaaaa gctaatgtgt gcacaggcac tgcctggaga tggtgaacag aaggaggaac
     3181 aggtctcata catgctcttc tgcagggcca caggagaagc
//
