LOCUS       NM_001001495            3769 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus TNFAIP3 interacting protein 3 (Tnip3), mRNA.
ACCESSION   NM_001001495
VERSION     NM_001001495.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3769)
  AUTHORS   Shi,H., Yu,Y., Li,D., Zhu,K., Cheng,X., Ma,T., Tao,Z., Hong,Y.,
            Liu,Z., Zhou,S., Zhang,J., Chen,Y., Zhang,X.J., Zhang,P. and Li,H.
  TITLE     TNIP3 protects against pathological cardiac hypertrophy by
            stabilizing STAT1
  JOURNAL   Cell Death Dis 15 (6), 450 (2024)
   PUBMED   38926347
  REMARK    GeneRIF: TNIP3 protects against pathological cardiac hypertrophy by
            stabilizing STAT1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3769)
  AUTHORS   Liu,D., Zhang,P., Zhou,J., Liao,R., Che,Y., Gao,M.M., Sun,J.,
            Cai,J., Cheng,X., Huang,Y., Chen,G., Nie,H., Ji,Y.X., Zhang,X.J.,
            Huang,Z., Xu,H., She,Z.G. and Li,H.
  TITLE     TNFAIP3 Interacting Protein 3 Overexpression Suppresses
            Nonalcoholic Steatohepatitis by Blocking TAK1 Activation
  JOURNAL   Cell Metab 31 (4), 726-740 (2020)
   PUBMED   32268115
  REMARK    GeneRIF: TNFAIP3 Interacting Protein 3 Overexpression Suppresses
            Nonalcoholic Steatohepatitis by Blocking TAK1 Activation.
REFERENCE   3  (bases 1 to 3769)
  AUTHORS   Kasowitz,S.D., Ma,J., Anderson,S.J., Leu,N.A., Xu,Y., Gregory,B.D.,
            Schultz,R.M. and Wang,P.J.
  TITLE     Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and
            splicing during mouse oocyte development
  JOURNAL   PLoS Genet 14 (5), e1007412 (2018)
   PUBMED   29799838
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3769)
  AUTHORS   Weaver,B.K., Bohn,E., Judd,B.A., Gil,M.P. and Schreiber,R.D.
  TITLE     ABIN-3: a molecular basis for species divergence in
            interleukin-10-induced anti-inflammatory actions
  JOURNAL   Mol Cell Biol 27 (13), 4603-4616 (2007)
   PUBMED   17485448
  REMARK    GeneRIF: ABIN-3 is, thus, an IL-10-induced gene product capable of
            attenuating NF-kappaB in human macrophages yet is inoperative in
            mice and represents a basis for species-specific differences in
            IL-10 actions.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102145.3, BC104393.1 and AC153884.1.
            
            [WARNING] On Jan 31, 2025 this sequence was replaced by
            NM_001001495.3.
            
            On Jul 25, 2006 this sequence version replaced NM_001001495.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033534.1, EF585494.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AC102145.3         29995-30191         c
            198-1083            BC104393.1         1-886
            1084-3769           AC153884.1         135231-137916       c
FEATURES             Location/Qualifiers
     source          1..3769
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 30.26 cM"
     gene            1..3769
                     /gene="Tnip3"
                     /gene_synonym="9030611K07Rik; ABIN-3; LIND"
                     /note="TNFAIP3 interacting protein 3"
                     /db_xref="GeneID:414084"
                     /db_xref="MGI:MGI:3041165"
     exon            1..255
                     /gene="Tnip3"
                     /gene_synonym="9030611K07Rik; ABIN-3; LIND"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..837
                     /gene="Tnip3"
                     /gene_synonym="9030611K07Rik; ABIN-3; LIND"
                     /note="TNIP3 beta; ABIN-3 beta; TNFAIP3-interacting
                     protein 3 beta"
                     /codon_start=1
                     /product="TNFAIP3-interacting protein 3"
                     /protein_id="NP_001001495.2"
                     /db_xref="CCDS:CCDS39501.1"
                     /db_xref="GeneID:414084"
                     /db_xref="MGI:MGI:3041165"
                     /translation="MSGLSAAGACMEHTECAPPRRKDLTNSLERKIKHLEKQRQELLD
                     VNQQWDQQFRNMKELYERKVLELKTKLAATENTHTLVKEQKQSVTEGDRQLEKEKDSL
                     RKELQALKKENKLLKENNALANRKKEHYACEIKRLNKVLQDALTIGSSSLSEDSGKCK
                     GRCSHAEMRREVEWHKQQPAYQWNALSQLPPRVQHKAHGFSSERKTDL"
     exon            256..333
                     /gene="Tnip3"
                     /gene_synonym="9030611K07Rik; ABIN-3; LIND"
                     /inference="alignment:Splign:2.1.0"
     exon            334..399
                     /gene="Tnip3"
                     /gene_synonym="9030611K07Rik; ABIN-3; LIND"
                     /inference="alignment:Splign:2.1.0"
     exon            400..498
                     /gene="Tnip3"
                     /gene_synonym="9030611K07Rik; ABIN-3; LIND"
                     /inference="alignment:Splign:2.1.0"
     exon            499..627
                     /gene="Tnip3"
                     /gene_synonym="9030611K07Rik; ABIN-3; LIND"
                     /inference="alignment:Splign:2.1.0"
     exon            628..744
                     /gene="Tnip3"
                     /gene_synonym="9030611K07Rik; ABIN-3; LIND"
                     /inference="alignment:Splign:2.1.0"
     exon            745..805
                     /gene="Tnip3"
                     /gene_synonym="9030611K07Rik; ABIN-3; LIND"
                     /inference="alignment:Splign:2.1.0"
     exon            806..3769
                     /gene="Tnip3"
                     /gene_synonym="9030611K07Rik; ABIN-3; LIND"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1495..1500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnip3"
                     /gene_synonym="9030611K07Rik; ABIN-3; LIND"
                     /note="hexamer: AATAAA"
     polyA_site      1515
                     /gene="Tnip3"
                     /gene_synonym="9030611K07Rik; ABIN-3; LIND"
     regulatory      1988..1993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnip3"
                     /gene_synonym="9030611K07Rik; ABIN-3; LIND"
                     /note="hexamer: AATAAA"
     polyA_site      2010
                     /gene="Tnip3"
                     /gene_synonym="9030611K07Rik; ABIN-3; LIND"
                     /note="major polyA site"
ORIGIN      
        1 atccttattc tgtgtggtta acatacagtc acttctgctg gagtctaagg agaacttgtt
       61 attattttct accgcgagtc aacagagaca taggttttcc aaagcttgcc cgttctcatc
      121 gtgaaaggca ctataagagc ttttctttct ctctttttcc ttctgcttta caagactctc
      181 agaaaaacag cttccttgtc ttcccaggac atgtctggac tgagtgcggc tggagcttgc
      241 atggagcaca cagagtgtgc tccaccaaga agaaaggact tgacaaattc tcttgaacga
      301 aagataaaac acttggaaaa acagagacaa gagctcctgg atgtcaatca acaatgggac
      361 cagcaattcc gaaatatgaa agagttatat gaaagaaagg tcctggagct gaaaactaaa
      421 ctggcggcca cagaaaacac tcacacccta gtgaaggaac agaagcaaag tgtgacagag
      481 ggcgacaggc agctcgagaa ggaaaaggac agcctaagga aagaattaca ggcactgaag
      541 aaggagaata agctgttgaa agaaaacaac gctctggcca acaggaagaa agagcattat
      601 gcatgtgaaa ttaaacgcct caataaggtt cttcaggatg ccttgaccat tgggagctct
      661 tcgctttctg aggactcagg gaagtgtaaa ggcaggtgca gccatgcaga gatgagaaga
      721 gaggtggaat ggcacaagca gcagccagcc tatcagtgga atgctctcag ccagcttcct
      781 ccacgtgtac agcacaaggc acatggtttc tcctcagaaa ggaaaaccga cctgtagcat
      841 tacgttagca gagaagagca gagggttgtg agctctcagc tgtgaccgct ttgctgcttc
      901 aggacatctg tgaacgttct ccttcgagat ctgctcccag ttaccttctc tgtgaccctc
      961 ataggggaaa cctcatagtg gtctcagtca ggaccactgg gacccagtag aactctacag
     1021 acaaatcggg cttctcttct caaatgacac aggacatgat tacatgctcc tcctcacagc
     1081 tctcctcaac taactactga tggctttggg aagatgcctc caggatggag atgactccag
     1141 ctctggtgct gtgacattat atacttttga gaatgtacag ttcttaagcc aggcacagtg
     1201 gtgcctctta taattccatg agaagttgct gcaggaagat tgtaatgatt tcaaggccag
     1261 cctgggttgc aacacaaata ccacataagc caattctgca tctcaaaaaa ttagtaatac
     1321 accgtgtagt ccctggaaga aaactttttt ctataatggc taagttaatt cttcagtggt
     1381 ttgacagttg gactaggtga caagttcatt attattgaac tgaaactaca tgaattttaa
     1441 tagacaatca aaagacctac acactcccct gactaaaaag agtgagtcaa actaaataaa
     1501 atgacaaaca tgaaattgcc cttccagtgg atcattttat gcttgtcaga agttatgagc
     1561 ctctttcatc ttttggtaac atacataatg aaaaggaact gtcctgacag gatggtgacg
     1621 gccaccttct gtctatatgt agtcagccag aattgccaaa aacagccttt gaggttctgt
     1681 gtttttgcca gcctgtgaat ttgagcaatg gttgaagaaa tttgactatg acattttgaa
     1741 cttactaaca taaaaataac acatctatac attttattgc agttgaattg caaagtaacc
     1801 taacagattt cttaaaaagc cagcagtttt aaaagcatta agttcatctt ctgtaagatt
     1861 ttgctcatgt caacttgagt ttctgtttgt aaggatgaat gttcctgaca agagtgcgag
     1921 aactgcacat atctaacact tctagatgaa cctaaataga accaataaca tccagcaaac
     1981 atgtgcaaat aaaactaccg gatctatcta tcttcgcttc cataattatg cagcttgtct
     2041 aactcaaact atttttgttt taatttgtgg gtacacactg cataatgaga aggtaaaaaa
     2101 gtcccaggaa actgaacatt tccccttcag tctttatcta tggtgtaact taacccttaa
     2161 gagaagcaga atgaccctgc gacatttgct cccaagtcct ttgtttatgc agctatttat
     2221 cggaaagata agtcatcctt ggctatcact ttaagtcaga aaaacaactg tcagctctag
     2281 gaagacattc tacatattgg aattttcagt ttcttcagat tgctaacaaa atcattgtaa
     2341 tgtctgttac tcctgctaaa ttaagtttat gaaacaagat gtgcttatag aattttttaa
     2401 aatgtacact cttcccaggc cagtagctaa tgtctgcagc aaaaatacat ggtttgtcta
     2461 ttcaaactgc ccctattcta ttaacaaggt gccaaacact ggaagaatgc ataaatgtta
     2521 acctaggtgg agaatagtta aaaaggacta atatcatttt tcatcccaga ctctttttta
     2581 ttttttcatt cagactctgt taccagagag atttcaaccc ctcattctta tgtccttttc
     2641 cccataacat gtctggagac atctctgccc ggaatcataa taaggttcag actctcctct
     2701 gtgggtctgt tttatttttg acacagagtt tgtgggcatt agtgagcaat agctgtatgg
     2761 ctttcaaagg aacagaggtc atgatgcctg tctgaggaag gaaacttaaa agcaggcata
     2821 cttcaagagt ctggatgatc atggagaatt tgatctttga cttgaagata tcacatgaag
     2881 agaaacatgt gttcactttg ttttggttgt tacataagtt tagaaggaaa ctgcaggtct
     2941 ggtaacatcc agggcatagg tcagccatgc ctcctcctcg atggctttat tttgcttcat
     3001 tggttttagg ctttattttc tattttgtac tgtgttcact gagctctgat accagaaaaa
     3061 aagaaaaaag aagaaaaaaa ggaaagacaa agaaaaaata tataattatg tttttgtgat
     3121 ggctgattga tctgaaactt acagaggctc gggtatcttt cctgagacaa cctcagaggg
     3181 ggaagcccag gtgtgtggat gccacagctc tgctttctag tctacaccag aaagttatgc
     3241 tctctgtgtt gatgcatttg gttttcatta attctatcat aggatcatag ttctgaaaaa
     3301 aaatatttag aaaaaatact acattataca gaattattaa gttatatcct gagttaaaag
     3361 aaatgtctta tttagatgat gtgaggaaag aaatgtgcac aaagtgtatg agatacccca
     3421 agaatgggta tgttgttgct tttgacttca aacattttta tcagaggtct gtcgtagtac
     3481 aatcagatat aaaatatata tcgtaggtaa tagaaatggc agtgaaacag tcactccagc
     3541 tgtcatgact tacataacct cttaattctt ttaaatgact gccctcttgc actgcacgtg
     3601 ggtagatcca catttggaaa ggacagggca gttaccagcc caaaatctcc ccaacttaag
     3661 ggtctcattg ttacttttct gtctatttgt ttttgtcatt tctctcctat cttgctgaaa
     3721 tcctcatggt tagagtctct agattctgta gcattaaaag tgcagctgc
//
