LOCUS       NM_001199275            2996 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus TNFAIP3 interacting protein 1 (Tnip1), transcript
            variant 2, mRNA.
ACCESSION   NM_001199275
VERSION     NM_001199275.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2996)
  AUTHORS   Medhavy,A., Athanasopoulos,V., Bassett,K., He,Y., Stanley,M., Enosi
            Tuipulotu,D., Cappello,J., Brown,G.J., Gonzalez-Figueroa,P.,
            Turnbull,C., Shanmuganandam,S., Tummala,P., Hart,G., Lea-Henry,T.,
            Wang,H., Nambadan,S., Shen,Q., Roco,J.A., Burgio,G., Wu,P., Cho,E.,
            Andrews,T.D., Field,M.A., Wu,X., Ding,H., Guo,Q., Shen,N.,
            Man,S.M., Jiang,S.H., Cook,M.C. and Vinuesa,C.G.
  TITLE     A TNIP1-driven systemic autoimmune disorder with elevated IgG4
  JOURNAL   Nat Immunol 25 (9), 1678-1691 (2024)
   PUBMED   39060650
REFERENCE   2  (bases 1 to 2996)
  AUTHORS   Janusova,S., Paprckova,D., Michalik,J., Uleri,V., Drobek,A.,
            Salyova,E., Chorfi,L., Neuwirth,A., Andreyeva,A., Prochazka,J.,
            Sedlacek,R., Draber,P. and Stepanek,O.
  TITLE     ABIN1 is a negative regulator of effector functions in cytotoxic T
            cells
  JOURNAL   EMBO Rep 25 (8), 3456-3485 (2024)
   PUBMED   38877170
REFERENCE   3  (bases 1 to 2996)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2996)
  AUTHORS   Wu,X., Wang,Y., Chen,B., Liu,Y., Li,F., Ou,Y., Zhang,H., Wu,X.,
            Li,X., Wang,L., Rong,W., Liu,J., Xing,M., Zhao,X., Liu,H., Ge,L.,
            Lv,A., Wang,L., Wang,Z., Li,M. and Zhang,H.
  TITLE     ABIN1 (Q478) is Required to Prevent Hematopoietic Deficiencies
            through Regulating Type I IFNs Expression
  JOURNAL   Adv Sci (Weinh) 11 (3), e2303555 (2024)
   PUBMED   38009796
  REMARK    GeneRIF: ABIN1 (Q478) is Required to Prevent Hematopoietic
            Deficiencies through Regulating Type I IFNs Expression.
REFERENCE   5  (bases 1 to 2996)
  AUTHORS   Bao,J., Ye,B. and Ren,Y.
  TITLE     ABIN1 Inhibits Inflammation through Necroptosis-Dependent Pathway
            in Ulcerative Colitis
  JOURNAL   Genet Res (Camb) 2022, 9313559 (2022)
   PUBMED   36034412
  REMARK    GeneRIF: ABIN1 Inhibits Inflammation through Necroptosis-Dependent
            Pathway in Ulcerative Colitis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2996)
  AUTHORS   Wagner,S., Carpentier,I., Rogov,V., Kreike,M., Ikeda,F., Lohr,F.,
            Wu,C.J., Ashwell,J.D., Dotsch,V., Dikic,I. and Beyaert,R.
  TITLE     Ubiquitin binding mediates the NF-kappaB inhibitory potential of
            ABIN proteins
  JOURNAL   Oncogene 27 (26), 3739-3745 (2008)
   PUBMED   18212736
REFERENCE   7  (bases 1 to 2996)
  AUTHORS   El Bakkouri,K., Wullaert,A., Haegman,M., Heyninck,K. and Beyaert,R.
  TITLE     Adenoviral gene transfer of the NF-kappa B inhibitory protein
            ABIN-1 decreases allergic airway inflammation in a murine asthma
            model
  JOURNAL   J Biol Chem 280 (18), 17938-17944 (2005)
   PUBMED   15722346
  REMARK    GeneRIF: Using a murine model of allergen-induced asthma, we have
            demonstrated that adenovirus-mediated delivery of ABIN-1 to the
            lung epithelium results in a reduction of allergen-induced
            eosinophil infiltration into the lungs.
REFERENCE   8  (bases 1 to 2996)
  AUTHORS   Heyninck,K., Kreike,M.M. and Beyaert,R.
  TITLE     Structure-function analysis of the A20-binding inhibitor of
            NF-kappa B activation, ABIN-1
  JOURNAL   FEBS Lett 536 (1-3), 135-140 (2003)
   PUBMED   12586352
REFERENCE   9  (bases 1 to 2996)
  AUTHORS   Gupta,K., Ott,D., Hope,T.J., Siliciano,R.F. and Boeke,J.D.
  TITLE     A human nuclear shuttling protein that interacts with human
            immunodeficiency virus type 1 matrix is packaged into virions
  JOURNAL   J Virol 74 (24), 11811-11824 (2000)
   PUBMED   11090181
REFERENCE   10 (bases 1 to 2996)
  AUTHORS   Heyninck,K., De Valck,D., Vanden Berghe,W., Van Criekinge,W.,
            Contreras,R., Fiers,W., Haegeman,G. and Beyaert,R.
  TITLE     The zinc finger protein A20 inhibits TNF-induced
            NF-kappaB-dependent gene expression by interfering with an RIP- or
            TRAF2-mediated transactivation signal and directly binds to a novel
            NF-kappaB-inhibiting protein ABIN
  JOURNAL   J Cell Biol 145 (7), 1471-1482 (1999)
   PUBMED   10385526
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL593846.15.
            
            On Sep 27, 2012 this sequence version replaced NM_001199275.1.
            
            Transcript Variant: This variant (2) contains an alternate exon in
            the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same
            isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC008186.1, SRR13422592.265381.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849374,
                                    SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AL593846.15        87325-87432         c
            109-266             AL593846.15        80513-80670         c
            267-438             AL593846.15        65203-65374         c
            439-576             AL593846.15        64090-64227         c
            577-695             AL593846.15        62439-62557         c
            696-776             AL593846.15        60953-61033         c
            777-968             AL593846.15        58481-58672         c
            969-1063            AL593846.15        55257-55351         c
            1064-1187           AL593846.15        53587-53710         c
            1188-1277           AL593846.15        51196-51285         c
            1278-1343           AL593846.15        48868-48933         c
            1344-1475           AL593846.15        48590-48721         c
            1476-1604           AL593846.15        45253-45381         c
            1605-1736           AL593846.15        43098-43229         c
            1737-1862           AL593846.15        42292-42417         c
            1863-1928           AL593846.15        41748-41813         c
            1929-2120           AL593846.15        41288-41479         c
            2121-2211           AL593846.15        39989-40079         c
            2212-2996           AL593846.15        35279-36063         c
FEATURES             Location/Qualifiers
     source          1..2996
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 32.13 cM"
     gene            1..2996
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /note="TNFAIP3 interacting protein 1"
                     /db_xref="GeneID:57783"
                     /db_xref="MGI:MGI:1926194"
     exon            1..108
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            109..266
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            267..438
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..2246
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /note="isoform 1 is encoded by transcript variant 2;
                     A20-binding inhibitor of NF-kappa B activation;
                     virion-associated nuclear shuttling protein;
                     Nef-associated factor 1"
                     /codon_start=1
                     /product="TNFAIP3-interacting protein 1 isoform 1"
                     /protein_id="NP_001186204.1"
                     /db_xref="CCDS:CCDS24704.1"
                     /db_xref="GeneID:57783"
                     /db_xref="MGI:MGI:1926194"
                     /translation="MEGRGPYGIYDPGGSTPLGEVSAAFERLVEENTRLKGKMQGIKM
                     LGELLEESQMEASRLRQKAEELVKDSELSPPTSAPSLVSFDDLAELTGQDTKVQVHPA
                     TSTAATTTATATTGNSMEKPEPASKSPSNGASSDFEVVPTEEQNSPETGSHPTNMMDL
                     GPPPPEDSNLKLHLQRLETTLSVCAEEPDHSQLFTHLGRMALEFNRLASKVHKNEQRT
                     SILQTLCEQLRQENEALKAKLDKGLEQRDLAAERLREENTELKKLLMNSSCKEGLCGQ
                     PSSPKPEGAGKKGVAGQQQASVMASKVPEAGAFGAAEKKVKLLEQQRMELLEVNKQWD
                     QHFRSMKQQYEQKITELRQKLVDLQKQVTELEAEREQKQRDFDRKLLLAKSKIEMEET
                     DKEQLTAEAKELRQKVRYLQDQLSPLTRQREYQEKEIQRLNKALEEALSIQASPSSPP
                     AAFGSPEGVGGHLRKQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQVE
                     KLQAQVTLTNAQLKTLKEEEKAKEALKQQKRKAKASGERYHMEPHPEHVCGAYPYAYP
                     PMPAMVPHHAYKDWSQIRYPPPPVPMEHPPPHPNSRLFHLPEYTWRPPCAGIRNQSSQ
                     VMDPPPDRPAEPESADNDCDGPQ"
     exon            439..576
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            577..695
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            696..776
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            777..968
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1063
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1187
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1277
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1343
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1475
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1604
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1736
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1862
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1928
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2120
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2211
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2996
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2974..2979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /note="hexamer: CATAAA"
     polyA_site      2996
                     /gene="Tnip1"
                     /gene_synonym="ABIN; ABIN-1; ABIN1; Naf1; Nef; VAN"
                     /note="major polyA site"
ORIGIN      
        1 tcagaaagcc cagcaacctt cacagggaca cagggaggca tggccgcact cactgggcac
       61 atcttcagat cacctcgtgc attctcggat gagtgacctg ggctgaagac cccgccccgg
      121 cgcccagcgc gcaacgccat tggacagacc gtacatcggt ctccggggac tttcccaggg
      181 gcgtggcgtg gccctggcat ttcctggtac cgaccggagc ttagattctg cgagtctggc
      241 cccggccccg aagctctcgt cctaggctag gcggccgtca cggcaggggt tgagccaccc
      301 tcatggaagg gagaggaccc tacgggatct acgacccagg gggcagcacg cctctgggag
      361 aggtgtccgc agcttttgaa cgtctagtgg aggagaatac tcggctgaag ggaaaaatgc
      421 aagggataaa gatgttaggg gagcttctgg aggagtctca gatggaagcg tccagactcc
      481 ggcagaaggc agaggagctg gtcaaggaca gcgagctgtc accaccgaca tctgccccct
      541 ccttggtctc ctttgatgac ctggctgagc tcacaggaca ggatacaaag gtccaggtac
      601 atcctgctac cagcactgcc gccaccacca ccgccaccgc caccacggga aactccatgg
      661 agaagcccga gccagcctcc aaatctccgt ccaatggcgc ctcctcggac tttgaagtgg
      721 tccctactga ggagcagaat tcacccgaaa ctggcagcca ccctacgaac atgatggacc
      781 tggggccccc acccccagag gacagcaacc tgaagctcca cctgcagcgc ctggagacca
      841 cccttagcgt gtgtgcagag gagccagacc acagccagct cttcacccac ctgggccgca
      901 tggccctcga gttcaacagg ttggcctcca aagtgcataa aaatgagcag cgcacctcca
      961 tcctgcagac cttatgtgag cagctgcgcc aggagaatga agccctgaag gccaagctgg
     1021 acaagggcct ggaacagcgg gatctggctg ctgagaggct gcgggaggaa aacacggagc
     1081 tcaagaaact gttgatgaac agcagctgca aagagggact ctgtgggcag cccagctccc
     1141 caaagccaga gggtgctggc aagaagggcg tggctggaca gcagcaggcc agtgtgatgg
     1201 cgagtaaagt ccctgaagcg ggggcctttg gagcagctga gaagaaggtg aagttgctag
     1261 aacagcaacg catggagctg ctggaagtga acaagcagtg ggaccagcat ttccggtcca
     1321 tgaagcagca gtatgagcag aagatcacag agcttcgcca gaagctggtg gacctgcaga
     1381 aacaggtaac tgagctggag gccgaacggg agcagaagca gcgtgacttt gaccggaaac
     1441 tcctcctggc caaatcgaag atagagatgg aagagaccga caaggagcag ctgacagcag
     1501 aggccaagga actgcgccag aaggtcaggt acctacagga tcagctgagc ccgctcacaa
     1561 ggcaacgaga ataccaggag aaggagatcc agcggctcaa taaggccctg gaggaggccc
     1621 tcagcatcca ggcctctcca tcatctccgc ctgcagcttt tgggagtcca gaaggcgttg
     1681 ggggccatct gaggaagcag gaactagtga cacagaatga gttgctgaaa cagcaggtaa
     1741 agatctttga agaggacttc cagagggaac ggagtgaccg tgaacgcatg aatgaagaga
     1801 aggaggagct gaagaagcaa gtagagaagc tgcaggccca ggtcaccctg actaatgccc
     1861 agctcaaaac tctcaaagag gaggagaagg ccaaggaagc cctcaaacag cagaagagga
     1921 aagcaaaggc ttcgggagag cgctaccaca tggaacccca ccctgagcac gtctgcggcg
     1981 cctatcccta tgcctaccca cccatgccag ccatggtacc tcaccatgcc tacaaggact
     2041 ggtcccagat ccgataccct ccaccccctg tgcccatgga gcacccgccc ccacacccca
     2101 actctcgcct cttccatctg ccggagtaca cctggcgtcc accctgtgca gggattcgga
     2161 atcagagctc tcaagtgatg gacccgcccc cagacaggcc tgcagagcca gagtctgcag
     2221 acaatgactg tgatgggccc cagtgaggct gcagtgggtc atttggttcc accttcatct
     2281 ttcagagcca gctgacctca gattgccaaa agtttgaagg ccatgtgcat gttctgtgtg
     2341 acccaagcct tggcagagga gaggctggga tgggtagctg gctcacatcc ccagccaagc
     2401 ctcgaactgt tgacaagacc agggagaatc cacccatggg cgcccaccag gttcttatgg
     2461 atgcaagcag gagaagctca acaccctgcc tcttgccaag acaaggaagc ctcacctggc
     2521 tttgacctgc catccgttgc tgaggccact ggcttccatc ctaagaatga ggtgcaacaa
     2581 gaccccattc tcacagaacc tcaaagactt ggttccaggc tctccagaga ccatacccaa
     2641 ctcatgtgca tgtgccgttt ttgcttcaag ctcagtagca ggacctgccc cgagccccct
     2701 gctccttgcc cctctgtgag gagttacgga gagggctttg tctctagagc agaagagaat
     2761 gatgggacgg cctgatgctg tcatgctctc cactgcacct gtggcagcct cctgagagcc
     2821 accaagatct gggatgaagg ccacaccagc catgtctgct gaagggcccc agactgagat
     2881 gactccggcc tccacagtta gatgtttatg gtgccagagg tctatattaa ggtagctgtc
     2941 tgttgctagg cagccgtttg cacaaatctt ggacataaat ccaacttgaa gatcaa
//
