LOCUS       NM_001034097            2235 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus tumor necrosis factor (ligand) superfamily,
            membrane-bound member 13 (Tnfsfm13), transcript variant 1, mRNA.
ACCESSION   NM_001034097
VERSION     NM_001034097.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2235)
  AUTHORS   Howard L, Wosnitzka E, Okakpu D, White MA, Wyatt S and Davies AM.
  TITLE     TWE-PRIL reverse signalling suppresses sympathetic axon growth and
            tissue innervation
  JOURNAL   Development 145 (22) (2018)
   PUBMED   30337376
  REMARK    GeneRIF: the first and physiologically relevant role for TWE-PRIL
            is reported and suggests that it mediates reverse signalling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2235)
  AUTHORS   Pradet-Balade B, Medema JP, Lopez-Fraga M, Lozano JC, Kolfschoten
            GM, Picard A, Martinez-A C, Garcia-Sanz JA and Hahne M.
  TITLE     An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell
            surface TWEAK-APRIL fusion protein
  JOURNAL   EMBO J 21 (21), 5711-5720 (2002)
   PUBMED   12411489
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044387.1.
            
            On Oct 29, 2010 this sequence version replaced NM_001034097.1.
            
            Summary: This gene represents read-through transcription between
            neighboring genes encoding tumor necrosis factor family members.
            This results a hybrid protein composed of the cytoplasmic and
            transmembrane domains of family member 12 fused to the C-terminal
            domain of family member 13. The homologous fusion protein in human
            is known to be membrane-anchored and presents the receptor-binding
            domain of family member 13 at the cell surface. It stimulates
            cycling in T- and B-lymphoma cell lines. Alternative splicing of
            this mouse gene results in multiple transcript variants. [provided
            by RefSeq, Oct 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044387.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 21944, 69583
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2235              AK044387.1         2-2236
FEATURES             Location/Qualifiers
     source          1..2235
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.86 cM"
     gene            1..2235
                     /gene="Tnfsfm13"
                     /gene_synonym="Tnfsf12-Tnfsf13; Tnfsf12tnfsf13;
                     Tnfsf12Tnfsf13; Twe-pril"
                     /note="tumor necrosis factor (ligand) superfamily,
                     membrane-bound member 13"
                     /db_xref="GeneID:619441"
                     /db_xref="MGI:MGI:3845075"
     exon            1..503
                     /gene="Tnfsfm13"
                     /gene_synonym="Tnfsf12-Tnfsf13; Tnfsf12tnfsf13;
                     Tnfsf12Tnfsf13; Twe-pril"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..1577
                     /gene="Tnfsfm13"
                     /gene_synonym="Tnfsf12-Tnfsf13; Tnfsf12tnfsf13;
                     Tnfsf12Tnfsf13; Twe-pril"
                     /note="isoform a is encoded by transcript variant 1; tumor
                     necrosis factor (ligand) superfamily, member 12-member 13;
                     Tnfsf12-Tnfsf13 readthrough transcript"
                     /codon_start=1
                     /product="tumor necrosis factor (ligand) superfamily,
                     member 12-member 13 isoform a"
                     /protein_id="NP_001029269.1"
                     /db_xref="GeneID:619441"
                     /db_xref="MGI:MGI:3845075"
                     /translation="MAARRSQRRRGRRGEPGTALLAPLVLSLGLALACLGLLLVVVSL
                     GSWATLSAQQEPSQEELTAEDRREPPELNPQTEESQDVVPFLEQLVRPRRSAPKGRKA
                     RPRRAIAAHYEVHPRPGQDGAQAGVDGTVSGWEETKINSSSPLRYDRQIGEFTVIRAG
                     LYYLYCQVHFDEGKAVYLKLDLLVNGVLALRCLEEFSATAASSPGPQLRLCQTELQSL
                     RREVSRLQRSGGPSQKQGERPWQSLWEQSPDVLEAWKDGAKSRRRRAVLTQKHKKKHS
                     VLHLVPVNITSKADSDVTEVMWQPVLRRGRGLEAQGDIVRVWDTGIYLLYSQVLFHDV
                     TFTMGQVVSREGQGRRETLFRCIRSMPSDPDRAYNSCYSAGVFHLHQGDIITVKIPRA
                     NAKLSLSPHGTFLGFVKL"
     exon            504..554
                     /gene="Tnfsfm13"
                     /gene_synonym="Tnfsf12-Tnfsf13; Tnfsf12tnfsf13;
                     Tnfsf12Tnfsf13; Twe-pril"
                     /inference="alignment:Splign:2.1.0"
     exon            555..630
                     /gene="Tnfsfm13"
                     /gene_synonym="Tnfsf12-Tnfsf13; Tnfsf12tnfsf13;
                     Tnfsf12Tnfsf13; Twe-pril"
                     /inference="alignment:Splign:2.1.0"
     exon            631..684
                     /gene="Tnfsfm13"
                     /gene_synonym="Tnfsf12-Tnfsf13; Tnfsf12tnfsf13;
                     Tnfsf12Tnfsf13; Twe-pril"
                     /inference="alignment:Splign:2.1.0"
     exon            685..720
                     /gene="Tnfsfm13"
                     /gene_synonym="Tnfsf12-Tnfsf13; Tnfsf12tnfsf13;
                     Tnfsf12Tnfsf13; Twe-pril"
                     /inference="alignment:Splign:2.1.0"
     exon            721..845
                     /gene="Tnfsfm13"
                     /gene_synonym="Tnfsf12-Tnfsf13; Tnfsf12tnfsf13;
                     Tnfsf12Tnfsf13; Twe-pril"
                     /inference="alignment:Splign:2.1.0"
     exon            846..980
                     /gene="Tnfsfm13"
                     /gene_synonym="Tnfsf12-Tnfsf13; Tnfsf12tnfsf13;
                     Tnfsf12Tnfsf13; Twe-pril"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1082
                     /gene="Tnfsfm13"
                     /gene_synonym="Tnfsf12-Tnfsf13; Tnfsf12tnfsf13;
                     Tnfsf12Tnfsf13; Twe-pril"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1161
                     /gene="Tnfsfm13"
                     /gene_synonym="Tnfsf12-Tnfsf13; Tnfsf12tnfsf13;
                     Tnfsf12Tnfsf13; Twe-pril"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1209
                     /gene="Tnfsfm13"
                     /gene_synonym="Tnfsf12-Tnfsf13; Tnfsf12tnfsf13;
                     Tnfsf12Tnfsf13; Twe-pril"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1328
                     /gene="Tnfsfm13"
                     /gene_synonym="Tnfsf12-Tnfsf13; Tnfsf12tnfsf13;
                     Tnfsf12Tnfsf13; Twe-pril"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1467
                     /gene="Tnfsfm13"
                     /gene_synonym="Tnfsf12-Tnfsf13; Tnfsf12tnfsf13;
                     Tnfsf12Tnfsf13; Twe-pril"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..2235
                     /gene="Tnfsfm13"
                     /gene_synonym="Tnfsf12-Tnfsf13; Tnfsf12tnfsf13;
                     Tnfsf12Tnfsf13; Twe-pril"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2214..2219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfsfm13"
                     /gene_synonym="Tnfsf12-Tnfsf13; Tnfsf12tnfsf13;
                     Tnfsf12Tnfsf13; Twe-pril"
                     /note="putative"
ORIGIN      
        1 ggggccaggg cccgcgtccc atccctggca cactggcctg ggtgggtgcc tgtccacttc
       61 tgctttcact ggccctcaga gttcttggtc tggagtgcca ctgcggtcgc ctgcctgcac
      121 gcgcccgggc gcaggacgtc tcttacttct tgcacagcac tccggggagg ttggagttta
      181 atcacacaaa cagtgtccgg cttcctgtcc tcatccgccc cccctccggc ccgcttccct
      241 ggtccctccc tctcccctgg cccgatccgc ccaccagctc cccctcccca tccctcgggt
      301 cccgggatgg gggggcggtg aggcaggcac agccccccgc ccccatggcc gcccgtcgga
      361 gccagaggcg gagggggcgc cggggggagc cgggcaccgc cctgctggcc ccgctggtgc
      421 tgagcctggg cctggcgctg gcctgccttg gcctcctgct ggtcgtggtc agcctgggga
      481 gctgggcaac gctgtctgcc cagcaggagc cttctcagga ggagctgaca gcagaggacc
      541 gccgggagcc ccctgaactg aatccccaga cagaggaaag ccaggatgtg gtacctttct
      601 tggaacaact agtccggcct cgaagaagtg ctcctaaagg ccggaaggcg cggcctcgcc
      661 gagctattgc agcccattat gaggttcatc ctcggccagg acaggatgga gcacaagcag
      721 gtgtggatgg gacagtgagt ggctgggaag agaccaaaat caacagctcc agccctctgc
      781 gctacgaccg ccagattggg gaatttacag tcatcagggc tgggctctac tacctgtact
      841 gtcaggtgca ctttgatgag ggaaaggctg tctacctgaa gctggacttg ctggtgaacg
      901 gtgtgctggc cctgcgctgc ctggaagaat tctcagccac agcagcaagc tctcctgggc
      961 cccagctccg tttgtgccag acagagctgc aaagcctaag gcgggaggtg agccggctgc
     1021 agcggagtgg agggccttcc cagaagcagg gagagcgccc atggcagagc ctctgggagc
     1081 agagtcctga tgtcctggaa gcctggaagg atggggcgaa atctcggaga aggagagcag
     1141 tactcaccca gaagcacaag aagaagcact cagtcctgca tcttgttcca gttaacatta
     1201 cctccaaggc agactctgac gtgacagagg tgatgtggca accagtactt aggcgtggga
     1261 gaggcctgga ggcccaggga gacattgtac gagtctggga cactggaatt tatctgctct
     1321 atagtcaggt cctgtttcat gatgtgactt tcacaatggg tcaggtggta tctcgggaag
     1381 gacaagggag aagagaaact ctattccgat gtatcagaag tatgccttct gatcctgacc
     1441 gtgcctacaa tagctgctac agtgcaggtg tctttcattt acatcaaggg gatattatca
     1501 ctgtcaaaat tccacgggca aacgcaaaac ttagcctttc tccgcatgga acattcctgg
     1561 ggtttgtgaa actatgattg ttataaaggg ggtggggatt tcccattcca aaaactggct
     1621 agacaaagga caaggaacgg tcaagaacag ctctccatgg ctttgccttg actgttgttc
     1681 ctccctttgc ctttcccgct cccactatct gggctttgac tccatggata ttaaaaaagt
     1741 agaatatttt gtgtttatct cccacacagc cccaaattct tttgttgtgt gtgcgaaggg
     1801 ggttttgcgc actgtgccaa gccttgtcca ctggaatgca tccagaacag cagcaccatc
     1861 tagcggcagg ttgaggaaag actatggtct ctgctaggga aaaccttatc caactcttca
     1921 agtaccctct gcttcaatta acaagaagcc cggctttcag tatttcacct attgcgtcca
     1981 aattcttgtt actatctaga aaaagatata tgttaggtgc ctcgatatgc atgccattca
     2041 tcctccccat tctcctatac acttccgagc tgggcactga gctttacgcc ttaaatcaca
     2101 gtactcggga ggcagatctc gatgagttcg aggccaactt ggtctaaata gtgagttcca
     2161 ggccacccag gggttacaat ggtgagaccc tgtctcaaac aaactaacaa acaaataaac
     2221 gaaaggctct ccacg
//
