LOCUS       NM_009403               2228 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus tumor necrosis factor (ligand) superfamily, member 8
            (Tnfsf8), mRNA.
ACCESSION   NM_009403
VERSION     NM_009403.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2228)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2228)
  AUTHORS   Foreman,T.W., Nelson,C.E., Sallin,M.A., Kauffman,K.D., Sakai,S.,
            Otaizo-Carrasquero,F., Myers,T.G. and Barber,D.L.
  TITLE     CD30 co-stimulation drives differentiation of protective T cells
            during Mycobacterium tuberculosis infection
  JOURNAL   J Exp Med 220 (8) (2023)
   PUBMED   37097292
REFERENCE   3  (bases 1 to 2228)
  AUTHORS   Fukushima,Y., Sakamoto,K., Matsuda,M., Yoshikai,Y., Yagita,H.,
            Kitamura,D., Chihara,M., Minato,N. and Hattori,M.
  TITLE     cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic
            activation of senescence-associated T cells
  JOURNAL   Cell Rep 40 (12), 111373 (2022)
   PUBMED   36130493
  REMARK    GeneRIF: cis interaction of CD153 with TCR/CD3 is crucial for the
            pathogenic activation of senescence-associated T cells.
REFERENCE   4  (bases 1 to 2228)
  AUTHORS   Mei,C., Meng,F., Wang,X., Yan,S., Zheng,Q., Zhang,X., Fu,W.,
            Xue,J., Wang,S., He,Y., Sun,X., Jiang,X. and Wang,Y.
  TITLE     CD30L is involved in the regulation of the inflammatory response
            through inducing homing and differentiation of monocytes via
            CCL2/CCR2 axis and NF-kappaB pathway in mice with colitis
  JOURNAL   Int Immunopharmacol 110, 108934 (2022)
   PUBMED   35834956
  REMARK    GeneRIF: CD30L is involved in the regulation of the inflammatory
            response through inducing homing and differentiation of monocytes
            via CCL2/CCR2 axis and NF-kappaB pathway in mice with colitis.
REFERENCE   5  (bases 1 to 2228)
  AUTHORS   Sato,Y., Oguchi,A., Fukushima,Y., Masuda,K., Toriu,N.,
            Taniguchi,K., Yoshikawa,T., Cui,X., Kondo,M., Hosoi,T.,
            Komidori,S., Shimizu,Y., Fujita,H., Jiang,L., Kong,Y.,
            Yamanashi,T., Seita,J., Yamamoto,T., Toyokuni,S., Hamazaki,Y.,
            Hattori,M., Yoshikai,Y., Boor,P., Floege,J., Kawamoto,H.,
            Murakawa,Y., Minato,N. and Yanagita,M.
  TITLE     CD153/CD30 signaling promotes age-dependent tertiary lymphoid
            tissue expansion and kidney injury
  JOURNAL   J Clin Invest 132 (2) (2022)
   PUBMED   34813503
  REMARK    GeneRIF: CD153/CD30 signaling promotes age-dependent tertiary
            lymphoid tissue expansion and kidney injury.
REFERENCE   6  (bases 1 to 2228)
  AUTHORS   Qureshi,S.T., Lariviere,L., Sebastiani,G., Clermont,S., Skamene,E.,
            Gros,P. and Malo,D.
  TITLE     A high-resolution map in the chromosomal region surrounding the Lps
            locus
  JOURNAL   Genomics 31 (3), 283-294 (1996)
   PUBMED   8838309
REFERENCE   7  (bases 1 to 2228)
  AUTHORS   Hahne,M., Peitsch,M.C., Irmler,M., Schroter,M., Lowin,B.,
            Rousseau,M., Bron,C., Renno,T., French,L. and Tschopp,J.
  TITLE     Characterization of the non-functional Fas ligand of gld mice
  JOURNAL   Int Immunol 7 (9), 1381-1386 (1995)
   PUBMED   7495745
REFERENCE   8  (bases 1 to 2228)
  AUTHORS   Vogel,S.N., Wax,J.S., Perera,P.Y., Padlan,C., Potter,M. and
            Mock,B.A.
  TITLE     Construction of a BALB/c congenic mouse, C.C3H-Lpsd, that expresses
            the Lpsd allele: analysis of chromosome 4 markers surrounding the
            Lps gene
  JOURNAL   Infect Immun 62 (10), 4454-4459 (1994)
   PUBMED   7927709
REFERENCE   9  (bases 1 to 2228)
  AUTHORS   McClive,P.J. and Morahan,G.
  TITLE     Assignment of the mouse homologues of 6 loci from HSA1p to
            chromosomes 3 and 4
  JOURNAL   Genomics 23 (1), 243-246 (1994)
   PUBMED   7829080
REFERENCE   10 (bases 1 to 2228)
  AUTHORS   Smith,C.A., Gruss,H.J., Davis,T., Anderson,D., Farrah,T., Baker,E.,
            Sutherland,G.R., Brannan,C.I., Copeland,N.G., Jenkins,N.A. et al.
  TITLE     CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose
            ligand defines an emerging family of cytokines with homology to TNF
  JOURNAL   Cell 73 (7), 1349-1360 (1993)
   PUBMED   8391931
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK030916.1.
            
            On Apr 5, 2007 this sequence version replaced NM_009403.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030916.1, L09754.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2228              AK030916.1         2-2229
FEATURES             Location/Qualifiers
     source          1..2228
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 34.06 cM"
     gene            1..2228
                     /gene="Tnfsf8"
                     /gene_synonym="CD153; Cd30l; CD30LG; Tnlg3a"
                     /note="tumor necrosis factor (ligand) superfamily, member
                     8"
                     /db_xref="GeneID:21949"
                     /db_xref="MGI:MGI:88328"
     exon            1..435
                     /gene="Tnfsf8"
                     /gene_synonym="CD153; Cd30l; CD30LG; Tnlg3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..945
                     /gene="Tnfsf8"
                     /gene_synonym="CD153; Cd30l; CD30LG; Tnlg3a"
                     /note="CD30-L; CD30 ligand; tumor necrosis factor ligand
                     3a"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     8"
                     /protein_id="NP_033429.1"
                     /db_xref="CCDS:CCDS18264.1"
                     /db_xref="GeneID:21949"
                     /db_xref="MGI:MGI:88328"
                     /translation="MEPGLQQAGSCGAPSPDPAMQVQPGSVASPWRSTRPWRSTSRSY
                     FYLSTTALVCLVVAVAIILVLVVQKKDSTPNTTEKAPLKGGNCSEDLFCTLKSTPSKK
                     SWAYLQVSKHLNNTKLSWNEDGTIHGLIYQDGNLIVQFPGLYFIVCQLQFLVQCSNHS
                     VDLTLQLLINSKIKKQTLVTVCESGVQSKNIYQNLSQFLLHYLQVNSTISVRVDNFQY
                     VDTNTFPLDNVLSVFLYSSSD"
     exon            436..478
                     /gene="Tnfsf8"
                     /gene_synonym="CD153; Cd30l; CD30LG; Tnlg3a"
                     /inference="alignment:Splign:2.1.0"
     exon            479..550
                     /gene="Tnfsf8"
                     /gene_synonym="CD153; Cd30l; CD30LG; Tnlg3a"
                     /inference="alignment:Splign:2.1.0"
     exon            551..2228
                     /gene="Tnfsf8"
                     /gene_synonym="CD153; Cd30l; CD30LG; Tnlg3a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1015..1020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfsf8"
                     /gene_synonym="CD153; Cd30l; CD30LG; Tnlg3a"
                     /note="hexamer: AAGAAA"
     polyA_site      1042
                     /gene="Tnfsf8"
                     /gene_synonym="CD153; Cd30l; CD30LG; Tnlg3a"
                     /note="major polyA site"
     regulatory      1849..1854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfsf8"
                     /gene_synonym="CD153; Cd30l; CD30LG; Tnlg3a"
                     /note="hexamer: AACAAA"
     polyA_site      1876
                     /gene="Tnfsf8"
                     /gene_synonym="CD153; Cd30l; CD30LG; Tnlg3a"
ORIGIN      
        1 agattaatcc caggcgatga aaaatgaacc tctcccccac ccttgcagcc acccttcgcc
       61 tcacgccccc agagaagagt ttctccatcc ggcaactggt gaaggctttt ttccaagtca
      121 catgatccag gatgcagggg aaaatccttc ttggaacaga gctgggtaca gaaccgaatc
      181 agatgaggag agataaggtg tgatgtggga cagactatat aaagcatgga gccagggctg
      241 caacaagcag gcagctgtgg ggctccttcc cctgacccag ccatgcaggt gcagcccggc
      301 tcggtagcca gcccctggag aagcacgagg ccctggagaa gcacaagtcg cagctacttc
      361 tacctcagca ccaccgcact ggtgtgcctt gttgtggcag tggcgatcat tctggtactg
      421 gtagtccaga aaaaggactc cactccaaat acaactgaga aggcccccct taaaggagga
      481 aattgctcag aggatctctt ctgtaccctg aaaagtactc catccaagaa gtcatgggcc
      541 tacctccaag tgtcaaagca tctcaacaat accaaactgt catggaacga agatggcacc
      601 atccacggac tcatatacca ggacgggaac ctgatagtcc aattccctgg cttgtacttc
      661 atcgtttgcc aactgcagtt cctcgtgcag tgctcaaatc attctgtgga cctgacattg
      721 cagctcctca tcaattccaa gatcaaaaag cagacgttgg taacagtgtg tgagtctgga
      781 gttcagagta agaacatcta ccagaatctc tctcagtttt tgctgcatta cttacaggtc
      841 aactctacca tatcagtcag ggtggataat ttccagtatg tggatacaaa cactttccct
      901 cttgataatg tgctatccgt cttcttatat agtagctcag actgaatagt tgttcttaac
      961 ctttatgaaa atgctgtcta ccatacagta cttcatctgt ccaaacatgg gccaaagaaa
     1021 atattaggac aactcaaact aagcatgtga gttagtgcac ttctctttct gtcctttgga
     1081 aaaatacaaa cccaggattt agaaagtgga gtctccttca gatgcacaaa caggaaagaa
     1141 tgtgatatgt gcacagagac ctacttgggc actagaaggg gttgagttgt cccagtataa
     1201 ccactaattc actgaccttg agccattttt ccttcccctg gaacttgggg tctgaatctg
     1261 gaaaagtagg agatgagatt tacatttccc caatattttc ttcaactcag aagacgagac
     1321 tgtggagctg agctccctac acagatgaag gcctcccatg gcatgaggaa aatgatggta
     1381 ccagtaatgt ctgtctgact gtcatctcag caagtcctaa ggacttccat gctgccttgt
     1441 tgaaagatac tctaacctct tgtaatgggc aaagtgatcc tgtctctcac tgaggggagt
     1501 agctgctgcc atctcctgag acatacatgg agacattttc tgcccaaatt ccattctgtg
     1561 tgcagttttt aagtattccc ccaaaagttc ttgacaatga gaactttgaa tgtgggaaga
     1621 gcttctggac agcaaacatt aacagcttct cctgaccaga gagaccatgc aagcttggtc
     1681 ttagacccat caagcttgag gtttctacat tgtgggagac agacttttga caaaccattt
     1741 gagttgatgt ctgggcccct gggagttctc cttcagtaag gagagcaagc cgttctagtg
     1801 ctgtgtcaga ggatggagta aaatagacac ttttctgaag gaaaggagaa caaagttcca
     1861 gaaaaaggct agaaaatgtt taaaaggaaa agaaaaaact cagcttttct catatgagag
     1921 gaacccagaa aaacaacact gaaaaagaag agtggctctg tcaacctcct cttaggtctc
     1981 ctcctctcta gttattggga aaggagttgc atggtacagg acaagttctg gtgtgtggtc
     2041 aaatagaatc agatgtggag aacaccatgc agagaataag gagacctgtc atatttgtgt
     2101 tgtactcaaa tgaggggcaa atgaatctta ggctaaatca aataacagtc tctgtcaagc
     2161 tgtgctcaga aagtcaacca ctgaagatgg agggtgaggc acgtcattta aaaaaagtga
     2221 aatgtagc
//
